General Information of Disease (ID: DISL1SAV)

Disease Name Herpes simplex infection
Synonyms
herpes simplex; herpes simplex infection; herpes simplex viral infection; herpes simplex complex; Simplexvirus infectious disease; Simplexvirus caused disease or disorder; Simplexvirus disease or disorder; Herpesvirus hominis disease
Disease Class 1F00: Herpes simplex infection
Definition
A group of acute infections caused by herpes simplex virus type 1 or type 2 that is characterized by the development of one or more small fluid-filled vesicles with a raised erythematous base on the skin or mucous membrane. It occurs as a primary infection or recurs due to a reactivation of a latent infection. (Dorland, 27th ed.)
Disease Hierarchy
DISW24AQ: Herpesviridae infectious disease
DISEM33Q: Infectious disease
DISL1SAV: Herpes simplex infection
ICD Code
ICD-11
ICD-11: 1F00
Disease Identifiers
MONDO ID
MONDO_0004609
MESH ID
D006561
UMLS CUI
C0019348
MedGen ID
9234
SNOMED CT ID
88594005

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 2 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Aciclovir DMYLOVR Approved Small molecular drug [1]
Vidarabine DM0N85H Approved Small molecular drug [2]
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This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
BNT163 DMLCP8I Phase 1 Vaccine [3]
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This Disease is Treated as An Indication in 1 Preclinical Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
mRNA-1608 DMRQW66 Preclinical Vaccine [4]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 89 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
IFNB1 TT4TZ8J Limited Altered Expression [5]
LAG3 TTNVXAW Limited Biomarker [6]
FDXR TT3W4IX moderate Biomarker [7]
PML TTLH9NY moderate Biomarker [8]
VCP TTHNLSB moderate Altered Expression [9]
AADAT TTT3IXG Strong Genetic Variation [10]
AFP TTCFEA1 Strong Biomarker [11]
ANTXR2 TTOD34I Strong Biomarker [12]
APOE TTKS9CB Strong Biomarker [13]
ARRB2 TT8SO2I Strong Altered Expression [14]
BPHL TTTZ3EU Strong Biomarker [15]
BTLA TTER58P Strong Altered Expression [16]
CCR1 TTC24WT Strong Biomarker [17]
CD160 TTOFEAS Strong Altered Expression [16]
CD96 TT83C4X Strong Biomarker [18]
CDK1 TTH6V3D Strong Biomarker [19]
CDK9 TT1LVF2 Strong Biomarker [20]
CEACAM5 TTY6DTE Strong Biomarker [21]
CLEC9A TTGUSRB Strong Biomarker [22]
CPS1 TT42M75 Strong Biomarker [23]
CTSA TT5NILS Strong Biomarker [24]
CXXC5 TTVS4C3 Strong Biomarker [25]
DCK TTJOCE4 Strong Biomarker [26]
DDX58 TTVB0O3 Strong Biomarker [24]
DNAJB1 TTPXAWS Strong Biomarker [27]
DUT TTH6MBO Strong Altered Expression [28]
EIF2AK2 TTXEZJ4 Strong Altered Expression [29]
ENPEP TT9PBIL Strong Altered Expression [30]
FUT3 TTUPAD7 Strong Altered Expression [31]
G3BP1 TTG0R8Z Strong Biomarker [32]
GAD1 TTKGEP3 Strong Biomarker [33]
GAD2 TT7UY6K Strong Biomarker [34]
GLB1 TTNGJPH Strong Biomarker [35]
GRIN1 TTLD29N Strong Genetic Variation [36]
GRIN2A TTKJEMQ Strong Genetic Variation [36]
GRIN2D TT5POTG Strong Genetic Variation [36]
