Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM29I0Y)

Drug Name
ANTHRAQUINONE Drug Info
Synonyms
84-65-1; 9,10-Anthraquinone; anthracene-9,10-dione; 9,10-Anthracenedione; Anthradione; Hoelite; 9,10-Dioxoanthracene; Corbit; Morkit; 9,10-Anthrachinon; Anthra-9,10-quinone; Anthrapel; 9,10-quinone; Anthrachinon; Caswell No. 052A; Anthraquinone [BSI:ISO]; UNII-030MS0JBDO; NSC 7957; Bis-alkylamino anthraquinone; 9,10-Anthrachinon [Czech]; CCRIS 649; 9,10-Anthracendion; Anthracene, 9,10-dihydro-9,10-dioxo-; CHEBI:40448; HSDB 2074; EINECS 201-549-0; Anthracene-9,10-quinone; EPA Pesticide Chemical Code 122701
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
6780
ChEBI ID
CHEBI:40448
CAS Number
CAS 84-65-1
TTD Drug ID
DM29I0Y

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting M-phase inducer phosphatase 2 (MPIP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Avastin+/-Tarceva DMA86FL Non-small-cell lung cancer 2C25.Y Phase 3 [1]
MX-7065 DMP26BW Solid tumour/cancer 2A00-2F9Z Terminated [5]
2-Sulfhydryl-Ethanol DMJBO3D Discovery agent N.A. Investigative [6]
Double Oxidized Cysteine DM6TU84 Discovery agent N.A. Investigative [6]
Cysteinesulfonic Acid DMXI8FP Discovery agent N.A. Investigative [6]
Cysteine Sulfenic Acid DM4GZUJ N. A. N. A. Investigative [7]
3-isopropyl-4-(phenylthio)naphthalene-1,2-dione DMJZEMB Discovery agent N.A. Investigative [8]
4-(p-toluidino)-3-isopropylnaphthalene-1,2-dione DMQA0EJ Discovery agent N.A. Investigative [8]
ADOCIAQUINONE B DMPOU86 Discovery agent N.A. Investigative [9]
3-isopropyl-4-phenylnaphthalene-1,2-dione DMYZCWX Discovery agent N.A. Investigative [8]
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Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [10]
Riluzole DMECBWN Amyotrophic lateral sclerosis 8B60.0 Approved [11]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [12]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [13]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [14]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [15]
Ethacrynic acid DM60QMR Edema MG29 Approved [16]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [17]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [18]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [19]
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Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [11]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [20]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [21]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [22]
Estrone DM5T6US Acne vulgaris ED80 Approved [23]
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [24]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [25]
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [26]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [27]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [28]
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Drug(s) Affected By Bcl-2-like protein 11 (BCL2L11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [29]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [30]
Quercetin DM3NC4M Obesity 5B81 Approved [31]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [33]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [34]
Panobinostat DM58WKG Chronic graft versus host disease Approved [35]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [36]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [37]
Testosterone DM7HUNW Hot flushes GA30 Approved [38]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [39]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [40]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [41]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [42]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [43]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [44]
Verapamil DMA7PEW Angina pectoris BA40 Approved [45]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [46]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [47]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [48]
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Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [49]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [50]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [48]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [51]
Gefitinib DM15F0X Colon adenocarcinoma Approved [52]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [53]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [54]
Selenium DM25CGV N. A. N. A. Approved [55]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [56]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [57]
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Drug(s) Affected By G1/S-specific cyclin-D2 (CCND2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [58]
Selenium DM25CGV N. A. N. A. Approved [59]
Methotrexate DM2TEOL Anterior urethra cancer Approved [60]
Quercetin DM3NC4M Obesity 5B81 Approved [61]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [62]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [63]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [64]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [65]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [66]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
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Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [68]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [69]
Gamolenic acid DMQN30Z Allergy 4A80-4A85 Approved [70]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [71]
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [72]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [73]
Ibandronate DM0QZBN Hypercalcaemia 5B91.0 Approved [74]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [75]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [76]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [77]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [78]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [79]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [80]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [81]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [82]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [83]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [84]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [85]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [86]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [87]
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Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [88]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [89]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [44]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [46]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [90]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [91]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [92]
Meloxicam DM2AR7L Arthritis FA20 Approved [93]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [94]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [95]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [39]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [87]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [44]
