Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OT1UUVYY)

DOT Name Phosducin (PDC)
Synonyms PHD; 33 kDa phototransducing protein; Protein MEKA
Gene Name PDC
Related Disease
Breast carcinoma ( )
Lung adenocarcinoma ( )
Metastatic malignant neoplasm ( )
Acute myelogenous leukaemia ( )
Advanced cancer ( )
Alopecia ( )
Alzheimer disease ( )
Anemia ( )
Atopic dermatitis ( )
Bladder cancer ( )
Blindness ( )
Brain cancer ( )
Cardiac failure ( )
Chronic kidney disease ( )
Clear cell renal carcinoma ( )
Colorectal carcinoma ( )
Congestive heart failure ( )
Depression ( )
Esophageal squamous cell carcinoma ( )
Inflammatory bowel disease ( )
Insomnia ( )
Leukemia ( )
Movement disorder ( )
Neoplasm ( )
Non-small-cell lung cancer ( )
Obesity ( )
Parkinson disease ( )
Pheochromocytoma ( )
Plasma cell myeloma ( )
Psoriasis ( )
Renal cell carcinoma ( )
Retinitis pigmentosa ( )
Retinopathy ( )
Rheumatoid arthritis ( )
Tauopathy ( )
Urinary bladder cancer ( )
Urinary bladder neoplasm ( )
Amyotrophic lateral sclerosis ( )
Breast cancer ( )
Dementia ( )
High blood pressure ( )
Parkinsonian disorder ( )
Stroke ( )
Autoimmune hepatitis ( )
Colitis ( )
Non-insulin dependent diabetes ( )
Primary biliary cholangitis ( )
Type-1/2 diabetes ( )
UniProt ID
PHOS_HUMAN
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Pfam ID
PF02114
Sequence
MEEAKSQSLEEDFEGQATHTGPKGVINDWRKFKLESQDSDSIPPSKKEILRQMSSPQSRN
GKDSKERVSRKMSIQEYELIHKEKEDENCLRKYRRQCMQDMHQKLSFGPRYGFVYELETG
KQFLETIEKELKITTIVVHIYEDGIKGCDALNSSLTCLAAEYPIVKFCKIKASNTGAGDR
FSLDVLPTLLIYKGGELISNFISVAEQFAEEFFAGDVESFLNEYGLLPEREVHVLEHTKI
EEEDVE
Function May participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. Inhibits the transcriptional activation activity of the cone-rod homeobox CRX.

Molecular Interaction Atlas (MIA) of This DOT

48 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Breast carcinoma DIS2UE88 Definitive Biomarker [1]
Lung adenocarcinoma DISD51WR Definitive Biomarker [2]
Metastatic malignant neoplasm DIS86UK6 Definitive Biomarker [1]
Acute myelogenous leukaemia DISCSPTN Strong Biomarker [3]
Advanced cancer DISAT1Z9 Strong Biomarker [4]
Alopecia DIS37HU4 Strong Altered Expression [5]
Alzheimer disease DISF8S70 Strong Biomarker [6]
Anemia DISTVL0C Strong Biomarker [7]
Atopic dermatitis DISTCP41 Strong Biomarker [8]
Bladder cancer DISUHNM0 Strong Biomarker [9]
Blindness DISTIM10 Strong Genetic Variation [10]
Brain cancer DISBKFB7 Strong Biomarker [4]
Cardiac failure DISDC067 Strong Biomarker [11]
Chronic kidney disease DISW82R7 Strong Biomarker [7]
Clear cell renal carcinoma DISBXRFJ Strong Genetic Variation [12]
Colorectal carcinoma DIS5PYL0 Strong Biomarker [13]
Congestive heart failure DIS32MEA Strong Biomarker [11]
Depression DIS3XJ69 Strong Biomarker [6]
Esophageal squamous cell carcinoma DIS5N2GV Strong Genetic Variation [14]
Inflammatory bowel disease DISGN23E Strong Altered Expression [15]
Insomnia DIS0AFR7 Strong Biomarker [16]
Leukemia DISNAKFL Strong Biomarker [17]
Movement disorder DISOJJ2D Strong Genetic Variation [18]
Neoplasm DISZKGEW Strong Biomarker [13]
Non-small-cell lung cancer DIS5Y6R9 Strong Altered Expression [19]
Obesity DIS47Y1K Strong Biomarker [20]
Parkinson disease DISQVHKL Strong Biomarker [21]
Pheochromocytoma DIS56IFV Strong Biomarker [12]
Plasma cell myeloma DIS0DFZ0 Strong Genetic Variation [22]
Psoriasis DIS59VMN Strong Biomarker [8]
