Details of Disease

General Information of Disease (ID: DISTM18U)

Disease Name	Skin cancer
Synonyms	cancer of skin; zone of skin cancer; skin neoplasm, malignant; skin cancer, Including melanoma; skin cancer; melanoma and non-melanoma skin cancer; malignant zone of skin neoplasm; malignant tumour of the skin; malignant tumour of skin; malignant tumor of the skin; malignant tumor of skin; malignant skin tumour; malignant skin tumor; malignant skin neoplasm; malignant neoplasm of zone of skin; malignant neoplasm of the skin; malignant neoplasm of skin; cancer of zone of skin; CA - skin cancer
Disease Class	2C30-2C37: Skin cancer
Definition	A malignant neoplasm involving the zone of skin
Disease Hierarchy	DISZQRYL: Integumentary system cancer DIS16DDV: Skin neoplasm DISAT1Z9: Advanced cancer DISTM18U: Skin cancer
ICD Code	ICD-11 ICD-11: 2C30-2C37 Expand ICD-11 '2C3Z Expand ICD-10 'C43-C44; 'C44.0; 'C44.1; 'C44.2; 'C44.3; 'C44.4; 'C44.5; 'C44.6; 'C44.7; 'C44.8; 'C44.9 Expand ICD-9 172173
Disease Identifiers	MONDO ID MONDO_0002898 MESH ID D012878 UMLS CUI C0007114 MedGen ID 40101 SNOMED CT ID 372130007

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 3 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Imiquimod	DM1TMA3	Approved	Small molecular drug	[1]
Rasagiline	DM3WKQ4	Approved	Small molecular drug	[2]
Sunscreens	DMXNNR7	Approved	NA	[3]
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This Disease is Treated as An Indication in 2 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
A-007	DMI9MYQ	Phase 2	Small molecular drug	[4]
LDE225	DMM9F25	Phase 2	Small molecular drug	[5]
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This Disease is Treated as An Indication in 1 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
CytoregUNO	DM7UOIE	Investigative	NA	[6]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 75 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
VDR	TTK59TV	Limited	Biomarker	[7]
GPRC6A	TTI1PRE	Disputed	Altered Expression	[8]
LPAR3	TTE2YJR	Disputed	Altered Expression	[8]
MRGPRX1	TTIX6PK	Disputed	Altered Expression	[8]
NFE2L2	TTA6ZN2	Disputed	Biomarker	[9]
OXER1	TT7WBSV	Disputed	Altered Expression	[8]
PTAFR	TTQL5VC	Disputed	Biomarker	[10]
BRIP1	TTZV7LJ	moderate	Biomarker	[11]
CASP10	TTX5HEK	moderate	Biomarker	[12]
CASP8	TT6SZNG	moderate	Biomarker	[12]
CD27	TTDO1MV	moderate	Altered Expression	[13]
COL7A1	TTBCOKN	moderate	Genetic Variation	[14]
CSF3	TT5TQ2W	moderate	Therapeutic	[15]
CSNK2A1	TTER6YH	moderate	Biomarker	[16]
CSNK2A2	TT7GR5W	moderate	Biomarker	[16]
ERBB4	TTWALCO	moderate	Biomarker	[17]
FLT1	TT1VAUK	moderate	Biomarker	[17]
GJA1	TT4F7SL	moderate	Biomarker	[18]
