Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMY6T31)

Drug Name

Isoflurane Drug Info

Synonyms

Aerrane; Forane; Forene; IsoFlo; Isoflurano; Isofluranum; AErrane (Veterinary); Forane (TN); Isoflurane [Anaesthetics, volatile]; Isoflurano [INN-Spanish]; Isofluranum [INN-Latin]; R-E 235dal; Isoflurane (JP15/USP/INN); Isoflurane [USAN:BAN:INN:JAN]; Isoflurane [USAN:INN:BAN:JAN]; Ether, 1-chloro-2,2,2-trifluoroethyl difluoromethyl; 1-Chloro-2,2,2-trifluoroethyl difluoromethyl ether; 2-Chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane; 2-chloro-2-difluoromethoxy-1,1,1-trifluoroethane

Indication

Disease Entry	ICD 11	Status	REF
Anaesthesia	9A78.6	Approved	[1]

Therapeutic Class

Anesthetics

Cross-matching ID

PubChem CID: 3763
ChEBI ID: CHEBI:6015
CAS Number: CAS 26675-46-7
TTD Drug ID: DMY6T31
INTEDE Drug ID: DR0885

Molecule-Related Drug Atlas

Molecule Type:

DTT

DME

DOT

Drug Status:

Approved Drug(s)

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Drug(s) Targeting Glutamate receptor AMPA (GRIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Halothane	DM80OZ5	Anaesthesia	9A78.6	Approved	[8]
E-2007	DMJDYNQ	Diabetic neuropathy	8C0Z	Approved	[9]
Zopiclone	DMPI6Z0	Insomnia	7A00-7A0Z	Approved	[10]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[11]
Enflurane	DM0YJSB	Anaesthesia	9A78.6	Approved	[12]
Bromazepam	DMY9TCW	Anxiety disorder	6B00-6B0Z	Approved	[13]
Artemisinin SP	DMFETDK	Malaria	1F40-1F45	Approved	[14]
Dihydroergotoxine	DM5D6WZ	Alzheimer disease	8A20	Approved	[15]
Barbiturate	DMJIA6T	Anaesthesia	9A78.6	Approved	[16]
Fospropofol disodium	DMKLJRD	Monitored anaesthesia care	N.A.	Approved	[17]
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Drug(s) Metabolized By Cytochrome P450 2E1 (CYP2E1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[18]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[19]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[20]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[21]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[22]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[23]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[4]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[24]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[25]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[26]
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Drug(s) Metabolized By Cytochrome P450 2B6 (CYP2B6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[27]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[4]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[28]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[31]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[32]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[33]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[34]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[35]
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Drug(s) Affected By Renin (REN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[36]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[37]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[38]
Reboxetine	DM26PRD	Depression	6A70-6A7Z	Approved	[39]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[40]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[41]
Rhucin	DM3ADGP	Erectile dysfunction	HA01.1	Approved	[42]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[43]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[44]
Chlorthalidone	DM4DMBT	Edema	MG29	Approved	[45]
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Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[47]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[48]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[49]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[50]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[51]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[52]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[53]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[55]
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Drug(s) Affected By Beta-secretase 1 (BACE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[56]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[57]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[60]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[61]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
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Drug(s) Affected By Nicastrin (NCSTN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[56]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[67]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[68]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[70]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[71]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[72]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glutamate receptor AMPA (GRIA)	TTAN6JD	NOUNIPROTAC	Agonist	[2]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 2E1 (CYP2E1)	DEVDYN7	CP2E1_HUMAN	Substrate	[3]
Cytochrome P450 2B6 (CYP2B6)	DEPKLMQ	CP2B6_HUMAN	Substrate	[4]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Beta-secretase 1 (BACE1)	OTCA7B6A	BACE1_HUMAN	Gene/Protein Processing	[5]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Protein Interaction/Cellular Processes	[6]
Nicastrin (NCSTN)	OT5QBTA4	NICA_HUMAN	Gene/Protein Processing	[5]
Renin (REN)	OT52GZR2	RENI_HUMAN	Gene/Protein Processing	[7]

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