Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OT4LUTZU)

• DOT Name: Large ribosomal subunit protein bL28m (MRPL28)
• Synonyms: 39S ribosomal protein L28, mitochondrial; L28mt; MRP-L28; Melanoma antigen p15; Melanoma-associated antigen recognized by T-lymphocytes
• Gene Name: MRPL28
• Related Disease:
  Bladder cancer
  Chromosomal disorder
  Pancreatic cancer
  Transitional cell carcinoma
  Urinary bladder neoplasm
  Acute monocytic leukemia
  Adult T-cell leukemia/lymphoma
  Advanced cancer
  Astrocytoma
  Breast cancer
  Breast carcinoma
  Carcinoma of esophagus
  Colorectal carcinoma
  Follicular lymphoma
  Haematological malignancy
  Head-neck squamous cell carcinoma
  Hepatitis B virus infection
  Hepatitis C virus infection
  Hepatocellular carcinoma
  Leukemia
  Lymphoma
  Myelodysplastic syndrome
  Neoplasm of esophagus
  Non-small-cell lung cancer
  Ovarian neoplasm
  Plasma cell myeloma
  Promyelocytic leukaemia
  Prostate cancer
  Schistosomiasis
  Small lymphocytic lymphoma
  Squamous cell carcinoma
  T-cell acute lymphoblastic leukaemia
  T-cell lymphoma
  Urinary bladder cancer
  Acute lymphocytic leukaemia
  Acute myelogenous leukaemia
  Gastric cancer
  Lung adenocarcinoma
  Malignant mesothelioma
  Childhood acute lymphoblastic leukemia
  Acute leukaemia
  Carcinoma
  leukaemia
  Lymphoma, non-Hodgkin, familial
  Non-hodgkin lymphoma
  Retinoblastoma
  Stomach cancer
  T-cell leukaemia
• UniProt ID: RM28_HUMAN
• PDB ID: 3J7Y ; 5OOL ; 5OOM ; 6I9R ; 6NU2 ; 6NU3 ; 6VLZ ; 6VMI ; 6ZM5 ; 6ZM6 ; 6ZS9 ; 6ZSA ; 6ZSB ; 6ZSC ; 6ZSD ; 6ZSE ; 6ZSG ; 7A5F ; 7A5G ; 7A5H ; 7A5I ; 7A5J ; 7A5K ; 7L08 ; 7L20 ; 7O9K ; 7O9M ; 7ODR ; 7ODS ; 7ODT ; 7OF0 ; 7OF2 ; 7OF3 ; 7OF4 ; 7OF5 ; 7OF6 ; 7OF7 ; 7OG4 ; 7OI6 ; 7OI7 ; 7OI8 ; 7OI9 ; 7OIA ; 7OIB ; 7OIC ; 7OID ; 7OIE ; 7PD3 ; 7PO4 ; 7QH6 ; 7QH7 ; 7QI4 ; 7QI5 ; 7QI6 ; 8ANY ; 8OIR ; 8OIT
• Pfam ID: PF00830
• Sequence:
  MPLHKYPVWLWKRLQLREGICSRLPGHYLRSLEEERTPTPVHYRPHGAKFKINPKNGQRE
  RVEDVPIPIYFPPESQRGLWGGEGWILGQIYANNDKLSKRLKKVWKPQLFEREFYSEILD
  KKFTVTVTMRTLDLIDEAYGLDFYILKTPKEDLCSKFGMDLKRGMLLRLARQDPQLHPED
  PERRAAIYDKYKEFAIPEEEAEWVGLTLEEAIEKQRLLEEKDPVPLFKIYVAELIQQLQQ
  QALSEPAVVQKRASGQ
• Tissue Specificity: Found in a variety of normal tissues including spleen, testes, thymus, liver, kidney, brain, adrenal, lung and retinal tissue.
• KEGG Pathway: Ribosome (hsa03010)
• Reactome Pathway:
  Mitochondrial translation elongation (R-HSA-5389840)
  Mitochondrial translation termination (R-HSA-5419276)
  Mitochondrial translation initiation (R-HSA-5368286)