Verapamil DMA7PEW Angina pectoris BA40 Approved [45]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [96]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [90]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [53]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [97]
Meloxicam DM2AR7L Arthritis FA20 Approved [98]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [99]
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Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [100]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [101]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [92]
Selenium DM25CGV N. A. N. A. Approved [55]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [102]
Methotrexate DM2TEOL Anterior urethra cancer Approved [60]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [103]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [104]
Quercetin DM3NC4M Obesity 5B81 Approved [105]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [15]
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Drug(s) Affected By Bcl2-associated agonist of cell death (BAD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [106]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [87]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [107]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [108]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [109]
Quercetin DM3NC4M Obesity 5B81 Approved [110]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [111]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [112]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [36]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [113]
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Drug(s) Affected By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zolmitriptan DM1IB4Q Migraine 8A80 Approved [114]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [114]
Etoricoxib DM6A4NW Rheumatoid arthritis FA20 Approved [114]
Capsaicin DMGMF6V Back pain ME84.Z Approved [115]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [116]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [117]
Nifedipine DMSVOZT Angina pectoris BA40 Approved [118]
Zileuton DMVRIC2 Allergic asthma CA23.0 Approved [119]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [120]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [43]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [121]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [122]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [123]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [28]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [124]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [125]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [76]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [126]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [127]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [76]
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Drug(s) Affected By C-C motif chemokine 5 (CCL5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [128]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [129]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [130]
Methotrexate DM2TEOL Anterior urethra cancer Approved [131]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [132]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [133]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [134]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [135]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [136]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [137]
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Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [138]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [139]
Gefitinib DM15F0X Colon adenocarcinoma Approved [140]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [141]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [142]
Quercetin DM3NC4M Obesity 5B81 Approved [105]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [143]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [144]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [142]
Ethacrynic acid DM60QMR Edema MG29 Approved [145]
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Drug(s) Affected By Caspase-4 (CASP4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [107]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [146]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [128]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [147]
Quercetin DM3NC4M Obesity 5B81 Approved [31]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [148]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [149]
Testosterone DM7HUNW Hot flushes GA30 Approved [38]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [150]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [151]
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Drug(s) Affected By Caspase-7 (CASP7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [152]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [146]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [153]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [154]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [155]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [155]
Methotrexate DM2TEOL Anterior urethra cancer Approved [60]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [156]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [157]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [158]
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Drug(s) Affected By P2Y purinoceptor 12 (P2RY12)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clopidogrel DMOL54H Acute coronary syndrome BA41 Approved [159]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [160]
adenosine diphosphate DMFUHKP N. A. N. A. Investigative [161]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
M-phase inducer phosphatase 2 (MPIP2) TTR0SWN MPIP2_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [2]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [2]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Gene/Protein Processing [2]
Bcl-2-like protein 11 (BCL2L11) OTNQQWFJ B2L11_HUMAN Gene/Protein Processing [2]
Bcl2-associated agonist of cell death (BAD) OT63ERYM BAD_HUMAN Gene/Protein Processing [2]
C-C motif chemokine 5 (CCL5) OTSCA5CK CCL5_HUMAN Gene/Protein Processing [3]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [2]
Caspase-4 (CASP4) OTVQTV1L CASP4_HUMAN Protein Interaction/Cellular Processes [4]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Protein Interaction/Cellular Processes [4]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Gene/Protein Processing [2]

References

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2 In vitro antiproliferative activity of 2,3-dihydroxy-9,10-anthraquinone induced apoptosis against COLO320 cells through cytochrome c release caspase mediated pathway with PI3K/AKT and COX-2 inhibition. Chem Biol Interact. 2016 Apr 5;249:23-35.
3 Genotoxic and inflammatory effects of organic extracts from traffic-related particulate matter in human lung epithelial A549 cells: the role of quinones. Toxicol In Vitro. 2013 Mar;27(2):922-31. doi: 10.1016/j.tiv.2013.01.008. Epub 2013 Jan 16.
4 Methylanthraquinone from Hedyotis diffusa WILLD induces Ca(2+)-mediated apoptosis in human breast cancer cells. Toxicol In Vitro. 2010 Feb;24(1):142-7. doi: 10.1016/j.tiv.2009.08.002. Epub 2009 Aug 15.
