Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTBKGP48)

• DOT Name: Small ribosomal subunit protein eS19 (RPS19)
• Synonyms: 40S ribosomal protein S19
• Gene Name: RPS19
• Related Disease:
  Childhood myelodysplastic syndrome
  Diamond-Blackfan anemia
  Diamond-Blackfan anemia 1
  Hyperglycemia
  Nervous system inflammation
  Acute myelogenous leukaemia
  Anemia
  Arteriosclerosis
  Atherosclerosis
  Autoimmune disease
  Bone marrow failure syndrome
  Breast cancer
  Breast carcinoma
  Epilepsy
  Gastric cancer
  Gastric neoplasm
  Hematologic disease
  Hepatocellular carcinoma
  Hereditary diffuse gastric adenocarcinoma
  Hereditary glaucoma
  Influenza
  Leukemia
  Li-Fraumeni syndrome
  Lupus
  Neoplasm
  Nephropathy
  Open-angle glaucoma
  Pneumonia
  Pneumonitis
  Post-traumatic stress disorder
  Prostate neoplasm
  Pure red-cell aplasia
  Rheumatoid arthritis
  Severe congenital neutropenia
  Systemic lupus erythematosus
  Myelodysplastic syndrome
  Aplastic anemia
  Diabetic kidney disease
  Advanced cancer
  Aicardi-Goutieres syndrome
  Congenital diaphragmatic hernia
  Congenital dyserythropoietic anemia
  Dyskeratosis congenita
  Fanconi anemia complementation group A
  Fanconi's anemia
  Melanoma
  Prostate cancer
  Shwachman-Diamond syndrome
• UniProt ID: RS19_HUMAN
• PDB ID: 4UG0 ; 4V6X ; 5A2Q ; 5AJ0 ; 5FLX ; 5LKS ; 5OA3 ; 5T2C ; 5VYC ; 6G18 ; 6G4S ; 6G4W ; 6G51 ; 6G53 ; 6G5H ; 6G5I ; 6IP5 ; 6IP6 ; 6IP8 ; 6OLE ; 6OLF ; 6OLG ; 6OLI ; 6OLZ ; 6OM0 ; 6OM7 ; 6QZP ; 6XA1 ; 6Y0G ; 6Y2L ; 6Y57 ; 6YBS ; 6Z6L ; 6Z6M ; 6Z6N ; 6ZLW ; 6ZM7 ; 6ZME ; 6ZMI ; 6ZMO ; 6ZMT ; 6ZMW ; 6ZN5 ; 6ZOJ ; 6ZOL ; 6ZON ; 6ZP4 ; 6ZUO ; 6ZV6 ; 6ZVH ; 6ZVJ ; 6ZXD ; 6ZXE ; 6ZXF ; 6ZXG ; 6ZXH ; 7A09 ; 7K5I ; 7MQA ; 7QP6 ; 7QP7 ; 7R4X ; 7TQL ; 7WTT ; 7WTU ; 7WTV ; 7WTW ; 7WTX ; 7WTZ ; 7WU0 ; 7XNX ; 7XNY ; 8G5Y ; 8G5Z ; 8G60 ; 8G61 ; 8G6J ; 8GLP ; 8JDJ ; 8JDK ; 8JDL ; 8JDM ; 8PPK ; 8PPL ; 8T4S
• Pfam ID: PF01090
• Sequence:
  MPGVTVKDVNQQEFVRALAAFLKKSGKLKVPEWVDTVKLAKHKELAPYDENWFYTRAAST
  ARHLYLRGGAGVGSMTKIYGGRQRNGVMPSHFSRGSKSVARRVLQALEGLKMVEKDQDGG
  RKLTPQGQRDLDRIAGQVAAANKKH
• Function: Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Required for pre-rRNA processing and maturation of 40S ribosomal subunits. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
• Tissue Specificity: Higher level expression is seen in the colon carcinoma tissue than normal colon tissue.
• KEGG Pathway:
  Ribosome (hsa03010)
  Coro.virus disease - COVID-19 (hsa05171)
• Reactome Pathway:
  Peptide chain elongation (R-HSA-156902)
  SRP-dependent cotranslational protein targeting to membrane (R-HSA-1799339)
  Viral mRNA Translation (R-HSA-192823)
  Selenocysteine synthesis (R-HSA-2408557)
  Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)
  Translation initiation complex formation (R-HSA-72649)
  Formation of a pool of free 40S subunits (R-HSA-72689)
  Formation of the ternary complex, and subsequently, the 43S complex (R-HSA-72695)
  Ribosomal scanning and start codon recognition (R-HSA-72702)
  GTP hydrolysis and joining of the 60S ribosomal subunit (R-HSA-72706)
  Eukaryotic Translation Termination (R-HSA-72764)
  Regulation of expression of SLITs and ROBOs (R-HSA-9010553)
  Response of EIF2AK4 (GCN2) to amino acid deficiency (R-HSA-9633012)
  SARS-CoV-1 modulates host translation machinery (R-HSA-9735869)
  SARS-CoV-2 modulates host translation machinery (R-HSA-9754678)
  Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (R-HSA-975956)
  Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (R-HSA-975957)
  L13a-mediated translational silencing of Ceruloplasmin expression (R-HSA-156827)