GJB2	TTRGZX3	moderate	Biomarker	[18]
GJB5	TTL9MHP	moderate	Biomarker	[18]
HCAR3	TT8WFXV	moderate	Biomarker	[19]
HIF1A	TTSN6QU	moderate	Altered Expression	[20]
IGF1R	TTQFBMY	moderate	Biomarker	[21]
IL1A	TTPM6HI	moderate	Biomarker	[22]
LRRK2	TTK0FEA	moderate	Biomarker	[23]
MMP12	TTXZ0KQ	moderate	Altered Expression	[24]
NOTCH2	TT82FVD	moderate	Biomarker	[25]
NOTCH3	TTVX7IA	moderate	Biomarker	[25]
NOTCH4	TTXDIK2	moderate	Biomarker	[25]
PDE5A	TTJ0IQB	moderate	Genetic Variation	[26]
PTK2B	TTTEFBV	moderate	Biomarker	[17]
SMO	TT8J1S3	moderate	Biomarker	[27]
SULF2	TTLQTHB	moderate	Biomarker	[28]
TNKS2	TTFQI4H	moderate	Genetic Variation	[29]
TYR	TTULVH8	moderate	Genetic Variation	[30]
AKT1	TTWTSCV	Strong	Biomarker	[31]
AQP3	TTLDNMQ	Strong	Altered Expression	[32]
ATF3	TTCE793	Strong	Altered Expression	[33]
CA1	TTHQPL7	Strong	Biomarker	[34]
CDC25B	TTR0SWN	Strong	Biomarker	[35]
CDC25C	TTESBNC	Strong	Biomarker	[35]
CDC42BPA	TT5Z0EF	Strong	Genetic Variation	[36]
CDK3	TTMYWL7	Strong	Altered Expression	[37]
CEBPA	TT5LWG1	Strong	Altered Expression	[38]
CHUK	TT1F8OQ	Strong	Biomarker	[39]
ERBB3	TTSINU2	Strong	Biomarker	[40]
GLI2	TT045OH	Strong	Biomarker	[41]
GPR55	TTNET8J	Strong	Biomarker	[42]
HCAR2	TTWNV8U	Strong	Biomarker	[19]
HRAS	TT28ZON	Strong	Biomarker	[43]
HRH4	TTXJ178	Strong	Altered Expression	[44]
IGF1	TTT6LOU	Strong	Biomarker	[45]
KHDRBS1	TTAT6C7	Strong	Altered Expression	[46]
KLF4	TTTI53X	Strong	Biomarker	[47]
KLK6	TTLPF4X	Strong	Biomarker	[48]
KRT17	TTKV0EC	Strong	Biomarker	[49]
LTA4H	TTXZEAJ	Strong	Biomarker	[50]
MC1R	TT0MV2T	Strong	Biomarker	[51]
NLRP1	TTQX29T	Strong	Genetic Variation	[52]
NOTCH1	TTB1STW	Strong	Biomarker	[39]
NR1H2	TTXA6PH	Strong	Biomarker	[53]
ODC1	TTUMGNO	Strong	Biomarker	[54]
PEMT	TT735V2	Strong	Genetic Variation	[55]
PIGU	TT2LHI6	Strong	Biomarker	[56]
PPARD	TT2JWF6	Strong	Biomarker	[57]
PPIB	TT6ZFQ4	Strong	Altered Expression	[58]
RBPJ	TT72D4Z	Strong	Altered Expression	[46]
RPL15	TTQRVC9	Strong	Altered Expression	[59]
SORD	TTLSRBZ	Strong	Biomarker	[60]
SP1	TTZEP6S	Strong	Altered Expression	[61]
TDG	TTEXRQD	Strong	Biomarker	[56]
TERF2	TT5XSLT	Strong	Genetic Variation	[29]
TRIM27	TTTO3QN	Strong	Altered Expression	[62]
XPA	TTGT87E	Strong	Genetic Variation	[63]
TGFBR1	TTP4520	Definitive	Biomarker	[64]
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⏷ Show the Full List of 75 DTT(s)

This Disease Is Related to 3 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
CYP27A1	DEBS639	Strong	Altered Expression	[65]
EPHX1	DELB4KP	Strong	Biomarker	[66]
TGM3	DEOEB3Q	Strong	Altered Expression	[67]
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This Disease Is Related to 120 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
