Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMGQFYB)

Drug Name
Mecamylamine Drug Info
Synonyms
Mecamilamina; Mecamine; Mecamylaminum; Mekamine; Mevasine; Revertina; Versamine; Inversine hydrochloride; Mecamilamina [DCIT]; Mecamilamina [Italian]; Mevasin hydrochloride; Inversine (TN); Mecamylamine [INN:BAN]; Mecamylaminum [INN-Latin]; N-Methyl-2-isocamphanamine; N,2,3,3-Tetramethyl-2-norbornamine; N,2,3,3-Tetramethyl-2-norcamphanamine; N,2,2,3-tetramethylbicyclo[2.2.1]heptan-3-amine; N,2,3,3-Tetramethylbicyclo[2.2.1]heptan-2-amine; 2-Methylamino-2,3,3-trimethylnorbornane; 2-Methylaminoisocamphane; 3-Methylaminoisocamphane; 3-Methylaminoisokamfan; 3-Methylaminoisokamfan [Czech]; 3-beta-Methylamino-2,2,3-trimethylbicyclo(2.2.1)heptane
Indication
Disease Entry ICD 11 Status REF
Essential hypertension BA00 Approved [1]
Therapeutic Class
Antihypertensive Agents
Cross-matching ID
PubChem CID
4032
ChEBI ID
CHEBI:6706
CAS Number
CAS 60-40-2
TTD Drug ID
DMGQFYB
ACDINA Drug ID
D00386

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Nicotinic acetylcholine receptor (nAChR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [5]
Cotinine DMCEZ1B Insecticide N.A. Approved [6]
Pancuronium DMB0VY8 Anaesthesia 9A78.6 Approved [7]
Atracurium DM42HXN Anaesthesia 9A78.6 Approved [7]
CYTISINE DMUF0BJ Tobacco dependence 6C4A.2 Phase 3 [8]
Dexefaroxan DMTY4KN Parkinson disease 8A00.0 Phase 2 [9]
BMS-954561 DM7XV4R Diabetic neuropathy 8C0Z Phase 2 [10]
ASM-024 DM35S2I Asthma CA23 Phase 2 [11]
NIC-002 DMKLJMI Nicotine dependence 6C4A.2 Phase 2 [12]
TRIDMAC DMWU41P Mood disorder 6A60-6E23 Phase 2 [13]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dihydrofolate reductase (DHFR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Folic Acid DMEMBJC Colorectal carcinoma Approved [14]
Methotrexate DM2TEOL Anterior urethra cancer Approved [15]
Ceftazidime DM41GRA Bacteremia 1A73 Approved [16]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [17]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [18]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [19]
Tubocurarine DMBZIVP Anaesthesia 9A78.6 Approved [3]
Ceftriaxone DMCEW64 Acute gonococcal cervicitis Approved [16]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [20]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [21]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Receptor-type tyrosine-protein phosphatase alpha (PTPRA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [22]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [23]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [24]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [25]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [26]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [22]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [27]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [28]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [3]
Urethane DM7NSI0 N. A. N. A. Phase 4 [29]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Contactin-1 (CNTN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [23]
Panobinostat DM58WKG Chronic graft versus host disease Approved [30]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [31]
Tubocurarine DMBZIVP Anaesthesia 9A78.6 Approved [4]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [24]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [25]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [32]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [33]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [3]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [34]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fasciculation and elongation protein zeta-1 (FEZ1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [35]
Aripiprazole DM3NUMH Bipolar I disorder Approved [36]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [37]
Panobinostat DM58WKG Chronic graft versus host disease Approved [30]
Testosterone enanthate DMB6871 N. A. N. A. Approved [38]
Tubocurarine DMBZIVP Anaesthesia 9A78.6 Approved [3]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [24]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [21]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [39]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [32]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [40]
Methotrexate DM2TEOL Anterior urethra cancer Approved [41]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [17]
Testosterone DM7HUNW Hot flushes GA30 Approved [42]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [43]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [20]
