Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6JN19)

Drug Name
ME-344 Drug Info
Synonyms NV-128; NV-344; MTOR inhibitor (cancer), Novogen; MTOR inhibitors (cancer), Marshall Edwards
Indication
Disease Entry ICD 11 Status REF
Breast cancer 2C60-2C65 Phase 1/2 [1]
Solid tumour/cancer 2A00-2F9Z Preclinical [2]
Cross-matching ID
PubChem CID
68026984
CAS Number
CAS 1374524-68-1
TTD Drug ID
DM6JN19

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Clinical Trial Drug(s)
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Mammalian target of rapamycin complex 1 (mTORC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
RBT-101 DMDZW8K Respiratory tract infection CA45 Phase 3 [7]
AZD2014 DMOEARH Solid tumour/cancer 2A00-2F9Z Phase 2 [1]
VS-5584 DMMO3G5 Malignant mesothelioma 2C26.0 Phase 1 [8]
Palomid-529 DM428Y3 Alzheimer disease 8A20 Phase 1 [9]
NV-5138 DMLKS7W Major depressive disorder 6A70.3 Phase 1 [10]
Drug(s) Targeting Serine/threonine-protein kinase mTOR (mTOR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sirolimus DMGW1ID Advanced cancer 2A00-2F9Z Approved [11]
Temsirolimus DMS104F Renal cell carcinoma 2C90 Approved [12]
PF-04449913 DMSB068 Chronic myelomonocytic leukaemia 2A40 Approved [13]
Everolimus DM8X2EH Advanced cancer 2A00-2F9Z Approved [14]
Novolimus DM6ZPLQ Artery stenosis BD52 Approved [15]
Zotarolimus DMRMCXW Solid tumour/cancer 2A00-2F9Z Approved [16]
Ridaforolimus DMLHEU7 Sarcoma 2A60-2C35 Phase 3 [17]
AZD2014 DMOEARH Solid tumour/cancer 2A00-2F9Z Phase 2 [18]
MM-141 DM2RJ4D Pancreatic cancer 2C10 Phase 2 [1]
PQR309 DMMCYZ8 Squamous head and neck cell carcinom 2D60.0 Phase 2 [15]
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Drug(s) Targeting Target of rapamycin complex 2 MAPKAP1 (MTORC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
AZD2014 DMOEARH Solid tumour/cancer 2A00-2F9Z Phase 2 [1]
VS-5584 DMMO3G5 Malignant mesothelioma 2C26.0 Phase 1 [8]
Palomid-529 DM428Y3 Alzheimer disease 8A20 Phase 1 [9]
Drug(s) Affected By Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [19]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [20]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [21]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [22]
Quercetin DM3NC4M Obesity 5B81 Approved [23]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [22]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [24]
Pyrazinamide DM4IF32 Meningeal tuberculosis Approved [25]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [26]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [22]
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Drug(s) Affected By Protein disulfide-isomerase (P4HB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [22]
Etretinate DM2CZFA Keratosis ED56 Approved [27]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [22]
Quercetin DM3NC4M Obesity 5B81 Approved [28]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [29]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [22]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [30]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [31]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [22]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [32]
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Drug(s) Affected By Glutathione S-transferase P (GSTP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Busulfan DMXYJ9C Chronic myelogenous leukaemia 2A20.0 Approved [33]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [34]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [35]
Chlorambucil DMRKE63 Chronic lymphocytic leukaemia 2A82.0 Approved [35]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [36]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [37]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [38]
Selenium DM25CGV N. A. N. A. Approved [39]
Etretinate DM2CZFA Keratosis ED56 Approved [27]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [40]
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Drug(s) Affected By Heme oxygenase 1 (HMOX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [41]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [42]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [43]
Verapamil DMA7PEW Angina pectoris BA40 Approved [44]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [45]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [46]
Selenium DM25CGV N. A. N. A. Approved [47]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [48]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [49]
Methotrexate DM2TEOL Anterior urethra cancer Approved [50]
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Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [51]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [22]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [52]
Etretinate DM2CZFA Keratosis ED56 Approved [27]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [53]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [54]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [55]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [56]
Quercetin DM3NC4M Obesity 5B81 Approved [57]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [58]
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Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-4 (ATF4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [20]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [59]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [38]
Selenium DM25CGV N. A. N. A. Approved [39]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [60]
Pyrazinamide DM4IF32 Meningeal tuberculosis Approved [25]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [26]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [61]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [62]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [63]