Molecular Interaction Atlas (MIA) of This DOT

48 Disease(s) Related to This DOT

Disease Name	Disease ID	Evidence Level	Mode of Inheritance	REF
Childhood myelodysplastic syndrome	DISMN80I	Definitive	Genetic Variation	[1]
Diamond-Blackfan anemia	DISI2SNW	Definitive	Autosomal dominant	[2]
Diamond-Blackfan anemia 1	DISP4NUV	Definitive	Autosomal dominant	[3]
Hyperglycemia	DIS0BZB5	Definitive	Biomarker	[4]
Nervous system inflammation	DISB3X5A	Definitive	Biomarker	[5]
Acute myelogenous leukaemia	DISCSPTN	Strong	Biomarker	[6]
Anemia	DISTVL0C	Strong	Genetic Variation	[7]
Arteriosclerosis	DISK5QGC	Strong	Biomarker	[8]
Atherosclerosis	DISMN9J3	Strong	Biomarker	[8]
Autoimmune disease	DISORMTM	Strong	Biomarker	[9]
Bone marrow failure syndrome	DISVUY1J	Strong	Biomarker	[10]
Breast cancer	DIS7DPX1	Strong	Biomarker	[11]
Breast carcinoma	DIS2UE88	Strong	Biomarker	[11]
Epilepsy	DISBB28L	Strong	Genetic Variation	[12]
Gastric cancer	DISXGOUK	Strong	Biomarker	[13]
Gastric neoplasm	DISOKN4Y	Strong	Biomarker	[13]
Hematologic disease	DIS9XD9A	Strong	Genetic Variation	[14]
Hepatocellular carcinoma	DIS0J828	Strong	Biomarker	[15]
Hereditary diffuse gastric adenocarcinoma	DISUIBYS	Strong	Biomarker	[13]
Hereditary glaucoma	DISJYSR1	Strong	Biomarker	[16]
Influenza	DIS3PNU3	Strong	Biomarker	[17]
Leukemia	DISNAKFL	Strong	Biomarker	[18]
Li-Fraumeni syndrome	DISR64XA	Strong	Genetic Variation	[19]
Lupus	DISOKJWA	Strong	Biomarker	[20]
Neoplasm	DISZKGEW	Strong	Biomarker	[11]
Nephropathy	DISXWP4P	Strong	Biomarker	[21]
Open-angle glaucoma	DISSZEE8	Strong	Genetic Variation	[22]
Pneumonia	DIS8EF3M	Strong	Biomarker	[23]
Pneumonitis	DIS88E0K	Strong	Biomarker	[23]
Post-traumatic stress disorder	DISHL1EY	Strong	Biomarker	[24]
Prostate neoplasm	DISHDKGQ	Strong	Biomarker	[25]
Pure red-cell aplasia	DIST91OT	Strong	Biomarker	[26]
Rheumatoid arthritis	DISTSB4J	Strong	Biomarker	[27]
Severe congenital neutropenia	DISES99N	Strong	Biomarker	[28]
Systemic lupus erythematosus	DISI1SZ7	Strong	Biomarker	[20]
Myelodysplastic syndrome	DISYHNUI	moderate	Genetic Variation	[19]
Aplastic anemia	DISJRSC0	Disputed	Biomarker	[29]
Diabetic kidney disease	DISJMWEY	Disputed	Biomarker	[30]
Advanced cancer	DISAT1Z9	Limited	Genetic Variation	[31]
Aicardi-Goutieres syndrome	DIS1NH4X	Limited	Biomarker	[32]
Congenital diaphragmatic hernia	DIS0IPVU	Limited	Genetic Variation	[33]
Congenital dyserythropoietic anemia	DIS6FAT6	Limited	Biomarker	[34]
Dyskeratosis congenita	DISSXV0K	Limited	Genetic Variation	[35]
Fanconi anemia complementation group A	DIS8PZLI	Limited	Genetic Variation	[35]
Fanconi's anemia	DISGW6Q8	Limited	Genetic Variation	[35]
Melanoma	DIS1RRCY	Limited	Genetic Variation	[36]
Prostate cancer	DISF190Y	Limited	Biomarker	[37]
Shwachman-Diamond syndrome	DISW57NW	Limited	Biomarker	[38]

