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Oseltamivir FDA Label
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Clinical pipeline report, company report or official report of Sanofi Pasteur.
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ClinicalTrials.gov (NCT05333289) Phase 1/2, Randomized, Observer-Blind, Dose-Ranging Study to Evaluate the Safety, Reactogenicity, and Immunogenicity of mRNA-1020 and mRNA-1030 Candidate Seasonal Influenza Vaccines in Healthy Adults. U.S.National Institutes of Health.
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ClinicalTrials.gov (NCT03121339) Pharmacodynamic Open-Label Trial With VXA-A1.1 Oral H1 Vaccine in Healthy Adults. U.S. National Institutes of Health.
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ClinicalTrials.gov (NCT05446740) A Phase 1 Randomized, Observer-blind, Dose-escalation Study to Evaluate the Safety, Reactogenicity and Immunogenicity of an mRNA-based Monovalent Influenza Vaccine Candidate in Healthy Younger and Older Adults. U.S.National Institutes of Health.
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ClinicalTrials.gov (NCT04439695) Study to Evaluate the Safety and Immunogenicity of KBP-V001 Quadrivalent Influenza Vaccine in Healthy Adults. U.S. National Institutes of Health.
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ClinicalTrials.gov (NCT02500680) The Safety, Tolerance, and Immunogenicity of MAS-1-Adjuvanted Seasonal Inactivated Influenza Vaccine (MER4101) (MER4101). U.S. National Institutes of Health.
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ClinicalTrials.gov (NCT05585632) Phase 1, Randomized, Observer-blind Study to Evaluate the Safety, Reactogenicity, and Immunogenicity of Multi-component Vaccines mRNA-1045 (Influenza and RSV) or mRNA-1230 (Influenza, RSV, and SARS-CoV-2) Compared With mRNA-1010 (Influenza), mRNA-1345 (RSV), and mRNA-1273.214 (SARS-CoV-2) Vaccines in Healthy Adults 50-75 Years of Age. U.S.National Institutes of Health.
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ClinicalTrials.gov (NCT05788237) A Study to Evaluate the Safety, Tolerability, and Immunogenicity of Respiratory Combination Vaccine Candidates in Older Adults. U.S.National Institutes of Health.
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Clinical pipeline report, company report or official report of Pfizer
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Clinical pipeline report, company report or official report of Sanofi
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Clinical pipeline report, company report or official report of Moderna
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The parasite-derived rOv-ASP-1 is an effective antigen-sparing CD4(+) T cell-dependent adjuvant for the trivalent inactivated influenza vaccine, and functions in the absence of MyD88 pathway.Vaccine. 2018 Jun 14;36(25):3650-3665. doi: 10.1016/j.vaccine.2018.05.029.
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Type 1 IFN signaling critically regulates influenza-induced alloimmunization to transfused KEL RBCs in a murine model.Transfusion. 2019 Oct;59(10):3243-3252. doi: 10.1111/trf.15482. Epub 2019 Aug 12.
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Conjugation of an scFab domain to the oligomeric HIV envelope protein for use in immune targeting.PLoS One. 2019 Aug 20;14(8):e0220986. doi: 10.1371/journal.pone.0220986. eCollection 2019.
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Regulation of influenza A virus mRNA splicing by CLK1.Antiviral Res. 2019 Aug;168:187-196. doi: 10.1016/j.antiviral.2019.06.003. Epub 2019 Jun 6.
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Detecting early-warning signals of influenza outbreak based on dynamic network marker.J Cell Mol Med. 2019 Jan;23(1):395-404. doi: 10.1111/jcmm.13943. Epub 2018 Oct 19.
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The DOT1L inhibitor Pinometostat decreases the host-response against infections: Considerations about its use in human therapy.Sci Rep. 2019 Nov 14;9(1):16862. doi: 10.1038/s41598-019-53239-6.
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Eleutheroside B1 mediates its anti-influenza activity through POLR2A and N-glycosylation.Int J Mol Med. 2018 Nov;42(5):2776-2792. doi: 10.3892/ijmm.2018.3863. Epub 2018 Sep 7.