DPH3	OT59Q6C4	Limited	Genetic Variation	[68]
HERC2	OTNQYKOB	Limited	Genetic Variation	[69]
MAL	OTBM30SW	Limited	Biomarker	[70]
OXNAD1	OT5I11J1	Limited	Genetic Variation	[68]
SEC14L2	OTJST64D	Limited	Biomarker	[71]
SEM1	OTASLBM1	Limited	Biomarker	[72]
SERPINB9	OTJ811IF	Limited	Biomarker	[73]
STAT2	OTO9G2RZ	Limited	Altered Expression	[74]
TP53RK	OTARRZAB	Limited	Biomarker	[75]
FZD4	OTGLZIE0	Disputed	Altered Expression	[8]
GPR151	OT7EACU6	Disputed	Altered Expression	[8]
LGR6	OTPZ1PWR	Disputed	Altered Expression	[8]
MRGPRX3	OTRKCCDS	Disputed	Altered Expression	[8]
MRGPRX4	OTOBHZVA	Disputed	Altered Expression	[8]
AMFR	OTQRX7LC	moderate	Altered Expression	[76]
ATRN	OTTCLOPV	moderate	Biomarker	[77]
CDX2	OTCG4TSY	moderate	Biomarker	[78]
CSMD1	OTIVDSC4	moderate	Biomarker	[79]
CSNK2B	OT2WW7R1	moderate	Biomarker	[16]
CYLD	OT37FKH0	moderate	Biomarker	[80]
DDB2	OTO8HVVB	moderate	Genetic Variation	[81]
DLX3	OTARP5SQ	moderate	Biomarker	[82]
GTF2H2	OTK72L9I	moderate	Altered Expression	[83]
GTF2H3	OT87W5QJ	moderate	Altered Expression	[83]
GTF2H4	OTPD1DIU	moderate	Altered Expression	[83]
GTF2H5	OTRL219S	moderate	Altered Expression	[83]
IVL	OT4VPNGY	moderate	Biomarker	[16]
KRT1	OTIOJWA4	moderate	Biomarker	[16]
KRT10	OTSVRD3Q	moderate	Biomarker	[16]
LORICRIN	OTFRPVEO	moderate	Biomarker	[16]
MYO6	OTJQYRC7	moderate	Biomarker	[84]
NBEAL1	OTLJ11N3	moderate	Biomarker	[85]
NPPA	OTMQNTNX	moderate	Therapeutic	[86]
RELA	OTUJP9CN	moderate	Biomarker	[87]
RHCE	OTS18IZ5	moderate	Genetic Variation	[88]
ADA2	OTGCV24S	Strong	Biomarker	[34]
ADAM12	OTZKOTDB	Strong	Altered Expression	[89]
AGO1	OTD3R434	Strong	Biomarker	[90]
AIRE	OTA7G1Y1	Strong	Biomarker	[49]
APOBEC3A	OTYO6F5P	Strong	Altered Expression	[91]
BTG2	OTZF6K1H	Strong	Biomarker	[92]
CABIN1	OT4G5CIK	Strong	Genetic Variation	[93]
CASP14	OTKY93H9	Strong	Biomarker	[94]
CD81	OTQFXNAZ	Strong	Altered Expression	[95]
CDC42SE1	OTV3MRFE	Strong	Biomarker	[96]
CDK2AP2	OTR99SJ8	Strong	Genetic Variation	[97]
CIRBP	OTXWTPBL	Strong	Biomarker	[98]
CSH1	OT33HTRR	Strong	Biomarker	[99]
CSH2	OTW8JVAN	Strong	Biomarker	[99]
CSHL1	OTQKU2F5	Strong	Altered Expression	[46]
CUL4A	OTTBV70J	Strong	Biomarker	[100]
DCTN4	OTM7C943	Strong	Altered Expression	[46]
DGCR8	OT62LXE4	Strong	Biomarker	[90]
DMBT1	OTVNU9D9	Strong	Altered Expression	[101]
DOCK8	OTNQLL21	Strong	Biomarker	[102]
DUSP22	OTEZ3U85	Strong	Biomarker	[103]
E2F7	OTWW358N	Strong	Altered Expression	[104]
E2F8	OTQKZGFP	Strong	Altered Expression	[104]
EI24	OTD4NOYS	Strong	Biomarker	[105]
EIF4B	OTE8TXA8	Strong	Altered Expression	[106]
EIF6	OTEXMUED	Strong	Biomarker	[34]
ENDOV	OTX2GXXX	Strong	Biomarker	[107]
