Details of the Drug

General Information of Drug (ID: DMBSHMF)

Drug Name
BOCEPREVIR
Synonyms
Boceprevir; Victrelis; 394730-60-0; SCH 503034; EBP 520; UNII-89BT58KELH; SCH-503034; 89BT58KELH; CHEBI:68621; (1R,2S,5S)-N-(4-amino-1-cyclobutyl-3,4-dioxobutan-2-yl)-3-[N-(tert-butylcarbamoyl)-3-methyl-L-valyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide; 3-{[(1R,2S,5S)-3-[(2S)-2-[(tert-butylcarbamoyl)amino]-3,3-dimethylbutanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2-yl]formamido}-4-cyclobutyl-2-oxobutanamide
Indication
Disease Entry ICD 11 Status REF
Hepatitis C virus infection 1E51.1 Approved [1]
Coronavirus Disease 2019 (COVID-19) 1D6Y Investigative [2]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 1 Molecular Weight (mw) 519.7
Logarithm of the Partition Coefficient (xlogp) 3.1
Rotatable Bond Count (rotbonds) 10
Hydrogen Bond Donor Count (hbonddonor) 4
Hydrogen Bond Acceptor Count (hbondacc) 5
ADMET Property
BDDCS Class
Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 1: high solubility and high permeability [3]
Chemical Identifiers
Formula
C27H45N5O5
IUPAC Name
(1R,2S,5S)-N-(4-amino-1-cyclobutyl-3,4-dioxobutan-2-yl)-3-[(2S)-2-(tert-butylcarbamoylamino)-3,3-dimethylbutanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
Canonical SMILES
CC1([C@@H]2[C@H]1[C@H](N(C2)C(=O)[C@H](C(C)(C)C)NC(=O)NC(C)(C)C)C(=O)NC(CC3CCC3)C(=O)C(=O)N)C
InChI
InChI=1S/C27H45N5O5/c1-25(2,3)20(30-24(37)31-26(4,5)6)23(36)32-13-15-17(27(15,7)8)18(32)22(35)29-16(19(33)21(28)34)12-14-10-9-11-14/h14-18,20H,9-13H2,1-8H3,(H2,28,34)(H,29,35)(H2,30,31,37)/t15-,16?,17-,18-,20+/m0/s1
InChIKey
LHHCSNFAOIFYRV-DOVBMPENSA-N
Cross-matching ID
PubChem CID
10324367
ChEBI ID
CHEBI:68621
CAS Number
394730-60-0
DrugBank ID
DB08873
TTD ID
D0V3YT
VARIDT ID
DR01333
INTEDE ID
DR0218
ACDINA ID
D00073
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Hepatitis C virus Serine protease NS3/4A (HCV NS3/4A) TTHC7JD POLG_HCV1 Modulator [4]
COVID-19 3C-like protease (3CLpro) TT1D53B R1AB_SARS2 (3264-3569) Inhibitor [2]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [5]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [6]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Substrate [7]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Same Disease as BOCEPREVIR
DDI Drug Name DDI Drug ID Severity Mechanism Disease REF
Daclatasvir DMSFK9V Major Decreased metabolism of Boceprevir caused by Daclatasvir mediated inhibition of CYP450 enzyme. Hepatitis virus infection [1E50-1E51] [8]
GS-9857 DMYU6P5 Moderate Decreased clearance of Boceprevir due to the transporter inhibition by GS-9857. Hepatitis virus infection [1E50-1E51] [9]
Coadministration of a Drug Treating the Disease Different from BOCEPREVIR (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Ivosidenib DM8S6T7 Major Decreased metabolism of Boceprevir caused by Ivosidenib mediated inhibition of CYP450 enzyme. Acute myeloid leukaemia [2A60] [10]
Arn-509 DMT81LZ Major Increased metabolism of Boceprevir caused by Arn-509 mediated induction of CYP450 enzyme. Acute myeloid leukaemia [2A60] [11]
Gilteritinib DMTI0ZO Major Decreased metabolism of Boceprevir caused by Gilteritinib mediated inhibition of CYP450 enzyme. Acute myeloid leukaemia [2A60] [12]
Oliceridine DM6MDCF Major Decreased metabolism of Boceprevir caused by Oliceridine mediated inhibition of CYP450 enzyme. Acute pain [MG31] [13]
