Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMCQP0B)

• Drug Name: Flavonoid derivative 1 Drug Info
• Synonyms: PMID26394986-Compound-45
• Cross-matching ID:
  PubChem CID: 5280445
  ChEBI ID: CHEBI:15864
  CAS Number: CAS 491-70-3
  TTD Drug ID: DMCQP0B

Molecule-Related Drug Atlas

Drug(s) Targeting Signal transducer and activator of transcription 3 (STAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acitretin	DM8BKU9	Psoriasis vulgaris	EA90	Approved	[9]
Napabucasin	DMDZ6Q3	Colorectal cancer	2B91.Z	Phase 3	[10]
Golotimod	DMKZN3A	Immune System disease	4A01-4B41	Phase 2	[11]
NT219	DMOYS1N	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[12]
WP-1066	DMUGHWR	Recurrent glioblastoma	2A00.00	Phase 1/2	[10]
Atiprimod	DM84YEC	Multiple myeloma	2A83	Phase 1/2	[13]
OPB-31121	DM6VGO3	Hepatocellular carcinoma	2C12.02	Phase 1/2	[14]
IMX-110	DMNHZS4	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[10]
GLG-801	DMY1CP9	Chronic lymphocytic leukaemia	2A82.0	Phase 1/2	[10]
OPB-51602	DM760FA	Solid tumour/cancer	2A00-2F9Z	Phase 1	[15]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[16]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[17]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[18]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[19]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[20]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[21]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[22]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[23]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[24]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]

Drug(s) Affected By Amine oxidase A (MAOA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[26]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[27]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[30]
Selegiline	DM6034S	Major depressive disorder	6A70.3	Approved	[31]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[33]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]

Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[36]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[38]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[39]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[40]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[41]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[42]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[43]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[44]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[45]

Drug(s) Affected By Cytochrome P450 2C9 (CYP2C9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[46]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[47]
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[48]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[49]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[50]
Zafirlukast	DMHNQOG	Asthma	CA23	Approved	[51]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[48]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[52]
Fluconazole	DMOWZ6B	Cryptococcal meningitis		Approved	[49]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[48]

Drug(s) Affected By Cytochrome P450 2C19 (CYP2C19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[46]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[53]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[49]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[54]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[50]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[48]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[55]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[48]
Desipramine	DMT2FDC	Attention deficit hyperactivity disorder	6A05.Z	Approved	[53]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[16]

Drug(s) Affected By Tumor protein p73 (TP73)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[56]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[57]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[58]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[60]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[63]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[64]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[58]

Drug(s) Affected By Prostate stem cell antigen (PSCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[65]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[2]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[33]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[68]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[69]
ACYLINE	DM9GRTK	Prostate cancer	2C82.0	Phase 2	[70]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[71]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 beta (GADD45B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[72]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[73]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[74]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[26]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[2]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[77]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[78]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[79]

Drug(s) Affected By CCN family member 5 (CCN5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[80]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[81]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[81]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[81]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[68]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[82]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[83]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[84]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[85]

Drug(s) Affected By Superoxide dismutase (SOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[86]
Haloperidol	DM96SE0	Delirium		Approved	[16]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[87]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[88]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[89]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[90]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[91]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[92]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[93]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[94]

Drug(s) Affected By Epidermal growth factor receptor (EGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BIBW 2992	DMTKD7Q	Non-small-cell lung cancer	2C25.Y	Approved	[95]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[96]
Erlotinib	DMCMBHA	Adrenal gland neoplasm		Approved	[97]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[98]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[99]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[100]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[73]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[101]
Selenium	DM25CGV	N. A.	N. A.	Approved	[102]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[103]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[104]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[105]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[106]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[73]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[106]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[107]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[109]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[111]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[17]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[112]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[113]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[114]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[89]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[114]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[115]
Selenium	DM25CGV	N. A.	N. A.	Approved	[116]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[117]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[118]

Drug(s) Affected By Estrogen receptor (ESR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[119]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[120]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[121]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[122]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[98]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[123]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[125]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[122]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[126]

Drug(s) Affected By Interstitial collagenase (MMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[129]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[130]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[26]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[131]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[132]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[133]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[32]