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Human V9V2-T Cells Synergize CD4(+) T Follicular Helper Cells to Produce Influenza Virus-Specific Antibody.Front Immunol. 2018 Apr 4;9:599. doi: 10.3389/fimmu.2018.00599. eCollection 2018.
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Disruption of Type III Interferon (IFN) Genes Ifnl2 and Ifnl3 Recapitulates Loss of the Type III IFN Receptor in the Mucosal Antiviral Response.J Virol. 2019 Oct 29;93(22):e01073-19. doi: 10.1128/JVI.01073-19. Print 2019 Nov 15.
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Long non-coding RNA PSMB8-AS1 regulates influenza virus replication.RNA Biol. 2019 Mar;16(3):340-353. doi: 10.1080/15476286.2019.1572448. Epub 2019 Jan 28.
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Revealing hub pathway cross-talk for premature newborns with bronchopulmonary dysplasia by the integration of pathway analysis and Monte Carlo Cross-Validation.Exp Ther Med. 2019 Apr;17(4):2715-2719. doi: 10.3892/etm.2019.7257. Epub 2019 Feb 12.
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Targeting the IL-22/IL-22BP axis enhances tight junctions and reduces inflammation during influenza infection.Mucosal Immunol. 2020 Jan;13(1):64-74. doi: 10.1038/s41385-019-0206-9. Epub 2019 Oct 9.
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IL-32: a host proinflammatory factor against influenza viral replication is upregulated by aberrant epigenetic modifications during influenza A virus infection.J Immunol. 2010 Nov 1;185(9):5056-65. doi: 10.4049/jimmunol.0902667. Epub 2010 Oct 1.
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Enhanced CD103 Expression and Reduced Frequencies of Virus-Specific CD8(+) T Cells Among Airway Lymphocytes After Influenza Vaccination of Mice Deficient in Vitamins A?D.Viral Immunol. 2017 Dec;30(10):737-743. doi: 10.1089/vim.2017.0086. Epub 2017 Nov 13.
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Kallikrein-related peptidase 5 and seasonal influenza viruses, limitations of the experimental models for activating proteases.Biol Chem. 2018 Sep 25;399(9):1053-1064. doi: 10.1515/hsz-2017-0340.
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IL-15 Promotes Polyfunctional NK Cell Responses to Influenza by Boosting IL-12 Production.J Immunol. 2018 Apr 15;200(8):2738-2747. doi: 10.4049/jimmunol.1701614. Epub 2018 Feb 28.
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DMO-CAP inhibits influenza virus replication by activating heme oxygenase-1-mediated IFN response.Virol J. 2019 Feb 20;16(1):21. doi: 10.1186/s12985-019-1125-9.
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Dissecting influenza virus pathogenesis uncovers a novel chemical approach to combat the infection.Virology. 2013 Jan 5;435(1):92-101. doi: 10.1016/j.virol.2012.09.039.
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Soluble human LAG-3 molecule amplifies the in vitro generation of type 1 tumor-specific immunity.Cancer Res. 2006 Apr 15;66(8):4450-60. doi: 10.1158/0008-5472.CAN-05-2728.
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Upregulation of cell-surface mucin MUC15 in human nasal epithelial cells upon influenza A virus infection.BMC Infect Dis. 2019 Jul 15;19(1):622. doi: 10.1186/s12879-019-4213-y.
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Overexpressing mouse model demonstrates the protective role of Muc5ac in the lungs.Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16528-33. doi: 10.1073/pnas.1206552109. Epub 2012 Sep 24.
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The C-Terminal Tail of TRIM56 Dictates Antiviral Restriction of Influenza A and B Viruses by Impeding Viral RNA Synthesis.J Virol. 2016 Apr 14;90(9):4369-4382. doi: 10.1128/JVI.03172-15. Print 2016 May.
