General Information of Drug (ID: DM0DTF7)

Drug Name
Zonisamide Drug Info
Synonyms
Exceglan; Excegram; Excegran; Tremode; Trerief; Zonegran; Zonisamida; Zonisamidum; Elan brand of zonisamide; Zonisamida [Spanish]; Zonisamide monosodium; Zonisamidum [Latin]; AD 810; PD 110843; SPR_2; AD-810; AD-810N; E-2090; Excegran (TN); PD-110843; Zonegran (TN); Zonegran, Zonisamide; Zonisamide (ZNS); Zonisamide (JAN/USAN/INN); Zonisamide [USAN:BAN:INN:JAN]; 1,2-Benzisoxazole-3-methanesulfonamide; 1,2-benzoxazol-3-ylmethanesulfonamide; 1-(1,2-Benzoxazol-3-Yl)methanesulfonamide; 1-(1,2-benzisoxazol-3-yl)methanesulfonamide; 3-(Sulfamoylmethyl)-1,2-benzisoxazole; 3-sulfamoylmethyl-1,2-benzisoxazole
Indication
Disease Entry ICD 11 Status REF
Alcohol dependence 6C40.2 Approved [1]
Alcohol use disorder 6C40.2 Approved [1]
Bipolar disorder 6A60 Approved [1]
Epilepsy 8A60-8A68 Approved [2]
Therapeutic Class
Analgesics
Cross-matching ID
PubChem CID
5734
CAS Number
CAS 68291-97-4
TTD Drug ID
DM0DTF7
INTEDE Drug ID
DR1737
ACDINA Drug ID
D00745

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [11]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [12]
Eslicarbazepine DMZREFQ Seizure disorder 8A6Z Approved [13]
LIDOFLAZINE DMV23GL Angina pectoris BA40 Approved [14]
LOMERIZINE DME0TC8 Migraine 8A80 Approved [15]
Levobupivacaine DM783CH Anaesthesia 9A78.6 Approved [16]
Tetrodotoxin DMWMPRG Bacterial infection 1A00-1C4Z Approved [17]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [18]
Rufinamide DMWE60C Epilepsy 8A60-8A68 Approved [19]
Butacaine DM584TM Pain MG30-MG3Z Approved [20]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [21]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [22]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [23]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [24]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [25]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [26]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [27]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [28]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [22]
Verapamil DMA7PEW Angina pectoris BA40 Approved [29]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [30]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [31]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [32]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [33]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [34]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [35]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [36]
Metronidazole DMTIVEN Abscess Approved [37]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [38]
Ethanol DMDRQZU Chronic pain MG30 Approved [39]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 3A5 (CYP3A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [41]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [42]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [43]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [44]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [45]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [46]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [47]
Verapamil DMA7PEW Angina pectoris BA40 Approved [48]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [43]
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Drug(s) Metabolized By Cytochrome P450 3A7 (CYP3A7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [49]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [43]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [43]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [43]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [50]
Verapamil DMA7PEW Angina pectoris BA40 Approved [51]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [43]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [43]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [43]
Metronidazole DMTIVEN Abscess Approved [52]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Mephenytoin 4-hydroxylase (CYP2C19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [53]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [54]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [55]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [56]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [50]
Verapamil DMA7PEW Angina pectoris BA40 Approved [57]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [58]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [59]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [60]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [61]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tyrosine 3-monooxygenase (TH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [62]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [63]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [64]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [65]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [66]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [67]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [68]
Methamphetamine DMPM4SK Anxiety Approved [69]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [70]
Piperazine DMTY9LU Ascariasis 1F62 Approved [71]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Sodium channel unspecific (NaC) TTRK8B9 NOUNIPROTAC Blocker [3]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) Main DME DE4LYSA CP3A4_HUMAN Substrate [4]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DEYGVN4 UD11_HUMAN Substrate [5]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Substrate [6]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Substrate [7]
Cytochrome P450 3A7 (CYP3A7) DERD86B CP3A7_HUMAN Substrate [8]
Aldehyde oxidase (AOX) DE8UGTM A0A1V9IQJ2_CLOSG Substrate [9]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Tyrosine 3-monooxygenase (TH) OT6ZORKP TY3H_HUMAN Gene/Protein Processing [10]

References

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36 Characterization of rat intestinal microsomal UDP-glucuronosyltransferase activity toward mycophenolic acid. Drug Metab Dispos. 2006 Sep;34(9):1632-9.
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