5 Handbook of Assay Development in Drug Discovery, Lisa K. Minor, 2013. Page(11).
6 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
7 DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
8 Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1905-8.
9 Novel naphthoquinone and quinolinedione inhibitors of CDC25 phosphatase activity with antiproliferative properties. Bioorg Med Chem. 2008 Oct 1;16(19):9040-9.
10 Cytochrome P450 1A1/2 induction by antiparasitic drugs: dose-dependent increase in ethoxyresorufin O-deethylase activity and mRNA caused by quinine, primaquine and albendazole in HepG2 cells. Eur J Clin Pharmacol. 2002 Nov;58(8):537-42.
11 Association of CYP1A1 and CYP1B1 inhibition in in vitro assays with drug-induced liver injury. J Toxicol Sci. 2021;46(4):167-176. doi: 10.2131/jts.46.167.
12 Anti-androgenic effect of 6-formylindolo[3,2-b]carbazole (FICZ) in LNCaP cells is mediated by the aryl hydrocarbon-androgen receptors cross-talk. Steroids. 2020 Jan;153:108508. doi: 10.1016/j.steroids.2019.108508. Epub 2019 Oct 3.
13 Pharmacologic profiling of human and rat cytochrome P450 1A1 and 1A2 induction and competition. Arch Toxicol. 2008 Dec;82(12):909-21.
14 Effect of CYP1A1 gene polymorphisms on estrogen metabolism and bone density. J Bone Miner Res. 2005 Feb;20(2):232-9. doi: 10.1359/JBMR.041110. Epub 2004 Nov 16.
15 Increased sensitivity for troglitazone-induced cytotoxicity using a human in vitro co-culture model. Toxicol In Vitro. 2009 Oct;23(7):1387-95.
16 Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress: implications for the alternative pathway of PAH activation catalyzed by human dihydrodiol dehydrogenase. Cancer Res. 1999 Feb 1;59(3):607-14.
17 Gene expression changes in human small airway epithelial cells exposed to Delta9-tetrahydrocannabinol. Toxicol Lett. 2005 Aug 14;158(2):95-107.
18 The metallohormone cadmium modulates AhR-associated gene expression in the small intestine of rats similar to ethinyl-estradiol. Arch Toxicol. 2013 Apr;87(4):633-43.
19 Evidence for a new human CYP1A1 regulation pathway involving PPAR-alpha and 2 PPRE sites. Gastroenterology. 2004 Nov;127(5):1436-45.
20 Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
21 Convergent transcriptional profiles induced by endogenous estrogen and distinct xenoestrogens in breast cancer cells. Carcinogenesis. 2006 Aug;27(8):1567-78.
22 Gene expression in endometrial cancer cells (Ishikawa) after short time high dose exposure to progesterone. Steroids. 2008 Jan;73(1):116-28.
23 In vitro aromatic bioactivation of the weak estrogen E(2)alpha and genesis of DNA adducts. Steroids. 2005 Mar;70(3):161-72. doi: 10.1016/j.steroids.2004.11.004.
24 Metabolism of melatonin by human cytochromes p450. Drug Metab Dispos. 2005 Apr;33(4):489-94.
25 Metabolism of retinoids and arachidonic acid by human and mouse cytochrome P450 1b1. Drug Metab Dispos. 2004 Aug;32(8):840-7.
26 Apoptosis contributes to the cytotoxicity induced by amodiaquine and its major metabolite N-desethylamodiaquine in hepatic cells. Toxicol In Vitro. 2020 Feb;62:104669. doi: 10.1016/j.tiv.2019.104669. Epub 2019 Oct 16.
27 Genetic variants contributing to daunorubicin-induced cytotoxicity. Cancer Res. 2008 May 1;68(9):3161-8. doi: 10.1158/0008-5472.CAN-07-6381.
28 Calcium pantothenate modulates gene expression in proliferating human dermal fibroblasts. Exp Dermatol. 2009 Nov;18(11):969-78. doi: 10.1111/j.1600-0625.2009.00884.x. Epub 2009 Apr 8.
29 Selenium sensitizes MCF-7 breast cancer cells to doxorubicin-induced apoptosis through modulation of phospho-Akt and its downstream substrates. Mol Cancer Ther. 2007 Mar;6(3):1031-8. doi: 10.1158/1535-7163.MCT-06-0643. Epub 2007 Mar 5.
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