HBB TTM6HK1 Strong Biomarker [37]
HDAC5 TTUELN5 Strong Biomarker [38]
HIPK2 TTOB49C Strong Biomarker [39]
HMGB2 TTA78JQ Strong Biomarker [40]
HSPA8 TTMQL3K Strong Biomarker [41]
IFNL1 TTM624L Strong Biomarker [42]
IL11 TTGUYTR Strong Altered Expression [43]
IL36G TT8SLDN Strong Biomarker [44]
IRAK4 TTILUKB Strong Biomarker [45]
IRF3 TTYR7OH Strong Biomarker [46]
ITGAL TT48WR6 Strong Biomarker [47]
ITPR1 TT5HWAT Strong Biomarker [48]
KDM4A TTZHPB8 Strong Altered Expression [49]
KIR2DL2 TTU0P73 Strong Altered Expression [50]
KLK3 TTS78AZ Strong Altered Expression [51]
LGR4 TTY6C71 Strong Biomarker [52]
LHCGR TT2O4W9 Strong Biomarker [53]
LTA TTP73TM Strong Altered Expression [16]
LTBR TTFO0PM Strong Biomarker [54]
LTF TTSZDQU Strong Genetic Variation [55]
MDK TTV8UE7 Strong Biomarker [56]
MOG TTQAFX5 Strong Biomarker [57]
NEDD4 TT1QU6G Strong Biomarker [58]
PABPC1 TTHC8EF Strong Biomarker [59]
PARG TT39J16 Strong Biomarker [15]
PNP TTMCF1Y Strong Biomarker [60]
PPIB TT6ZFQ4 Strong Biomarker [61]
PRKCE TT57MT2 Strong Biomarker [62]
PTGER2 TT1ZAVI Strong Biomarker [63]
SELPLG TTS5K8U Strong Altered Expression [64]
SENP1 TTW9HY5 Strong Altered Expression [65]
SLC15A3 TTAYPWS Strong Biomarker [66]
SLC18A2 TTNZRI3 Strong Biomarker [67]
SLC29A1 TTLXAKE Strong Biomarker [68]
SLC3A2 TT5CZSM Strong Biomarker [69]
SLC5A5 TTW7HI9 Strong Biomarker [70]
SLC6A5 TTI0138 Strong Biomarker [71]
SP1 TTZEP6S Strong Altered Expression [72]
SRPK1 TTU3WV6 Strong Altered Expression [73]
TAF2 TTHMP8B Strong Biomarker [74]
TAP1 TT7JZI8 Strong Biomarker [75]
TBK1 TTMP03S Strong Biomarker [76]
TH TTUHP71 Strong Biomarker [77]
TICAM1 TT2GQT6 Strong Genetic Variation [78]
TLR3 TTD24Y0 Strong Biomarker [79]
TLR7 TTRJ1K4 Strong Biomarker [80]
TLR9 TTSHG0T Strong Biomarker [81]
TMPRSS11D TTWHYC8 Strong Biomarker [82]
TNFRSF14 TTWGTC1 Strong Biomarker [83]
TNFSF14 TTKVENM Strong Altered Expression [84]
TNKS TTVUSO7 Strong Biomarker [85]
TOR1A TTF85KW Strong Genetic Variation [86]
TYRO3 TTIEMFN Strong Biomarker [87]
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⏷ Show the Full List of 89 DTT(s)
This Disease Is Related to 1 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
SLC25A37 DTLBGTZ Strong Biomarker [88]
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This Disease Is Related to 8 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
ASNS DEXISVQ Strong Biomarker [89]
CES2 DETHCPD Strong Biomarker [90]
CYP4B1 DEMF740 Strong Biomarker [91]
DTYMK DEOTVYU Strong Genetic Variation [92]
FXN DEXVHDB Strong Genetic Variation [93]
HPRT1 DEVXTP5 Strong Genetic Variation [94]
SPR DEJVDAT Strong Biomarker [95]
UPRT DE20ETR Strong Biomarker [96]
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⏷ Show the Full List of 8 DME(s)
This Disease Is Related to 188 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
ERVW-1 OTWV8DXJ Limited Biomarker [97]
FLNB OTPCOYL6 Limited Genetic Variation [98]
GDPD3 OTOHM9QM Limited Biomarker [99]
PJA1 OTFKTMEI Limited Biomarker [100]
PRKRA OTUTVZZU Limited Biomarker [101]