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Drug(s) Affected By Aldehyde dehydrogenase, dimeric NADP-preferring (ALDH3A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [64]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [65]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [66]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [67]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [68]
Leflunomide DMR8ONJ Arthritis FA20 Approved [69]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [70]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [71]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [72]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [34]
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Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [42]
Triacetin DM0AEPG Onychomycosis EE12.1 Approved [73]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [20]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [59]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [22]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [74]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [53]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [75]
Methotrexate DM2TEOL Anterior urethra cancer Approved [76]
Quercetin DM3NC4M Obesity 5B81 Approved [57]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [77]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [78]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [79]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [80]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [81]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [82]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [83]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [84]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [85]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [86]
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Drug(s) Affected By Proliferation marker protein Ki-67 (MKI67)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [87]
Methotrexate DM2TEOL Anterior urethra cancer Approved [76]
Quercetin DM3NC4M Obesity 5B81 Approved [88]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [89]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [90]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [91]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [92]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [93]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [94]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [95]
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Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [96]
Verapamil DMA7PEW Angina pectoris BA40 Approved [44]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [20]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [97]
Selenium DM25CGV N. A. N. A. Approved [39]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [98]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [99]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [100]
Quercetin DM3NC4M Obesity 5B81 Approved [57]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [101]
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Drug(s) Affected By NADH dehydrogenase 1 alpha subcomplex subunit 9, mitochondrial (NDUFA9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [19]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [102]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [103]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [104]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [106]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [107]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [108]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [109]
Fenretinide DMRD5SP Macular degeneration 9B78.3 Phase 3 [110]
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Drug(s) Affected By Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [19]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [20]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [22]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [111]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [22]
Quercetin DM3NC4M Obesity 5B81 Approved [112]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [22]
Pyrazinamide DM4IF32 Meningeal tuberculosis Approved [25]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [26]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [62]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Mammalian target of rapamycin complex 1 (mTORC1) TTX4GLS MTOR_HUMAN-RPTOR_HUMAN-LST8_HUMAN-AKTS1_HUMAN-DPTOR_HUMAN Inhibitor [1]
Serine/threonine-protein kinase mTOR (mTOR) TTCJG29 MTOR_HUMAN Inhibitor [3]
Target of rapamycin complex 2 MAPKAP1 (MTORC2) TTWDKCL SIN1_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Aldehyde dehydrogenase, dimeric NADP-preferring (ALDH3A1) OTAYZZE6 AL3A1_HUMAN Gene/Protein Processing [4]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [5]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4) OTRFV19J ATF4_HUMAN Gene/Protein Processing [4]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Gene/Protein Processing [4]
Endoplasmic reticulum chaperone BiP (HSPA5) OTFUIRAO BIP_HUMAN Gene/Protein Processing [4]
Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3) OT0DZGY4 E2AK3_HUMAN Gene/Protein Processing [4]
Glutathione S-transferase P (GSTP1) OTLP0A0Y GSTP1_HUMAN Gene/Protein Processing [4]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Gene/Protein Processing [4]
NADH dehydrogenase 1 alpha subcomplex subunit 9, mitochondrial (NDUFA9) OTMKQJJ8 NDUA9_HUMAN Protein Interaction/Cellular Processes [6]
Nuclear factor erythroid 2-related factor 2 (NFE2L2) OT0HENJ5 NF2L2_HUMAN Gene/Protein Processing [4]

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
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22 Drug-induced hepatic steatosis in absence of severe mitochondrial dysfunction in HepaRG cells: proof of multiple mechanism-based toxicity. Cell Biol Toxicol. 2021 Apr;37(2):151-175. doi: 10.1007/s10565-020-09537-1. Epub 2020 Jun 14.
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30 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
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