16 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Ciclosporin	DMAZJFX	Approved	Ciclosporin increases the expression of Small ribosomal subunit protein eS19 (RPS19).	[39]
Doxorubicin	DMVP5YE	Approved	Doxorubicin affects the expression of Small ribosomal subunit protein eS19 (RPS19).	[40]
Ivermectin	DMDBX5F	Approved	Ivermectin decreases the expression of Small ribosomal subunit protein eS19 (RPS19).	[41]
Calcitriol	DM8ZVJ7	Approved	Calcitriol decreases the expression of Small ribosomal subunit protein eS19 (RPS19).	[42]
Testosterone	DM7HUNW	Approved	Testosterone decreases the expression of Small ribosomal subunit protein eS19 (RPS19).	[42]
Bortezomib	DMNO38U	Approved	Bortezomib increases the expression of Small ribosomal subunit protein eS19 (RPS19).	[43]
Diethylstilbestrol	DMN3UXQ	Approved	Diethylstilbestrol increases the expression of Small ribosomal subunit protein eS19 (RPS19).	[44]
Aspirin	DM672AH	Approved	Aspirin increases the expression of Small ribosomal subunit protein eS19 (RPS19).	[45]
Enzalutamide	DMGL19D	Approved	Enzalutamide affects the expression of Small ribosomal subunit protein eS19 (RPS19).	[46]
Urethane	DM7NSI0	Phase 4	Urethane increases the expression of Small ribosomal subunit protein eS19 (RPS19).	[48]
Genistein	DM0JETC	Phase 2/3	Genistein decreases the expression of Small ribosomal subunit protein eS19 (RPS19).	[49]
Tocopherol	DMBIJZ6	Phase 2	Tocopherol decreases the expression of Small ribosomal subunit protein eS19 (RPS19).	[50]
PMID28870136-Compound-52	DMFDERP	Patented	PMID28870136-Compound-52 decreases the expression of Small ribosomal subunit protein eS19 (RPS19).	[51]
Bisphenol A	DM2ZLD7	Investigative	Bisphenol A decreases the expression of Small ribosomal subunit protein eS19 (RPS19).	[52]
chloropicrin	DMSGBQA	Investigative	chloropicrin increases the expression of Small ribosomal subunit protein eS19 (RPS19).	[53]
Z-Pro-Prolinal	DM43O2U	Investigative	Z-Pro-Prolinal increases the expression of Small ribosomal subunit protein eS19 (RPS19).	[54]

1 Drug(s) Affected the Protein Interaction/Cellular Processes of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Dihydroartemisinin	DMBXVMZ	Approved	Dihydroartemisinin affects the binding of Small ribosomal subunit protein eS19 (RPS19).	[47]

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