RBBP6 OTTVG4HU Limited Biomarker [101]
SEC14L2 OTJST64D Limited Genetic Variation [98]
SMC5 OT91M6N4 Limited Biomarker [100]
TRIML2 OT5QWTD2 Disputed Altered Expression [102]
CFDP1 OTXY7J96 moderate Altered Expression [9]
EIF4G2 OTEO98CR moderate Altered Expression [9]
GEMIN4 OTX7402E moderate Altered Expression [9]
NECTIN1 OTTE5ZR6 moderate Altered Expression [18]
PSMD2 OT6HZHN7 moderate Altered Expression [9]
ACY1 OT9WU7X3 Strong Genetic Variation [103]
ADGRB1 OTJSEXRC Strong Biomarker [104]
ADRM1 OTOU4EY6 Strong Biomarker [105]
ADSS2 OTW26XXB Strong Biomarker [106]
AFDN OTTRU341 Strong Biomarker [107]
AFM OTPOR8IO Strong Biomarker [108]
AGBL2 OTCX9987 Strong Altered Expression [109]
AGFG1 OTI8ZKC4 Strong Biomarker [110]
ANKRD1 OTHJ7JV9 Strong Biomarker [111]
ATRX OT77RSQW Strong Biomarker [8]
BCLAF1 OT7T8H6A Strong Biomarker [112]
CBLL2 OTB4AD3V Strong Biomarker [113]
CDC34 OTNBK390 Strong Biomarker [114]
CGAS OTJYIXNB Strong Biomarker [115]
CH25H OT9S2BSW Strong Biomarker [116]
CHMP3 OT0963JJ Strong Altered Expression [117]
CHP1 OTHTXN1A Strong Biomarker [118]
CISH OT8T5NYL Strong Altered Expression [119]
CLDN11 OTNN6UTL Strong Altered Expression [120]
CPVL OTOJL31C Strong Biomarker [121]
CTCF OT8ZB70U Strong Biomarker [122]
CYTIP OTRJ3ZC5 Strong Biomarker [123]
DBR1 OTLTWLTE Strong Genetic Variation [124]
DCAF1 OT3ZDVOE Strong Biomarker [110]
DCLRE1C OTW3KB1I Strong Biomarker [125]
DDX53 OTHK3EGZ Strong Biomarker [126]
DEFA5 OT95CBQ9 Strong Altered Expression [127]
DPP6 OTWW3H0K Strong Genetic Variation [128]
EEA1 OTIBXC1B Strong Altered Expression [129]
EIF2S1 OTM0GDTP Strong Biomarker [130]
EIF4A2 OT08H03R Strong Altered Expression [131]
EIF4G1 OT2CF1E6 Strong Altered Expression [131]
EIF4H OTGZI072 Strong Biomarker [132]
ELAVL3 OTI2VI8B Strong Biomarker [133]
EMD OTR8ZANE Strong Biomarker [134]
ERBIN OTNWTUA8 Strong Biomarker [135]
ETFA OTXX61VZ Strong Biomarker [136]
ETV5 OTE2OBM4 Strong Biomarker [137]
FCGBP OT63T6XQ Strong Biomarker [138]
FLT3LG OTU0YGC4 Strong Altered Expression [139]
FUT6 OTBZUQ7F Strong Altered Expression [31]
GADD45G OT8V1J4M Strong Biomarker [140]
GPR146 OTFDR1WJ Strong Altered Expression [141]
GTF2A1L OTDQHVAI Strong Biomarker [108]
GZMA OT43R33L Strong Biomarker [142]
HBZ OTMHGFSS Strong Biomarker [143]
HCFC1 OT0UCK62 Strong Biomarker [144]
HIRA OTON40EJ Strong Biomarker [145]
HM13 OTGEO1LP Strong Biomarker [146]
HNRNPC OT47AK4C Strong Biomarker [147]
HNRNPDL OTB3BFCV Strong Biomarker [147]
HRG OTPLUFOG Strong Biomarker [148]
HS3ST1 OT5DVN9P Strong Biomarker [149]
HS3ST6 OTGSRHS4 Strong Biomarker [150]
HSPB6 OTFPLGZI Strong Biomarker [151]
IFI16 OT4SPU0U Strong Biomarker [152]
IFNGR1 OTCTQBWW Strong Biomarker [153]
IKBKG OTNWJWSD Strong Biomarker [154]
INSM1 OTG8RV8E Strong Biomarker [155]
INTU OTXB13E6 Strong Biomarker [156]
IRF2 OTAZRUW3 Strong Genetic Variation [157]
IRF7 OTC1A2PQ Strong Biomarker [158]
ITIH4 OT460OO1 Strong Biomarker [159]
KCNIP4 OTB1BS0X Strong Biomarker [160]
KIAA1210 OTB8NJZX Strong Biomarker [161]
KIF23 OTY850JC Strong Biomarker [162]