Ivabradine DM0L594 Major Decreased metabolism of Boceprevir caused by Ivabradine mediated inhibition of CYP450 enzyme. Angina pectoris [BA40] [14]
Bedaquiline DM3906J Moderate Decreased metabolism of Boceprevir caused by Bedaquiline mediated inhibition of CYP450 enzyme. Antimicrobial drug resistance [MG50-MG52] [15]
Erdafitinib DMI782S Major Decreased metabolism of Boceprevir caused by Erdafitinib mediated inhibition of CYP450 enzyme. Bladder cancer [2C94] [16]
Pexidartinib DMS2J0Z Major Decreased metabolism of Boceprevir caused by Pexidartinib mediated inhibition of CYP450 enzyme. Bone/articular cartilage neoplasm [2F7B] [17]
Talazoparib DM1KS78 Moderate Decreased clearance of Boceprevir due to the transporter inhibition by Talazoparib. Breast cancer [2C60-2C6Y] [18]
HKI-272 DM6QOVN Major Decreased metabolism of Boceprevir caused by HKI-272 mediated inhibition of CYP450 enzyme. Breast cancer [2C60-2C6Y] [19]
LY2835219 DM93VBZ Major Decreased metabolism of Boceprevir caused by LY2835219 mediated inhibition of CYP450 enzyme. Breast cancer [2C60-2C6Y] [20]
Palbociclib DMD7L94 Major Decreased metabolism of Boceprevir caused by Palbociclib mediated inhibition of CYP450 enzyme. Breast cancer [2C60-2C6Y] [21]
Macitentan DMP79A1 Major Decreased metabolism of Boceprevir caused by Macitentan mediated inhibition of CYP450 enzyme. Cardiovascular disease [BA00-BE2Z] [22]
PF-04449913 DMSB068 Major Decreased metabolism of Boceprevir caused by PF-04449913 mediated inhibition of CYP450 enzyme. Chronic myelomonocytic leukaemia [2A40] [23]
Vilanterol DMF5EK1 Moderate Decreased metabolism of Boceprevir caused by Vilanterol mediated inhibition of CYP450 enzyme. Chronic obstructive pulmonary disease [CA22] [24]
Revefenacin DMMP5SI Moderate Decreased clearance of Boceprevir due to the transporter inhibition by Revefenacin. Chronic obstructive pulmonary disease [CA22] [25]
Levomilnacipran DMV26S8 Major Decreased metabolism of Boceprevir caused by Levomilnacipran mediated inhibition of CYP450 enzyme. Chronic pain [MG30] [26]
Fidaxomicin DMFP6MV Minor Decreased clearance of Boceprevir due to the transporter inhibition by Fidaxomicin. Clostridium difficile enterocolitis [1A04] [14]
Regorafenib DMHSY1I Moderate Decreased metabolism of Boceprevir caused by Regorafenib mediated inhibition of CYP450 enzyme. Colorectal cancer [2B91] [14]
Intedanib DMSTA36 Moderate Decreased clearance of Boceprevir due to the transporter inhibition by Intedanib. Colorectal cancer [2B91] [27]
Osilodrostat DMIJC9X Major Decreased metabolism of Boceprevir caused by Osilodrostat mediated inhibition of CYP450 enzyme. Cushing syndrome [5A70] [28]
OPC-34712 DMHG57U Major Decreased metabolism of Boceprevir caused by OPC-34712 mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [29]
Polatuzumab vedotin DMF6Y0L Major Decreased metabolism of Boceprevir caused by Polatuzumab vedotin mediated inhibition of CYP450 enzyme. Diffuse large B-cell lymphoma [2A81] [30]
Ingrezza DMVPLNC Major Additive CNS depression effects by the combination of Boceprevir and Ingrezza. Dystonic disorder [8A02] [31]
Oestradiol valerate and dienogest DMZK0FQ Major Increased metabolism of Boceprevir caused by Oestradiol valerate and dienogest mediated induction of CYP450 enzyme. Endometriosis [GA10] [32]
Stiripentol DMMSDOY Moderate Decreased metabolism of Boceprevir caused by Stiripentol mediated inhibition of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [8]
Eslicarbazepine DMZREFQ Moderate Increased metabolism of Boceprevir caused by Eslicarbazepine mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [33]
