General Information of Drug (ID: DMINUWH)

Drug Name
NS398 Drug Info
Synonyms
ns-398; 123653-11-2; NS398; NS 398; N-(2-Cyclohexyloxy-4-nitrophenyl)methanesulfonamide; N-[2-(Cyclohexyloxy)-4-nitrophenyl]methanesulfonamide; CHEMBL7162; CHEBI:73458; Methanesulfonamide, N-(2-(cyclohexyloxy)-4-nitrophenyl)-; n-(2-cyclohexyloxy-4-nitrophenyl)methane sulfonamide; N-(2-Cyclohexyloxy-4-nitro-phenyl)-methanesulfonamide; Taisho NS 398; SR-01000597479; N-[2-Cyclohexyloxy-4-nitrophenyl]methanesulfonamide; N-(2-(cyclohexyloxy)-4-nitrophenyl)methanesulfonamide; CCRIS 8523; KTDZCOWXCWUPEO-UHFFFAOYSA-N; Tocris-0942
Indication
Disease Entry ICD 11 Status REF
Endometriosis GA10 Terminated [1]
Therapeutic Class
Analgesics
Cross-matching ID
PubChem CID
4553
ChEBI ID
CHEMBL7162
CAS Number
CAS 123653-11-2
TTD Drug ID
DMINUWH

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Discontinued Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [8]
Naproxen DMZ5RGV Bursitis Approved [9]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [10]
Indomethacin DMSC4A7 Bursitis Approved [11]
Celecoxib DM6LOQU Dysmenorrhea GA34.3 Approved [12]
Nabumetone DMAT2XH Osteoarthritis FA00-FA05 Approved [13]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [14]
Flurbiprofen DMGN4BY Osteoarthritis FA00-FA05 Approved [15]
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [16]
Aminosalicylic Acid DMENSL5 Crohn disease DD70 Approved [11]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [17]
Quercetin DM3NC4M Obesity 5B81 Approved [18]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [17]
Testosterone DM7HUNW Hot flushes GA30 Approved [19]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [18]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [20]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [17]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [17]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [21]
Indomethacin DMSC4A7 Bursitis Approved [22]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [23]
Selenium DM25CGV N. A. N. A. Approved [24]
Methotrexate DM2TEOL Anterior urethra cancer Approved [25]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [26]
Epinephrine DM3KJBC Acute asthma CA23 Approved [27]
Quercetin DM3NC4M Obesity 5B81 Approved [28]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [29]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [30]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [31]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [33]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [34]
Quercetin DM3NC4M Obesity 5B81 Approved [18]
Fluoxetine DM3PD2C Bipolar depression Approved [35]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [30]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [36]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [37]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [38]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [39]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [40]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clavulanate DM2FGRT Bacteremia 1A73 Approved [41]
Methotrexate DM2TEOL Anterior urethra cancer Approved [33]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [30]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [42]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [43]
Testosterone DM7HUNW Hot flushes GA30 Approved [19]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [44]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [46]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [47]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [48]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [49]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [50]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [51]
Cepharanthine DM9Y5JB N. A. N. A. Approved [52]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [53]
Clozapine DMFC71L Schizophrenia 6A20 Approved [54]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [55]
Trifluoperazine DMKBYWI Anxiety Approved [56]
Olanzapine DMPFN6Y Bipolar depression Approved [54]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [57]
Quercetin DM3NC4M Obesity 5B81 Approved [18]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [58]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [59]
Vismodegib DM5IXKQ Basal cell carcinoma 2C32 Approved [60]
Bupropion DM5PCS7 Depression 6A70-6A7Z Approved [61]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [62]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [63]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [64]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [65]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [66]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [67]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [68]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [69]
Selenium DM25CGV N. A. N. A. Approved [70]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [65]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [71]
Methotrexate DM2TEOL Anterior urethra cancer Approved [72]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [71]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protocadherin-7 (PCDH7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [72]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [73]
Panobinostat DM58WKG Chronic graft versus host disease Approved [74]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [75]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [76]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [77]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [78]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [79]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [74]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-K (CCNK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [80]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [81]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [82]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [83]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [84]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [85]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [86]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [87]
Geldanamycin DMS7TC5 Kidney cancer 2C90.0 Discontinued in Phase 2 [88]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [87]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Prothrombin (F2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [89]
Methotrexate DM2TEOL Anterior urethra cancer Approved [90]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [91]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [92]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [93]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [94]
Phytonadione DM8HDOL Bleeding disorder GA20-GA21 Approved [95]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
Testosterone enanthate DMB6871 N. A. N. A. Approved [96]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [97]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [98]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [99]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [100]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [101]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [102]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [103]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [104]
Gefitinib DM15F0X Colon adenocarcinoma Approved [105]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [106]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [107]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [108]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [99]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [109]
Paclitaxel DMLB81S Breast carcinoma Approved [110]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [111]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [98]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [112]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [67]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [101]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [102]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [113]
Triacetin DM0AEPG Onychomycosis EE12.1 Approved [114]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [115]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [68]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [116]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [117]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [118]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [119]
Methotrexate DM2TEOL Anterior urethra cancer Approved [120]
Quercetin DM3NC4M Obesity 5B81 Approved [18]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [121]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [122]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [123]
Gefitinib DM15F0X Colon adenocarcinoma Approved [124]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [125]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [117]
Etretinate DM2CZFA Keratosis ED56 Approved [126]
Prednisone DM2HG4X Acute asthma CA23 Approved [127]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [128]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [65]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [129]
Gefitinib DM15F0X Colon adenocarcinoma Approved [130]
Prednisone DM2HG4X Acute asthma CA23 Approved [127]
Methotrexate DM2TEOL Anterior urethra cancer Approved [131]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [132]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [133]
Quercetin DM3NC4M Obesity 5B81 Approved [134]
Fluoxetine DM3PD2C Bipolar depression Approved [135]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [136]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [137]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dynamin-2 (DNM2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [82]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [138]
Bortezomib DMNO38U Leukemia Approved [139]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [140]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [86]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [141]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [87]
Z-Pro-Prolinal DM43O2U Discovery agent N.A. Investigative [142]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [143]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Liprin-alpha-1 (PPFIA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [144]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [138]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [83]
Arsenic DMTL2Y1 N. A. N. A. Approved [145]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [146]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [147]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [140]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [85]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [144]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By PCNA-associated factor (PCLAF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [148]
Methotrexate DM2TEOL Anterior urethra cancer Approved [120]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [149]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [150]
Testosterone DM7HUNW Hot flushes GA30 Approved [151]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [151]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [82]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [152]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [138]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [153]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [154]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [155]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [153]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [156]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [157]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [158]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [159]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [153]
Testosterone DM7HUNW Hot flushes GA30 Approved [19]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [160]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [73]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [157]
Haloperidol DM96SE0 Delirium Approved [161]
Leflunomide DMR8ONJ Arthritis FA20 Approved [162]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [81]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [163]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [138]
Folic Acid DMEMBJC Colorectal carcinoma Approved [164]
Benzatropine DMF7EXL Parkinsonian disorder Approved [161]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [165]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [166]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [167]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [168]
Leflunomide DMR8ONJ Arthritis FA20 Approved [162]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [82]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [169]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [138]
Bendamustine hydrochloride DMFH15Z leukaemia 2A60-2B33 Approved [170]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [58]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Testosterone DM7HUNW Hot flushes GA30 Approved [151]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [151]
Leflunomide DMR8ONJ Arthritis FA20 Approved [162]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [82]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [152]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [138]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [171]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Prostaglandin G/H synthase 2 (COX-2) TTVKILB PGH2_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Gene/Protein Processing [3]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [4]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Gene/Protein Processing [4]
Cyclin-K (CCNK) OTZ7JBPK CCNK_HUMAN Gene/Protein Processing [5]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Gene/Protein Processing [6]
Dynamin-2 (DNM2) OTUYU2U3 DYN2_HUMAN Gene/Protein Processing [5]
Liprin-alpha-1 (PPFIA1) OTYYFA9C LIPA1_HUMAN Gene/Protein Processing [5]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [7]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Post-Translational Modifications [7]
PCNA-associated factor (PCLAF) OTMVIOUU PAF15_HUMAN Gene/Protein Processing [5]

