Details of the Drug Combination

General Information of Drug Combination (ID: DC0FII1)

Drug Combination Name
PDX-101 Idarubicin
Indication
Disease Entry Status REF
Acute Myeloid Leukemia Phase 1 [1]
Component Drugs PDX-101   DM6OC53 Idarubicin   DMM0XGL
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of PDX-101
Disease Entry ICD 11 Status REF
Plasma cell myeloma 2A83.1 Approved [2]
Primary cutaneous peripheral T-cell lymphoma not otherwise specified N.A. Approved [2]
Primary cutaneous T-cell lymphoma N.A. Approved [2]
Solid tumour/cancer 2A00-2F9Z Phase 2 [3]
Haematological malignancy 2B33.Y Phase 1 [4]
Peripheral T-cell lymphoma 2A90.C Phase 1 [4]
PDX-101 Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Histone deacetylase (HDAC) TTBH0VX NOUNIPROTAC Modulator [12]
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PDX-101 Interacts with 2 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [7]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DEYGVN4 UD11_HUMAN Metabolism [13]
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PDX-101 Interacts with 566 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Aurora kinase A (AURKA) OTMX0HYT AURKA_HUMAN Decreases Expression [8]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Decreases Expression [8]
Transforming acidic coiled-coil-containing protein 1 (TACC1) OTGX20TE TACC1_HUMAN Increases Expression [8]
Tyrosine-protein kinase ABL1 (ABL1) OT09YVXH ABL1_HUMAN Decreases Expression [8]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Decreases Expression [8]
Cyclin-dependent kinase 1 (CDK1) OTW1SC2N CDK1_HUMAN Decreases Expression [8]
Histone H1.0 (H1-0) OTRLJK4Z H10_HUMAN Increases Expression [8]
Clusterin (CLU) OTQGG0JM CLUS_HUMAN Increases Expression [8]
Cyclin-dependent kinase 4 (CDK4) OT7EP05T CDK4_HUMAN Decreases Expression [8]
Ornithine decarboxylase (ODC1) OTNDAGRR DCOR_HUMAN Increases Expression [8]
G2/mitotic-specific cyclin-B1 (CCNB1) OT19S7E5 CCNB1_HUMAN Decreases Expression [8]
Interferon gamma receptor 1 (IFNGR1) OTCTQBWW INGR1_HUMAN Increases Expression [8]
CTP synthase 1 (CTPS1) OTZ9J6ZG PYRG1_HUMAN Decreases Expression [8]
Cyclin-A2 (CCNA2) OTPHHYZJ CCNA2_HUMAN Decreases Expression [8]
Diamine acetyltransferase 1 (SAT1) OT52AU22 SAT1_HUMAN Increases Expression [8]
DNA replication licensing factor MCM3 (MCM3) OTOOHQPM MCM3_HUMAN Decreases Expression [8]
DnaJ homolog subfamily B member 1 (DNAJB1) OTCOSEVH DNJB1_HUMAN Increases Expression [8]
Multifunctional protein CAD (CAD) OTNCUYYE PYR1_HUMAN Decreases Expression [8]
CCN family member 2 (CCN2) OTC39NSU CCN2_HUMAN Increases Expression [8]
M-phase inducer phosphatase 2 (CDC25B) OT12MSRY MPIP2_HUMAN Decreases Expression [8]
DNA replication licensing factor MCM7 (MCM7) OT6FXC6K MCM7_HUMAN Decreases Expression [8]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [8]
Cyclin-dependent kinase inhibitor 2A (CDKN2A) OTN0ZWAE CDN2A_HUMAN Decreases Expression [8]
GTP-binding nuclear protein Ran (RAN) OT2TER5M RAN_HUMAN Decreases Expression [8]
Ras-related C3 botulinum toxin substrate 1 (RAC1) OTKRO61U RAC1_HUMAN Decreases Expression [8]
Eukaryotic translation initiation factor 4 gamma 2 (EIF4G2) OTEO98CR IF4G2_HUMAN Decreases Expression [8]
