General Information of Drug (ID: DMSZQAK)

Drug Name
Amphetamine Drug Info
Synonyms Amphetamine (tamper and abuse-resistant, Bio-MD/MPAR, ADHD); Amphetamine (tamper and abuse-resistant, Bio-MD/MPAR, ADHD), PharmacoFore; PF-08 (Bio-MD/MPAR/prodrug/oral, ADHD), PharmacoFore
Indication
Disease Entry ICD 11 Status REF
Attention deficit hyperactivity disorder 6A05.Z Approved [1]
Depression 6A70-6A7Z Approved [2]
Narcolepsy 7A20 Approved [2]
Obesity 5B81 Approved [2]
Cross-matching ID
PubChem CID
3007
ChEBI ID
CHEBI:2679
CAS Number
CAS 300-62-9
TTD Drug ID
DMSZQAK
VARIDT Drug ID
DR00084
INTEDE Drug ID
DR0106
ACDINA Drug ID
D00036

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Discontinued Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lisdexamfetamine DM6W8V5 Attention deficit hyperactivity disorder 6A05.Z Approved [15]
Dextroamphetamine DMMIHVP Attention deficit hyperactivity disorder 6A05.Z Approved [3]
Hydroxyamphetamine Hydrobromide DMQSGM0 Horner syndrome 8D8A.1 Approved [16]
SEP-363856 DMG2QP4 Schizophrenia 6A20 Phase 3 [17]
NT0202 DMCMIJ1 Attention deficit hyperactivity disorder 6A05.Z Phase 3 [3]
SPD-465 DM7NV1I Attention deficit hyperactivity disorder 6A05.Z Phase 3 [3]
RG-7351 DMFGR98 Major depressive disorder 6A70.3 Phase 1 [18]
tyramine DM4UXT1 Discovery agent N.A. Investigative [19]
EPPTB DMK3VID Discovery agent N.A. Investigative [20]
R(-)amphetamine DM72ES1 Discovery agent N.A. Investigative [21]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Propranolol DM79NTF Angina pectoris BA40 Approved [22]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [23]
Metformin DM89QE1 Colorectal carcinoma Approved [24]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [22]
Entecavir DM7VTQO Hepatitis B virus infection 1E51.0 Approved [25]
Epinephrine DM3KJBC Acute asthma CA23 Approved [23]
Norepinephrine DMOUC09 Alopecia ED70 Approved [23]
Acetylcholine DMDF79Z Cataract 9B10 Approved [26]
Sodium chloride DMM3950 Skin burns ME65.0 Approved [27]
Etilefrine DM67PWD Cardiovascular disease BA00-BE2Z Withdrawn from market [28]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [29]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [30]
Entecavir DM7VTQO Hepatitis B virus infection 1E51.0 Approved [25]
Levacecarnine hci DMJBOCR Cognitive impairment 6D71 Approved [31]
Potassium Chloride DMMTAJC Hypokalemia 5C77 Approved [32]
Tiotropium DMFDC0Q Chronic obstructive pulmonary disease CA22 Approved [33]
Ipratropium DMFQ320 Obstructive lung disease CA22.Z Approved [33]
Mepyramine DMB4SFH Allergic rhinitis CA08.0 Approved [34]
Acetylcarnitine DM4UE3K Chronic fatigue syndrome 8E49 Phase 4 [35]
acetyl-L-carnitine DM74HGJ Discovery agent N.A. Investigative [30]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Norepinephrine DMOUC09 Alopecia ED70 Approved [36]
Norepinephrine DMOUC09 Alopecia ED70 Approved [61]
Selenium DM25CGV N. A. N. A. Approved [62]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [63]
Dextroamphetamine DMMIHVP Attention deficit hyperactivity disorder 6A05.Z Approved [64]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [65]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [66]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [67]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [68]
Nortriptyline DM4KDYJ Depression 6A70-6A7Z Approved [69]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [70]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [37]
OPC-34712 DMHG57U Major depressive disorder 6A70.3 Approved [38]
Bretylium DM1FX74 Long QT syndrome BC65.0 Approved [39]
Benztropine DMGZOVN Parkinson disease 8A00.0 Approved [40]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [71]
Bupropion DM5PCS7 Depression 6A70-6A7Z Approved [72]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [73]
Testosterone DM7HUNW Hot flushes GA30 Approved [74]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [74]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [75]
Dextroamphetamine DMMIHVP Attention deficit hyperactivity disorder 6A05.Z Approved [64]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [76]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [77]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [78]
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Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [41]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [42]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [43]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [44]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [45]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [46]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [47]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [48]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [49]
Propranolol DM79NTF Angina pectoris BA40 Approved [50]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [51]
Paliperidone DM7NPJS Psychotic disorder 6A20-6A25 Approved [52]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [53]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [54]
Oxatomide DM1F42Z Hay fever CA08.00 Approved [55]
Cinacalcet DMCX0K3 Hyperparathyroidism 5A51 Approved [56]
Capsaicin DMGMF6V Back pain ME84.Z Approved [57]
Pentamidine DMHZJCG African trypanosomiasis 1F51 Approved [58]
Quinidine DMLPICK N. A. N. A. Approved [59]
Buprenorphine DMPRI8G Opioid dependence 6C43.2Z Approved [60]