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Be Aware of Immunogenic But not Protective Antigens: The Actinobacillus pleuropneumoniae PalA as an Example.Protein Pept Lett. 2017;24(11):1059-1065. doi: 10.2174/0929866524666170822121558.
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Insights into the roles of cyclophilin A during influenza virus infection.Viruses. 2013 Jan 15;5(1):182-91. doi: 10.3390/v5010182.
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Influenza Virus Hemagglutinins H2, H5, H6, and H11 Are Not Targets of Pulmonary Surfactant Protein D: N-Glycan Subtypes in Host-Pathogen Interactions.J Virol. 2020 Feb 14;94(5):e01951-19. doi: 10.1128/JVI.01951-19. Print 2020 Feb 14.
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Optimized Expression, Purification, and Rapid Detection of Recombinant Influenza Nucleoproteins Expressed in Sf9 Insect Cells.J Microbiol Biotechnol. 2018 Oct 28;28(10):1683-1690. doi: 10.4014/jmb.1805.05053.
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A Decoy Peptide that Disrupts TIRAP Recruitment to TLRs Is Protective in a Murine Model of Influenza.Cell Rep. 2015 Jun 30;11(12):1941-52. doi: 10.1016/j.celrep.2015.05.035. Epub 2015 Jun 18.
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Generation of a KSCBi005-A-5(TLR8KO-A10) homozygous knockout human induced pluripotent stem cell line using CRISPR/Cas9.Stem Cell Res. 2019 Oct;40:101561. doi: 10.1016/j.scr.2019.101561. Epub 2019 Aug 27.
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Bax Inhibitor-1 Acts as an Anti-Influenza Factor by Inhibiting ROS Mediated Cell Death and Augmenting Heme-Oxygenase 1 Expression in Influenza Virus Infected Cells.Int J Mol Sci. 2018 Mar 2;19(3):712. doi: 10.3390/ijms19030712.
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Influenza-Activated ILC1s Contribute to Antiviral Immunity Partially Influenced by Differential GITR Expression.Front Immunol. 2018 Mar 22;9:505. doi: 10.3389/fimmu.2018.00505. eCollection 2018.
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Highly immunogenic influenza virus-like particles containing B-cell-activating factor (BAFF) for multi-subtype vaccine development.Antiviral Res. 2019 Apr;164:12-22. doi: 10.1016/j.antiviral.2019.02.004. Epub 2019 Feb 6.
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An influenza virus-triggered SUMO switch orchestrates co-opted endogenous retroviruses to stimulate host antiviral immunity.Proc Natl Acad Sci U S A. 2019 Aug 27;116(35):17399-17408. doi: 10.1073/pnas.1907031116. Epub 2019 Aug 7.
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miRNA-200c-3p is crucial in acute respiratory distress syndrome.Cell Discov. 2017 Jun 27;3:17021. doi: 10.1038/celldisc.2017.21. eCollection 2017.
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A host transcriptional signature for presymptomatic detection of infection in humans exposed to influenza H1N1 or H3N2.PLoS One. 2013;8(1):e52198. doi: 10.1371/journal.pone.0052198. Epub 2013 Jan 9.
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Vaccination using recombinants influenza and adenoviruses encoding amastigote surface protein-2 are highly effective on protection against Trypanosoma cruzi infection.PLoS One. 2013 Apr 24;8(4):e61795. doi: 10.1371/journal.pone.0061795. Print 2013.
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Limiting Respiratory Viral Infection by Targeting Antiviral and Immunological Functions of BST-2/Tetherin: Knowledge and Gaps.Bioessays. 2018 Oct;40(10):e1800086. doi: 10.1002/bies.201800086. Epub 2018 Aug 16.
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RIP3 deficiency ameliorates inflammatory response in mice infected with influenza H7N9 virus infection.Oncotarget. 2017 Apr 25;8(17):27715-27724. doi: 10.18632/oncotarget.16016.
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Differential responses to rhinovirus- and influenza-associated pulmonary exacerbations in patients with cystic fibrosis.Ann Am Thorac Soc. 2014 May;11(4):554-61. doi: 10.1513/AnnalsATS.201310-346OC.
