Details of Disease

General Information of Disease (ID: DISJMWEY)

Disease Name	Diabetic kidney disease
Synonyms	type 2 diabetes nephropathy; type 1 diabetes nephropathy; diabetic nephropathy; DKD
Disease Class	GB61: Chronic kidney disease
Definition	Progressive kidney disorder caused by vascular damage to the glomerular capillaries, in patients with diabetes mellitus. It is usually manifested with nephritic syndrome and glomerulosclerosis.
Disease Hierarchy	DISW82R7: Chronic kidney disease DIS71G5H: Metabolic disorder DISJMWEY: Diabetic kidney disease
ICD Code	ICD-11 ICD-11: GB61.Z Expand ICD-11 'GB61.Z
Disease Identifiers	MONDO ID MONDO_0005016 MESH ID D003928 UMLS CUI C0011881 MedGen ID 8352 SNOMED CT ID 127013003

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 3 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Captopril	DM458UM	Approved	Small molecular drug	[1]
Irbesartan	DMTP1DC	Approved	Small molecular drug	[2]
Losartan	DM72JXH	Approved	Small molecular drug	[3]
------------------------------------------------------------------------------------

This Disease is Treated as An Indication in 5 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Pyridoxamine	DMVDCGZ	Phase 3	Small molecular drug	[4]
Pimagedine HCl	DMPWH30	Phase 2/3	Small molecular drug	[5]
CSL346	DMDWJCT	Phase 2	Antibody	[6]
LY2382770	DMH3YKJ	Phase 2	Antibody	[7]
CLBS201	DMIXD53	Phase 1	Cell therapy	[8]
------------------------------------------------------------------------------------

This Disease is Treated as An Indication in 1 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
EXO-226	DMV4UIG	Discontinued in Phase 3	NA	[9]
------------------------------------------------------------------------------------

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 271 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
AOC3	TT7HC21	Limited	Biomarker	[10]
ARRB2	TT8SO2I	Limited	Altered Expression	[11]
AXL	TTZPY6J	Limited	Biomarker	[12]
BMP7	TTKOBRA	Limited	Posttranslational Modification	[13]
CCR1	TTC24WT	Limited	Genetic Variation	[14]
CCR2	TTFZYTO	Limited	Biomarker	[15]
CDKN1A	TT9GUW0	Limited	Altered Expression	[16]
CHIT1	TTDYX6T	Limited	Biomarker	[17]
CXCL9	TTWE5PB	Limited	Altered Expression	[18]
EBI3	TTJF68X	Limited	Biomarker	[19]
EGF	TTED8JB	Limited	Biomarker	[20]
ENPP1	TTZTIWS	Limited	Genetic Variation	[21]
FN3K	TTP6W8J	Limited	Genetic Variation	[22]
GCG	TT6Y4PN	Limited	Biomarker	[23]
HIF1A	TTSN6QU	Limited	Biomarker	[24]
HNMT	TT2B6EV	Limited	Biomarker	[25]
ICAM1	TTA1L39	Limited	Biomarker	[26]
IGF1	TTT6LOU	Limited	Altered Expression	[27]
KDR	TTUTJGQ	Limited	Biomarker	[28]
KLK1	TT5T3P6	Limited	Altered Expression	[29]
LCN2	TTKTLAI	Limited	Biomarker	[30]
LEPR	TT0HD6V	Limited	Biomarker	[31]
MDK	TTV8UE7	Limited	Altered Expression	[32]
MMP2	TTLM12X	Limited	Altered Expression	[33]
MTOR	TTCJG29	Limited	Biomarker	[34]
MYH2	TTBIL13	Limited	Biomarker	[35]
NCK1	TTMA3VF	Limited	Biomarker	[36]
NMUR2	TT2L6C5	Limited	Biomarker	[19]
NOX4	TTQRBSJ	Limited	Biomarker	[37]
PRKCB	TTYPXQF	Limited	Biomarker	[38]
PRKCE	TT57MT2	Limited	Biomarker	[39]
SERPINF1	TTR59S1	Limited	Biomarker	[40]
SLC22A2	TT0XOJN	Limited	Genetic Variation	[41]
SLC2A1	TT79TKF	Limited	Biomarker	[42]
TGFBR2	TTZE3P7	Limited	Genetic Variation	[43]
TRPC6	TTRBT3W	Limited	Biomarker	[44]
TXNIP	TTTLDZK	Limited	Genetic Variation	[34]
VDAC1	TTAMKGB	Limited	Biomarker	[45]
VDAC2	TTM1I7L	Limited	Biomarker	[45]
ADM	TTV14YH	Disputed	Biomarker	[46]
APLN	TT87D3J	Disputed	Biomarker	[47]
CETP	TTFQAYR	Disputed	Genetic Variation	[48]
ENTPD1	TTYM8DJ	Disputed	Genetic Variation	[49]
FOXC1	TTNT3YA	Disputed	Altered Expression	[50]
IRS1	TTAJSQ0	Disputed	Genetic Variation	[51]
MASP2	TTR01E9	Disputed	Altered Expression	[52]
MME	TT5TKPM	Disputed	Biomarker	[53]
ABCA1	TTJW1GN	moderate	Biomarker	[54]
ABCC8	TTP835K	moderate	Altered Expression	[55]
ACVRL1	TTGYPTC	moderate	Biomarker	[56]
ANGPTL4	TTWALY5	moderate	Biomarker	[57]
APEX1	TTHGL48	moderate	Biomarker	[58]
APLNR	TTJ8E43	moderate	Biomarker	[47]
APOA4	TTNC3WS	moderate	Biomarker	[59]
APOC3	TTXOZQ1	moderate	Genetic Variation	[60]
APOL1	TTDB8PW	moderate	Genetic Variation	[61]
ARRB1	TTMVD4A	moderate	Altered Expression	[62]
CALCRL	TTY6O0Q	moderate	Biomarker	[63]
CD59	TTBGTEJ	moderate	Biomarker	[64]