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Drug(s) Affected By Catalase (CAT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [79]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [80]
Haloperidol DM96SE0 Delirium Approved [81]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [82]
Selenium DM25CGV N. A. N. A. Approved [83]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [84]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [85]
Methotrexate DM2TEOL Anterior urethra cancer Approved [86]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [87]
Quercetin DM3NC4M Obesity 5B81 Approved [88]
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Drug(s) Affected By Protein c-Fos (FOS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [89]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [90]
Verapamil DMA7PEW Angina pectoris BA40 Approved [91]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [92]
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [91]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [93]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [94]
Methotrexate DM2TEOL Anterior urethra cancer Approved [95]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [96]
Quercetin DM3NC4M Obesity 5B81 Approved [97]
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Drug(s) Affected By Proenkephalin-A (PENK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [98]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [99]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [100]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [76]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [78]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [68]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [101]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [102]
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Drug(s) Affected By Transcription factor Jun (JUN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [103]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [104]
Fructose DM43AN2 Vomiting MD90 Approved [81]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [105]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [106]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [92]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [107]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [108]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [109]
Methotrexate DM2TEOL Anterior urethra cancer Approved [110]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [111]
Quercetin DM3NC4M Obesity 5B81 Approved [88]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [112]
Panobinostat DM58WKG Chronic graft versus host disease Approved [113]
Estrone DM5T6US Acne vulgaris ED80 Approved [111]
Testosterone DM7HUNW Hot flushes GA30 Approved [114]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [115]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [99]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [116]
Ethanol DMDRQZU Chronic pain MG30 Approved [117]
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Drug(s) Affected By Tissue factor (F3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [118]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [119]
Methotrexate DM2TEOL Anterior urethra cancer Approved [120]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [121]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [122]
Quercetin DM3NC4M Obesity 5B81 Approved [123]
Fructose DM43AN2 Vomiting MD90 Approved [124]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [125]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [119]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [126]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Penicillin V DMKVOYF Acute otitis media AB00 Approved [81]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [81]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [127]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [128]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [129]
Testosterone DM7HUNW Hot flushes GA30 Approved [130]
Haloperidol DM96SE0 Delirium Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [75]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [132]
Ethanol DMDRQZU Chronic pain MG30 Approved [133]
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Drug(s) Affected By Fos-related antigen 1 (FOSL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [134]
Quercetin DM3NC4M Obesity 5B81 Approved [88]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [135]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [136]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [137]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [138]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [139]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [140]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [141]
Leflunomide DMR8ONJ Arthritis FA20 Approved [142]
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Drug(s) Affected By Fos-related antigen 2 (FOSL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [143]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [141]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [144]