LAT OTZC1XZ1 Strong Altered Expression [163]
LGALS4 OTKQCG0H Strong Biomarker [164]
LMNB1 OT100T3P Strong Biomarker [165]
LSM2 OTHL77NY Strong Biomarker [147]
MAL OTBM30SW Strong Biomarker [166]
MARCO OT0NW2Q0 Strong Biomarker [167]
MCRS1 OT8K2X8P Strong Biomarker [168]
MED23 OTKZQT0R Strong Biomarker [169]
MED25 OTDBY87B Strong Biomarker [137]
MICB OTS2DVDW Strong Biomarker [170]
MON1B OTJGDN94 Strong Biomarker [171]
MTMR3 OTBIT23O Strong Biomarker [46]
MTMR4 OTZLYE6J Strong Biomarker [46]
MUL1 OT2JC9YR Strong Biomarker [113]
MX1 OT6X8G5T Strong Altered Expression [5]
MYBL2 OTZ3JX8Q Strong Altered Expression [172]
NANOG OTUEY1FM Strong Genetic Variation [173]
NBPF1 OTAZ55UQ Strong Biomarker [174]
NCKIPSD OT24UORN Strong Biomarker [175]
NECTIN2 OTIE0W6O Strong Biomarker [176]
NET1 OTZHNMJV Strong Biomarker [71]
NFIA OTDHQ9CG Strong Altered Expression [177]
NFIB OTX94PD0 Strong Altered Expression [177]
NFIC OTLMCUIB Strong Altered Expression [177]
NFIX OT1DPZAE Strong Altered Expression [177]
NFYA OTWFFOVH Strong Altered Expression [178]
NHS OTKE8QAT Strong Biomarker [179]
NLRC3 OTWLLFFN Strong Biomarker [180]
NOLC1 OTKDZU0D Strong Biomarker [181]
NOP53 OTA2YKO6 Strong Biomarker [182]
NT5C3A OT67KZJA Strong Biomarker [183]
NUMA1 OTTKAVG4 Strong Biomarker [184]
NUPR2 OTNS6IEC Strong Biomarker [185]
NXF1 OTEFHXG6 Strong Genetic Variation [98]
PDYN OTEJ6430 Strong Genetic Variation [186]
PDZD8 OTCQYNBU Strong Biomarker [187]
PENK OT8P3HMP Strong Altered Expression [188]
PHPT1 OTFYWNFX Strong Altered Expression [189]
PILRA OTBE0PLF Strong Genetic Variation [190]
PLAAT4 OTI66SAJ Strong Biomarker [24]
POLD1 OTWO4UCJ Strong Biomarker [191]
POU2F3 OTIOOJWD Strong Altered Expression [192]
PPP1R15A OTYG179K Strong Biomarker [193]
PRKN OTJBN41W Strong Biomarker [113]
PRPF38B OTQLH551 Strong Biomarker [71]
PSMD13 OTNQ351N Strong Biomarker [194]
PSMG1 OTZ5I6UM Strong Biomarker [195]
PSMG2 OTEMF20S Strong Biomarker [195]
PUS3 OT6WG6M2 Strong Biomarker [196]
PYHIN1 OT30GD05 Strong Biomarker [197]
RAB39B OTDCLLT0 Strong Biomarker [52]
RAB3GAP1 OT4DQ8F2 Strong Biomarker [181]
RAET1E OTLR3CEC Strong Biomarker [198]
RBL2 OTBQSOE6 Strong Biomarker [181]
RCOR1 OTREADPC Strong Altered Expression [199]
RHOV OTW4N3QN Strong Biomarker [118]
RNASE1 OTKZ7CO9 Strong Biomarker [200]
ROBO3 OTPVG40S Strong Biomarker [24]
RPAIN OTBMXAYK Strong Biomarker [110]
RPL11 OT3VZ6OE Strong Biomarker [201]
RPL21 OT74GE74 Strong Biomarker [202]
RPL22 OTVCN8K0 Strong Altered Expression [30]
RPL26 OTFNRC27 Strong Altered Expression [201]
RPL29 OTUFIBJL Strong Genetic Variation [203]
RPL41 OTFW5IFO Strong Biomarker [204]
RPS11 OTILZE44 Strong Biomarker [194]
RPS23 OTAJMUPF Strong Biomarker [205]
RPUSD2 OTVA8XFH Strong Biomarker [206]
SALL1 OTYYZGLH Strong Biomarker [207]
SAMHD1 OTBCIBC7 Strong Biomarker [208]
SENP7 OTQJ05ZS Strong Biomarker [209]
SFTPC OTIZJD09 Strong Altered Expression [210]
SH3KBP1 OTIUA60B Strong Biomarker [211]
SIDT2 OTU2L002 Strong Biomarker [212]
SLPI OTUNFUU8 Strong Biomarker [213]
SMARCA5 OT5GR4Z2 Strong Biomarker [214]
SMC4 OTEJE6AG Strong Biomarker [162]