DGKA	TTGL8F0	moderate	Altered Expression	[65]
EHMT1	TTOFXD7	moderate	Biomarker	[23]
EPHX2	TT7WVHI	moderate	Genetic Variation	[66]
F10	TTCIHJA	moderate	Biomarker	[67]
F2R	TTL935N	moderate	Altered Expression	[68]
FABP4	TTHWMFZ	moderate	Altered Expression	[69]
GAS6	TT69QD2	moderate	Biomarker	[70]
GDF15	TT4MXVG	moderate	Altered Expression	[71]
GHRL	TT1OCL0	moderate	Genetic Variation	[72]
GLO1	TTV9A7R	moderate	Genetic Variation	[73]
GPBAR1	TTSDVTR	moderate	Biomarker	[74]
GSK3B	TTRSMW9	moderate	Biomarker	[75]
HPSE	TTR7GJO	moderate	Altered Expression	[76]
IL20	TTNZMY2	moderate	Biomarker	[77]
IRS2	TTF95B8	moderate	Altered Expression	[78]
JAK2	TTRMX3V	moderate	Biomarker	[79]
KCNQ1	TT846HF	moderate	Genetic Variation	[80]
KHDRBS1	TTAT6C7	moderate	Biomarker	[81]
LIN28A	TTO50LN	moderate	Biomarker	[82]
LOXL2	TTFSUHX	moderate	Biomarker	[83]
LPAR1	TTQ6S1K	moderate	Biomarker	[84]
LPAR3	TTE2YJR	moderate	Biomarker	[84]
LRP6	TTSXOWE	moderate	Biomarker	[85]
MAP3K7	TTJQT60	moderate	Posttranslational Modification	[86]
MCAM	TTHRE05	moderate	Biomarker	[87]
NLRC5	TTWZC78	moderate	Biomarker	[88]
NOD2	TTYPUHA	moderate	Altered Expression	[89]
NPPB	TTY63XT	moderate	Genetic Variation	[90]
NR1H4	TTS4UGC	moderate	Biomarker	[74]
ORAI1	TTE76YK	moderate	Biomarker	[91]
PDGFA	TTSM78N	moderate	Altered Expression	[92]
PKM	TT4LOT8	moderate	Biomarker	[93]
PPARA	TTJ584C	moderate	Altered Expression	[94]
PPIA	TTL2ADK	moderate	Biomarker	[95]
PROC	TTZUXYS	moderate	Biomarker	[96]
PTAFR	TTQL5VC	moderate	Altered Expression	[97]
ROCK2	TTGWKQJ	moderate	Biomarker	[98]
S100A8	TT4AF6N	moderate	Altered Expression	[55]
SDC2	TT5H2F0	moderate	Genetic Variation	[99]
SEMA3A	TTVKD3S	moderate	Biomarker	[100]
SGK1	TTTV8EJ	moderate	Biomarker	[101]
SLC12A3	TTP362L	moderate	Genetic Variation	[102]
SLC33A1	TTL69WB	moderate	Biomarker	[103]
SLC5A1	TT2UE56	moderate	Altered Expression	[104]
SMN1	TT8QL6X	moderate	Biomarker	[105]
SYK	TT2HUPM	moderate	Biomarker	[106]
SYVN1	TT8XKYM	moderate	Altered Expression	[107]
TREM1	TTHZQP0	moderate	Altered Expression	[108]
TYRO3	TTIEMFN	moderate	Altered Expression	[109]
UCP1	TTI12YJ	moderate	Altered Expression	[110]
ULK1	TT4D7MJ	moderate	Biomarker	[94]
UTRN	TTNO1VA	moderate	Biomarker	[111]
ACACB	TTY84UG	Strong	Biomarker	[112]
ACVR1	TTJNBQA	Strong	Biomarker	[113]
ADORA1	TTK25J1	Strong	Biomarker	[114]
AGTR2	TTQVOEI	Strong	Altered Expression	[115]
AIMP2	TTXWHGF	Strong	Biomarker	[116]
ALOX12	TT12ABZ	Strong	Genetic Variation	[117]
ANGPT2	TTKLQTJ	Strong	Biomarker	[118]
APOH	TT2OUI9	Strong	Biomarker	[119]
ARG2	TTV1AG6	Strong	Altered Expression	[120]
ATP2A2	TTE6THL	Strong	Biomarker	[121]
AVPR2	TTK8R02	Strong	Biomarker	[122]
B2M	TTY7FKA	Strong	Biomarker	[123]
BBOX1	TT9FOLC	Strong	Biomarker	[124]
BDKRB2	TTGY8IW	Strong	Genetic Variation	[125]
BDNF	TTSMLOH	Strong	Biomarker	[126]
BECN1	TT5M7LN	Strong	Altered Expression	[127]
C3	TTJGY7A	Strong	Biomarker	[128]
C3AR1	TTI6B3F	Strong	Altered Expression	[128]
C5	TTKANGO	Strong	Biomarker	[129]
C5AR1	TTHXFA1	Strong	Biomarker	[130]
CAMKK2	TTV298Y	Strong	Biomarker	[131]
CASP3	TTPF2QI	Strong	Altered Expression	[132]
CASP7	TTM7Y45	Strong	Therapeutic	[133]
CASP8	TT6SZNG	Strong	Therapeutic	[134]
CCL20	TT2XAZY	Strong	Biomarker	[135]
CCNE1	TTCEJ4F	Strong	Biomarker	[136]
CD36	TTPJMCU	Strong	Genetic Variation	[137]
CD38	TTPURFN	Strong	Biomarker	[138]
CDKN1B	TTLGFVW	Strong	Biomarker	[139]
CFD	TT8D13I	Strong	Biomarker	[140]
CHN2	TT39YVO	Strong	Genetic Variation	[141]
CMKLR1	TT4UGZL	Strong	Biomarker	[116]
COL6A3	TT5WCAH	Strong	Biomarker	[142]
CPB2	TTP18AY	Strong	Genetic Variation	[143]
CPT1B	TTDL0NY	Strong	Biomarker	[144]
CR1	TTEA8OW	Strong	Biomarker	[145]
CREB1	TTH4AN3	Strong	Altered Expression	[146]
CRTC1	TT4GO0F	Strong	Altered Expression	[147]
CSNK2A2	TT7GR5W	Strong	Altered Expression	[148]
CUBN	TT9YLCR	Strong	Biomarker	[149]
DCN	TTB3XAN	Strong	Biomarker	[150]
DKK1	TTE3RAC	Strong	Genetic Variation	[151]
E2F3	TTWIJYH	Strong	Biomarker	[152]
EDNRA	TTKRD0G	Strong	Biomarker	[153]
ELAVL1	TTPC9D0	Strong	Biomarker	[154]
ENPEP	TT9PBIL	Strong	Biomarker	[155]
EP300	TTGH73N	Strong	Genetic Variation	[156]
EPAS1	TTWPA54	Strong	Therapeutic	[157]
EREG	TTYSB89	Strong	Altered Expression	[158]
ESR1	TTZAYWL	Strong	Genetic Variation	[159]
FABP1	TTIV96N	Strong	Biomarker	[160]