Renal cell carcinoma DISQZ2X8 Strong Genetic Variation [12]
Retinitis pigmentosa DISCGPY8 Strong Genetic Variation [10]
Retinopathy DISB4B0F Strong Biomarker [23]
Rheumatoid arthritis DISTSB4J Strong Biomarker [5]
Tauopathy DISY2IPA Strong Biomarker [24]
Urinary bladder cancer DISDV4T7 Strong Biomarker [9]
Urinary bladder neoplasm DIS7HACE Strong Biomarker [9]
Amyotrophic lateral sclerosis DISF7HVM moderate Genetic Variation [25]
Breast cancer DIS7DPX1 moderate Biomarker [1]
Dementia DISXL1WY moderate Genetic Variation [25]
High blood pressure DISY2OHH moderate Biomarker [26]
Parkinsonian disorder DISHGY45 moderate Biomarker [25]
Stroke DISX6UHX moderate Genetic Variation [27]
Autoimmune hepatitis DISOX03Q Limited Genetic Variation [28]
Colitis DISAF7DD Limited Biomarker [29]
Non-insulin dependent diabetes DISK1O5Z Limited Genetic Variation [26]
Primary biliary cholangitis DIS43E0O Limited Genetic Variation [28]
Type-1/2 diabetes DISIUHAP Limited Biomarker [26]
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⏷ Show the Full List of 48 Disease(s)
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
2 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Valproate DMCFE9I Approved Valproate decreases the methylation of Phosducin (PDC). [30]
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene increases the methylation of Phosducin (PDC). [31]
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References

1 Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis.EMBO Rep. 2015 Oct;16(10):1394-408. doi: 10.15252/embr.201540107. Epub 2015 Aug 31.
2 pH-responsive hybrid nanoparticle with enhanced dissociation characteristic for siRNA delivery.Int J Nanomedicine. 2018 Oct 26;13:6885-6902. doi: 10.2147/IJN.S180119. eCollection 2018.
3 Uterine leiomyomata with t(10;17) disrupt the histone acetyltransferase MORF.Cancer Res. 2004 Aug 15;64(16):5570-7. doi: 10.1158/0008-5472.CAN-04-0050.
4 Plasmacytoid dendritic cell in immunity and cancer.J Neuroimmunol. 2018 Sep 15;322:63-73. doi: 10.1016/j.jneuroim.2018.06.012. Epub 2018 Jun 26.
5 Association of Autoimmune Regulator Gene Rs2075876 Variant, but Not Gene Expression with Alopecia Areata in Males: A Case-control Study.Immunol Invest. 2020 Feb;49(1-2):146-165. doi: 10.1080/08820139.2019.1671450. Epub 2019 Oct 11.
6 The 2002 NIMH Provisional Diagnostic Criteria for Depression of Alzheimer's Disease (PDC-dAD): Gauging their Validity over a Decade Later.J Alzheimers Dis. 2017;58(2):449-462. doi: 10.3233/JAD-161061.
7 Hypoxia-inducible factor stabilizers for treating anemia of chronic kidney disease.Curr Opin Nephrol Hypertens. 2018 Sep;27(5):331-338. doi: 10.1097/MNH.0000000000000431.
8 Hypoxia inhibits TNF--induced TSLP expression in keratinocytes.PLoS One. 2019 Nov 4;14(11):e0224705. doi: 10.1371/journal.pone.0224705. eCollection 2019.
9 Epigenetic repression of regulator of G-protein signaling 2 by ubiquitin-like with PHD and ring-finger domain1 promotes bladder cancer progression.FEBS J. 2015 Jan;282(1):174-82. doi: 10.1111/febs.13116. Epub 2014 Dec 3.
10 Mutation screening of the phosducin gene PDC in patients with retinitis pigmentosa and allied diseases.Mol Vis. 2004 Jan 26;10:62-4.
11 Effects of two Gbetagamma-binding proteins--N-terminally truncated phosducin and beta-adrenergic receptor kinase C terminus (betaARKct)--in heart failure.Gene Ther. 2003 Aug;10(16):1354-61. doi: 10.1038/sj.gt.3301995.