Drug(s) Affected By Catalase (CAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[89]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[135]
Haloperidol	DM96SE0	Delirium		Approved	[16]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[136]
Selenium	DM25CGV	N. A.	N. A.	Approved	[137]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[138]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[139]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[140]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[141]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[27]

Drug(s) Affected By Granulocyte-macrophage colony-stimulating factor (CSF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[144]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[145]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[146]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[147]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[148]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[149]
Acetylcholine	DMDF79Z	Cataract	9B10	Approved	[150]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[151]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[152]
Selenium	DM25CGV	N. A.	N. A.	Approved	[116]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[81]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[153]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[93]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[154]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[155]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[156]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[157]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]

Drug(s) Affected By HLA class II histocompatibility antigen gamma chain (CD74)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[159]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[76]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[161]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[104]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[162]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[163]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[164]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[165]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[166]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[36]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[167]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[168]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[169]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[144]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[170]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[171]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[172]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[173]

Drug(s) Affected By Interleukin-4 (IL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[174]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[175]
Tolnaftate	DM28MU7	Dermatophytosis	1F28.2	Approved	[176]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[177]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[178]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[179]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[180]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[140]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[181]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[182]

Drug(s) Affected By Cyclin-dependent kinase 1 (CDK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[183]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[184]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[65]
Selenium	DM25CGV	N. A.	N. A.	Approved	[185]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[58]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[186]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[26]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[187]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[188]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[189]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[190]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[191]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[192]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[193]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[194]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[195]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[196]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[197]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[195]

Drug(s) Affected By Fructose-1,6-bisphosphatase 1 (FBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[2]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[156]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[198]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[200]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[201]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[202]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[203]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[204]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[205]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[206]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[45]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[207]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[112]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[152]
Selenium	DM25CGV	N. A.	N. A.	Approved	[208]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[209]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[210]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[26]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[72]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[211]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[212]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[213]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[214]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[215]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[214]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[216]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[217]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[218]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[219]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[220]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[221]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[222]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[16]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[72]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[223]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[224]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[225]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[226]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[87]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[227]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[228]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[229]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[123]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[27]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[230]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[231]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[76]

Drug(s) Affected By Pyruvate kinase PKM (PKM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[232]
Selenium	DM25CGV	N. A.	N. A.	Approved	[159]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[233]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[27]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[234]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[235]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[236]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[237]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[238]

Drug(s) Affected By G2/mitotic-specific cyclin-B1 (CCNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[183]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[88]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[65]
Selenium	DM25CGV	N. A.	N. A.	Approved	[185]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[58]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[215]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[239]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[240]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[241]

Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[242]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[80]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[243]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[244]
Selenium	DM25CGV	N. A.	N. A.	Approved	[102]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[245]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[216]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[246]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[247]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[248]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[249]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[250]
Selenium	DM25CGV	N. A.	N. A.	Approved	[159]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[251]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[252]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[253]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[254]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[255]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[256]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[257]

Drug(s) Affected By Transcription factor JunB (JUNB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[258]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[80]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[65]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[27]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[156]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[104]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[78]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[259]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[260]

Drug(s) Affected By Transcription factor JunD (JUND)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[258]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[73]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[240]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[27]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[261]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[262]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[263]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[32]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[264]

Drug(s) Affected By Early growth response protein 1 (EGR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[206]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[22]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[59]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[144]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[265]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[266]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[267]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[104]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[171]

Drug(s) Affected By Cadherin-2 (CDH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[27]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[155]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[268]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[235]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[269]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[270]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[271]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[272]

Drug(s) Affected By Cyclin-A2 (CCNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[273]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[183]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[107]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[274]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[275]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[241]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[187]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[276]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[27]

Drug(s) Affected By Nuclear receptor subfamily 1 group D member 1 (NR1D1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[277]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[163]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[278]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[279]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[280]
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[281]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[282]