FABP2	TTS4YLO	Strong	Genetic Variation	[161]
FAS	TT7LTUJ	Strong	Biomarker	[162]
FFAR2	TT0FYAN	Strong	Biomarker	[163]
FGF1	TTMY81X	Strong	Biomarker	[164]
FGF21	TTQ916P	Strong	Biomarker	[165]
FGF23	TT2IZ4K	Strong	Biomarker	[166]
FOXO1	TTLRVIA	Strong	Biomarker	[167]
G6PD	TTKN8W0	Strong	Biomarker	[168]
GCK	TTDLNGZ	Strong	Biomarker	[169]
GHR	TTHJWYD	Strong	Biomarker	[170]
GIPR	TTYMKBE	Strong	Biomarker	[171]
GLP1R	TTVIMDE	Strong	Biomarker	[23]
GRB2	TTEYRJ9	Strong	Biomarker	[172]
GREM1	TTOUZN5	Strong	Biomarker	[173]
GRK2	TTAZ3MN	Strong	Therapeutic	[174]
GRK3	TT5A4DX	Strong	Therapeutic	[174]
GSR	TTEP6RV	Strong	Therapeutic	[175]
HCN1	TTNB6UQ	Strong	Genetic Variation	[176]
HDAC2	TTSHTOI	Strong	Biomarker	[177]
HDAC4	TTTQGH8	Strong	Biomarker	[178]
HDAC5	TTUELN5	Strong	Biomarker	[177]
HNF4A	TT2F3CD	Strong	Biomarker	[169]
HP	TTLC8E1	Strong	Biomarker	[179]
HSPA5	TTW26OG	Strong	Altered Expression	[50]
HSPB1	TT9AZWY	Strong	Biomarker	[180]
HTR2A	TTJQOD7	Strong	Biomarker	[181]
ID2	TTW8A5N	Strong	Biomarker	[182]
IGF1R	TTQFBMY	Strong	Biomarker	[183]
IGF2	TTE8WGO	Strong	Biomarker	[184]
IL19	TT87RWS	Strong	Altered Expression	[185]
IL1RL1	TT4GZA4	Strong	Altered Expression	[186]
INS	TTZOPHG	Strong	Genetic Variation	[51]
IRAK4	TTILUKB	Strong	Genetic Variation	[187]
ITGA1	TTPERWV	Strong	Biomarker	[188]
ITPR1	TT5HWAT	Strong	Genetic Variation	[189]
JAK1	TT6DM01	Strong	Biomarker	[190]
KCNJ11	TT329V4	Strong	Altered Expression	[191]
KEAP1	TT3Z6Y9	Strong	Biomarker	[192]
KHK	TTPAFR9	Strong	Biomarker	[193]
KNG1	TTDJ4MY	Strong	Genetic Variation	[125]
LCK	TT860QF	Strong	Biomarker	[194]
LIMK2	TTASMD8	Strong	Genetic Variation	[195]
LRP2	TTPH1AJ	Strong	Altered Expression	[196]
LYZ	TTAOZBW	Strong	Biomarker	[197]
MAP2K2	TT8H9GB	Strong	Biomarker	[198]
MAP3K1	TTW8TJI	Strong	Posttranslational Modification	[199]
MBNL2	TTH9OLG	Strong	Biomarker	[200]
MGAM	TTXWASR	Strong	Biomarker	[201]
MMP10	TTXLEG7	Strong	Biomarker	[71]
NCF1	TTZ4JC3	Strong	Biomarker	[202]
NFE2L2	TTA6ZN2	Strong	Biomarker	[203]
NOS1	TTZUFI5	Strong	Therapeutic	[204]
NQO1	TT8XK6L	Strong	Altered Expression	[205]
NR1H3	TTECBXN	Strong	Biomarker	[206]
NR3C2	TT26PHO	Strong	Biomarker	[207]
NRG4	TTWAGKJ	Strong	Biomarker	[208]
NTRK2	TTKN7QR	Strong	Biomarker	[126]
NUAK1	TT65FL0	Strong	Altered Expression	[209]
PCSK1	TTED9LZ	Strong	Biomarker	[210]
PGC	TT7K6AD	Strong	Biomarker	[211]
PLA2G7	TTDNFMT	Strong	Biomarker	[212]
PLA2R1	TTHKW7D	Strong	Biomarker	[213]
PLAU	TTGY7WI	Strong	Biomarker	[214]
PLK2	TT976FS	Strong	Biomarker	[215]
PRMT1	TTVOJAI	Strong	Biomarker	[216]
PRSS1	TT2WR1T	Strong	Altered Expression	[217]
RBPJ	TT72D4Z	Strong	Biomarker	[218]
RENBP	TTZCG0Q	Strong	Biomarker	[219]
RHBDF2	TTH1ZOP	Strong	Biomarker	[220]
RIPK2	TTCQ2E5	Strong	Biomarker	[221]
ROS1	TTSZ6Y3	Strong	Biomarker	[222]
SAA1	TTY0DN9	Strong	Biomarker	[223]
SETD7	TTJ0FSU	Strong	Biomarker	[224]
SLC12A1	TTS087L	Strong	Biomarker	[225]
SLC22A6	TTTYH7A	Strong	Altered Expression	[226]
SLC22A8	TTTQR47	Strong	Altered Expression	[226]
SLC2A12	TTZO36H	Strong	Altered Expression	[227]
SMAD1	TT9GR53	Strong	Biomarker	[228]
SMAD6	TTON5JB	Strong	Biomarker	[229]
SMAD7	TT0J32Z	Strong	Altered Expression	[230]
SOD2	TT9O4C5	Strong	Biomarker	[144]
SORD	TTLSRBZ	Strong	Altered Expression	[231]
SPARC	TTBQFM7	Strong	Biomarker	[232]
SPP1	TT8ME6I	Strong	Genetic Variation	[233]
SREBF1	TTER0UB	Strong	Biomarker	[234]
SREBF2	TTRQ4AP	Strong	Biomarker	[235]
SUV39H1	TTUWQTK	Strong	Altered Expression	[236]
TCF7L2	TT80QAL	Strong	Genetic Variation	[237]
TF	TT8WXAV	Strong	Biomarker	[238]
THBS1	TTKI0H1	Strong	Biomarker	[239]
TKT	TT04R7I	Strong	Biomarker	[240]
TNFRSF1A	TTG043C	Strong	Biomarker	[241]
TRH	TT2Z39D	Strong	Biomarker	[242]
TRIP10	TTKHTGE	Strong	Biomarker	[243]
TRPC5	TT32NQ1	Strong	Genetic Variation	[244]
UCP2	TTSC2YM	Strong	Biomarker	[245]
UCP3	TT12RJK	Strong	Genetic Variation	[246]
UNC13B	TT948FC	Strong	Genetic Variation	[247]
UTS2	TTERU0T	Strong	Biomarker	[248]
UTS2R	TTW5UDX	Strong	Biomarker	[249]
VCAM1	TTHCEF6	Strong	Biomarker	[26]
VDR	TTK59TV	Strong	Biomarker	[250]
VEGFB	TTPJQHE	Strong	Biomarker	[251]
XDH	TT7RJY8	Strong	Therapeutic	[252]
MAP3K5	TTOQCD8	Definitive	Biomarker	[253]
NLRX1	TTKT026	Definitive	Biomarker	[254]
PDE3A	TT06AWU	Definitive	Genetic Variation	[195]
PON1	TT9LX82	Definitive	Genetic Variation	[255]
