Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM7QGHO)

Drug Name

AZD5991 Drug Info

Synonyms

KBQCEQAXHPIRTF-UHFFFAOYSA-N; AZD-5991 (Racemate); 2143061-81-6; UNII-E3T5XXY9HX; E3T5XXY9HX; SCHEMBL19472011; EX-A2673; HY-101533A; CS-0077938; E4W

Indication

Disease Entry	ICD 11	Status	REF
Haematological malignancy	2B33.Y	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

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Drug(s) Targeting Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Obatoclax	DMPF9ZM	Solid tumour/cancer	2A00-2F9Z	Phase 2	[2]
AMG 176	DM0Q7NO	Acute myeloid leukaemia	2A60	Phase 1	[1]
PRT1419	DMIKE0O	Melanoma	2C30	Phase 1	[3]
ABBV-467	DM87SM9	Multiple myeloma	2A83	Phase 1	[4]
MIK665	DMTUVCG	Acute myeloid leukaemia	2A60	Phase 1	[5]
AMG 397	DM7CNTG	Refractory hematologic malignancy	2A85.5	Phase 1	[6]
PMID27744724-Compound-18	DM73S2C	N. A.	N. A.	Patented	[7]
Indole-based analog 2	DM0NEVC	N. A.	N. A.	Patented	[7]
PMID27744724-Compound-10	DMFKS2P	N. A.	N. A.	Patented	[7]
PMID27744724-Compound-21	DM18UA5	N. A.	N. A.	Patented	[7]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)	TTL53M6	MCL1_HUMAN	Inhibitor	[1]

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References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	Phase II study of obatoclax mesylate (GX15-070), a small-molecule BCL-2 family antagonist, for patients with myelofibrosis. Clin Lymphoma Myeloma Leuk. 2010 Aug;10(4):285-9.
3	Clinical pipeline report, company report or official report of Prelude Therapeutics.
4	Clinical pipeline report, company report or official report of AbbVie.
5	MCL1 inhibitors S63845/MIK665 plus Navitoclax synergistically kill difficult-to-treat melanoma cells. Cell Death Dis. 2020 Jun 8;11(6):443.
6	Clinical pipeline report, company report or official report of Amgen.
7	Mcl-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Feb;27(2):163-178.