Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMAPO0T)

• Drug Name: Ciglitazone Drug Info
• Synonyms: ciglitazone; 74772-77-3; Ciglitizone; ADD-3878; Ciglitazonum; Ciglitazona; Ciglitazonum [Latin]; Ciglitazona [Spanish]; Ciglitazone [USAN:INN]; ADD 3878; CHEBI:64227; U-63287; (+-)-5-(p-((1-Methylcyclohexyl)methoxy)benzyl)-2,4-thiazolidinedione; C18H23NO3S; 5-(4-((1-methylcyclohexyl)methoxy)benzyl)thiazolidine-2,4-dione; YZFWTZACSRHJQD-UHFFFAOYSA-N; (+/-)-5-[4-(1-Methylcyclohexylmethoxy)benzyl]thiazolidine-2,4-dione; U 63287; 5-{4-[(1-methylcyclohexyl)methoxy]benzyl}-1,3-thiazolidine-2,4-dione; NCGC00164446-01

Indication

Disease Entry	ICD 11	Status	REF
Pulmonary fibrosis	CB03.4	Preclinical	[1]

• Cross-matching ID:
  PubChem CID: 2750
  ChEBI ID: CHEBI:64227
  CAS Number: CAS 74772-77-3
  TTD Drug ID: DMAPO0T
  INTEDE Drug ID: DR0322

Molecule-Related Drug Atlas

Drug(s) Targeting Peroxisome proliferator-activated receptor gamma (PPAR-gamma)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[11]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[12]
Lobeglitazone	DMHY3IP	Type-2 diabetes	5A11	Approved	[13]
Rosiglitazone XR	DMT45MU	Type-2 diabetes	5A11	Approved	[14]
Thiazolidinedione	DMC1NBW	Alzheimer disease	8A20	Approved	[12]
Glitazone	DMDN4A1	N. A.	N. A.	Phase 4	[15]
MURAGLITAZAR	DMG3NFZ	N. A.	N. A.	Phase 3	[16]
Rivoglitazone	DMBY31K	Ocular inflammation	9C61.24	Phase 3	[17]
Balaglitazone	DMXBHR6	Type-1 diabetes	5A10	Phase 3	[18]
Ragaglitazar	DMFSHEM	Type-1 diabetes	5A10	Phase 3	[19]

Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[20]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[21]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[22]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[23]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[24]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[25]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[26]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[27]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[21]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[28]

Drug(s) Metabolized By Cytochrome P450 2C8 (CYP2C8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[29]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[30]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[30]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[31]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[32]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[33]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[34]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[30]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[35]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[36]

Drug(s) Affected By Liver carboxylesterase 1 (CES1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[37]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[38]
Dextropropoxyphene	DM23HCX	Pain	MG30-MG3Z	Approved	[39]
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[43]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[44]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[47]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[48]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[49]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[50]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[51]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[52]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[53]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[54]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[55]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[50]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[57]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[61]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[62]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[63]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[64]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[65]

Drug(s) Affected By Peroxisome proliferator-activated receptor alpha (PPARA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[66]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[68]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[64]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[69]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[70]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[71]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[74]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[75]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[76]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[55]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[77]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[55]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[78]
Selenium	DM25CGV	N. A.	N. A.	Approved	[79]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[80]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[81]

Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[82]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[83]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[74]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[75]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[84]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[85]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[86]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[87]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[88]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[89]

Drug(s) Affected By Proline dehydrogenase 1, mitochondrial (PRODH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[91]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[71]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[71]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[90]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[93]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[94]

Drug(s) Affected By Acyl-CoA (FADS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[66]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[95]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[71]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[71]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[4]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[98]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[99]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[100]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[101]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[102]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[103]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[104]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[105]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[106]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[82]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[74]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[107]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[108]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[109]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[38]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[110]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[111]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[112]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[113]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[114]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[115]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[116]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[117]

Drug(s) Affected By Bile salt export pump (ABCB11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[7]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[118]
Glipizide	DMZA5PQ	Diabetic complication	5A2Y	Approved	[118]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[119]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[7]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[118]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[120]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[7]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[121]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[7]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[122]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[123]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[125]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[126]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[116]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[126]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[127]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[128]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[129]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[130]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[131]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[132]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[133]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[134]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[113]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[135]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[136]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[137]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[89]

Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[138]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[139]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[140]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[74]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[141]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[125]
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[143]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[66]