Cannabidiol DM0659E Minor Decreased metabolism of Boceprevir caused by Cannabidiol mediated inhibition of CYP450 enzyme. Epileptic encephalopathy [8A62] [8]
Bay 80-6946 DMLOS5R Major Decreased metabolism of Boceprevir caused by Bay 80-6946 mediated inhibition of CYP450 enzyme. Follicular lymphoma [2A80] [34]
Tazemetostat DMWP1BH Major Decreased metabolism of Boceprevir caused by Tazemetostat mediated inhibition of CYP450 enzyme. Follicular lymphoma [2A80] [35]
Mirabegron DMS1GYT Minor Decreased metabolism of Boceprevir caused by Mirabegron mediated inhibition of CYP450 enzyme. Functional bladder disorder [GC50] [36]
Ripretinib DM958QB Major Decreased metabolism of Boceprevir caused by Ripretinib mediated inhibition of CYP450 enzyme. Gastrointestinal stromal tumour [2B5B] [14]
MK-1439 DM215WE Minor Decreased metabolism of Boceprevir caused by MK-1439 mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [37]
Fostemsavir DM50ILT Moderate Decreased metabolism of Boceprevir caused by Fostemsavir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [38]
Dolutegravir DMCZGRE Minor Decreased metabolism of Boceprevir caused by Dolutegravir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [39]
Aliskiren DM1BV7W Moderate Decreased metabolism of Boceprevir caused by Aliskiren mediated inhibition of CYP450 enzyme. Hypertension [BA00-BA04] [40]
Levamlodipine DM92S6N Moderate Decreased metabolism of Boceprevir caused by Levamlodipine mediated inhibition of CYP450 enzyme. Hypertension [BA00-BA04] [33]
TP-434 DM5A31S Minor Decreased metabolism of Boceprevir caused by TP-434 mediated inhibition of CYP450 enzyme. Infectious gastroenteritis/colitis [1A40] [41]
Suvorexant DM0E6S3 Major Decreased metabolism of Boceprevir caused by Suvorexant mediated inhibition of CYP450 enzyme. Insomnia [7A00-7A0Z] [14]
Tasimelteon DMLOQ1V Moderate Decreased metabolism of Boceprevir caused by Tasimelteon mediated inhibition of CYP450 enzyme. Insomnia [7A00-7A0Z] [42]
Eluxadoline DMYZ0P1 Moderate Decreased metabolism of Boceprevir caused by Eluxadoline mediated inhibition of CYP450 enzyme. Irritable bowel syndrome [DD91] [43]
Naloxegol DML0B41 Major Decreased metabolism of Boceprevir caused by Naloxegol mediated inhibition of CYP450 enzyme. Large intestine motility disorder [DB32] [14]
Pemigatinib DM819JF Major Decreased metabolism of Boceprevir caused by Pemigatinib mediated inhibition of CYP450 enzyme. Liver cancer [2C12] [44]
Brigatinib DM7W94S Major Decreased metabolism of Boceprevir caused by Brigatinib mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [45]
Ceritinib DMB920Z Major Decreased metabolism of Boceprevir caused by Ceritinib mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [14]
Lurbinectedin DMEFRTZ Major Decreased metabolism of Boceprevir caused by Lurbinectedin mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [46]
PF-06463922 DMKM7EW Major Decreased metabolism of Boceprevir caused by PF-06463922 mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [47]
Osimertinib DMRJLAT Major Decreased metabolism of Boceprevir caused by Osimertinib mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [48]
Pralsetinib DMWU0I2 Major Decreased metabolism of Boceprevir caused by Pralsetinib mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [49]
Capmatinib DMYCXKL Major Decreased metabolism of Boceprevir caused by Capmatinib mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [50]
