Details of Disease

General Information of Disease (ID: DISTIM10)

Disease Name	Blindness
Synonyms	blindness; visual impairment; vision loss; vision impairment
Disease Class	9D90: Vision impairment
Definition	The lack of vision. It is caused by neurological or physiological factors.
Disease Hierarchy	DIS8R6NJ: Vision disorder DISTIM10: Blindness
ICD Code	ICD-11 ICD-11: 9D90
Disease Identifiers	MONDO ID MONDO_0001941 MESH ID D001766 UMLS CUI C0456909 MedGen ID 99138 HPO ID HP:0000618

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
TgAAG76	DMNKLZM	Phase 1/2	NA	[1]
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This Disease is Treated as An Indication in 1 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
DYN-15	DMDELIJ	Investigative	NA	[2]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 37 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CEP290	TT3XBOV	Limited	Genetic Variation	[3]
CLN3	TTORF9W	Limited	Biomarker	[4]
PNPLA6	TTWAQU2	Limited	Biomarker	[5]
PROM1	TTXMZ81	Limited	Biomarker	[6]
RPGR	TTHBDA9	Limited	Biomarker	[7]
SCN1A	TTANOZH	Limited	Genetic Variation	[8]
ACKR1	TTKY2NS	moderate	Biomarker	[9]
CNTLN	TT8MI6U	moderate	Genetic Variation	[3]
IMPDH1	TT3GRLK	moderate	Genetic Variation	[10]
MOG	TTQAFX5	moderate	Biomarker	[11]
OAT	TTTSCQ2	moderate	Biomarker	[12]
OPA1	TTTU49Q	moderate	Genetic Variation	[13]
PLTP	TTZF6SN	moderate	Biomarker	[14]
RHO	TTH0KSX	moderate	Genetic Variation	[15]
SUCNR1	TT4FX9Y	moderate	Biomarker	[16]
TBK1	TTMP03S	moderate	Genetic Variation	[17]
TYR	TTULVH8	moderate	Genetic Variation	[18]
ABCA4	TTLB52K	Strong	Genetic Variation	[19]
AHR	TT037IE	Strong	Biomarker	[20]
AMD1	TTBFROQ	Strong	Biomarker	[21]
ATIC	TT9NVXQ	Strong	Biomarker	[22]
CASP4	TT6KIOT	Strong	Biomarker	[23]
CFH	TTUW6OP	Strong	Genetic Variation	[24]
CHM	TTOA18V	Strong	Biomarker	[25]
CLCN3	TT8XNZ7	Strong	Biomarker	[26]
CLN6	TTJCOQ7	Strong	Genetic Variation	[27]
CRYBB1	TTDS503	Strong	Genetic Variation	[28]
GUCY2D	TTWNFC2	Strong	Biomarker	[29]
HTRA1	TT8POQR	Strong	Genetic Variation	[30]
LRP5	TT7VMG4	Strong	Genetic Variation	[31]
MCOLN1	TT9XBVO	Strong	Genetic Variation	[32]
NLRP3	TT4EN8X	Strong	Altered Expression	[33]
RPE65	TTBOH16	Strong	Genetic Variation	[34]
RS1	TTT2CZY	Strong	Genetic Variation	[35]
TST	TT51OTS	Strong	Genetic Variation	[36]
USH2A	TTVCLLA	Strong	Genetic Variation	[37]
PTPRC	TTUS45N	Definitive	Biomarker	[29]
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⏷ Show the Full List of 37 DTT(s)