Menthol DMG2KW7 Back pain ME84.Z Approved [44]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [39]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [26]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [45]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Echinoderm microtubule-associated protein-like 4 (EML4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [35]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [17]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [46]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [47]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [43]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [24]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [25]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [48]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [49]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [26]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Stress-induced-phosphoprotein 1 (STIP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [50]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [51]
Haloperidol DM96SE0 Delirium Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [43]
Tubocurarine DMBZIVP Anaesthesia 9A78.6 Approved [4]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [25]
Benzatropine DMF7EXL Parkinsonian disorder Approved [52]
Clozapine DMFC71L Schizophrenia 6A20 Approved [52]
Paclitaxel DMLB81S Breast carcinoma Approved [53]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [54]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Golgin subfamily A member 4 (GOLGA4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [55]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [43]
Testosterone enanthate DMB6871 N. A. N. A. Approved [38]
Tubocurarine DMBZIVP Anaesthesia 9A78.6 Approved [4]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [56]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [25]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [32]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [26]
Arsenic DMTL2Y1 N. A. N. A. Approved [57]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [4]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Nicotinic acetylcholine receptor (nAChR) TTJSZTB NOUNIPROTAC Antagonist [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Contactin-1 (CNTN1) OT7RNPEY CNTN1_HUMAN Gene/Protein Processing [3]
Dihydrofolate reductase (DHFR) OT3DVIGM DYR_HUMAN Gene/Protein Processing [3]
Echinoderm microtubule-associated protein-like 4 (EML4) OTJC45TA EMAL4_HUMAN Gene/Protein Processing [3]
Fasciculation and elongation protein zeta-1 (FEZ1) OTWCXPRE FEZ1_HUMAN Gene/Protein Processing [3]
Golgin subfamily A member 4 (GOLGA4) OTCMEHNJ GOGA4_HUMAN Gene/Protein Processing [4]
Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF) OTT5JX1F LITAF_HUMAN Gene/Protein Processing [3]
Receptor-type tyrosine-protein phosphatase alpha (PTPRA) OTZA82J1 PTPRA_HUMAN Gene/Protein Processing [3]
Stress-induced-phosphoprotein 1 (STIP1) OT7TXLOX STIP1_HUMAN Gene/Protein Processing [4]
Ubiquitin-protein ligase E3A OTIA27P3 UBE3A_HUMAN Gene/Protein Processing [3]
Zinc finger RNA-binding protein OTYDAOT8 ZFR_HUMAN Gene/Protein Processing [3]

References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 Mecamylamine (Inversine): an old antihypertensive with new research directions. J Hum Hypertens. 2002 Jul;16(7):453-7.
3 Nicotine modulates the expression of a diverse set of genes in the neuronal SH-SY5Y cell line. J Biol Chem. 2003 May 2;278(18):15633-40.
4 Nicotinic modulation of gene expression in SH-SY5Y neuroblastoma cells. Brain Res. 2006 Oct 20;1116(1):39-49.
5 Atypical antipsychotics as noncompetitive inhibitors of alpha4beta2 and alpha7 neuronal nicotinic receptors. Neuropharmacology. 2009 Aug;57(2):183-91.
6 Functional versus chemical diversity: is biodiversity important for drug discovery. Trends Pharmacol Sci. 2002 May;23(5):225-31.
7 Pharmacological characteristics of the inhibition of nondepolarizing neuromuscular blocking agents at human adult muscle nicotinic acetylcholine receptor. Anesthesiology. 2009 Jun;110(6):1244-52.
8 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
9 The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22.
10 EP patent application no. 2774991, Drug delivery system for use in the treatment or diagnosis of neurological disorders.
11 Effects of ASM-024, a modulator of acetylcholine receptor function, on airway responsiveness and allergen-induced responses in patients with mild asthma. Can Respir J. 2015 Jul-Aug;22(4):230-4.
12 Therapeutic advances in the treatment of nicotine addiction: present and future. Ther Adv Chronic Dis. 2010 May; 1(3): 95-106.
13 Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92.
14 Dihydrofolate reductase deficiency due to a homozygous DHFR mutation causes megaloblastic anemia and cerebral folate deficiency leading to severe neurologic disease. Am J Hum Genet. 2011 Feb 11;88(2):226-31. doi: 10.1016/j.ajhg.2011.01.007.
15 Role of caveolin 1, E-cadherin, Enolase 2 and PKCalpha on resistance to methotrexate in human HT29 colon cancer cells. BMC Med Genomics. 2008 Aug 11;1:35. doi: 10.1186/1755-8794-1-35.
16 Investigation of the effects of some drugs and phenolic compounds on human dihydrofolate reductase activity. J Biochem Mol Toxicol. 2015 Mar;29(3):135-9.