12 Mutation analysis of HIF prolyl hydroxylases (PHD/EGLN) in individuals with features of phaeochromocytoma and renal cell carcinoma susceptibility.Endocr Relat Cancer. 2010 Dec 21;18(1):73-83. doi: 10.1677/ERC-10-0113. Print 2011 Feb.
13 Molecular characterization of colorectal cancer patients and concomitant patient-derived tumor cell establishment.Oncotarget. 2016 Apr 12;7(15):19610-9. doi: 10.18632/oncotarget.7526.
14 Genetic alterations of candidate tumor suppressor ING1 in human esophageal squamous cell cancer.Cancer Res. 2001 Jun 1;61(11):4345-9.
15 Prolyl hydroxylase 2 is dispensable for homeostasis of intestinal epithelium in mice.Acta Biochim Biophys Sin (Shanghai). 2018 Jun 1;50(6):540-546. doi: 10.1093/abbs/gmy037.
16 Expression and Purification of Delta Sleep-Inducing Peptide Fused with Protein Transduction Domain and Human Serum Albumin in Pichia pastoris.Protein Pept Lett. 2017;24(7):668-675. doi: 10.2174/0929866524666170426113022.
17 The leucine zipper motif of the Drosophila AF10 homologue can inhibit PRE-mediated repression: implications for leukemogenic activity of human MLL-AF10 fusions.Mol Cell Biol. 2003 Jan;23(1):119-30. doi: 10.1128/MCB.23.1.119-130.2003.
18 Paroxysmal dystonic choreoathetosis: tight linkage to chromosome 2q.Am J Hum Genet. 1996 Jul;59(1):140-5.
19 The expression of prolyl hydroxylase domain enzymes are up-regulated and negatively correlated with Bcl-2 in non-small cell lung cancer.Mol Cell Biochem. 2011 Dec;358(1-2):257-63. doi: 10.1007/s11010-011-0976-1. Epub 2011 Jul 12.
20 Phosducin rs12402521 polymorphism predicts development of hypertension in young subjects with overweight or obesity.Nutr Metab Cardiovasc Dis. 2013 Apr;23(4):323-9. doi: 10.1016/j.numecd.2011.08.004. Epub 2012 Feb 23.
21 L-dopa co-drugs in nanostructured lipid carriers: A comparative study.Mater Sci Eng C Mater Biol Appl. 2017 Mar 1;72:168-176. doi: 10.1016/j.msec.2016.11.060. Epub 2016 Nov 18.
22 NSD2 is recruited through its PHD domain to oncogenic gene loci to drive multiple myeloma.Cancer Res. 2013 Oct 15;73(20):6277-88. doi: 10.1158/0008-5472.CAN-13-1000. Epub 2013 Aug 26.
23 Analysis of phosducin as a candidate gene for retinopathies.Ophthalmic Genet. 1996 Mar;17(1):3-14. doi: 10.3109/13816819609057863.
24 Cerebrovascular inflammation is associated with tau pathology in Guam parkinsonism dementia.J Neural Transm (Vienna). 2018 Jul;125(7):1013-1025. doi: 10.1007/s00702-018-1883-3. Epub 2018 Apr 26.
25 Two sites in the MAPT region confer genetic risk for Guam ALS/PDC and dementia.Hum Mol Genet. 2007 Feb 1;16(3):295-306. doi: 10.1093/hmg/ddl463. Epub 2006 Dec 21.
26 Adolescent type 2 diabetes: Comparing the Pediatric Diabetes Consortium and Germany/Austria/Luxemburg Pediatric Diabetes Prospective registries.Pediatr Diabetes. 2018 Nov;19(7):1156-1163. doi: 10.1111/pedi.12712. Epub 2018 Jul 17.
27 HIF-prolyl hydroxylases and cardiovascular diseases.Toxicol Mech Methods. 2012 Jun;22(5):347-58. doi: 10.3109/15376516.2012.673088.
28 Autoimmune regulator AIRE: evidence for genetic differences between autoimmune hepatitis and hepatitis as part of the autoimmune polyglandular syndrome type 1.Hepatology. 2001 May;33(5):1047-52. doi: 10.1053/jhep.2001.24031.
29 Loss of prolyl hydroxylase-1 protects against colitis through reduced epithelial cell apoptosis and increased barrier function.Gastroenterology. 2010 Dec;139(6):2093-101. doi: 10.1053/j.gastro.2010.06.068. Epub 2010 Jun 30.
30 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
31 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.