SLC30A8	TTXIGT7	Definitive	Genetic Variation	[256]
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⏷ Show the Full List of 271 DTT(s)

This Disease Is Related to 7 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
ABCC11	DTWN7FC	moderate	Altered Expression	[55]
ABCC6	DT582KR	Strong	Biomarker	[200]
KCNH7	DT3WXPI	Strong	Genetic Variation	[189]
SLC2A2	DTUJPOL	Strong	Biomarker	[257]
SLC30A7	DTQK38X	Strong	Biomarker	[258]
SLC7A2	DTWY9RT	Strong	Biomarker	[225]
SLC9A8	DTNY0C2	Strong	Biomarker	[225]
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⏷ Show the Full List of 7 DTP(s)

This Disease Is Related to 10 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
PRKCSH	DE073GW	Limited	Genetic Variation	[259]
CRMP1	DE0EUXB	moderate	Biomarker	[111]
CYP4B1	DEMF740	moderate	Biomarker	[260]
CYP2R1	DEBIHM3	Strong	Genetic Variation	[261]
DDAH1	DEY0TQC	Strong	Biomarker	[262]
GFPT2	DERQCJM	Strong	Genetic Variation	[263]
MEP1B	DEKBXUC	Strong	Genetic Variation	[264]
NDUFS3	DE741FI	Strong	Biomarker	[265]
SI	DE5EO4Y	Strong	Biomarker	[201]
PON2	DEHJU7E	Definitive	Genetic Variation	[266]
------------------------------------------------------------------------------------


⏷ Show the Full List of 10 DME(s)

This Disease Is Related to 311 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ACKR2	OTWYY14H	Limited	Biomarker	[267]
ADD2	OTRCPCD2	Limited	Genetic Variation	[268]
APOL3	OT95SQHR	Limited	Genetic Variation	[269]
CCT2	OTW1VV4E	Limited	Biomarker	[270]
COL4A1	OTL6D1YE	Limited	Biomarker	[271]
CST3	OTNZ6AO4	Limited	Altered Expression	[272]
DGKH	OTYNPJ4B	Limited	Biomarker	[39]
EFNA1	OTU2NUA2	Limited	Biomarker	[19]
HAVCR1	OT184CRZ	Limited	Biomarker	[273]
IGF2BP2	OT4ZSEEE	Limited	Genetic Variation	[274]
KL	OTD4VWU6	Limited	Biomarker	[275]
MCF2L2	OTOGFMIH	Limited	Genetic Variation	[276]
MYH9	OT94Z706	Limited	Biomarker	[118]
NFAT5	OTKIE59S	Limited	Biomarker	[277]
PICK1	OT8QE6EU	Limited	Biomarker	[278]
POTEF	OTV3WXYE	Limited	Altered Expression	[279]
RAB38	OTU0NZU0	Limited	Altered Expression	[280]
SOCS5	OTN1ABYR	Limited	Biomarker	[281]
STAP2	OTEB1VVI	Limited	Biomarker	[282]
TINAG	OTY7BSD7	Limited	Biomarker	[45]
TNFAIP1	OT37EWR0	Limited	Biomarker	[39]
CALB1	OTM7IXDG	Disputed	Biomarker	[283]
CCHCR1	OT22C116	Disputed	Genetic Variation	[284]
GPRC5A	OTPOCWR7	Disputed	Biomarker	[285]
MLLT3	OTXH4DDG	Disputed	Therapeutic	[286]
NRK	OTGR01FF	Disputed	Biomarker	[287]
PRKAA1	OT7TNF0L	Disputed	Biomarker	[144]
PRKAB1	OT1OG4QZ	Disputed	Biomarker	[144]
PTX3	OTPXHRKU	Disputed	Biomarker	[288]
RPS19	OTBKGP48	Disputed	Biomarker	[168]
SHBG	OTPWU5IW	Disputed	Genetic Variation	[284]
SUMO4	OT9B447E	Disputed	Genetic Variation	[289]
THG1L	OTUK054V	Disputed	Altered Expression	[50]
ADD1	OTTF68DC	moderate	Genetic Variation	[290]
ADIPOR1	OT65ZFZN	moderate	Biomarker	[291]
ADIPOR2	OT2HDTL8	moderate	Altered Expression	[292]
ATP6AP2	OT0IABVV	moderate	Altered Expression	[293]
CARS1	OTOUZF6O	moderate	Biomarker	[294]
CD2AP	OTC76KQM	moderate	Altered Expression	[295]
CD68	OTOYEY3J	moderate	Altered Expression	[296]
CXCL16	OTD49T9R	moderate	Biomarker	[297]
DAPK2	OTWODUQG	moderate	Biomarker	[111]
DENR	OTXP9HOY	moderate	Biomarker	[111]
DNM1L	OTXK1Q1G	moderate	Biomarker	[111]
FGF13	OTHNNVSG	moderate	Biomarker	[298]
FRMD3	OT0CD2GG	moderate	Biomarker	[294]
GPRC5B	OTF3S5E3	moderate	Altered Expression	[299]
HYOU1	OTBGBSOV	moderate	Altered Expression	[300]
IL17B	OTS86H50	moderate	Biomarker	[77]
IQGAP1	OTZRWTGA	moderate	Biomarker	[301]
KDM6A	OTZM3MJJ	moderate	Biomarker	[302]
KLF15	OTGMQMVR	moderate	Biomarker	[303]
KLF2	OTIP1UFX	moderate	Altered Expression	[304]
KLF6	OTQY9S7F	moderate	Altered Expression	[305]
LIPC	OTZY5SC9	moderate	Genetic Variation	[306]
LRPAP1	OT6DVD2Q	moderate	Altered Expression	[307]
MEFV	OTRJ6S6K	moderate	Biomarker	[308]
MIOX	OTDD9G4E	moderate	Biomarker	[309]
MOK	OTQK7M9V	moderate	Biomarker	[309]
MRTFA	OTCVXASM	moderate	Altered Expression	[148]
NOX1	OTZPJQCC	moderate	Biomarker	[310]
NR2C2	OTDZWVOJ	moderate	Posttranslational Modification	[86]
OPTN	OT2UXWH9	moderate	Altered Expression	[311]
PAQR3	OTTKJ9Y4	moderate	Biomarker	[312]
PLEKHO1	OTMVUQ9W	moderate	Altered Expression	[313]
RAMP2	OTGQXLH5	moderate	Biomarker	[63]
RARRES2	OT1BJE8K	moderate	Biomarker	[116]
RMC1	OT7K8MTJ	moderate	Altered Expression	[314]
