Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMAPO0T)

Drug Name
Ciglitazone Drug Info
Synonyms
ciglitazone; 74772-77-3; Ciglitizone; ADD-3878; Ciglitazonum; Ciglitazona; Ciglitazonum [Latin]; Ciglitazona [Spanish]; Ciglitazone [USAN:INN]; ADD 3878; CHEBI:64227; U-63287; (+-)-5-(p-((1-Methylcyclohexyl)methoxy)benzyl)-2,4-thiazolidinedione; C18H23NO3S; 5-(4-((1-methylcyclohexyl)methoxy)benzyl)thiazolidine-2,4-dione; YZFWTZACSRHJQD-UHFFFAOYSA-N; (+/-)-5-[4-(1-Methylcyclohexylmethoxy)benzyl]thiazolidine-2,4-dione; U 63287; 5-{4-[(1-methylcyclohexyl)methoxy]benzyl}-1,3-thiazolidine-2,4-dione; NCGC00164446-01
Indication
Disease Entry ICD 11 Status REF
Pulmonary fibrosis CB03.4 Preclinical [1]
Cross-matching ID
PubChem CID
2750
ChEBI ID
CHEMBL7002
CAS Number
CAS 74772-77-3
TTD Drug ID
DMAPO0T
INTEDE Drug ID
DR0322