Selpercatinib DMZR15V Major Decreased metabolism of Boceprevir caused by Selpercatinib mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [51]
Idelalisib DM602WT Moderate Decreased clearance of Boceprevir due to the transporter inhibition by Idelalisib. Mature B-cell leukaemia [2A82] [52]
GDC-0199 DMH0QKA Major Decreased metabolism of Boceprevir caused by GDC-0199 mediated inhibition of CYP450 enzyme. Mature B-cell leukaemia [2A82] [53]
IPI-145 DMWA24P Major Decreased metabolism of Boceprevir caused by IPI-145 mediated inhibition of CYP450 enzyme. Mature B-cell leukaemia [2A82] [54]
Acalabrutinib DM7GCVW Major Decreased metabolism of Boceprevir caused by Acalabrutinib mediated inhibition of CYP450 enzyme. Mature B-cell lymphoma [2A85] [55]
Ibrutinib DMHZCPO Major Decreased metabolism of Boceprevir caused by Ibrutinib mediated inhibition of CYP450 enzyme. Mature B-cell lymphoma [2A85] [14]
Ponatinib DMYGJQO Major Decreased metabolism of Boceprevir caused by Ponatinib mediated inhibition of CYP450 enzyme. Mature B-cell lymphoma [2A85] [14]
Arry-162 DM1P6FR Moderate Decreased clearance of Boceprevir due to the transporter inhibition by Arry-162. Melanoma [2C30] [14]
Vemurafenib DM62UG5 Moderate Decreased metabolism of Boceprevir caused by Vemurafenib mediated inhibition of CYP450 enzyme. Melanoma [2C30] [56]
Selumetinib DMC7W6R Major Decreased metabolism of Boceprevir caused by Selumetinib mediated inhibition of CYP450 enzyme. Melanoma [2C30] [57]
LGX818 DMNQXV8 Major Decreased metabolism of Boceprevir caused by LGX818 mediated inhibition of CYP450 enzyme. Melanoma [2C30] [58]
Dabrafenib DMX6OE3 Moderate Decreased metabolism of Boceprevir caused by Dabrafenib mediated inhibition of CYP450 enzyme. Melanoma [2C30] [14]
Ubrogepant DM749I3 Major Decreased metabolism of Boceprevir caused by Ubrogepant mediated inhibition of CYP450 enzyme. Migraine [8A80] [59]
Rimegepant DMHOAUG Moderate Decreased metabolism of Boceprevir caused by Rimegepant mediated inhibition of CYP450 enzyme. Migraine [8A80] [60]
Siponimod DM2R86O Major Decreased metabolism of Boceprevir caused by Siponimod mediated inhibition of CYP450 enzyme. Multiple sclerosis [8A40] [14]
Fedratinib DM4ZBK6 Major Decreased metabolism of Boceprevir caused by Fedratinib mediated inhibition of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [8]
Ruxolitinib DM7Q98D Major Decreased metabolism of Boceprevir caused by Ruxolitinib mediated inhibition of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [61]
Vorapaxar DMA16BR Major Decreased metabolism of Boceprevir caused by Vorapaxar mediated inhibition of CYP450 enzyme. Myocardial infarction [BA41-BA43] [14]
Netupitant DMEKAYI Minor Decreased metabolism of Boceprevir caused by Netupitant mediated inhibition of CYP450 enzyme. Nausea/vomiting [MD90] [62]
E-2007 DMJDYNQ Minor Decreased metabolism of Boceprevir caused by E-2007 mediated inhibition of CYP450 enzyme. Neuropathy [8C0Z] [8]
Entrectinib DMMPTLH Major Decreased metabolism of Boceprevir caused by Entrectinib mediated inhibition of CYP450 enzyme. Non-small cell lung cancer [2C25] [8]
S-297995 DM26IH8 Moderate Decreased metabolism of Boceprevir caused by S-297995 mediated inhibition of CYP450 enzyme. Opioid use disorder [6C43] [8]
Olaparib DM8QB1D Major Decreased metabolism of Boceprevir caused by Olaparib mediated inhibition of CYP450 enzyme. Ovarian cancer [2C73] [14]
