Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM15HAT)

Drug Name
Leuprorelin acetate Drug Info
Synonyms Leuprolide acetate; Leuplin (TN); Leuprorelin acetate (JAN); 5-oxoPro-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-ProNHC2H5 dihydrate
Indication
Disease Entry ICD 11 Status REF
Prostate cancer 2C82.0 Approved [1]
Cross-matching ID
PubChem CID
657180
ChEBI ID
CHEBI:63597
CAS Number
CAS 74381-53-6
TTD Drug ID
DM15HAT
ACDINA Drug ID
D01205

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Gonadotropin-releasing hormone receptor (GNRHR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gonadorelin DMAQ469 Amenorrhea GA20.0 Approved [6]
Relugolix DMK7IWL Prostate cancer 2C82.0 Approved [7]
Ganirelix DMGMB30 Ovulation dysfunction 5A80 Approved [8]
Abarelix DM5WFNP Prostate cancer 2C82.0 Approved [9]
Triptorelin DMTK4LS Infertility GB04 Approved [10]
Nafarelin DMAHEFY Endometriosis GA10 Approved [11]
Cetrorelix DMFD9Q6 Ovarian stimulation LB45.1 Approved [12]
Elagolix sodium DMRDUC0 Endometriosis GA10 Approved [13]
Degarelix DM3O8QY Prostate cancer 2C82.0 Approved [14]
AEZS-108 DMAYO46 Acute lymphoblastic leukaemia 2A85 Phase 3 [15]
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Drug(s) Affected By Claudin-4 (CLDN4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [16]
Selenium DM25CGV N. A. N. A. Approved [17]
Methotrexate DM2TEOL Anterior urethra cancer Approved [18]
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [20]
Panobinostat DM58WKG Chronic graft versus host disease Approved [21]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [22]
Testosterone DM7HUNW Hot flushes GA30 Approved [4]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [23]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [24]
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Drug(s) Affected By Lutropin subunit beta (LHB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [25]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [26]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [27]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [28]
Alprazolam DMC7XDN Anxiety Approved [29]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [30]
Norethindrone acetate DMDGCQP N. A. N. A. Approved [25]
Metoclopramide DMFA5MY Nausea MD90 Approved [27]
Cetrorelix DMFD9Q6 Ovarian stimulation LB45.1 Approved [31]
Ganirelix DMGMB30 Ovulation dysfunction 5A80 Approved [32]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [33]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [34]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [35]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [36]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [37]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [38]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [39]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [40]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [41]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [42]
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Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [43]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [44]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [45]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [46]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [47]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [48]
Meloxicam DM2AR7L Arthritis FA20 Approved [49]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [50]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [51]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [52]
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Drug(s) Affected By Claudin-8 (CLDN8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [53]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [54]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [55]
Testosterone DM7HUNW Hot flushes GA30 Approved [56]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [56]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [53]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [57]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [58]
Tetracycline DMZA017 Acne vulgaris ED80 Approved [59]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [60]
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Drug(s) Affected By Cytochrome c (CYCS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [61]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [62]
Gefitinib DM15F0X Colon adenocarcinoma Approved [63]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [64]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [65]
Methotrexate DM2TEOL Anterior urethra cancer Approved [66]
Quercetin DM3NC4M Obesity 5B81 Approved [67]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [68]
Pefloxacin DM49IGF Gonococcal urethritis 1A70.0Y Approved [69]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [70]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [71]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [42]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [45]
Verapamil DMA7PEW Angina pectoris BA40 Approved [72]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [73]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [74]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [75]
Meloxicam DM2AR7L Arthritis FA20 Approved [76]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [77]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [51]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Gonadotropin-releasing hormone receptor (GNRHR) TT8R70G GNRHR_HUMAN Agonist [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [3]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [3]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Gene/Protein Processing [3]
Claudin-4 (CLDN4) OT9C4PZ4 CLD4_HUMAN Gene/Protein Processing [4]
Claudin-8 (CLDN8) OT7IIWXG CLD8_HUMAN Gene/Protein Processing [4]
Cytochrome c (CYCS) OTBFALJD CYC_HUMAN Protein Interaction/Cellular Processes [3]
Lutropin subunit beta (LHB) OT5GBOVJ LSHB_HUMAN Gene/Protein Processing [5]

References

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2 Clinical pipeline report, company report or official report of Takeda (2009).
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76 Combining kallistatin gene therapy and meloxicam to treat hepatocellular carcinoma in mice. Cancer Sci. 2009 Nov;100(11):2226-33. doi: 10.1111/j.1349-7006.2009.01306.x. Epub 2009 Aug 4.
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