SEMA6A	OTDQ7QAW	moderate	Biomarker	[315]
SMAD2	OTC6VB4K	moderate	Genetic Variation	[165]
SMN2	OT54RLO1	moderate	Biomarker	[105]
SNRNP70	OTP52YZ3	moderate	Biomarker	[316]
SOCS2	OTBPNKJQ	moderate	Altered Expression	[183]
TRIB3	OTG5OS7X	moderate	Genetic Variation	[317]
ACCS	OTHIHI9D	Strong	Altered Expression	[94]
ADCY8	OTR1WCZX	Strong	Biomarker	[318]
ADGRG1	OTQBB8NT	Strong	Biomarker	[319]
AFM	OTPOR8IO	Strong	Biomarker	[320]
AHSA1	OTC7AFHT	Strong	Biomarker	[116]
AIFM1	OTKPWB7Q	Strong	Altered Expression	[321]
AKAP1	OTIIB2JB	Strong	Biomarker	[322]
ALKBH1	OTADGU5D	Strong	Biomarker	[323]
ALPK1	OTBW6SGD	Strong	Biomarker	[324]
AMT	OTQYEWZQ	Strong	Genetic Variation	[325]
ANGPTL2	OTB6JG41	Strong	Biomarker	[326]
ANKRD1	OTHJ7JV9	Strong	Altered Expression	[327]
APOA5	OTEVKLVA	Strong	Altered Expression	[328]
APOC1	OTA58CED	Strong	Genetic Variation	[329]
APOM	OTI3FQQC	Strong	Biomarker	[330]
AQP11	OT1IQMHV	Strong	Genetic Variation	[331]
AQP2	OTQLBKK6	Strong	Biomarker	[332]
AQP5	OT77GBY8	Strong	Biomarker	[332]
ARF6	OTVV7KJO	Strong	Biomarker	[333]
ATP5F1B	OTLFZUQK	Strong	Biomarker	[334]
AZIN1	OTX5W77I	Strong	Therapeutic	[335]
AZU1	OTHXU264	Strong	Biomarker	[336]
B3GALNT1	OT8GFSQL	Strong	Biomarker	[337]
BASP1	OTF4VS5G	Strong	Biomarker	[338]
BEST1	OTWHE1ZC	Strong	Biomarker	[339]
CALD1	OTNJKJ6Q	Strong	Genetic Variation	[340]
CAPN10	OTS9LJW4	Strong	Biomarker	[341]
CASP12	OTY2W6FG	Strong	Biomarker	[342]
CCL1	OT23NON8	Strong	Biomarker	[343]
CCNG2	OTII38K2	Strong	Biomarker	[344]
CD5L	OTPY4WQR	Strong	Biomarker	[59]
CDC42	OT5QBC5M	Strong	Biomarker	[345]
CDKAL1	OTA0SGNE	Strong	Genetic Variation	[346]
CFL1	OTT6D5MH	Strong	Biomarker	[347]
CNBP	OTTGM9NK	Strong	Biomarker	[235]
CNKSR3	OTXP4QH8	Strong	Genetic Variation	[189]
COL1A1	OTI31178	Strong	Biomarker	[265]
COL4A5	OTHG60RE	Strong	Biomarker	[348]
COL8A1	OTWBTED2	Strong	Biomarker	[349]
COL8A2	OTASWJ69	Strong	Altered Expression	[349]
COPB2	OT82JIGC	Strong	Biomarker	[350]
CREM	OTJIJ5AL	Strong	Altered Expression	[351]
CST2	OTRKRW50	Strong	Altered Expression	[352]
CUL5	OTMTZD47	Strong	Altered Expression	[353]
CXCL6	OTFTCQ4O	Strong	Biomarker	[354]
DAAM1	OT0VHIYZ	Strong	Genetic Variation	[355]
DBP	OTE0W7LN	Strong	Biomarker	[356]
DDAH2	OT8Q40G2	Strong	Genetic Variation	[357]
DDT	OTF5HTYL	Strong	Biomarker	[358]
DEFA1	OT5N1B9B	Strong	Biomarker	[359]
DEFA3	OTO3N8E1	Strong	Biomarker	[359]
DERL2	OTI3TUUZ	Strong	Altered Expression	[360]
DMP1	OTBWBWW7	Strong	Biomarker	[361]
DMTF1	OTDKO9OO	Strong	Biomarker	[361]
DPYS	OTLTUIVL	Strong	Biomarker	[362]
DSEL	OTVNQD3I	Strong	Genetic Variation	[363]
DSPP	OT1TYNDN	Strong	Genetic Variation	[364]
DUOX1	OTQ2AEW0	Strong	Biomarker	[365]
DUOX2	OTU14HCN	Strong	Biomarker	[365]
DUSP26	OTI7WIYN	Strong	Biomarker	[222]
EDA	OTAKS5WS	Strong	Biomarker	[366]
EIF3M	OTVWEV60	Strong	Biomarker	[367]
ELF3	OTUTLEQO	Strong	Altered Expression	[368]
ERP44	OT7ZI7AG	Strong	Biomarker	[369]
ERRFI1	OT7VZ2IZ	Strong	Biomarker	[370]
ESAM	OTF518AI	Strong	Biomarker	[371]
ESCO1	OTZ9P12A	Strong	Biomarker	[372]
ESM1	OT331Y8V	Strong	Altered Expression	[373]
ETF1	OTH8C5U5	Strong	Biomarker	[367]
FAR2	OTRYY709	Strong	Altered Expression	[374]
FGF11	OT6513W2	Strong	Biomarker	[375]
FIS1	OT2HL10J	Strong	Biomarker	[376]
FITM1	OTBKC6PT	Strong	Altered Expression	[186]
FNDC5	OT5CSK9X	Strong	Genetic Variation	[377]
FUT8	OTJJCVG1	Strong	Biomarker	[378]
GABPA	OT9YB2SA	Strong	Biomarker	[73]
GFPT1	OTQBDO45	Strong	Altered Expression	[379]
GLIPR2	OTFTH6ZY	Strong	Altered Expression	[380]
GOLGA6A	OTHU9MRX	Strong	Biomarker	[381]
GRAP	OTO1P7YX	Strong	Biomarker	[382]
GRAP2	OTS5NIZ3	Strong	Biomarker	[116]
GREM2	OTE91EWT	Strong	Biomarker	[383]
GRK4	OTUU8V2S	Strong	Biomarker	[174]
GRK6	OT4LZTP9	Strong	Therapeutic	[174]
GSDMD	OTH39BKI	Strong	Biomarker	[384]
GUCY1A1	OTPTCBUN	Strong	Genetic Variation	[189]
HAS2	OTTD3PAL	Strong	Biomarker	[385]
HDLBP	OTKDEEYX	Strong	Biomarker	[336]
HEBP1	OTR9MPDX	Strong	Biomarker	[336]
HHIP	OT77RQYS	Strong	Altered Expression	[386]
HLA-DPA1	OT7OG7Y2	Strong	Biomarker	[387]
HMCN1	OTLZAS0P	Strong	Genetic Variation	[388]
HMGN1	OTSMGH99	Strong	Altered Expression	[389]
IGFBP4	OT2HZRBD	Strong	Biomarker	[57]
IL12RB1	OTM1IJO2	Strong	Biomarker	[390]
IL34	OTZ15VVK	Strong	Genetic Variation	[391]
INHBC	OT8SUTZR	Strong	Biomarker	[392]