References

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4 Molecular mechanisms involved in the antiproliferative effect of two COX-2 inhibitors, nimesulide and NS-398, on colorectal cancer cell lines. Dig Liver Dis. 2003 Aug;35(8):557-65. doi: 10.1016/s1590-8658(03)00272-x.
5 Detection of differentially expressed genes in human colon carcinoma cells treated with a selective COX-2 inhibitor. Oncogene. 2001 Jul 27;20(33):4450-6. doi: 10.1038/sj.onc.1204588.
6 CHOP transcription factor mediates IL-8 signaling in cystic fibrosis bronchial epithelial cells. Am J Respir Cell Mol Biol. 2008 Feb;38(2):176-84. doi: 10.1165/rcmb.2007-0197OC. Epub 2007 Aug 20.
7 COX-2 inhibitors suppress lung cancer cell growth by inducing p21 via COX-2 independent signals. Lung Cancer. 2006 Mar;51(3):283-96. doi: 10.1016/j.lungcan.2005.10.015. Epub 2006 Jan 10.
8 Maternal toxicity of nonsteroidal anti-inflammatory drugs as an important factor affecting prenatal development. Reprod Toxicol. 2009 Sep;28(2):239-44.
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10 Membranous nephropathy associated with the relatively selective cyclooxygenase-2 inhibitor, etodolac, in a patient with early rheumatoid arthritis. Intern Med. 2007;46(13):1055-8.
11 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
12 Pfizer. Product Development Pipeline. March 31 2009.
13 Renal effects of nabumetone, a COX-2 antagonist: impairment of function in isolated perfused rat kidneys contrasts with preserved renal function in vivo. Exp Nephrol. 2001;9(6):387-96.
14 Privileged structures: a useful concept for the rational design of new lead drug candidates. Mini Rev Med Chem. 2007 Nov;7(11):1108-19.
15 Flurbiprofen, a cyclooxygenase inhibitor, protects mice from hepatic ischemia/reperfusion injury by inhibiting GSK-3 signaling and mitochondrial permeability transition.Mol Med.2012 Sep 25;18:1128-35.
16 Cox-2 inhibitory effects of naturally occurring and modified fatty acids. J Nat Prod. 2001 Jun;64(6):745-9.
17 Beta-carotene and apocarotenals promote retinoid signaling in BEAS-2B human bronchioepithelial cells. Arch Biochem Biophys. 2006 Nov 1;455(1):48-60.
18 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
19 The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
20 Design principles of concentration-dependent transcriptome deviations in drug-exposed differentiating stem cells. Chem Res Toxicol. 2014 Mar 17;27(3):408-20.
21 Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
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