Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMF8DNE)

Drug Name
Framycetin Drug Info
Synonyms
Neomycin; neomycin; NEOMYCIN B; Soframycin; Actiline; Mycifradin; Fradiomycin; Soframycine; Framycetinum; Framycetine; Framicetina; Neomas; Fradiomycinum; Antibiotique; Nivemycin; Actilin; Neolate; Enterfram; Myacyne; Framygen; Caswell No 595; Vonamycin powder V; Neomycin B sulfate; Neomin; Neomcin; Fradiomycin B; Neo-Rx; Neomicina [DCIT]; Framycetinum [INN-Latin]; PIMAVECORT; Neobrettin; Neo-Fradin; 119-04-0; Neomycine [INN-French]; Neomycinum [INN-Latin]; Framycetine [INN-French]; Framicetina [INN-Spanish]; USAF CB-19; Endomixin; Fraquinol; Myacine; Myciguent; NMY; Neobiotic; Neomicina; Neomycinum; Tuttomycin; VONAMYCIN; NEOMYCIN AND POLYMYXIN B SULFATES; NEOMYCIN SULFATE; Neomycin solution; Soframycin Ophthalmic; Antibiotic 10676; Antibiotic produced by Streptomyces decaris Neomycin B; Framycetin (INN); Soframycin (TN); Framycetin [INN:BAN:DCF]; Sofra-Tulle (TN); BDG-(1-4)CYY-(5-1)RIB-(3-1)IDG; BDG-(1-4)NEB-(5-1)RIB-(3-1)NED; (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside; (2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4S,5R)-4-[(2R,3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxycyclohexyl]oxyoxane-3,4-diol; D-Streptamine, O-2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl-(1->3)-O-beta-D-ribofuranosyl-(1->5)]-O-[2,6-diamino-2,6-dideoxy-alpha-D-glucopyranosyl-(1->4)]-2-deoxy
Indication
Disease Entry ICD 11 Status REF
Acute liver failure DB91 Approved [1]
Alcoholic cirrhosis of liver DB94 Approved [1]
Bacterial infection 1A00-1C4Z Approved [2]
Blepharoconjunctivitis Approved [3]
Corneal abrasion NA06.4 Approved [3]
Hepatic coma Approved [3]
Hepatic encephalopathy DB99.5 Approved [3]
Keratitis Approved [4]
Urinary tract infection GC08 Approved [5]
Uveitis 9A96.Z Investigative [3]
Therapeutic Class
Antibiotics
Cross-matching ID
PubChem CID
8378
ChEBI ID
CHEBI:7508
CAS Number
CAS 119-04-0
TTD Drug ID
DMF8DNE
INTEDE Drug ID
DR2158
ACDINA Drug ID
D00462

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Clinical Trial Drug(s)
Investigative Drug(s)
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Bacterial 16S ribosomal RNA (Bact 16S rRNA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Oxazolidinones DMBM47Z Gram-positive bacterial infection 1B74-1G40 Phase 2 [11]
Apramycin DMU8QD2 Gram-negative bacterial infection 1B74-1G40 Phase 1 [12]
G418 DMKTJBU Discovery agent N.A. Investigative [12]
Hygromycin B DMEZ92A Discovery agent N.A. Investigative [12]
Ribostamycin DMXWUHA Discovery agent N.A. Investigative [12]
Neamine DMNCU6H Discovery agent N.A. Investigative [12]
Butirosin B DMR6GJK Discovery agent N.A. Investigative [12]
Aminodeoxykanamycin DM79E2K Discovery agent N.A. Investigative [12]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Targeting Staphylococcus 30S ribosomal subunit (Stap-coc pbp2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tetracycline DMZA017 Acne vulgaris ED80 Approved [13]
Netilmicin DMRD1QK Bacterial infection 1A00-1C4Z Approved [14]
Amikacin DM5PDRB Bacteremia 1A73 Approved [15]
Clomocycline DM0ZRMQ Bacterial infection 1A00-1C4Z Approved [16]
Spectinomycin DM0MQ35 Acute gonococcal cervicitis Approved [17]
Paromomycin DM1AGXN Amoebiasis 1A36 Approved [18]
Lymecycline DMOMLHJ Bacterial infection 1A00-1C4Z Approved [19]
Rolitetracycline DMBR5Q7 Acne vulgaris ED80 Approved [20]
Meclocycline DMSFQ8I Bacterial infection 1A00-1C4Z Approved [21]
Minocycline DMVN5OH Acne vulgaris ED80 Approved [22]
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Drug(s) Metabolized By Aminoglycoside O-phosphotransferase (aphA6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gentamicin DMKINJO Bacteremia 1A73 Approved [8]
Tobramycin DMUI0CH Bacteremia 1A73 Approved [8]
Netilmicin DMRD1QK Bacterial infection 1A00-1C4Z Approved [8]
Amikacin DM5PDRB Bacteremia 1A73 Approved [8]
Kanamycin DM2DMPO Bacteremia 1A73 Approved [8]
Streptomycin DME1LQN Bacterial infection 1A00-1C4Z Approved [8]
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Drug(s) Metabolized By Aminoglycoside N-acetyltransferase (aacC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tobramycin DMUI0CH Bacteremia 1A73 Approved [8]
Netilmicin DMRD1QK Bacterial infection 1A00-1C4Z Approved [8]
Drug(s) Affected By T-lymphocyte activation antigen CD86 (CD86)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [23]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [24]
Kanamycin DM2DMPO Bacteremia 1A73 Approved [10]
Methotrexate DM2TEOL Anterior urethra cancer Approved [25]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [26]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [27]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [10]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [28]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [10]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [29]
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Drug(s) Affected By N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [30]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [27]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [31]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [32]
Testosterone enanthate DMB6871 N. A. N. A. Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [37]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [38]
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Drug(s) Affected By Glial fibrillary acidic protein (GFAP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Penicillin V DMKVOYF Acute otitis media AB00 Approved [9]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [9]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [39]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [40]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [41]
Testosterone DM7HUNW Hot flushes GA30 Approved [42]
Haloperidol DM96SE0 Delirium Approved [43]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [44]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Ethanol DMDRQZU Chronic pain MG30 Approved [45]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Bacterial 16S ribosomal RNA (Bact 16S rRNA) TT38DW5 NOUNIPROTAC Binder [6]
Staphylococcus 30S ribosomal subunit (Stap-coc pbp2) TTQ8KVI F4NA87_STAAU Binder [7]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Aminoglycoside O-phosphotransferase (aphA6) DEWPAJD KKA6_ACIBA Substrate [8]
Aminoglycoside N-acetyltransferase (aacC2) DEJADS9 AAC6_ACIBA Substrate [8]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Glial fibrillary acidic protein (GFAP) OTQ01ZAS GFAP_HUMAN Drug Response [9]
N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) OT53SIZG NAA15_HUMAN Drug Response [9]
T-lymphocyte activation antigen CD86 (CD86) OTJCSBPC CD86_HUMAN Gene/Protein Processing [10]

References

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27 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
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35 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
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