Leflunomide DMR8ONJ Arthritis FA20 Approved [142]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [145]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [145]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [146]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [75]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [132]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [65]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [106]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [147]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [148]
Quercetin DM3NC4M Obesity 5B81 Approved [88]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [149]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [135]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [89]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [150]
Nilotinib DM7HXWT Chronic myelogenous leukaemia 2A20.0 Approved [151]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [152]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [106]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [92]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [94]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [153]
Quercetin DM3NC4M Obesity 5B81 Approved [88]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [154]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [155]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [136]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [156]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [157]
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Drug(s) Affected By Protein FosB (FOSB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [158]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [148]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [159]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [160]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [161]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [162]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [150]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [163]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [164]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [165]
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Drug(s) Affected By Superoxide dismutase (SOD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [166]
Haloperidol DM96SE0 Delirium Approved [81]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [167]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [107]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [79]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [168]
SPI-1005 DM6XFHS Reperfusion injury ND56.Z Approved [169]
Methotrexate DM2TEOL Anterior urethra cancer Approved [170]
Epinephrine DM3KJBC Acute asthma CA23 Approved [171]
Quercetin DM3NC4M Obesity 5B81 Approved [172]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [173]
Selenium DM25CGV N. A. N. A. Approved [62]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [174]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [75]
Arsenic DMTL2Y1 N. A. N. A. Approved [175]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [176]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [177]
Sodium phenylbutyrate DMXLBCQ Spinal muscular atrophy 8B61 Approved [178]
ASP-8477 DMBZQS7 Neuropathic pain 8E43.0 Phase 2 [179]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [180]
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Drug(s) Affected By D(2) dopamine receptor (DRD2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Droperidol DM0DXA8 Nausea MD90 Approved [81]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [81]
Zuclopenthixol DMKYD5N Schizophrenia 6A20 Approved [81]
Meglitinides DM1OFHN Type-2 diabetes 5A11 Approved [181]
Sulpiride DMF54ZG Schizophrenia 6A20 Approved [182]
Risperidone DMN6DXL Bipolar I disorder Approved [183]
Olanzapine DMPFN6Y Bipolar depression Approved [184]
Methamphetamine DMPM4SK Anxiety Approved [185]
Bromocriptine DMVE3TK Acromegaly 5A60.0 Approved [186]
Fluphenazine DMIT8LX Psychotic disorder 6A20-6A25 Approved [187]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [188]
Selenium DM25CGV N. A. N. A. Approved [62]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [135]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [146]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [113]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [189]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [190]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [191]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [76]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [192]
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Drug(s) Affected By Cytochrome P450 2C19 (CYP2C19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [193]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [194]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [195]
Chloramphenicol DMFXEWT Bacterial infection 1A00-1C4Z Approved [196]
Capsaicin DMGMF6V Back pain ME84.Z Approved [57]
Pentamidine DMHZJCG African trypanosomiasis 1F51 Approved [58]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [197]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [58]
Desipramine DMT2FDC Attention deficit hyperactivity disorder 6A05.Z Approved [194]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [81]
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Drug(s) Affected By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zolmitriptan DM1IB4Q Migraine 8A80 Approved [198]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [198]