SOX3 OT1CRCOB Strong Altered Expression [189]
SPIN1 OT69VAOX Strong Biomarker [215]
SPRR2A OT62ZU6B Strong Biomarker [216]
STON1 OT2HPUAI Strong Biomarker [108]
STT3A OTDPS6AV Strong Biomarker [217]
SUCLA2 OTMZD4PW Strong Biomarker [218]
SUGCT OTA8L0TN Strong Biomarker [219]
SUPT5H OTCS9LW3 Strong Altered Expression [220]
TBCE OTGBSTKS Strong Biomarker [195]
TG OT3ELHIJ Strong Altered Expression [221]
TIA1 OTGPN3P8 Strong Biomarker [32]
TK2 OTS1V4XB Strong Genetic Variation [222]
TLX2 OTPFAUM8 Strong Genetic Variation [223]
TMPO OTL68EL4 Strong Biomarker [135]
TMX1 OTX4FHYQ Strong Altered Expression [5]
TOR1AIP1 OTTG8MAK Strong Altered Expression [224]
TRAF3 OT5TQBGV Strong Biomarker [154]
TRAT1 OTMPUNPD Strong Biomarker [225]
TREH OTJE0NOY Strong Genetic Variation [226]
TRIM14 OTLQKUG0 Strong Biomarker [227]
TRIM29 OT2DNESG Strong Biomarker [228]
TRIM41 OTU3ADNG Strong Genetic Variation [229]
TRIM56 OTFGU8E3 Strong Biomarker [230]
TRIM69 OTTEGTRD Strong Genetic Variation [78]
TSPAN1 OTZQPIYK Strong Biomarker [71]
CSH1 OT33HTRR Definitive Altered Expression [231]
CSH2 OTW8JVAN Definitive Altered Expression [231]
ERCC6 OT2QZKSF Definitive Altered Expression [231]
ERCC8 OT0T4WKI Definitive Altered Expression [231]
POLH OTN07WXU Definitive Biomarker [231]
POLQ OTBHK0E6 Definitive Biomarker [231]
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⏷ Show the Full List of 188 DOT(s)

References

1 Prevention and management of genital herpes simplex infection during pregnancy and delivery: Guidelines from the French College of Gynaecologists and Obstetricians (CNGOF). Eur J Obstet Gynecol Reprod Biol. 2018 May;224:93-101.
2 Vidarabine FDA Label
3 ClinicalTrials.gov (NCT05432583) Phase I, Randomized, Observer-blinded, Placebo-controlled, 2-part, Dose Escalation and Expanded Safety Evaluation Trial to Evaluate the Safety, Tolerability, and Immunogenicity of an Investigational Prophylactic Vaccine for the Prevention of Genital Lesions Caused by Herpes Simplex Virus (HSV)-2 and Potentially HSV-1. U.S.National Institutes of Health.
4 Clinical pipeline report, company report or official report of Moderna
5 Establishment and characterization of an immortalized renal cell line of the Chinese tree shrew (Tupaia belangeri chinesis).Appl Microbiol Biotechnol. 2019 Mar;103(5):2171-2180. doi: 10.1007/s00253-019-09615-3. Epub 2019 Jan 12.
6 Blockade of PD-1 and LAG-3 Immune Checkpoints Combined with Vaccination Restores the Function of Antiviral Tissue-Resident CD8(+) T(RM) Cells and Reduces Ocular Herpes Simplex Infection and Disease in HLA Transgenic Rabbits.J Virol. 2019 Aug 28;93(18):e00827-19. doi: 10.1128/JVI.00827-19. Print 2019 Sep 15.
7 Consequences of chemoresistance for the herpes simplex virus thymidine kinase/ganciclovir-induced bystander effect in a human small cell lung cancer cell line model.Anticancer Res. 2005 Jan-Feb;25(1A):255-61.
8 Synthetic lethality of cytolytic HSV-1 in cancer cells with ATRX and PML deficiency.J Cell Sci. 2019 Mar 14;132(5):jcs222349. doi: 10.1242/jcs.222349.