Drug(s) Affected By Cyclin-dependent kinase 2 (CDK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[183]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[283]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[284]
Selenium	DM25CGV	N. A.	N. A.	Approved	[185]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[215]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[285]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[246]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[286]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[188]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[287]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[288]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[289]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[225]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[290]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[291]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[292]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[293]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[294]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[295]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[296]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[288]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[297]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[298]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[299]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[287]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[16]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[17]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[225]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[290]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[300]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[301]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[302]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[226]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[303]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[304]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[305]
Selenium	DM25CGV	N. A.	N. A.	Approved	[159]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[306]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[307]

Drug(s) Affected By 14-3-3 protein sigma (SFN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[308]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[309]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[267]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[2]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[156]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[267]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[76]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[310]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[311]

Drug(s) Affected By Multidrug resistance-associated protein 1 (ABCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[312]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[313]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[314]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[315]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[316]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[317]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[318]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[319]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[320]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[320]

Drug(s) Affected By Catenin beta-1 (CTNNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[321]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[322]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[323]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[324]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[325]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[326]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[327]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[271]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[328]

Drug(s) Affected By Nitric oxide synthase, inducible (NOS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[282]
Indomethacin	DMSC4A7	Bursitis		Approved	[92]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[329]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[330]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[26]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[331]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[332]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[144]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[265]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[333]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[334]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[335]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[336]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[337]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[338]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[339]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[340]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[341]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[342]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[343]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[344]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[105]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[88]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[345]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[346]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[58]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[347]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[215]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[348]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[349]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[350]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[351]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[352]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[353]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[354]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[355]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[356]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[357]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[358]

Drug(s) Affected By Cyclin-dependent kinase 4 inhibitor C (CDKN2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[72]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[27]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[359]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[360]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[361]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[79]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[79]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[277]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[33]

Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[362]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[321]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[243]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[152]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[363]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[364]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[365]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[366]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[363]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[367]

Drug(s) Affected By Mitogen-activated protein kinase 9 (MAPK9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[321]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[363]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[368]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[369]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[363]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[370]
Sorbitol	DMAN0DE	Constipation	DD91.1	Approved	[371]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[33]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[372]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[96]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[347]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[368]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[373]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[98]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[374]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[375]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[376]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[377]

Drug(s) Affected By Serine/threonine-protein kinase PLK1 (PLK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[241]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[27]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[378]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[79]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[79]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[277]

Drug(s) Affected By Protein FosB (FOSB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[206]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[379]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[198]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[162]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[380]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[78]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[381]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[382]

Drug(s) Affected By Mitogen-activated protein kinase 10 (MAPK10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[338]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[76]
Sorbitol	DMAN0DE	Constipation	DD91.1	Approved	[383]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[201]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[384]
Dicumarol	DMFQCB1	Bleeding disorder	GA20-GA21	Approved	[383]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[63]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[385]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[386]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[383]

Drug(s) Affected By Caspase-7 (CASP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[242]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[73]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[387]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[388]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[389]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[389]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[26]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[390]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[391]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[256]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[392]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[393]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[72]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[224]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[394]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[329]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[213]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[395]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[396]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[397]

Drug(s) Affected By Sestrin-2 (SESN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[206]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[89]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[241]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[27]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[398]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[262]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[398]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[399]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[206]

Drug(s) Affected By Focal adhesion kinase 1 (PTK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[291]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[400]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[187]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[401]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[261]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[402]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[403]
Halothane	DM80OZ5	Anaesthesia	9A78.6	Approved	[404]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[164]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[219]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[358]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[72]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[223]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[87]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[394]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[346]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[405]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[215]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[302]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[406]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[213]
Selenium	DM25CGV	N. A.	N. A.	Approved	[159]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[407]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[26]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[408]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[409]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[364]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[144]

Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[225]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[87]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[410]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[246]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[411]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[323]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[265]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[412]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[413]

Drug(s) Affected By Beclin-1 (BECN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[414]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[72]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[415]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[26]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[416]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[417]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[418]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[419]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[420]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[421]

Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[422]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[423]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[424]
Triamterene	DM2HU9I	Congestive heart failure	BD10	Approved	[424]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[425]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[426]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[233]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[323]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[427]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[428]