INPPL1	OTCDAVBQ	Strong	Biomarker	[393]
INTU	OTXB13E6	Strong	Biomarker	[394]
IPCEF1	OTOUIHID	Strong	Altered Expression	[189]
KPNA2	OTU7FOE6	Strong	Posttranslational Modification	[395]
KRT16	OTGA0EQN	Strong	Biomarker	[210]
LAD1	OT6YGTVX	Strong	Biomarker	[396]
LAMB2	OT71OI2Y	Strong	Altered Expression	[397]
LCN1	OT8BWXTV	Strong	Biomarker	[398]
LRG1	OTLD0KWA	Strong	Biomarker	[399]
LTBP1	OTR7Q75L	Strong	Biomarker	[400]
MAK16	OTD546E5	Strong	Biomarker	[401]
MAP1LC3A	OTPMGIU4	Strong	Biomarker	[402]
MAP6	OTPUI00F	Strong	Genetic Variation	[403]
MB	OTYWYL2D	Strong	Biomarker	[71]
MCM3	OTOOHQPM	Strong	Biomarker	[350]
MFHAS1	OTS922CJ	Strong	Biomarker	[404]
MFN2	OTPYN8A3	Strong	Therapeutic	[271]
MGP	OTZWU3FU	Strong	Genetic Variation	[405]
MIXL1	OT584VOQ	Strong	Biomarker	[406]
MLN	OTBZ5SE5	Strong	Biomarker	[407]
MMRN1	OT7ZNYHT	Strong	Biomarker	[408]
MPRIP	OT5FV5NS	Strong	Biomarker	[409]
MSN	OTZJ4J6G	Strong	Genetic Variation	[294]
MSX2	OT1WDKE1	Strong	Biomarker	[218]
MTHFS	OTZ39JNR	Strong	Genetic Variation	[410]
MYOCD	OTSJNHTH	Strong	Biomarker	[411]
MZF1	OTMVZCPW	Strong	Altered Expression	[412]
NAV3	OT97M1TR	Strong	Genetic Variation	[189]
NCALD	OTJZ8UEL	Strong	Biomarker	[413]
NFIA	OTDHQ9CG	Strong	Biomarker	[372]
NFIB	OTX94PD0	Strong	Biomarker	[372]
NFIC	OTLMCUIB	Strong	Biomarker	[372]
NFIX	OT1DPZAE	Strong	Biomarker	[372]
NLRC4	OTAIA3NA	Strong	Biomarker	[414]
NOX3	OT0FFJH8	Strong	Biomarker	[415]
NOX5	OTHTH59G	Strong	Genetic Variation	[416]
NPPA	OTMQNTNX	Strong	Genetic Variation	[417]
OGA	OT7ZBWT1	Strong	Biomarker	[418]
OGN	OTKP5S4L	Strong	Biomarker	[419]
OR10A4	OTYYB8SY	Strong	Genetic Variation	[420]
PACSIN2	OTC2R00C	Strong	Biomarker	[421]
PALD1	OTLGUM8H	Strong	Altered Expression	[422]
PALLD	OTZ2MUJZ	Strong	Altered Expression	[422]
PAX2	OTKP1N8F	Strong	Biomarker	[423]
PEA15	OTKCKTSX	Strong	Altered Expression	[424]
PIAS4	OTB7SVMZ	Strong	Biomarker	[425]
PIK3C2B	OTY2PROB	Strong	Genetic Variation	[426]
PIK3R2	OTZSUQK5	Strong	Biomarker	[427]
PLA2G15	OT6VJTPA	Strong	Altered Expression	[94]
PLEKHH2	OT3TK3NN	Strong	Altered Expression	[428]
PLIN2	OTRXJ9UN	Strong	Biomarker	[429]
PNO1	OT010GIS	Strong	Biomarker	[401]
PNPLA2	OTR3ERMR	Strong	Altered Expression	[430]
POLDIP2	OT8SZSJ6	Strong	Biomarker	[116]
POU2F3	OTIOOJWD	Strong	Genetic Variation	[431]
PPARGC1A	OTHCDQ22	Strong	Biomarker	[144]
PPBP	OT1FHGQS	Strong	Biomarker	[432]
PPP1R8	OTH5KB2P	Strong	Altered Expression	[433]
PRKAA2	OTU1KZPV	Strong	Biomarker	[144]
PROS1	OTXQWNOI	Strong	Biomarker	[70]
PRSS2	OTOMVUWL	Strong	Altered Expression	[217]
PSMA6	OTJ6RPX5	Strong	Altered Expression	[434]
RAB3A	OT2GIUO5	Strong	Biomarker	[435]
RABGEF1	OTWC3Z3R	Strong	Biomarker	[436]
RB1CC1	OTZK8PFX	Strong	Biomarker	[402]
RCAN1	OT1MVXC7	Strong	Altered Expression	[437]
RCBTB1	OTAYELI8	Strong	Biomarker	[381]
RDX	OTNSYUN6	Strong	Biomarker	[294]
RMDN1	OTE1NB6U	Strong	Genetic Variation	[402]
RMDN2	OTK5WSFI	Strong	Genetic Variation	[402]
RMDN3	OTKO7AUM	Strong	Genetic Variation	[402]
RNF19A	OTKWCV80	Strong	Biomarker	[116]
RPL36A	OT1LYV85	Strong	Biomarker	[438]
RPLP0	OT3XKD6Y	Strong	Biomarker	[367]
RPS27A	OTIIGGZ2	Strong	Biomarker	[367]
RPS6	OTT4D1LN	Strong	Biomarker	[439]
RRAS	OTBBF28C	Strong	Genetic Variation	[440]
SAA2	OTYAVJWG	Strong	Biomarker	[223]
SCAF4	OTFGHB1E	Strong	Genetic Variation	[441]
SCAF8	OTSCFMK3	Strong	Biomarker	[442]
SELENBP1	OT3NZNTR	Strong	Genetic Variation	[284]
SEPTIN7	OTJI08YX	Strong	Biomarker	[443]
SFI1	OTI1P52G	Strong	Genetic Variation	[195]
SIRT4	OT5S0J23	Strong	Biomarker	[444]
SIRT7	OT5M4OT4	Strong	Biomarker	[445]
SKIL	OTNBXH32	Strong	Altered Expression	[86]
SLBP	OTVYYQRT	Strong	Biomarker	[336]
SMAD5	OTQNSVCQ	Strong	Biomarker	[446]
SMG1	OTTS3SXE	Strong	Biomarker	[447]
SMPDL3B	OTZ3KNFJ	Strong	Biomarker	[448]
SMURF2	OT3TRVL7	Strong	Altered Expression	[449]
SOAT1	OTB4Y5RJ	Strong	Biomarker	[450]
SORBS1	OTWH8762	Strong	Genetic Variation	[451]
SRGAP2	OTUWFMCQ	Strong	Altered Expression	[452]
SRRM2	OTSIMMC9	Strong	Biomarker	[401]
SRXN1	OTYDBO4L	Strong	Biomarker	[453]
ST3GAL4	OTNENJZQ	Strong	Biomarker	[454]
STAM2	OT9OBWPH	Strong	Biomarker	[336]
SYBU	OT3FQV7N	Strong	Genetic Variation	[402]
TALDO1	OTDKV2S2	Strong	Biomarker	[22]
TAS2R13	OTSTOX5G	Strong	Biomarker	[455]
TBC1D31	OT0LF0OW	Strong	Genetic Variation	[189]
TBX1	OTQLBPRA	Strong	Biomarker	[456]