ERCC3	OTVAW3P1	Strong	Biomarker	[108]
ERP29	OTNKANMH	Strong	Biomarker	[109]
ETV1	OT6PMJIK	Strong	Biomarker	[110]
FERMT1	OT626PBA	Strong	Biomarker	[111]
FOXN1	OTE80D6I	Strong	Biomarker	[112]
GSTM3	OTLA2WJT	Strong	Genetic Variation	[113]
GTF2H1	OTCRXC6B	Strong	Altered Expression	[46]
GYPA	OTABU4YV	Strong	Biomarker	[114]
HBM	OT8WB3RL	Strong	Biomarker	[115]
IL34	OTZ15VVK	Strong	Altered Expression	[116]
INPP5A	OT9CMGMS	Strong	Genetic Variation	[55]
INPP5K	OTQFLQKA	Strong	Biomarker	[117]
IRF4	OT1DHQ1P	Strong	Genetic Variation	[118]
LAMTOR2	OTHEDISB	Strong	Genetic Variation	[97]
MCM4	OT19PNNG	Strong	Genetic Variation	[119]
MMP19	OTLSTT2B	Strong	Biomarker	[120]
NFATC4	OTTDCUAO	Strong	Altered Expression	[37]
NPDC1	OT788NC8	Strong	Biomarker	[34]
NUP62	OTMN63DH	Strong	Altered Expression	[46]
OCA2	OTDWIGBF	Strong	Genetic Variation	[69]
PADI2	OTT40K94	Strong	Altered Expression	[121]
PAQR3	OTTKJ9Y4	Strong	Genetic Variation	[122]
PDCD5	OT6T2DDL	Strong	Biomarker	[123]
PHF14	OTZT3GV1	Strong	Altered Expression	[106]
PLEKHM2	OT4ZYV73	Strong	Biomarker	[117]
POLH	OTN07WXU	Strong	Biomarker	[124]
POLQ	OTBHK0E6	Strong	Biomarker	[125]
POT1	OTNBXJCQ	Strong	Biomarker	[126]
PTCH2	OTOQ0K9V	Strong	Biomarker	[127]
PTPN3	OTSLZBVY	Strong	Altered Expression	[128]
RAB11A	OTC4FW0J	Strong	Biomarker	[129]
RAD9A	OTJ3AJQU	Strong	Genetic Variation	[130]
RGCC	OTYJMLWM	Strong	Altered Expression	[50]
RPP14	OT4OYFSK	Strong	Genetic Variation	[97]
RRAS2	OT83NCEB	Strong	Altered Expression	[131]
S100A7	OTJFVJRF	Strong	Altered Expression	[132]
SDHB	OTRE1M1T	Strong	Biomarker	[60]
SERPINB4	OT88LHZ8	Strong	Genetic Variation	[133]
SF3B6	OTPRKS6S	Strong	Genetic Variation	[97]
SKP1	OT5BPAZ4	Strong	Biomarker	[134]
SMARCA2	OTSGJ8SV	Strong	Altered Expression	[135]
SMPX	OTLSHGBF	Strong	Altered Expression	[46]
SNW1	OTKWG3PS	Strong	Biomarker	[117]
SPHKAP	OT5RHUYJ	Strong	Biomarker	[117]
SRSF6	OTGLOSYE	Strong	Altered Expression	[136]
STT3A	OTDPS6AV	Strong	Genetic Variation	[137]
TALDO1	OTDKV2S2	Strong	Altered Expression	[138]
TARBP2	OT1QQ8H3	Strong	Biomarker	[90]
TBPL1	OT4I143E	Strong	Genetic Variation	[29]
TGIF2	OTMKKE3W	Strong	Biomarker	[139]
TMC6	OTKH50J4	Strong	Biomarker	[137]
TMC8	OTUAD95X	Strong	Biomarker	[140]
TSPAN1	OTZQPIYK	Strong	Biomarker	[141]
ATOX1	OT05LF59	Definitive	Altered Expression	[142]
RTN3	OTGZ51QF	Definitive	Biomarker	[143]
SAFB	OTGRV2LW	Definitive	Biomarker	[143]
SASH1	OTQA8BD4	Definitive	Genetic Variation	[144]
TRIM16	OTLRXYOZ	Definitive	Biomarker	[145]
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⏷ Show the Full List of 120 DOT(s)

References

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2	Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110.
