Details of Disease

General Information of Disease (ID: DIS6PD44)

• Disease Name: Schistosomiasis
• Synonyms: schistosomiasis; Bilharzia; snail fever; bilharziasis
• Disease Class: 1F86: Schistosomiasis
• Definition: An infectious disease caused by parasitic trematodes of the genus Schistosoma that colonize human blood vessels and release eggs that can cause granulomatous reactions leading to acute (swimmer's itch or acute schistosomiasis syndrome) or chronic disease. Depending on where the eggs lodge, manifestations of chronic schistosomiasis can include diarrhea, abdominal pain, loss of appetite, anemia (intestines), hepatosplenism, periportal fibrosis with portal hypertension (liver), urogenital inflammation and scarring, hematuria and dysuria (genitourinary system). Other patients may be asymptomatic.
• Disease Hierarchy:
  DISGFCIX: Vector-borne disease
  DIS7CGKY: Helminth infection
  DIS6PD44: Schistosomiasis
• ICD Code:
  ICD-11: ICD-11: 1F86
  ICD-10: ICD-10: B65, B65.9
  ICD-9: ICD-9: 120
  Expand ICD-11: '1F86
  Expand ICD-10: 'B65; 'B65.9
  Expand ICD-9: 120
• Disease Identifiers:
  MONDO ID: MONDO_0015254
  MESH ID: D012552
  UMLS CUI: C0036323
  MedGen ID: 48573
  SNOMED CT ID: 10087007

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 2 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Oxamniquine	DM2QDX1	Approved	Small molecular drug	[1]
Praziquantel	DMOU1PK	Approved	Small molecular drug	[2]

This Disease is Treated as An Indication in 2 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Sh-28-GST	DMKFPW2	Phase 3	NA	[3]
Sm-14	DM7CFO1	Phase 1	NA	[4]

This Disease is Treated as An Indication in 1 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Sm-p80-VR1020	DMII60L	Investigative	NA	[5]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 11 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CA1	TTHQPL7	Limited	Biomarker	[6]
DHODH	TTLVP78	Limited	Biomarker	[7]
HDAC8	TTT6LFV	Limited	Biomarker	[8]
LILRB2	TTHC6XU	Limited	Biomarker	[9]
TXNRD3	TTDYFVB	Limited	Biomarker	[10]
CXCR5	TTIW59R	Strong	Biomarker	[11]
FCER2	TTCH6MU	Strong	Biomarker	[12]
ICOS	TTE5VP6	Strong	Altered Expression	[11]
IL13	TT0GVCH	Strong	Biomarker	[13]
IL4R	TTDWHC3	Strong	Biomarker	[14]
TNFRSF18	TTG6LA7	Strong	Genetic Variation	[15]

This Disease Is Related to 30 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
BATF3	OTI61WXQ	Limited	Biomarker	[16]
C2	OTHMF4YM	Limited	Biomarker	[17]
CCL24	OT9LGHV0	Limited	Biomarker	[18]
COLEC11	OT4GC46Y	Limited	Altered Expression	[19]
DCTN3	OTQOSUES	Limited	Biomarker	[20]
DLGAP5	OTWCN39U	Limited	Altered Expression	[21]
DYNC1H1	OTD1KRKO	Limited	Biomarker	[20]
FBRS	OTUVH446	Limited	Biomarker	[22]
HLA-DPA1	OT7OG7Y2	Limited	Biomarker	[23]
IL4I1	OTK54C63	Limited	Altered Expression	[24]
LYPD5	OTGP7UKA	Limited	Genetic Variation	[25]
NBEAL2	OTMCAXWR	Limited	Biomarker	[26]
NDUFB2	OT4717TF	Limited	Genetic Variation	[27]
PDCD10	OTCHJTSF	Limited	Biomarker	[28]
PRDX1	OTZ3BEC4	Limited	Therapeutic	[29]
RAD23B	OT0PGOG3	Limited	Biomarker	[30]
RASSF1	OTEZIPB7	Limited	Biomarker	[31]
RRBP1	OT4ZTPTM	Limited	Biomarker	[32]
SELENOT	OTKQGMLB	Limited	Biomarker	[10]
STH	OTK8ULTH	Limited	Biomarker	[33]
STOML1	OTSIO2QA	Limited	Biomarker	[34]
SUCO	OT3I9VO9	Limited	Biomarker	[34]
SYTL1	OTP0R3S5	Limited	Biomarker	[34]
TIMP3	OTDGQAD1	Limited	Biomarker	[31]
FCN2	OTTHJBKZ	Strong	Altered Expression	[35]
FUZ	OTC427QQ	Strong	Biomarker	[36]
MRPL28	OT4LUTZU	Strong	Genetic Variation	[37]
NXT1	OT0VO6AY	Strong	Genetic Variation	[37]
SFXN1	OTL66767	Strong	Biomarker	[38]
THBS2	OTXET551	Strong	Biomarker	[39]

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