TCF7	OT1ID822	Strong	Biomarker	[457]
TERF2IP	OT3M5P3G	Strong	Biomarker	[436]
TFG	OT2KJENI	Strong	Biomarker	[458]
TGFBI	OTR443C5	Strong	Altered Expression	[209]
TGIF1	OTN9VHAG	Strong	Biomarker	[459]
TIMM44	OTXP7MXN	Strong	Biomarker	[460]
TIMP2	OT8S1RRP	Strong	Altered Expression	[461]
TIMP3	OTDGQAD1	Strong	Altered Expression	[462]
TNFAIP8	OT1G9297	Strong	Biomarker	[463]
TNFRSF10D	OTOSRDJT	Strong	Biomarker	[464]
TNMD	OTHLVA9G	Strong	Biomarker	[465]
TNS2	OTP72P0F	Strong	Biomarker	[466]
TPD52	OTPKSK43	Strong	Biomarker	[210]
TRAF5	OTSBTLO0	Strong	Altered Expression	[467]
TRDN	OTXVE9SF	Strong	Biomarker	[468]
TRIAP1	OTEAUJXN	Strong	Biomarker	[469]
TRIM11	OTMD6IM2	Strong	Biomarker	[470]
TSC22D1	OTN4GFWD	Strong	Genetic Variation	[471]
TSPYL2	OTGGW2EF	Strong	Biomarker	[472]
ARAP1	OTINOJJ7	Definitive	Biomarker	[473]
ARID2	OTIRJXWM	Definitive	Biomarker	[474]
BTRC	OT2EZDGR	Definitive	Biomarker	[475]
CDAN1	OTCVZRG6	Definitive	Biomarker	[472]
CORO2B	OTCJG5WM	Definitive	Altered Expression	[476]
DRG1	OTIFYMI3	Definitive	Genetic Variation	[195]
DUSP4	OT6WAO12	Definitive	Altered Expression	[477]
EFHD2	OTM9VMN3	Definitive	Biomarker	[478]
ENOX1	OT4WOLA8	Definitive	Genetic Variation	[195]
GPR158	OTYOC1RQ	Definitive	Genetic Variation	[256]
LARGE1	OTUH7H9F	Definitive	Genetic Variation	[195]
MLXIPL	OTR9MLLW	Definitive	Biomarker	[479]
NSA2	OTRU5QPO	Definitive	Biomarker	[480]
PES1	OTMZK7XE	Definitive	Biomarker	[480]
PHLPP1	OTIFXW8D	Definitive	Biomarker	[475]
RNF185	OTU1NS9O	Definitive	Genetic Variation	[195]
SASH1	OTQA8BD4	Definitive	Genetic Variation	[195]
SOD3	OTIOZQAB	Definitive	Altered Expression	[481]
------------------------------------------------------------------------------------


⏷ Show the Full List of 311 DOT(s)

References

1	Captopril FDA Label
2	Irbesartan FDA Label
3	Losartan FDA Label
4	ClinicalTrials.gov (NCT02156843) Pyridorin in Diabetic Nephropathy. U.S. National Institutes of Health.
5	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006816)
6	ClinicalTrials.gov (NCT04419467) A Phase 2a, Double-blind, Randomized, Placebo-controlled, Proof of Concept Study of Vascular Endothelial Growth Factor (VEGF)-B Blockade With the Monoclonal Antibody CSL346 in Subjects With Diabetic Kidney Disease. U.S.National Institutes of Health.
7	ClinicalTrials.gov (NCT01113801) A Study in Participants With Diabetic Kidney Disease. U.S. National Institutes of Health.
8	ClinicalTrials.gov (NCT04990427) A Phase 1 Open-Label, Proof-of-Concept Study to Evaluate the Safety and Efficacy of CLBS201 Autologous Peripheral Blood-Derived CD34+ Cells in Subjects With Chronic Kidney Disease and Type 2 Diabetes Mellitus. U.S.National Institutes of Health.
9	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008954)
10	Synthesis and structure activity relationships of carbamimidoylcarbamate derivatives as novel vascular adhesion protein-1 inhibitors.Bioorg Med Chem. 2017 Nov 1;25(21):6024-6038. doi: 10.1016/j.bmc.2017.09.036. Epub 2017 Sep 23.
11	-Arrestins promote podocyte injury by inhibition of autophagy in diabetic nephropathy.Cell Death Dis. 2016 Apr 7;7(4):e2183. doi: 10.1038/cddis.2016.89.
12	Growth arrest-specific gene 6 is involved in glomerular hypertrophy in the early stage of diabetic nephropathy.J Biol Chem. 2003 May 16;278(20):18229-34. doi: 10.1074/jbc.M213266200. Epub 2003 Mar 17.
13	Bone morphogenetic protein (BMP) 7 expression is regulated by the E3 ligase UBE4A in diabetic nephropathy.Arch Physiol Biochem. 2020 Dec;126(5):416-419. doi: 10.1080/13813455.2018.1551905. Epub 2019 Jan 19.
14	Risk of diabetic nephropathy in type 1 diabetes is associated with functional polymorphisms in RANTES receptor gene (CCR5): a sex-specific effect.Diabetes. 2005 Nov;54(11):3331-5. doi: 10.2337/diabetes.54.11.3331.
15	Podocyte-specific chemokine (C-C motif) receptor 2overexpression mediates diabetic renal injury inmice.Kidney Int. 2017 Mar;91(3):671-682. doi: 10.1016/j.kint.2016.09.042. Epub 2016 Dec 1.
16	Silencing of long noncoding RNA XIST protects against renal interstitial fibrosis in diabetic nephropathy via microRNA-93-5p-mediated inhibition of CDKN1A.Am J Physiol Renal Physiol. 2019 Nov 1;317(5):F1350-F1358. doi: 10.1152/ajprenal.00254.2019. Epub 2019 Sep 23.