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Monocytes Represent One Source of Bacterial Shielding from Antibiotics following Influenza Virus Infection.J Immunol. 2019 Apr 1;202(7):2027-2034. doi: 10.4049/jimmunol.1801471. Epub 2019 Feb 11.
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Influenza virus infection exacerbates experimental autoimmune encephalomyelitis disease by promoting type I T cells infiltration into central nervous system.J Autoimmun. 2017 Feb;77:1-10. doi: 10.1016/j.jaut.2016.10.006. Epub 2016 Oct 27.
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The novel carboxylesterase 1 variant c.662A>G may decrease the bioactivation of oseltamivir in humans.PLoS One. 2017 Apr 24;12(4):e0176320. doi: 10.1371/journal.pone.0176320. eCollection 2017.
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A new therapeutic strategy for lung tissue injury induced by influenza with CR2 targeting complement inhibitor.Virol J. 2010 Feb 9;7:30. doi: 10.1186/1743-422X-7-30.
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Therapeutic Targeting of the G-CSF Receptor Reduces Neutrophil Trafficking and Joint Inflammation in Antibody-Mediated Inflammatory Arthritis.J Immunol. 2016 Dec 1;197(11):4392-4402. doi: 10.4049/jimmunol.1600121. Epub 2016 Nov 2.
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Rhinovirus respiratory tract infection in hospitalized adult patients is associated with T(H)2 response irrespective of asthma.J Infect. 2018 May;76(5):465-474. doi: 10.1016/j.jinf.2018.02.005. Epub 2018 Feb 15.
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Influenza virus differentially activates mTORC1 and mTORC2 signaling to maximize late stage replication.PLoS Pathog. 2017 Sep 27;13(9):e1006635. doi: 10.1371/journal.ppat.1006635. eCollection 2017 Sep.
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Screening of Antiviral Components of Ma Huang Tang and Investigation on the Ephedra Alkaloids Efficacy on Influenza Virus Type A.Front Pharmacol. 2019 Sep 10;10:961. doi: 10.3389/fphar.2019.00961. eCollection 2019.
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Characterization of influenza H1N1 Gag virus-like particles and extracellular vesicles co-produced in HEK-293SF.Vaccine. 2019 Nov 8;37(47):7100-7107. doi: 10.1016/j.vaccine.2019.07.057. Epub 2019 Jul 26.
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Preclinical Evaluation of (203/212)Pb-Labeled Low-Molecular-Weight Compounds for Targeted Radiopharmaceutical Therapy of Prostate Cancer.J Nucl Med. 2020 Jan;61(1):80-88. doi: 10.2967/jnumed.119.229393. Epub 2019 Jun 28.
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The Annexin A1 Receptor FPR2 Regulates the Endosomal Export of Influenza Virus.Int J Mol Sci. 2018 May 8;19(5):1400. doi: 10.3390/ijms19051400.
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Influenza virus-like particles composed of conserved influenza proteins and GPI-anchored CCL28/GM-CSF fusion proteins enhance protective immunity against homologous and heterologous viruses.Int Immunopharmacol. 2018 Oct;63:119-128. doi: 10.1016/j.intimp.2018.07.011. Epub 2018 Aug 3.
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Progranulin aggravates pulmonary immunopathology during influenza virus infection.Thorax. 2019 Mar;74(3):305-308. doi: 10.1136/thoraxjnl-2018-211916. Epub 2018 Sep 18.
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Overarching Immunodominance Patterns and Substantial Diversity in Specificity and Functionality in the Circulating Human Influenza A and B Virus-Specific CD4+ T-Cell Repertoire.J Infect Dis. 2018 Aug 24;218(7):1169-1174. doi: 10.1093/infdis/jiy288.
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Type I interferon induced by DNA of nontypeable Haemophilus influenza modulates inflammatory cytokine profile to promote susceptibility to this bacterium.Int Immunopharmacol. 2019 Sep;74:105710. doi: 10.1016/j.intimp.2019.105710. Epub 2019 Jun 27.