Rucaparib DM9PVX8 Moderate Decreased metabolism of Boceprevir caused by Rucaparib mediated inhibition of CYP450 enzyme. Ovarian cancer [2C73] [63]
Istradefylline DM20VSK Major Decreased metabolism of Boceprevir caused by Istradefylline mediated inhibition of CYP450 enzyme. Parkinsonism [8A00] [64]
Abametapir DM2RX0I Moderate Decreased metabolism of Boceprevir caused by Abametapir mediated inhibition of CYP450 enzyme. Pediculosis [1G00] [65]
Lefamulin DME6G97 Major Decreased metabolism of Boceprevir caused by Lefamulin mediated inhibition of CYP450 enzyme. Pneumonia [CA40] [66]
Enzalutamide DMGL19D Major Increased metabolism of Boceprevir caused by Enzalutamide mediated induction of CYP450 enzyme. Prostate cancer [2C82] [11]
Darolutamide DMV7YFT Moderate Decreased metabolism of Boceprevir caused by Darolutamide mediated inhibition of CYP450 enzyme. Prostate cancer [2C82] [67]
Riociguat DMXBLMP Moderate Decreased clearance of Boceprevir due to the transporter inhibition by Riociguat. Pulmonary hypertension [BB01] [14]
Upadacitinib DM32B5U Major Decreased metabolism of Boceprevir caused by Upadacitinib mediated inhibition of CYP450 enzyme. Rheumatoid arthritis [FA20] [68]
Tofacitinib DMBS370 Major Decreased metabolism of Boceprevir caused by Tofacitinib mediated inhibition of CYP450 enzyme. Rheumatoid arthritis [FA20] [14]
Voxelotor DMCS6M5 Major Decreased metabolism of Boceprevir caused by Voxelotor mediated inhibition of CYP450 enzyme. Sickle-cell disorder [3A51] [69]
LDE225 DMM9F25 Major Decreased metabolism of Boceprevir caused by LDE225 mediated inhibition of CYP450 enzyme. Skin cancer [2C30-2C37] [70]
Telotristat ethyl DMDIYFZ Moderate Increased metabolism of Boceprevir caused by Telotristat ethyl mediated induction of CYP450 enzyme. Small intestine developmental anomaly [DA90] [8]
Larotrectinib DM26CQR Major Decreased metabolism of Boceprevir caused by Larotrectinib mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [14]
LEE011 DMMX75K Major Decreased metabolism of Boceprevir caused by LEE011 mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [8]
Pomalidomide DMTGBAX Moderate Decreased clearance of Boceprevir due to the transporter inhibition by Pomalidomide. Systemic sclerosis [4A42] [14]
Fostamatinib DM6AUHV Major Decreased metabolism of Boceprevir caused by Fostamatinib mediated inhibition of CYP450 enzyme. Thrombocytopenia [3B64] [71]
Lusutrombopag DMH6IKO Moderate Decreased clearance of Boceprevir due to the transporter inhibition by Lusutrombopag. Thrombocytopenia [3B64] [63]
As-1670542 DMV05SW Moderate Decreased metabolism of Boceprevir caused by As-1670542 mediated inhibition of CYP450 enzyme. Thrombocytopenia [3B64] [8]
Cabozantinib DMIYDT4 Major Decreased metabolism of Boceprevir caused by Cabozantinib mediated inhibition of CYP450 enzyme. Thyroid cancer [2D10] [14]
Elagolix DMB2C0E Major Decreased metabolism of Boceprevir caused by Elagolix mediated inhibition of CYP450 enzyme. Uterine fibroid [2E86] [72]
Fluticasone DMGCSVF Major Decreased metabolism of Boceprevir caused by Fluticasone mediated inhibition of CYP450 enzyme. Vasomotor/allergic rhinitis [CA08] [73]
Betrixaban DM2C4RF Moderate Decreased clearance of Boceprevir due to the transporter inhibition by Betrixaban. Venous thromboembolism [BD72] [74]
⏷ Show the Full List of 95 DDI Information of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG
DIG Name DIG ID PubChem CID Functional Classification
Allura red AC dye E00338 33258 Colorant
FD&C blue no. 1 E00263 19700 Colorant