17 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
18 Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
19 JunD is involved in the antiproliferative effect of Delta9-tetrahydrocannabinol on human breast cancer cells. Oncogene. 2008 Aug 28;27(37):5033-44.
20 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
21 Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
22 Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
23 Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
24 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
25 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
26 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
27 Transcriptional profiling in the human prefrontal cortex: evidence for two activational states associated with cocaine abuse. Pharmacogenomics J. 2003;3(1):27-40.
28 Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
29 Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
30 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
31 Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration. Arch Toxicol. 2016 Jan;90(1):159-80.
32 Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
33 Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
34 Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
35 Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One. 2010 Dec 17;5(12):e14352. doi: 10.1371/journal.pone.0014352.
36 Small Molecule Antipsychotic Aripiprazole Potentiates Ozone-Induced Inflammation in Airway Epithelium. Chem Res Toxicol. 2019 Oct 21;32(10):1997-2005. doi: 10.1021/acs.chemrestox.9b00149. Epub 2019 Sep 11.
37 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
38 Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss. J Clin Endocrinol Metab. 2007 Jul;92(7):2793-802. doi: 10.1210/jc.2006-2722. Epub 2007 Apr 17.
39 Interleukin-19 as a translational indicator of renal injury. Arch Toxicol. 2015 Jan;89(1):101-6.
40 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
41 Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
42 The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
43 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
44 Repurposing L-menthol for systems medicine and cancer therapeutics? L-menthol induces apoptosis through caspase 10 and by suppressing HSP90. OMICS. 2016 Jan;20(1):53-64.
45 Low doses of cisplatin induce gene alterations, cell cycle arrest, and apoptosis in human promyelocytic leukemia cells. Biomark Insights. 2016 Aug 24;11:113-21.
46 Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK. Proc Natl Acad Sci U S A. 2011 May 3;108(18):7535-40. doi: 10.1073/pnas.1019559108. Epub 2011 Apr 18.
47 Proteomics-based identification of differentially abundant proteins from human keratinocytes exposed to arsenic trioxide. J Proteomics Bioinform. 2014 Jul;7(7):166-178.
48 PPARgamma controls CD1d expression by turning on retinoic acid synthesis in developing human dendritic cells. J Exp Med. 2006 Oct 2;203(10):2351-62.
49 The proapoptotic effect of zoledronic acid is independent of either the bone microenvironment or the intrinsic resistance to bortezomib of myeloma cells and is enhanced by the combination with arsenic trioxide. Exp Hematol. 2011 Jan;39(1):55-65.
50 Gingival Stromal Cells as an In Vitro Model: Cannabidiol Modulates Genes Linked With Amyotrophic Lateral Sclerosis. J Cell Biochem. 2017 Apr;118(4):819-828. doi: 10.1002/jcb.25757. Epub 2016 Nov 28.
51 Gene microarray analysis of human renal cell carcinoma: the effects of HDAC inhibition and retinoid treatment. Cancer Biol Ther. 2008 Oct;7(10):1607-18.
52 Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13. Front Mol Neurosci. 2021 May 28;14:673144. doi: 10.3389/fnmol.2021.673144. eCollection 2021.
53 Proteomic analysis of anti-cancer effects by paclitaxel treatment in cervical cancer cells. Gynecol Oncol. 2005 Jul;98(1):45-53. doi: 10.1016/j.ygyno.2005.04.010.
54 Identification of biomarkers and outcomes of endocrine disruption in human ovarian cortex using In Vitro Models. Toxicology. 2023 Feb;485:153425. doi: 10.1016/j.tox.2023.153425. Epub 2023 Jan 5.
55 Oxidative stress modulates theophylline effects on steroid responsiveness. Biochem Biophys Res Commun. 2008 Dec 19;377(3):797-802.
56 Anti-oncogenic and pro-differentiation effects of clorgyline, a monoamine oxidase A inhibitor, on high grade prostate cancer cells. BMC Med Genomics. 2009 Aug 20;2:55. doi: 10.1186/1755-8794-2-55.
57 Gene expression profiles in peripheral lymphocytes by arsenic exposure and skin lesion status in a Bangladeshi population. Cancer Epidemiol Biomarkers Prev. 2006 Jul;15(7):1367-75. doi: 10.1158/1055-9965.EPI-06-0106.