Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMGQRON)

Drug Name
BETULIN Drug Info
Synonyms
Betulin; 473-98-3; Betulinol; Betuline; Trochol; Lup-20(29)-ene-3b,28-diol; Betulol; Lup-20(29)-ene-3beta,28-diol; UNII-6W70HN7X7O; NSC 4644; C30H50O2; EINECS 207-475-5; Lup-20(30)-ene-3beta,28-diol; AI3-62999; CHEBI:3086; 6W70HN7X7O; Lup-20(29)-ene-3,28-diol, (3beta)-; (1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-3a-(Hydroxymethyl)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)icosahydro-1H-cyclopenta[a]chrysen-9-ol; Betulinic alcohol; lup-20(29)-ene-3 beta,28-diol
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
72326
ChEBI ID
CHEBI:3086
CAS Number
CAS 473-98-3
TTD Drug ID
DMGQRON

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Approved Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Glycogen phosphorylase muscle form (GP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
URSOLIC ACID DM4SOAW Metabolic syndrome x 5C50-5D2Z Phase 2 [8]
JTT-651 DMGP42Q Type-2 diabetes 5A11 Discontinued in Phase 1 [9]
L-serine-O-phosphate DMTJ1NH Discovery agent N.A. Investigative [10]
Beta-D-Glucose DM5IHYP Discovery agent N.A. Investigative [10]
Indirubin-5-sulfonate DM08VHZ Discovery agent N.A. Investigative [10]
Inosinic Acid DMLR86H Discovery agent N.A. Investigative [10]
Alpha-D-Glucose-6-Phosphate DMR0EVN Discovery agent N.A. Investigative [10]
N'-Pyridoxyl-Lysine-5'-Monophosphate DM3ZHBO Discovery agent N.A. Investigative [10]
OLEANOLIC_ACID DMWDMJ3 Discovery agent N.A. Investigative [1]
Oleanonic acid DMYPJC3 Discovery agent N.A. Investigative [1]
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Drug(s) Affected By Stearoyl-CoA desaturase (SCD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clavulanate DM2FGRT Bacteremia 1A73 Approved [11]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [12]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [12]
Methotrexate DM2TEOL Anterior urethra cancer Approved [13]
Quercetin DM3NC4M Obesity 5B81 Approved [14]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [15]
Fluoxetine DM3PD2C Bipolar depression Approved [12]
Fructose DM43AN2 Vomiting MD90 Approved [16]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [17]
Bupropion DM5PCS7 Depression 6A70-6A7Z Approved [12]
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Drug(s) Affected By 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [18]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [19]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [20]
Digoxin DMQCTIH Arrhythmia BC9Z Approved [21]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [22]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [23]
Quercetin DM3NC4M Obesity 5B81 Approved [14]
Fluoxetine DM3PD2C Bipolar depression Approved [24]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [25]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [26]
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Drug(s) Affected By Fatty acid synthase (FASN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [27]
Selenium DM25CGV N. A. N. A. Approved [28]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [23]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [29]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [30]
Quercetin DM3NC4M Obesity 5B81 Approved [31]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [25]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [32]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [33]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [34]
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Drug(s) Affected By Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [35]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [36]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [37]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [12]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [12]
Quercetin DM3NC4M Obesity 5B81 Approved [31]
Fluoxetine DM3PD2C Bipolar depression Approved [12]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [25]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [38]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [17]
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Drug(s) Affected By Epidermal growth factor receptor (EGFR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
BIBW 2992 DMTKD7Q Non-small-cell lung cancer 2C25.Y Approved [39]
Gefitinib DM15F0X Colon adenocarcinoma Approved [40]
Erlotinib DMCMBHA Adrenal gland neoplasm Approved [41]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [42]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [43]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [44]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [45]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [46]
Selenium DM25CGV N. A. N. A. Approved [47]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [48]
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Drug(s) Affected By MARVEL domain-containing protein 1 (MARVELD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [49]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [50]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [51]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [52]
Gefitinib DM15F0X Colon adenocarcinoma Approved [6]
Paclitaxel DMLB81S Breast carcinoma Approved [6]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [53]
Epirubicin DMPDW6T Solid tumour/cancer 2A00-2F9Z Approved [53]
PDX-101 DM6OC53 Plasma cell myeloma 2A83.1 Phase 2 [52]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [54]
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Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [55]
Gefitinib DM15F0X Colon adenocarcinoma Approved [56]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [57]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [58]
Etretinate DM2CZFA Keratosis ED56 Approved [59]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [60]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [61]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [62]
Quercetin DM3NC4M Obesity 5B81 Approved [63]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [64]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [65]
Gefitinib DM15F0X Colon adenocarcinoma Approved [66]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [67]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [58]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [68]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [69]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [68]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [70]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [71]
Methotrexate DM2TEOL Anterior urethra cancer Approved [72]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [73]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [74]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [75]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [76]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [77]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [78]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [79]
Gefitinib DM15F0X Colon adenocarcinoma Approved [80]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [81]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [82]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [83]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [74]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [84]
Paclitaxel DMLB81S Breast carcinoma Approved [85]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [86]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [73]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [21]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [87]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [76]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [77]
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Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [88]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [89]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [90]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [91]
Gefitinib DM15F0X Colon adenocarcinoma Approved [92]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [93]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [94]
Selenium DM25CGV N. A. N. A. Approved [28]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [23]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [95]
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Drug(s) Affected By Phosphoenolpyruvate carboxykinase, cytosolic (PCK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [37]
Methotrexate DM2TEOL Anterior urethra cancer Approved [13]
Quercetin DM3NC4M Obesity 5B81 Approved [14]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [25]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [96]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [97]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [98]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [99]
Leflunomide DMR8ONJ Arthritis FA20 Approved [100]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [101]
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Drug(s) Affected By Glucose-6-phosphatase catalytic subunit 1 (G6PC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [14]
Fluoxetine DM3PD2C Bipolar depression Approved [102]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [38]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [97]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [99]
Leflunomide DMR8ONJ Arthritis FA20 Approved [103]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [101]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [38]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [38]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [104]
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Drug(s) Affected By Sterol regulatory element-binding protein 1 (SREBF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [105]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [21]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [106]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [107]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [11]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [108]
Quercetin DM3NC4M Obesity 5B81 Approved [14]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [25]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [49]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [109]
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Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [110]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [111]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [112]
Gefitinib DM15F0X Colon adenocarcinoma Approved [113]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [114]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [95]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [115]
Quercetin DM3NC4M Obesity 5B81 Approved [116]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [117]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [118]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [119]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [120]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [121]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [122]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [123]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [124]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [125]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [126]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [127]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [128]
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Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [129]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [130]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [65]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [131]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [132]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [133]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [58]
Meloxicam DM2AR7L Arthritis FA20 Approved [134]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [135]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [136]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [137]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [128]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [65]
Verapamil DMA7PEW Angina pectoris BA40 Approved [138]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [106]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [132]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [139]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [140]
Meloxicam DM2AR7L Arthritis FA20 Approved [141]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [69]
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Drug(s) Affected By Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [142]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [95]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [143]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [144]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [145]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [146]
Testosterone DM7HUNW Hot flushes GA30 Approved [147]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [148]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [101]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [149]
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Drug(s) Affected By Caspase-8 (CASP8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [150]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [151]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [152]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [87]
Gefitinib DM15F0X Colon adenocarcinoma Approved [153]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [154]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [58]
Selenium DM25CGV N. A. N. A. Approved [28]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [135]
Methotrexate DM2TEOL Anterior urethra cancer Approved [13]
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Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [155]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [156]
Prednisone DM2HG4X Acute asthma CA23 Approved [157]
Triamterene DM2HU9I Congestive heart failure BD10 Approved [157]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [158]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [159]
Epinephrine DM3KJBC Acute asthma CA23 Approved [160]
Quercetin DM3NC4M Obesity 5B81 Approved [161]
Fluoxetine DM3PD2C Bipolar depression Approved [24]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [162]
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Drug(s) Affected By Sulfotransferase 2A1 (SULT2A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [163]
Methotrexate DM2TEOL Anterior urethra cancer Approved [164]
Quercetin DM3NC4M Obesity 5B81 Approved [14]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [33]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [33]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [165]
Leflunomide DMR8ONJ Arthritis FA20 Approved [100]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [101]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [166]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [167]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Glycogen phosphorylase muscle form (GP) TTZHY6R PYGM_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) OTRT3F3U HMDH_HUMAN Gene/Protein Processing [2]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [3]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Gene/Protein Processing [4]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Protein Interaction/Cellular Processes [5]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Protein Interaction/Cellular Processes [5]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Protein Interaction/Cellular Processes [5]
Epidermal growth factor receptor (EGFR) OTAPLO1S EGFR_HUMAN Post-Translational Modifications [6]
Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1) OTHBQVD5 4EBP1_HUMAN Post-Translational Modifications [5]
Fatty acid synthase (FASN) OTFII9KG FAS_HUMAN Gene/Protein Processing [2]
Glucose-6-phosphatase catalytic subunit 1 (G6PC1) OTJ6FM9F G6PC1_HUMAN Gene/Protein Processing [7]

