Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMGQRON)

• Drug Name: BETULIN Drug Info
• Synonyms: Betulin; 473-98-3; Betulinol; Betuline; Trochol; Lup-20(29)-ene-3b,28-diol; Betulol; Lup-20(29)-ene-3beta,28-diol; UNII-6W70HN7X7O; NSC 4644; C30H50O2; EINECS 207-475-5; Lup-20(30)-ene-3beta,28-diol; AI3-62999; CHEBI:3086; 6W70HN7X7O; Lup-20(29)-ene-3,28-diol, (3beta)-; (1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-3a-(Hydroxymethyl)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)icosahydro-1H-cyclopenta[a]chrysen-9-ol; Betulinic alcohol; lup-20(29)-ene-3 beta,28-diol

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 72326
  ChEBI ID: CHEMBL23236
  CAS Number: CAS 473-98-3
  TTD Drug ID: DMGQRON

Molecule-Related Drug Atlas

Drug(s) Targeting Glycogen phosphorylase muscle form (GP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
URSOLIC ACID	DM4SOAW	Metabolic syndrome x	5C50-5D2Z	Phase 2	[9]
JTT-651	DMGP42Q	Type-2 diabetes	5A11	Discontinued in Phase 1	[10]
L-serine-O-phosphate	DMTJ1NH	Discovery agent	N.A.	Investigative	[11]
Beta-D-Glucose	DM5IHYP	Discovery agent	N.A.	Investigative	[11]
Indirubin-5-sulfonate	DM08VHZ	Discovery agent	N.A.	Investigative	[11]
Inosinic Acid	DMLR86H	Discovery agent	N.A.	Investigative	[11]
Alpha-D-Glucose-6-Phosphate	DMR0EVN	Discovery agent	N.A.	Investigative	[11]
N'-Pyridoxyl-Lysine-5'-Monophosphate	DM3ZHBO	Discovery agent	N.A.	Investigative	[11]
OLEANOLIC_ACID	DMWDMJ3	Discovery agent	N.A.	Investigative	[1]
Oleanonic acid	DMYPJC3	Discovery agent	N.A.	Investigative	[1]

Drug(s) Affected By Stearoyl-CoA desaturase (SCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[12]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[13]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[13]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[14]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[15]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[16]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[13]
Fructose	DM43AN2	Vomiting	MD90	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[13]

Drug(s) Affected By Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[19]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[20]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[21]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[13]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[13]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[22]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[13]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[23]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[24]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]

Drug(s) Affected By MARVEL domain-containing protein 1 (MARVELD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[27]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[28]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[5]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[5]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[29]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[29]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[28]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[30]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[31]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[32]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[34]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[35]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[36]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[37]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[38]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[41]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[42]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[34]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[44]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[45]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[44]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[46]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[47]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[48]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[49]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[50]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[51]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[52]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[53]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[54]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[55]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[56]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[57]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[58]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[59]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[50]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[60]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[61]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[62]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[49]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[63]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[64]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[52]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[53]

Drug(s) Affected By Phosphoenolpyruvate carboxykinase, cytosolic (PCK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[21]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[14]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[15]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[23]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[65]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[66]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[67]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[68]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[69]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]

Drug(s) Affected By Glucose-6-phosphatase catalytic subunit 1 (G6PC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[15]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[71]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[24]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[66]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[68]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[24]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[24]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[73]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glycogen phosphorylase muscle form (GP)	TTZHY6R	PYGM_HUMAN	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Gene/Protein Processing	[2]
Glucose-6-phosphatase catalytic subunit 1 (G6PC1)	OTJ6FM9F	G6PC1_HUMAN	Gene/Protein Processing	[3]
Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1)	OTCO26FV	HMCS1_HUMAN	Gene/Protein Processing	[4]
MARVEL domain-containing protein 1 (MARVELD1)	OT5CPOJE	MALD1_HUMAN	Gene/Protein Processing	[5]
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Post-Translational Modifications	[6]
Mitogen-activated protein kinase 3 (MAPK3)	OTCYKGKO	MK03_HUMAN	Post-Translational Modifications	[6]
Phosphoenolpyruvate carboxykinase, cytosolic (PCK1)	OTNWEJ5Y	PCKGC_HUMAN	Gene/Protein Processing	[3]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Protein Interaction/Cellular Processes	[7]
Stearoyl-CoA desaturase (SCD)	OTB1073G	SCD_HUMAN	Gene/Protein Processing	[4]
UDP-glucuronosyltransferase 1A3	OTUEOER3	UD13_HUMAN	Biotransformations	[8]

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