9 p97: An Emerging Target for Cancer, Neurodegenerative Diseases, and Viral Infections.J Med Chem. 2020 Mar 12;63(5):1892-1907. doi: 10.1021/acs.jmedchem.9b01318. Epub 2019 Oct 9.
10 Improvement in detrusor-sphincter dyssynergia by bladder-wall injection of replication-defective herpes simplex virus vector-mediated gene delivery of kynurenine aminotransferase II in spinal cord injury rats.Spinal Cord. 2017 Feb;55(2):155-161. doi: 10.1038/sc.2016.178. Epub 2016 Dec 20.
11 Construction of plasmid vector pAFP-HSVtk-IRES2-EGFP and its effect on the cytotoxicity of ganciclovir to hepatocellular carcinoma.Chin Med J (Engl). 2014;127(12):2337-41.
12 High efficiency of replication and expression of foreign genes in SV40-transformed human fibroblasts.EMBO J. 1983;2(12):2327-31. doi: 10.1002/j.1460-2075.1983.tb01742.x.
13 Herpes simplex virus type 1 and Alzheimer's disease: possible mechanisms and signposts.FASEB J. 2017 Aug;31(8):3216-3226. doi: 10.1096/fj.201700360.
14 Transcriptional and translational dual-regulated oncolytic herpes simplex virus type 1 for targeting prostate tumors.Mol Ther. 2010 May;18(5):929-35. doi: 10.1038/mt.2010.26. Epub 2010 Feb 23.
15 Herpes simplex virus 1 infection activates poly(ADP-ribose) polymerase and triggers the degradation of poly(ADP-ribose) glycohydrolase.J Virol. 2012 Aug;86(15):8259-68. doi: 10.1128/JVI.00495-12. Epub 2012 May 23.
16 The signaling networks of the herpesvirus entry mediator (TNFRSF14) in immune regulation.Immunol Rev. 2011 Nov;244(1):169-87. doi: 10.1111/j.1600-065X.2011.01064.x.
17 The role of CCR1 and therapeutic effects of anti-CCL3 antibody in herpes simplex virus-induced Behet's disease mouse model.Immunology. 2019 Nov;158(3):206-218. doi: 10.1111/imm.13102. Epub 2019 Sep 8.
18 Interaction between nectin-1 and the human natural killer cell receptor CD96.PLoS One. 2019 Feb 13;14(2):e0212443. doi: 10.1371/journal.pone.0212443. eCollection 2019.
19 Linking a cell-division gene and a suicide gene to define and improve cell therapy safety.Nature. 2018 Nov;563(7733):701-704. doi: 10.1038/s41586-018-0733-7. Epub 2018 Nov 14.
20 The efficacy of a cyclin dependent kinase 9 (CDK9) inhibitor, FIT039, on verruca vulgaris: study protocol for a randomized controlled trial.Trials. 2019 Aug 9;20(1):489. doi: 10.1186/s13063-019-3570-6.
21 Viral vector-induced expression of bone morphogenetic protein 2 produces inhibition of tumor growth and bone differentiation of stem cells.Cancer Gene Ther. 2010 Feb;17(2):80-5. doi: 10.1038/cgt.2009.56. Epub 2009 Oct 16.
22 The dendritic cell receptor DNGR-1 controls endocytic handling of necrotic cell antigens to favor cross-priming of CTLs in virus-infected mice.J Clin Invest. 2012 May;122(5):1615-27. doi: 10.1172/JCI60644. Epub 2012 Apr 16.
23 Relief of pain induced by varicella-zoster virus in a rat model of post-herpetic neuralgia using a herpes simplex virus vector expressing enkephalin.Gene Ther. 2014 Jul;21(7):694-702. doi: 10.1038/gt.2014.43. Epub 2014 May 15.
24 A Viral Deamidase Targets the Helicase Domain of RIG-I to Block RNA-Induced Activation.Cell Host Microbe. 2016 Dec 14;20(6):770-784. doi: 10.1016/j.chom.2016.10.011. Epub 2016 Nov 17.
25 Epigenetic regulator CXXC5 recruits DNA demethylase Tet2 to regulate TLR7/9-elicited IFN response in pDCs.J Exp Med. 2017 May 1;214(5):1471-1491. doi: 10.1084/jem.20161149. Epub 2017 Apr 17.
26 Treatment of thyroid carcinoma cells with four different suicide gene/prodrug combinations in vitro.Anticancer Res. 1998 May-Jun;18(3A):1521-5.