References

1 Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystal... J Med Chem. 2008 Jun 26;51(12):3540-54.
2 Fatostatin inhibits cancer cell proliferation by affecting mitotic microtubule spindle assembly and cell division. J Biol Chem. 2016 Aug 12;291(33):17001-8.
3 Hypoxia increases the apoptotic response to betulinic acid and betulin in human non-small cell lung cancer cells. Chem Biol Interact. 2021 Jan 5;333:109320. doi: 10.1016/j.cbi.2020.109320. Epub 2020 Nov 9.
4 Betulinyl Sulfamates as Anticancer Agents and Radiosensitizers in Human Breast Cancer Cells. Int J Mol Sci. 2015 Nov 3;16(11):26249-62. doi: 10.3390/ijms161125953.
5 Betulin inhibits mTOR and induces autophagy to promote apoptosis in human osteosarcoma cell lines. Environ Toxicol. 2020 Aug;35(8):879-887. doi: 10.1002/tox.22924. Epub 2020 Mar 19.
6 Inhibition of SREBP increases gefitinib sensitivity in non-small cell lung cancer cells. Oncotarget. 2016 Aug 9;7(32):52392-52403.
7 Anti-inflammatory action of betulin and its potential as a dissociated glucocorticoid receptor modulator. Food Chem Toxicol. 2021 Nov;157:112539. doi: 10.1016/j.fct.2021.112539. Epub 2021 Sep 7.
8 Synthesis of 3-deoxypentacyclic triterpene derivatives as inhibitors of glycogen phosphorylase. J Nat Prod. 2009 Aug;72(8):1414-8.
9 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026877)
10 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
11 Molecular mechanisms of hepatotoxic cholestasis by clavulanic acid: Role of NRF2 and FXR pathways. Food Chem Toxicol. 2021 Dec;158:112664. doi: 10.1016/j.fct.2021.112664. Epub 2021 Nov 9.
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