Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMA6S1D)

Drug Name
Ropinirole Drug Info
Synonyms
Ropinirol; Ropinirolum; Ropitor; ReQuip CR; ReQuip XL; SKF 101468; Adartrel (TN); Requip (TN); Ropark (TN); Ropinirol[INN-Spanish]; Ropinirole (INN); Ropinirole [INN:BAN]; Ropinirolum [INN-Latin]; Ropitor (TN); SK&F 101468; SK&F-101,468; 4-[2-(Dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one; 4-[2-(Dipropylamino)ethyl]indoline-2-one; 4-[2-(dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one; 4-[2-(dipropylamino)ethyl]-1,3-dihydroindol-2-one
Indication
Disease Entry ICD 11 Status REF
Parkinson disease 8A00.0 Approved [1]
Therapeutic Class
Antiparkinson Agents
Cross-matching ID
PubChem CID
5095
ChEBI ID
CHEBI:8888
CAS Number
CAS 91374-21-9
TTD Drug ID
DMA6S1D
INTEDE Drug ID
DR1440
ACDINA Drug ID
D00606

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Dopamine D3 receptor (D3R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cariprazine DMJYDVK Bipolar disorder 6A60 Approved [6]
Pramipexole DMNMW9R Parkinson disease 8A00.0 Approved [2]
CM-2395 DMASPWR Schizophrenia 6A20 Phase 3 [7]
P2B-001 DM9PVHX Parkinson disease 8A00.0 Phase 3 [8]
RP5063 DMKUE8O Schizophrenia 6A20 Phase 2 [9]
ONC201 DMM5SCF Endometrial cancer 2C76 Phase 2 [10]
TAK-906 DMBQD9H Diabetic gastroparesis DA41.00 Phase 2 [11]
GSK598809 DMGU05N Drug abuse 6C4G.1Z Phase 2 [12]
GSK618334 DMJPXZ4 Drug abuse 6C4G.1Z Phase 1 [12]
Pfizer 10 DM6ER9L Female sexual arousal dysfunction HA01.1 Phase 1 [13]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Dopamine D2 receptor (D2R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [14]
Haloperidol DM96SE0 Delirium Approved [15]
Perphenazine DMA4MRX Schizophrenia 6A20 Approved [16]
Perazine DM2AOTZ Psychotic disorder 6A20-6A25 Approved [17]
Domperidone DMBDPY0 Gastrointestinal disease DE2Z Approved [18]
Levodopa DMN3E57 Parkinson disease 8A00.0 Approved [19]
Quetiapine DM1N62C Anorexia nervosa cachexia 6B80 Approved [20]
Pimozide DMW83TP Schizophrenia 6A20 Approved [21]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [22]
Iloperidone DM6AUFY Schizophrenia 6A20 Approved [23]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [24]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [25]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [26]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [27]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [28]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [29]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [30]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [31]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [25]
Verapamil DMA7PEW Angina pectoris BA40 Approved [32]
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Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [33]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [34]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [35]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [36]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [37]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [38]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [30]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [39]
Verapamil DMA7PEW Angina pectoris BA40 Approved [40]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [41]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [42]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [43]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [44]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [45]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [46]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [47]
Verapamil DMA7PEW Angina pectoris BA40 Approved [48]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [49]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [50]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [51]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [52]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [53]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [54]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [50]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [55]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [56]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [57]
Gefitinib DM15F0X Colon adenocarcinoma Approved [58]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [59]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [60]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [61]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [53]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [62]
Paclitaxel DMLB81S Breast carcinoma Approved [63]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [64]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [52]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [46]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [65]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [50]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [55]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Dopamine D2 receptor (D2R) TTEX248 DRD2_HUMAN Modulator [2]
Dopamine D3 receptor (D3R) TT4C8EA DRD3_HUMAN Modulator [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [3]
Cytochrome P450 1A2 (CYP1A2) Main DME DEJGDUW CP1A2_HUMAN Substrate [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [5]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [5]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Post-Translational Modifications [5]

References

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