Drug(s) Affected By Solute carrier family 22 member 6 (SLC22A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[429]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[430]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[430]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[431]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[430]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[430]
Succinic acid	DMDWICP	Malnutrition	5B50-5B71	Approved	[432]
Mefenamic acid	DMK7HFI	Dysmenorrhea	GA34.3	Approved	[430]
Probenecid	DMMFWOJ	Acute gonococcal cervicitis		Approved	[433]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[430]

Drug(s) Affected By Quinone oxidoreductase PIG3 (TP53I3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[213]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[26]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[2]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[266]
Amifostine	DM5FL14	Mucositis	CA00	Approved	[434]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[148]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[435]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[436]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[436]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[436]

Drug(s) Affected By Dehydrogenase/reductase SDR family member 11 (DHRS11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[437]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[437]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[198]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[33]
Flufenamic Acid	DMC8VNH	Dysmenorrhea	GA34.3	Approved	[437]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[438]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[385]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[439]

Drug(s) Affected By Organic anion transporter 3 (SLC22A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valsartan	DMREUQ6	Chronic heart failure	BD1Z	Approved	[440]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[429]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[441]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[442]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[443]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[443]
Cefdinir	DMJ7A0H	Bacterial infection	1A00-1C4Z	Approved	[444]
Cefaclor	DMJXDGC	Bacterial infection	1A00-1C4Z	Approved	[444]
Famotidine	DMRL3AB	Gastric ulcer	DA60	Approved	[445]
Tetracycline	DMZA017	Acne vulgaris	ED80	Approved	[446]

Drug(s) Affected By Estrogen receptor beta (ESR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[80]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[447]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[448]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[449]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[450]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[451]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[452]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[453]
Mestranol	DMG3F94	Contraception	QA21	Approved	[454]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[455]

Drug(s) Affected By Autophagy protein 5 (ATG5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[456]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[457]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[458]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[459]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[420]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[460]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[461]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[163]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[219]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[462]

Drug(s) Affected By Tumor protein 63 (TP63)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[57]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[2]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[463]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[464]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[200]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[381]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[465]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[202]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[466]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]

Drug(s) Affected By Serine/threonine-protein kinase TBK1 (TBK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amlexanox	DM0DQM5	Respiratory tract inflammation	CA07	Approved	[467]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[468]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[469]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[163]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[165]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[202]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[470]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[471]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[472]

Drug(s) Affected By Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[473]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[473]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[474]
Sunitinib	DMCBJSR	Acute undifferentiated leukemia		Approved	[16]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[475]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[476]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[477]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[478]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[479]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[480]

Drug(s) Affected By Solute carrier organic anion transporter family member 1B1 (SLCO1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Enalapril	DMNFUZR	Congestive heart failure	BD10	Approved	[481]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[482]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[483]
Repaglinide	DM5SXUV	Diabetic complication	5A2Y	Approved	[484]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[485]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[486]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[487]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[487]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[488]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[489]

Drug(s) Affected By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zolmitriptan	DM1IB4Q	Migraine	8A80	Approved	[490]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[490]
Etoricoxib	DM6A4NW	Rheumatoid arthritis	FA20	Approved	[490]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[50]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[491]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[55]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[492]
Zileuton	DMVRIC2	Allergic asthma	CA23.0	Approved	[493]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[494]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[16]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Signal transducer and activator of transcription 3 (STAT3)	TTH8FZW	STAT3_HUMAN	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
14-3-3 protein sigma (SFN)	OTLJCZ1U	1433S_HUMAN	Gene/Protein Processing	[2]
Amine oxidase A (MAOA)	OT8NIWMQ	AOFA_HUMAN	Gene/Protein Processing	[3]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[4]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[5]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Gene/Protein Processing	[6]
Autophagy protein 5 (ATG5)	OT4T5SMS	ATG5_HUMAN	Gene/Protein Processing	[7]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Gene/Protein Processing	[4]
Beclin-1 (BECN1)	OT4X293M	BECN1_HUMAN	Gene/Protein Processing	[7]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)	OTW8V2V1	ABCG2_HUMAN	Gene/Protein Processing	[8]
Cadherin-1 (CDH1)	OTFJMXPM	CADH1_HUMAN	Gene/Protein Processing	[5]

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