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Peroxisome proliferator-activated receptor gamma (PPAR-gamma)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [10]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [11]
Lobeglitazone DMHY3IP Type-2 diabetes 5A11 Approved [12]
Rosiglitazone XR DMT45MU Type-2 diabetes 5A11 Approved [13]
Thiazolidinedione DMC1NBW Alzheimer disease 8A20 Approved [11]
Glitazone DMDN4A1 N. A. N. A. Phase 4 [14]
MURAGLITAZAR DMG3NFZ N. A. N. A. Phase 3 [15]
Rivoglitazone DMBY31K Ocular inflammation 9C61.24 Phase 3 [16]
Balaglitazone DMXBHR6 Type-1 diabetes 5A10 Phase 3 [17]
Ragaglitazar DMFSHEM Type-1 diabetes 5A10 Phase 3 [18]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [19]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [20]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [21]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [22]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [23]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [24]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [25]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [26]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [20]
Verapamil DMA7PEW Angina pectoris BA40 Approved [27]
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Drug(s) Metabolized By Cytochrome P450 2C8 (CYP2C8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [28]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [29]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [29]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [30]
Verapamil DMA7PEW Angina pectoris BA40 Approved [31]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [32]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [33]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [29]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [34]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [35]
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Drug(s) Affected By Proline dehydrogenase 1, mitochondrial (PRODH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [36]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [37]
Panobinostat DM58WKG Chronic graft versus host disease Approved [38]
Testosterone DM7HUNW Hot flushes GA30 Approved [39]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [39]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [40]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [41]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [36]
Menthol DMG2KW7 Back pain ME84.Z Approved [42]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [43]
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Drug(s) Affected By Acyl-CoA (FADS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [44]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [45]
Testosterone DM7HUNW Hot flushes GA30 Approved [39]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [39]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [46]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [47]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [4]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [48]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [49]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [50]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [51]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [52]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [53]
Paclitaxel DMLB81S Breast carcinoma Approved [54]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [55]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [56]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [57]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [58]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [59]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [60]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [61]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [62]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [63]
Gefitinib DM15F0X Colon adenocarcinoma Approved [64]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [65]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [66]
Etretinate DM2CZFA Keratosis ED56 Approved [67]
Prednisone DM2HG4X Acute asthma CA23 Approved [68]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [69]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [70]
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Drug(s) Affected By Bile salt export pump (ABCB11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [6]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [71]
Glipizide DMZA5PQ Diabetic complication 5A2Y Approved [71]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [72]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [6]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [71]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [73]
Gefitinib DM15F0X Colon adenocarcinoma Approved [6]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [74]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [6]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [75]
Gefitinib DM15F0X Colon adenocarcinoma Approved [76]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [77]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [78]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [79]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [69]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [79]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [80]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [81]
Methotrexate DM2TEOL Anterior urethra cancer Approved [82]
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Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [83]
Triacetin DM0AEPG Onychomycosis EE12.1 Approved [84]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [85]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [86]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [87]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [66]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [88]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [89]
Methotrexate DM2TEOL Anterior urethra cancer Approved [90]
Quercetin DM3NC4M Obesity 5B81 Approved [91]
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Drug(s) Affected By Eukaryotic translation initiation factor 2A (EIF2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [86]
Quercetin DM3NC4M Obesity 5B81 Approved [92]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [93]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [94]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [95]
Cerulenin DM6N4PR Weight loss MG43.5 Approved [96]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [97]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [98]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [40]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [99]
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Drug(s) Affected By Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [100]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [85]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [87]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [101]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [87]
Quercetin DM3NC4M Obesity 5B81 Approved [102]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [87]
Pyrazinamide DM4IF32 Meningeal tuberculosis Approved [103]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [104]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [105]
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Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [106]
Gefitinib DM15F0X Colon adenocarcinoma Approved [64]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [107]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [78]
Etretinate DM2CZFA Keratosis ED56 Approved [67]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [108]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [109]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [110]
Quercetin DM3NC4M Obesity 5B81 Approved [111]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [112]
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Drug(s) Affected By Myc proto-oncogene protein (MYC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [113]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [85]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [114]
Gefitinib DM15F0X Colon adenocarcinoma Approved [115]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [116]
Selenium DM25CGV N. A. N. A. Approved [117]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [118]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [119]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [120]
Methotrexate DM2TEOL Anterior urethra cancer Approved [44]
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Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [121]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [122]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [85]
Gefitinib DM15F0X Colon adenocarcinoma Approved [123]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [124]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [125]
Methotrexate DM2TEOL Anterior urethra cancer Approved [126]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [127]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [128]
Quercetin DM3NC4M Obesity 5B81 Approved [129]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [56]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [52]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [130]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [59]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [60]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [131]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [132]
Gefitinib DM15F0X Colon adenocarcinoma Approved [133]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [134]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [135]
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Drug(s) Affected By Transcription factor p65 (RELA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [58]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [136]
Selenium DM25CGV N. A. N. A. Approved [137]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [138]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [128]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [139]
Quercetin DM3NC4M Obesity 5B81 Approved [91]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [140]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [93]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [141]
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Drug(s) Affected By Type II iodothyronine deiodinase (DIO2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [75]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [143]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [144]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [145]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [99]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [43]
Ergocalciferol DMHO0AR Hypoparathyroidism 5A50 Approved [146]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [147]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [148]
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Drug(s) Affected By Nuclear receptor coactivator 1 (NCOA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [149]
Quercetin DM3NC4M Obesity 5B81 Approved [150]
Testosterone DM7HUNW Hot flushes GA30 Approved [151]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [99]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [152]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [153]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [154]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [155]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [156]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [157]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Peroxisome proliferator-activated receptor gamma (PPAR-gamma) TTZMAO3 PPARG_HUMAN Agonist [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [3]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Substrate [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Acyl-CoA (FADS1) OTUYOYHX FADS1_HUMAN Gene/Protein Processing [4]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Gene/Protein Processing [5]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Gene/Protein Processing [6]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [7]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Gene/Protein Processing [8]
E3 ubiquitin-protein ligase XIAP OT24GP9B XIAP_HUMAN Gene/Protein Processing [5]
Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3) OT0DZGY4 E2AK3_HUMAN Post-Translational Modifications [8]
Eukaryotic translation initiation factor 2A (EIF2A) OTWXELQP EIF2A_HUMAN Post-Translational Modifications [8]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [7]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Gene/Protein Processing [9]

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