17	Association of chitotriosidase enzyme activity and genotype with the risk of nephropathy in type 2 diabetes.Clin Biochem. 2016 Apr;49(6):444-448. doi: 10.1016/j.clinbiochem.2015.11.009. Epub 2015 Nov 14.
18	Biglycan, a novel trigger of Th1 and Th17 cell recruitment into the kidney.Matrix Biol. 2018 Aug;68-69:293-317. doi: 10.1016/j.matbio.2017.12.002. Epub 2017 Dec 15.
19	Genome-wide pathway analysis for diabetic nephropathy in type 1 diabetes.Endocr Res. 2016;41(1):21-7. doi: 10.3109/07435800.2015.1044011. Epub 2015 Jul 13.
20	Associations of urinary epidermal growth factor and monocyte chemotactic protein-1 with kidney involvement in patients with diabetic kidney disease.Nephrol Dial Transplant. 2020 Feb 1;35(2):291-297. doi: 10.1093/ndt/gfy314.
21	Association between the ENPP1 K121Q polymorphism and risk of diabetic kidney disease: a systematic review and meta-analysis.PLoS One. 2015 Mar 20;10(3):e0118416. doi: 10.1371/journal.pone.0118416. eCollection 2015.
22	Genetic variability in enzymes of metabolic pathways conferring protection against non-enzymatic glycation versus diabetes-related morbidity and mortality.Clin Chem Lab Med. 2014 Jan 1;52(1):77-83. doi: 10.1515/cclm-2012-0833.
23	Pharmacological Management of Diabetic Nephropathy.Curr Vasc Pharmacol. 2020;18(2):139-147. doi: 10.2174/1570161117666190405164749.
24	Interstitial HIF1A induces an estimated glomerular filtration rate decline through potentiating renal fibrosis in diabetic nephropathy.Life Sci. 2020 Jan 15;241:117109. doi: 10.1016/j.lfs.2019.117109. Epub 2019 Nov 28.
25	Role of Epigenetic Histone Modifications in Diabetic Kidney Disease Involving Renal Fibrosis.J Diabetes Res. 2017;2017:7242384. doi: 10.1155/2017/7242384. Epub 2017 Jun 13.
26	Potential role of serum fetuin-A in relation with pro-inflammatory, chemokine and adhesion molecules in diabetic kidney disease: a case-control study.Mol Biol Rep. 2019 Feb;46(1):1239-1246. doi: 10.1007/s11033-019-04592-2. Epub 2019 Jan 10.
27	IGF-1/IGF-1R blockade ameliorates diabetic kidney disease through normalizing Snail1 expression in a mouse model.Am J Physiol Endocrinol Metab. 2019 Oct 1;317(4):E686-E698. doi: 10.1152/ajpendo.00071.2019. Epub 2019 Jul 30.
28	VEGF regulates TRPC6 channels in podocytes.Nephrol Dial Transplant. 2012 Mar;27(3):921-9. doi: 10.1093/ndt/gfr457. Epub 2011 Aug 24.
29	Tissue kallikrein mediates pro-inflammatory pathways and activation of protease-activated receptor-4 in proximal tubular epithelial cells.PLoS One. 2014 Feb 21;9(2):e88894. doi: 10.1371/journal.pone.0088894. eCollection 2014.
30	Urinary N-acetyl-beta-d-glucosaminidase (NAG) with neutrophil gelatinase-associated lipocalin (NGAL) improves the diagnostic value for proximal tubule damage in diabetic kidney disease.3 Biotech. 2019 Mar;9(3):66. doi: 10.1007/s13205-019-1593-z. Epub 2019 Feb 4.
31	Coagonist of glucagon-like peptide-1 and glucagon receptors ameliorates kidney injury in murine models of obesity and diabetes mellitus.World J Diabetes. 2018 Jun 15;9(6):80-91. doi: 10.4239/wjd.v9.i6.80.
32	Midkine is involved in tubulointerstitial inflammation associated with diabetic nephropathy.Lab Invest. 2007 Sep;87(9):903-13. doi: 10.1038/labinvest.3700599. Epub 2007 Jul 2.
33	Herba Artemisiae Capillaris Extract Prevents the Development of Streptozotocin-Induced Diabetic Nephropathy of Rat.Evid Based Complement Alternat Med. 2018 Feb 14;2018:5180165. doi: 10.1155/2018/5180165. eCollection 2018.
34	Thioredoxin-interacting protein deficiency alleviates phenotypic alterations of podocytes via inhibition of mTOR activation in diabetic nephropathy.J Cell Physiol. 2019 Sep;234(9):16485-16502. doi: 10.1002/jcp.28317. Epub 2019 Feb 11.
35	MYH9 E1841K Mutation Augments Proteinuria and Podocyte Injury and Migration.J Am Soc Nephrol. 2018 Jan;29(1):155-167. doi: 10.1681/ASN.2015060707. Epub 2017 Oct 9.
36	A remote cis-acting variant at 3q links glomerular NCK1 to diabetic nephropathy.PLoS One. 2013;8(2):e56414. doi: 10.1371/journal.pone.0056414. Epub 2013 Feb 18.
37	Connexin32 ameliorates renal fibrosis in diabetic mice by promoting K48-linked NADPH oxidase 4 polyubiquitination and degradation.Br J Pharmacol. 2020 Jan;177(1):145-160. doi: 10.1111/bph.14853. Epub 2019 Dec 23.
38	The PKC-p66shc-NADPH oxidase pathway plays a crucial role in diabetic nephropathy.J Pharm Pharmacol. 2019 Mar;71(3):338-347. doi: 10.1111/jphp.13043. Epub 2018 Nov 12.
39	Hepatic expression profiling shows involvement of PKC epsilon, DGK eta, Tnfaip, and Rho kinase in type 2 diabetic nephropathy rats.J Cell Biochem. 2010 Nov 1;111(4):944-54. doi: 10.1002/jcb.22783.
40	Genetic Regulation of Pigment Epithelium-Derived Factor (PEDF): An Exome-Chip Association Analysis in Chinese Subjects With Type 2 Diabetes.Diabetes. 2019 Jan;68(1):198-206. doi: 10.2337/db18-0500. Epub 2018 Oct 10.
41	Association of the SLC22A1, SLC22A2, and SLC22A3 genes encoding organic cation transporters with diabetic nephropathy and hypertension.Ann Med. 2010 May 6;42(4):296-304. doi: 10.3109/07853891003777109.
42	SRT1720 retards renal fibrosis via inhibition of HIF1 /GLUT1 in diabetic nephropathy.J Endocrinol. 2019 Feb 1:JOE-18-0536.R2. doi: 10.1530/JOE-18-0536. Online ahead of print.
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