Molecular Interaction Atlas (MIA) of This DOT

48 Disease(s) Related to This DOT

Disease Name	Disease ID	Evidence Level	Mode of Inheritance	REF
Bladder cancer	DISUHNM0	Definitive	Biomarker	[1]
Chromosomal disorder	DISM5BB5	Definitive	Genetic Variation	[2]
Pancreatic cancer	DISJC981	Definitive	Biomarker	[3]
Transitional cell carcinoma	DISWVVDR	Definitive	Altered Expression	[1]
Urinary bladder neoplasm	DIS7HACE	Definitive	Biomarker	[1]
Acute monocytic leukemia	DIS28NEL	Strong	Posttranslational Modification	[4]
Adult T-cell leukemia/lymphoma	DIS882XU	Strong	Biomarker	[5]
Advanced cancer	DISAT1Z9	Strong	Biomarker	[6]
Astrocytoma	DISL3V18	Strong	Genetic Variation	[7]
Breast cancer	DIS7DPX1	Strong	Posttranslational Modification	[8]
Breast carcinoma	DIS2UE88	Strong	Posttranslational Modification	[8]
Carcinoma of esophagus	DISS6G4D	Strong	Altered Expression	[9]
Colorectal carcinoma	DIS5PYL0	Strong	Biomarker	[10]
Follicular lymphoma	DISVEUR6	Strong	Posttranslational Modification	[11]
Haematological malignancy	DISCDP7W	Strong	Biomarker	[12]
Head-neck squamous cell carcinoma	DISF7P24	Strong	Posttranslational Modification	[13]
Hepatitis B virus infection	DISLQ2XY	Strong	Biomarker	[14]
Hepatitis C virus infection	DISQ0M8R	Strong	Biomarker	[14]
Hepatocellular carcinoma	DIS0J828	Strong	Altered Expression	[15]
Leukemia	DISNAKFL	Strong	Genetic Variation	[16]
Lymphoma	DISN6V4S	Strong	Biomarker	[17]
Myelodysplastic syndrome	DISYHNUI	Strong	Posttranslational Modification	[18]
Neoplasm of esophagus	DISOLKAQ	Strong	Altered Expression	[9]
Non-small-cell lung cancer	DIS5Y6R9	Strong	Genetic Variation	[19]
Ovarian neoplasm	DISEAFTY	Strong	Posttranslational Modification	[20]
Plasma cell myeloma	DIS0DFZ0	Strong	Posttranslational Modification	[21]
Promyelocytic leukaemia	DISYGG13	Strong	Posttranslational Modification	[22]
Prostate cancer	DISF190Y	Strong	Genetic Variation	[23]
Schistosomiasis	DIS6PD44	Strong	Genetic Variation	[24]
Small lymphocytic lymphoma	DIS30POX	Strong	Biomarker	[25]
Squamous cell carcinoma	DISQVIFL	Strong	Genetic Variation	[26]
T-cell acute lymphoblastic leukaemia	DIS17AI2	Strong	Altered Expression	[27]
T-cell lymphoma	DISSXRTQ	Strong	Altered Expression	[28]
Urinary bladder cancer	DISDV4T7	Strong	Biomarker	[1]
Acute lymphocytic leukaemia	DISPX75S	moderate	Posttranslational Modification	[18]
Acute myelogenous leukaemia	DISCSPTN	moderate	Posttranslational Modification	[18]
Gastric cancer	DISXGOUK	moderate	Biomarker	[29]
Lung adenocarcinoma	DISD51WR	moderate	Biomarker	[30]
Malignant mesothelioma	DISTHJGH	moderate	Biomarker	[31]
Childhood acute lymphoblastic leukemia	DISJ5D6U	Disputed	Posttranslational Modification	[18]
Acute leukaemia	DISDQFDI	Limited	Biomarker	[18]
Carcinoma	DISH9F1N	Limited	Biomarker	[23]
leukaemia	DISS7D1V	Limited	Genetic Variation	[16]
Lymphoma, non-Hodgkin, familial	DISCXYIZ	Limited	Biomarker	[32]
Non-hodgkin lymphoma	DISS2Y8A	Limited	Biomarker	[32]
Retinoblastoma	DISVPNPB	Limited	Altered Expression	[33]
Stomach cancer	DISKIJSX	Limited	Biomarker	[29]
T-cell leukaemia	DISJ6YIF	Limited	Genetic Variation	[34]

2 Drug(s) Affected the Post-Translational Modifications of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Valproate	DMCFE9I	Approved	Valproate increases the methylation of Large ribosomal subunit protein bL28m (MRPL28).	[35]
Benzo(a)pyrene	DMN7J43	Phase 1	Benzo(a)pyrene affects the methylation of Large ribosomal subunit protein bL28m (MRPL28).	[43]

7 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Ciclosporin	DMAZJFX	Approved	Ciclosporin decreases the expression of Large ribosomal subunit protein bL28m (MRPL28).	[36]
Tretinoin	DM49DUI	Approved	Tretinoin increases the expression of Large ribosomal subunit protein bL28m (MRPL28).	[37]
Acetaminophen	DMUIE76	Approved	Acetaminophen decreases the expression of Large ribosomal subunit protein bL28m (MRPL28).	[38]
Temozolomide	DMKECZD	Approved	Temozolomide increases the expression of Large ribosomal subunit protein bL28m (MRPL28).	[39]
Marinol	DM70IK5	Approved	Marinol decreases the expression of Large ribosomal subunit protein bL28m (MRPL28).	[40]
Phenobarbital	DMXZOCG	Approved	Phenobarbital affects the expression of Large ribosomal subunit protein bL28m (MRPL28).	[41]
(+)-JQ1	DM1CZSJ	Phase 1	(+)-JQ1 decreases the expression of Large ribosomal subunit protein bL28m (MRPL28).	[44]

1 Drug(s) Affected the Protein Interaction/Cellular Processes of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
DNCB	DMDTVYC	Phase 2	DNCB affects the binding of Large ribosomal subunit protein bL28m (MRPL28).	[42]

References

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