Isopropyl alcohol E00070 3776 Antimicrobial preservative; Solvent
Quinoline yellow WS E00309 24671 Colorant
Sodium lauryl sulfate E00464 3423265 Emulsifying agent; Modified-release agent; Penetration agent; Solubilizing agent; Surfactant; lubricant
Sunset yellow FCF E00255 17730 Colorant
Ammonia E00007 222 Alkalizing agent
Butyl alcohol E00011 263 Flavoring agent; Solvent
Carmellose sodium E00625 Not Available Disintegrant
Eisenoxyd E00585 56841934 Colorant
Lactose monohydrate E00393 104938 Binding agent; Diluent; Dry powder inhaler carrier; Lyophilization aid
Magnesium stearate E00208 11177 lubricant
Propylene glycol E00040 1030 Antimicrobial preservative; Humectant; Plasticizing agent; Solvent
Titanium dioxide E00322 26042 Coating agent; Colorant; Opacifying agent
⏷ Show the Full List of 14 Pharmaceutical Excipients of This Drug
Pharmaceutical Formulation
Formulation Name Drug Dosage Dosage Form Route
Boceprevir 200 mg capsule 200 mg Oral Capsule Oral
Jump to Detail Pharmaceutical Formulation Page of This Drug

References

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2 Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease. 2020. April 20. doi: https://doi.org/10.1101/2020.04.20.051581
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47 Product Information. Lorbrena (lorlatinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
48 Product Information. Tagrisso (osimertinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
49 Product Information. Gavreto (pralsetinib). Blueprint Medicines Corporation, Cambridge, MA.
50 Product Information. Tabrecta (capmatinib). Novartis Pharmaceuticals, East Hanover, NJ.
51 Product Information. Retevmo (selpercatinib). Lilly, Eli and Company, Indianapolis, IN.
52 Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
53 Product Information. Venclexta (venetoclax). AbbVie US LLC, North Chicago, IL.
54 Product Information. Copiktra (duvelisib). Verastem, Inc., Needham, MA.
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57 Product Information. Koselugo (selumetinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
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60 Product Information. Nurtec ODT (rimegepant). Biohaven Pharmaceuticals, New Haven, CT.
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63 EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
64 Product Information. Nourianz (istradefylline). Kyowa Kirin, Inc, Bedminster, NJ.
65 Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
66 Product Information. VFEND (voriconazole). Pfizer U.S. Pharmaceuticals, New York, NY.
67 Product Information. Nubeqa (darolutamide). Bayer HealthCare Pharmaceuticals Inc., Whippany, NJ.
68 Product Information. Rinvoq (upadacitinib). AbbVie US LLC, North Chicago, IL.
69 Bailey DG, Arnold JMO, Spence JD "Grapefruit juice and drugs - how significant is the interaction." Clin Pharmacokinet 26 (1994): 91-8. [PMID: 8162660]
70 Product Information. Odomzo (sonidegib). Novartis Pharmaceuticals, East Hanover, NJ.
71 Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
72 Product Information. Orilissa (elagolix). AbbVie US LLC, North Chicago, IL.
73 Arrington-Sanders R, Hutton N, Siberry GK "Ritonavir-fluticasone interaction causing Cushing syndrome in HIV-infected children and adolescents." Pediatr Infect Dis J 25 (2006): 1044-1048. [PMID: 17072128]
74 Product Information. Bevyxxa (betrixaban). Portola Pharmaceuticals, South San Francisco, CA.