Drug(s) Affected By Eukaryotic translation initiation factor 2A (EIF2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[133]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[145]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[146]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[147]
Cerulenin	DM6N4PR	Weight loss	MG43.5	Approved	[148]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[149]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]

Drug(s) Affected By Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[152]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[132]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[134]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[153]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[134]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[154]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[134]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[155]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[156]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[157]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[158]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[111]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[159]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[125]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[114]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[160]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[161]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[162]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[163]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[164]

Drug(s) Affected By Epidermal growth factor receptor (EGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BIBW 2992	DMTKD7Q	Non-small-cell lung cancer	2C25.Y	Approved	[165]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[166]
Erlotinib	DMCMBHA	Adrenal gland neoplasm		Approved	[167]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[168]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[169]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[170]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[132]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Selenium	DM25CGV	N. A.	N. A.	Approved	[172]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[173]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[174]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[132]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[175]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[176]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[177]
Selenium	DM25CGV	N. A.	N. A.	Approved	[178]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[179]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[180]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[181]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[66]

Drug(s) Affected By Intercellular adhesion molecule 1 (ICAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[182]
Dicloxacillin	DM8EU0Z	Bacterial infection	1A00-1C4Z	Approved	[182]
Ergonovine	DM0VEC1	Postpartum haemorrhage	JA43	Approved	[82]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[183]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[184]
Mizolastine	DM1FDN8	Allergic rhinitis	CA08.0	Approved	[185]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[186]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[187]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[188]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[189]

Drug(s) Affected By Cyclin-dependent kinase 1 (CDK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[190]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[191]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[158]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[153]
Selenium	DM25CGV	N. A.	N. A.	Approved	[178]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[114]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[192]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[193]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[194]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[195]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[196]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[197]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[198]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[199]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[82]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[122]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[200]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[201]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[107]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[202]

Drug(s) Affected By Cyclin-dependent kinase 4 (CDK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[203]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[204]
Selenium	DM25CGV	N. A.	N. A.	Approved	[178]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[205]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[193]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[206]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[207]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[195]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[208]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]

Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[209]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[210]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[132]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[211]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[212]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[213]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[214]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[215]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[216]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[217]

Drug(s) Affected By Cyclin-A2 (CCNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[218]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[191]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[175]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[113]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[219]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[220]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[137]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[194]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[221]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[89]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[222]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[223]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[202]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[224]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[166]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[112]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[225]
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[179]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[226]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[106]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[102]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[227]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[107]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[108]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[228]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[229]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[230]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[231]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[232]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[233]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[234]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[235]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[236]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[237]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[238]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[239]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[240]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[241]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[83]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[74]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[202]
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[192]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[216]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[88]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[89]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[242]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[145]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[243]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[196]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[83]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[122]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[200]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[244]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[245]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[112]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[212]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[246]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[116]

Drug(s) Affected By Type II iodothyronine deiodinase (DIO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[122]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[247]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[248]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[249]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[250]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[94]
Ergocalciferol	DMHO0AR	Hypoparathyroidism	5A50	Approved	[251]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[252]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[253]

Drug(s) Affected By Nuclear receptor coactivator 1 (NCOA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[54]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[254]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[255]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[256]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[257]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[258]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[259]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[260]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[261]

Drug(s) Affected By CREB-binding protein (CREBBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[195]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[262]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[160]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[263]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[264]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[265]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[266]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[253]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[267]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Peroxisome proliferator-activated receptor gamma (PPAR-gamma)	TTZMAO3	PPARG_HUMAN	Agonist	[2]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Substrate	[3]
Cytochrome P450 2C8 (CYP2C8)	DES5XRU	CP2C8_HUMAN	Substrate	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Acyl-CoA (FADS1)	OTUYOYHX	FADS1_HUMAN	Gene/Protein Processing	[4]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[5]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[5]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Gene/Protein Processing	[6]
Bile salt export pump (ABCB11)	OTRU7THO	ABCBB_HUMAN	Gene/Protein Processing	[7]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Gene/Protein Processing	[8]
Caspase-8 (CASP8)	OTA8TVI8	CASP8_HUMAN	Gene/Protein Processing	[9]
CREB-binding protein (CREBBP)	OTPA4QGM	CBP_HUMAN	Drug Response	[10]
Cyclin-A2 (CCNA2)	OTPHHYZJ	CCNA2_HUMAN	Gene/Protein Processing	[10]
Cyclin-dependent kinase 1 (CDK1)	OTW1SC2N	CDK1_HUMAN	Gene/Protein Processing	[10]

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