This Disease Is Related to 4 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC25A22	DTJCWP8	Strong	Genetic Variation	[38]
SLC4A11	DTH2J1G	Strong	Altered Expression	[39]
SLC4A3	DT4X2AH	Strong	Biomarker	[40]
SLC4A4	DTWDEIL	Strong	Genetic Variation	[41]
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This Disease Is Related to 70 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ALMS1	OTW66JKS	Limited	Genetic Variation	[42]
ATXN7	OTL3YF1H	Limited	Genetic Variation	[43]
CAPN5	OTQ8QM7K	Limited	Biomarker	[44]
CDHR1	OT1ORXCM	Limited	Genetic Variation	[45]
FAM161A	OTF5ZRYJ	Limited	Genetic Variation	[46]
GUCA1B	OT85S0J3	Limited	Genetic Variation	[47]
KIZ	OT5VCKSM	Limited	Genetic Variation	[48]
LCA5	OTQTCUWS	Limited	Genetic Variation	[49]
LRAT	OTB7CJKY	Limited	Genetic Variation	[50]
MFSD8	OT455EIC	Limited	Genetic Variation	[51]
ND6	OTG47B7B	Limited	Genetic Variation	[52]
NDP	OTGDJ4US	Limited	Genetic Variation	[53]
NDUFS4	OTJKUYEE	Limited	Biomarker	[54]
NEO1	OTGJ1997	Limited	Biomarker	[55]
NR2E3	OTO3GBHQ	Limited	Genetic Variation	[56]
NUB1	OTWA6RTX	Limited	Biomarker	[57]
OPTN	OT2UXWH9	Limited	Genetic Variation	[58]
PRPF31	OTSJ0Z1Y	Limited	Genetic Variation	[59]
PRPF8	OTU39JZI	Limited	Genetic Variation	[60]
PRPH2	OTNH2G5H	Limited	Genetic Variation	[36]
RPE	OT0XT3JU	Limited	Genetic Variation	[61]
SNRNP200	OTSAU864	Limited	Biomarker	[60]
STARD9	OTZ5CIXU	Disputed	Genetic Variation	[62]
KCNJ13	OTG1CNND	moderate	Genetic Variation	[63]
MASP1	OTWWCNZP	moderate	Biomarker	[14]
SEMA4A	OT8901H3	moderate	Genetic Variation	[64]
ABHD12	OTDP4F02	Strong	Genetic Variation	[65]
AHI1	OT8K2YWY	Strong	Genetic Variation	[66]
AIPL1	OT4VBD78	Strong	Genetic Variation	[67]
ALPG	OTCIM29R	Strong	Genetic Variation	[68]
ARL13B	OT9PYPV1	Strong	Biomarker	[69]
ARMS2	OTUXHJ9H	Strong	Genetic Variation	[70]
ATF6B	OTT2ZGSR	Strong	Genetic Variation	[71]
ATOH7	OTUBW5PV	Strong	Genetic Variation	[72]
ATP6V1H	OTX17GQ9	Strong	Genetic Variation	[73]
CCDC102B	OTVDZVD0	Strong	Biomarker	[74]
CEP78	OTTAI5S2	Strong	Genetic Variation	[75]
CGAS	OTJYIXNB	Strong	Biomarker	[23]
CHML	OTW3VW8D	Strong	Biomarker	[76]
CLC	OTYMYR85	Strong	Biomarker	[77]
CLN5	OTY265P6	Strong	Biomarker	[78]
CLRN1	OT1ADI7Q	Strong	Biomarker	[79]
CORO7	OTG7MEAJ	Strong	Biomarker	[80]
CRB1	OTXYUNG0	Strong	Biomarker	[81]
CRB2	OTG0L2CE	Strong	Biomarker	[82]
CRX	OTH435SV	Strong	Biomarker	[83]
CRYBB2	OTL0Z8E6	Strong	Genetic Variation	[28]
CRYGS	OTF5XS0C	Strong	Biomarker	[84]
DHX16	OTW8KZAU	Strong	Genetic Variation	[60]
DPYSL5	OT6F9T6F	Strong	Genetic Variation	[85]
ELOVL4	OT2M9W26	Strong	Genetic Variation	[86]
FBLN5	OTLVNZ8U	Strong	Genetic Variation	[87]
GCA	OTAJ7ZHG	Strong	Biomarker	[88]
IFT172	OT12DW08	Strong	Biomarker	[89]
IQCB1	OTYQ28V9	Strong	Biomarker	[90]
MPEG1	OT7DAO0F	Strong	Biomarker	[91]
MPI	OTBH6ZK1	Strong	Biomarker	[92]
MYO7A	OTBZSPEL	Strong	Genetic Variation	[93]
MYOC	OT6DAHNF	Strong	Genetic Variation	[94]
NXNL1	OT92AILF	Strong	Biomarker	[95]
PCDH15	OTU9C2EH	Strong	Biomarker	[96]
PDC	OT1UUVYY	Strong	Genetic Variation	[97]
PRCD	OT64DNLW	Strong	Genetic Variation	[98]
RD3	OT2L9Y6M	Strong	Biomarker	[99]
RDH12	OTELFRRJ	Strong	Genetic Variation	[100]
RPF2	OTQSKXQF	Strong	Biomarker	[101]
RPS27	OTFXKY7P	Strong	Biomarker	[91]
SIX6	OTD1RD9D	Strong	Genetic Variation	[102]
TIMP3	OTDGQAD1	Strong	Altered Expression	[103]
CLTA	OTLHOXMQ	Definitive	Biomarker	[29]
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⏷ Show the Full List of 70 DOT(s)

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