Etoricoxib DM6A4NW Rheumatoid arthritis FA20 Approved [198]
Capsaicin DMGMF6V Back pain ME84.Z Approved [57]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [199]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [197]
Nifedipine DMSVOZT Angina pectoris BA40 Approved [200]
Zileuton DMVRIC2 Allergic asthma CA23.0 Approved [201]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [202]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [81]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 2B6 (CYP2B6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [196]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [203]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [204]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [205]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [206]
Clopidogrel DMOL54H Acute coronary syndrome BA41 Approved [207]
Artemisinin DMOY7W3 Malaria 1F40-1F45 Approved [208]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [209]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [210]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [211]
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Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [212]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [193]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [213]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [195]
Proguanil DMBL79I Malaria 1F40-1F45 Approved [58]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [58]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [214]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [215]
Capsaicin DMGMF6V Back pain ME84.Z Approved [216]
Axitinib DMGVH6N Renal cell carcinoma 2C90 Approved [217]
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Drug(s) Affected By Amine oxidase B (MAOB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [218]
Methotrexate DM2TEOL Anterior urethra cancer Approved [219]
Quercetin DM3NC4M Obesity 5B81 Approved [88]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [220]
Selegiline DM6034S Major depressive disorder 6A70.3 Approved [221]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [222]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [115]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [75]
BENZYL BENZOATE DMDPYI5 Infestations of lice and scabies 1G00.Z Approved [223]
Linezolid DMGFPU2 Bacteremia 1A73 Approved [224]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [225]
Quercetin DM3NC4M Obesity 5B81 Approved [88]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [135]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [226]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [227]
Leflunomide DMR8ONJ Arthritis FA20 Approved [142]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [75]
Adenosine DMM2NSK Paroxysmal supraventricular tachycardia BC81.Z Approved [228]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [226]
Prednisolone DMQ8FR2 Acute adrenal insufficiency Approved [226]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Trace amine-associated receptor-1 (TAAR1) TTIU98M TAAR1_HUMAN Modulator [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Sodium-dependent dopamine transporter (SLC6A3) DT3BA8L SC6A3_HUMAN Substrate [4]
Sodium-dependent noradrenaline transporter (SLC6A2) DT9JBVI SC6A2_HUMAN Substrate [4]
Organic cation/carnitine transporter 2 (SLC22A5) DT3HUVD S22A5_HUMAN Substrate [5]
Organic cation transporter 3 (SLC22A3) DT6201N S22A3_HUMAN Substrate [6]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 2D6 (CYP2D6) Main DME DECB0K3 CP2D6_HUMAN Substrate [7]
Tyramine oxidase (tynA) DEB3TNR AMO_ECOLI Substrate [8]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Adenosine receptor A2a (ADORA2A) OTVRBZ0I AA2AR_HUMAN Drug Response [9]
Amine oxidase B (MAOB) OTTDFM1O AOFB_HUMAN Drug Response [10]
Casein kinase I isoform epsilon (CSNK1E) OTF0UXX6 KC1E_HUMAN Drug Response [11]
Catalase (CAT) OTHEBX9R CATA_HUMAN Gene/Protein Processing [12]
Cytochrome P450 1A2 (CYP1A2) OTLLBX48 CP1A2_HUMAN Biotransformations [13]
Cytochrome P450 2B6 (CYP2B6) OTOYO4S7 CP2B6_HUMAN Biotransformations [13]
Cytochrome P450 2C19 (CYP2C19) OTFMJYYE CP2CJ_HUMAN Biotransformations [13]
Cytochrome P450 2D6 (CYP2D6) OTZJC802 CP2D6_HUMAN Biotransformations [13]
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Biotransformations [13]
D(2) dopamine receptor (DRD2) OTBLXKEG DRD2_HUMAN Drug Response [14]

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137 Effects of chlorpromazine with and without UV irradiation on gene expression of HepG2 cells. Mutat Res. 2005 Aug 4;575(1-2):47-60. doi: 10.1016/j.mrfmmm.2005.03.002. Epub 2005 Apr 26.
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139 Antitumor effect of aspirin in glioblastoma cells by modulation of -catenin/T-cell factor-mediated transcriptional activity. J Neurosurg. 2011 Oct;115(4):780-8. doi: 10.3171/2011.5.JNS113. Epub 2011 Jul 1.
140 Keratinocyte-derived IL-36gama plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes. Arch Toxicol. 2019 Aug;93(8):2307-2320.
141 JunD is involved in the antiproliferative effect of Delta9-tetrahydrocannabinol on human breast cancer cells. Oncogene. 2008 Aug 28;27(37):5033-44.
142 Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
143 Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
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