27 Nuclear sequestration of cellular chaperone and proteasomal machinery during herpes simplex virus type 1 infection.J Virol. 2004 Jul;78(13):7175-85. doi: 10.1128/JVI.78.13.7175-7185.2004.
28 Phosphorylation of herpes simplex virus 1 dUTPase regulates viral virulence and genome integrity by compensating for low cellular dUTPase activity in the central nervous system.J Virol. 2015 Jan;89(1):241-8. doi: 10.1128/JVI.02497-14. Epub 2014 Oct 15.
29 Expression of HSV-1 receptors in EBV-associated lymphoproliferative disease determines susceptibility to oncolytic HSV.Gene Ther. 2013 Jul;20(7):761-9. doi: 10.1038/gt.2012.93. Epub 2012 Dec 20.
30 Association of herpes simplex virus regulatory protein ICP22 with transcriptional complexes containing EAP, ICP4, RNA polymerase II, and viral DNA requires posttranslational modification by the U(L)13 proteinkinase.J Virol. 1997 Feb;71(2):1133-9. doi: 10.1128/JVI.71.2.1133-1139.1997.
31 NFB-mediated activation of the cellular FUT3, 5 and 6 gene cluster by herpes simplex virus type 1.Glycobiology. 2017 Nov 1;27(11):999-1005. doi: 10.1093/glycob/cwx079.
32 Herpes simplex virus 2 infection impacts stress granule accumulation.J Virol. 2012 Aug;86(15):8119-30. doi: 10.1128/JVI.00313-12. Epub 2012 May 23.
33 HSV vector-mediated GAD67 suppresses neuropathic pain induced by perineural HIV gp120 in rats through inhibition of ROS and Wnt5a.Gene Ther. 2016 Apr;23(4):340-8. doi: 10.1038/gt.2016.3. Epub 2016 Jan 11.
34 Audiogenic seizure activity following HSV-1 GAD65 sense or antisense injection into inferior colliculus of Long-Evans rat.Epilepsy Behav. 2017 Jun;71(Pt B):238-242. doi: 10.1016/j.yebeh.2016.08.024. Epub 2016 Dec 16.
35 Correlation between herpes simplex virus neutralizing antibody titers determined by ELVIS cell and traditional plaque reduction assays.PLoS One. 2019 Apr 4;14(4):e0214467. doi: 10.1371/journal.pone.0214467. eCollection 2019.
36 Association of GRIN1 and GRIN2A-D with schizophrenia and genetic interaction with maternal herpes simplex virus-2 infection affecting disease risk.Am J Med Genet B Neuropsychiatr Genet. 2011 Dec;156B(8):913-22. doi: 10.1002/ajmg.b.31234. Epub 2011 Sep 14.
37 A real-time PCR assay to identify and discriminate among wild-type and vaccine strains of varicella-zoster virus and herpes simplex virus in clinical specimens, and comparison with the clinical diagnoses.J Med Virol. 2009 Jul;81(7):1310-22. doi: 10.1002/jmv.21506.
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73 Molecular Mechanism of SR Protein Kinase 1 Inhibition by the Herpes Virus Protein ICP27.mBio. 2019 Oct 22;10(5):e02551-19. doi: 10.1128/mBio.02551-19.
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98 Vaccine-Mediated Inhibition of the Transporter Associated with Antigen Processing Is Insufficient To Induce Major Histocompatibility Complex E-Restricted CD8(+) T Cells in Nonhuman Primates.J Virol. 2019 Sep 12;93(19):e00592-19. doi: 10.1128/JVI.00592-19. Print 2019 Oct 1.
99 Herpes Simplex Virus Glycoprotein D Targets a Specific Dendritic Cell Subset and Improves the Performance of Vaccines to Human Papillomavirus-Associated Tumors.Mol Cancer Ther. 2017 Sep;16(9):1922-1933. doi: 10.1158/1535-7163.MCT-17-0071. Epub 2017 May 18.
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101 Suppression of PACT-induced type I interferon production by herpes simplex virus 1 Us11 protein.J Virol. 2013 Dec;87(24):13141-9. doi: 10.1128/JVI.02564-13. Epub 2013 Sep 25.
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119 SOCS and Herpesviruses, With Emphasis on Cytomegalovirus Retinitis.Front Immunol. 2019 Apr 11;10:732. doi: 10.3389/fimmu.2019.00732. eCollection 2019.
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