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Innate Immune Response to Influenza Virus at Single-Cell Resolution in Human Epithelial Cells Revealed Paracrine Induction of Interferon Lambda 1.J Virol. 2019 Sep 30;93(20):e00559-19. doi: 10.1128/JVI.00559-19. Print 2019 Oct 15.
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IL-27 promotes NK cell effector functions via Maf-Nrf2 pathway during influenza infection.Sci Rep. 2019 Mar 21;9(1):4984. doi: 10.1038/s41598-019-41478-6.
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IL-36 receptor deletion attenuates lung injury and decreases mortality in murine influenza pneumonia.Mucosal Immunol. 2017 Jul;10(4):1043-1055. doi: 10.1038/mi.2016.107. Epub 2016 Dec 14.
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IL-33 drives influenza-induced asthma exacerbations by halting innate and adaptive antiviral immunity.J Allergy Clin Immunol. 2019 Apr;143(4):1355-1370.e16. doi: 10.1016/j.jaci.2018.08.051. Epub 2018 Oct 12.
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Intrinsic 4-1BB signals are indispensable for the establishment of an influenza-specific tissue-resident memory CD8 T-cell population in the lung.Mucosal Immunol. 2017 Sep;10(5):1294-1309. doi: 10.1038/mi.2016.124. Epub 2017 Jan 4.
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Glucocorticoids suppress inflammation via the upregulation of negative regulator IRAK-M.Nat Commun. 2015 Jan 14;6:6062. doi: 10.1038/ncomms7062.
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IRF and STAT Transcription Factors - From Basic Biology to Roles in Infection, Protective Immunity, and Primary Immunodeficiencies.Front Immunol. 2019 Jan 8;9:3047. doi: 10.3389/fimmu.2018.03047. eCollection 2018.
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Lanthionine Synthetase C-Like 2 Modulates Immune Responses to Influenza Virus Infection.Front Immunol. 2017 Feb 21;8:178. doi: 10.3389/fimmu.2017.00178. eCollection 2017.
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Cutting Edge: Check Your Mice-A Point Mutation in the Ncr1 Locus Identified in CD45.1 Congenic Mice with Consequences in Mouse Susceptibility to Infection.J Immunol. 2018 Mar 15;200(6):1982-1987. doi: 10.4049/jimmunol.1701676. Epub 2018 Feb 9.
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Deficiency of the NOD-Like Receptor NLRC5 Results in Decreased CD8(+) T Cell Function and Impaired Viral Clearance.J Virol. 2017 Aug 10;91(17):e00377-17. doi: 10.1128/JVI.00377-17. Print 2017 Sep 1.
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NLRX1 prevents mitochondrial induced apoptosis and enhances macrophage antiviral immunity by interacting with influenza virus PB1-F2 protein.Proc Natl Acad Sci U S A. 2014 May 20;111(20):E2110-9. doi: 10.1073/pnas.1322118111. Epub 2014 May 5.
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2D-SAR, Topomer CoMFA and molecular docking studies on avian influenza neuraminidase inhibitors.Comput Struct Biotechnol J. 2018 Dec 7;17:39-48. doi: 10.1016/j.csbj.2018.11.007. eCollection 2019.
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Contribution of the Purinergic Receptor P2X7 to Development of Lung Immunopathology during Influenza Virus Infection.mBio. 2017 Mar 28;8(2):e00229-17. doi: 10.1128/mBio.00229-17.
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Molecular diagnosis and characterization of a culture-negative mycotic aneurysm due to ST54 Haemophilus influenzae type b with PBP 3 alterations.J Infect Chemother. 2018 Jul;24(7):570-572. doi: 10.1016/j.jiac.2017.12.013. Epub 2018 Jan 17.
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Prion Protein is a Novel Modulator of Influenza: Potential Implications for Anti-Influenza Therapeutics.Curr Issues Mol Biol. 2020;37:21-32. doi: 10.21775/cimb.037.021. Epub 2019 Dec 9.
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