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5	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8199).
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8	Expression of proton-sensing G-protein-coupled receptors in selected skin tumors.Exp Dermatol. 2019 Jan;28(1):66-71. doi: 10.1111/exd.13809. Epub 2018 Dec 13.
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13	T Regulatory Cell Subpopulations Associated with Recent Ultraviolet Radiation Exposure in a Skin Cancer Screening Cohort.J Immunol. 2018 Dec 1;201(11):3269-3281. doi: 10.4049/jimmunol.1800940. Epub 2018 Nov 2.
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20	Correlation of changes in HIF-1 and p53 expressions with vitamin B3 deficiency in skin cancer patients.G Ital Dermatol Venereol. 2019 Oct;154(5):513-518. doi: 10.23736/S0392-0488.17.05775-3. Epub 2017 Oct 23.
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23	Cancer outcomes among Parkinson's disease patients with leucine rich repeat kinase 2 mutations, idiopathic Parkinson's disease patients, and nonaffected controls.Mov Disord. 2019 Sep;34(9):1392-1398. doi: 10.1002/mds.27807. Epub 2019 Jul 26.
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25	Whole-Exome Sequencing Validates a Preclinical Mouse Model for the Prevention and Treatment of Cutaneous Squamous Cell Carcinoma.Cancer Prev Res (Phila). 2017 Jan;10(1):67-75. doi: 10.1158/1940-6207.CAPR-16-0218. Epub 2016 Dec 6.
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28	Antitumor activity of sulforaphane in mice model of skin cancer via blocking sulfatase-2.Exp Dermatol. 2019 Jan;28(1):28-34. doi: 10.1111/exd.13802. Epub 2018 Dec 11.
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32	Expression Pattern of Aquaporin 1 and Aquaporin 3 in Melanocytic and Nonmelanocytic Skin Tumors.Am J Clin Pathol. 2019 Sep 9;152(4):446-457. doi: 10.1093/ajcp/aqz066.
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45	Anticarcinogenic effect of quercetin by inhibition of insulin-like growth factor (IGF)-1 signaling in mouse skin cancer.Nutr Res Pract. 2013 Dec;7(6):439-45. doi: 10.4162/nrp.2013.7.6.439. Epub 2013 Nov 29.
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47	Deficiency of the Kruppel-like factor KLF4 correlates with increased cell proliferation and enhanced skin tumorigenesis.Carcinogenesis. 2012 Jun;33(6):1239-46. doi: 10.1093/carcin/bgs143. Epub 2012 Apr 9.
48	KLK6 protease accelerates skin tumor formation and progression.Carcinogenesis. 2018 Dec 31;39(12):1529-1536. doi: 10.1093/carcin/bgy110.
49	Keratin-dependent regulation of Aire and gene expression in skin tumor keratinocytes.Nat Genet. 2015 Aug;47(8):933-8. doi: 10.1038/ng.3355. Epub 2015 Jul 13.
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