Dehydrogenase/reductase SDR family member 2, mitochondrial (DHRS2) OTFHWIY8 DHRS2_HUMAN Increases Expression [8]
Kelch-like ECH-associated protein 1 (KEAP1) OTFHOD0C KEAP1_HUMAN Decreases Expression [8]
Importin subunit beta-1 (KPNB1) OTBT2HFL IMB1_HUMAN Decreases Expression [8]
Retrotransposon-derived protein PEG10 (PEG10) OTWD2278 PEG10_HUMAN Increases Expression [8]
Histone H1.10 (H1-10) OTBWDA4E H1X_HUMAN Increases Expression [8]
Aurora kinase B (AURKB) OTIY4VHU AURKB_HUMAN Decreases Expression [8]
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) OTUYHB84 MLP3B_HUMAN Increases Expression [8]
Inner centromere protein (INCENP) OT9HFRYK INCE_HUMAN Decreases Expression [8]
Nucleolar RNA helicase 2 (DDX21) OTV73GMZ DDX21_HUMAN Decreases Expression [8]
Bcl-2-associated transcription factor 1 (BCLAF1) OT7T8H6A BCLF1_HUMAN Decreases Expression [8]
Protein RCC2 (RCC2) OTUJVTLS RCC2_HUMAN Decreases Expression [8]
Targeting protein for Xklp2 (TPX2) OTWLJYH0 TPX2_HUMAN Decreases Expression [8]
Proliferation-associated protein 2G4 (PA2G4) OT7IG7HT PA2G4_HUMAN Decreases Expression [8]
Rho guanine nucleotide exchange factor 37 (ARHGEF37) OTXQSCDO ARH37_HUMAN Decreases Expression [9]
Homeobox protein HMX2 (HMX2) OTBRXY6D HMX2_HUMAN Increases Expression [9]
Developmental pluripotency-associated 5 protein (DPPA5) OTLZC371 DPPA5_HUMAN Increases Expression [9]
RNA binding protein fox-1 homolog 3 (RBFOX3) OTL0F3D6 RFOX3_HUMAN Decreases Expression [9]
Transmembrane protein 221 (TMEM221) OTNSYQ3L TM221_HUMAN Decreases Expression [9]
Coiled-coil domain-containing protein 69 (CCDC69) OT43MI0R CCD69_HUMAN Increases Expression [9]
Rab GTPase-activating protein 1-like, isoform 10 (RABGAP1L) OT7QO47I RBG10_HUMAN Increases Expression [9]
Suppressyn (ERVH48-1) OT303JGE SUPYN_HUMAN Increases Expression [9]
PDZ and LIM domain protein 1 (PDLIM1) OT4EGCPG PDLI1_HUMAN Increases Expression [9]
Bone morphogenetic protein receptor type-1B (BMPR1B) OTGFN0OD BMR1B_HUMAN Decreases Expression [9]
Beta-1,3-N-acetylglucosaminyltransferase manic fringe (MFNG) OTUX45ZF MFNG_HUMAN Decreases Expression [9]
Podocalyxin (PODXL) OTPNQXF3 PODXL_HUMAN Increases Expression [9]
Astrotactin-1 (ASTN1) OT23FQIB ASTN1_HUMAN Decreases Expression [9]
Suppressor of cytokine signaling 3 (SOCS3) OTY183WJ SOCS3_HUMAN Decreases Expression [9]
Neurocan core protein (NCAN) OT8OO6ZE NCAN_HUMAN Decreases Expression [9]
Neuropilin-1 (NRP1) OTCGULYV NRP1_HUMAN Increases Expression [9]
Semaphorin-3E (SEMA3E) OTD4S36H SEM3E_HUMAN Increases Expression [9]
Synaptojanin-2 (SYNJ2) OTLRHXP1 SYNJ2_HUMAN Decreases Expression [9]
DNA-directed RNA polymerase III subunit RPC7 (POLR3G) OTU3TGQ9 RPC7_HUMAN Increases Expression [9]
Cytochrome P450 26A1 (CYP26A1) OTL1DFWV CP26A_HUMAN Increases Expression [9]
Disintegrin and metalloproteinase domain-containing protein 12 (ADAM12) OTZKOTDB ADA12_HUMAN Decreases Expression [9]
Phospholipid-transporting ATPase IC (ATP8B1) OTALGS63 AT8B1_HUMAN Increases Expression [9]
Zinc finger protein SNAI2 (SNAI2) OT7Y8EJ2 SNAI2_HUMAN Increases Expression [9]
Integral membrane protein 2A (ITM2A) OT590V63 ITM2A_HUMAN Increases Expression [9]
Plexin-C1 (PLXNC1) OTJ5XKYY PLXC1_HUMAN Decreases Expression [9]
Gremlin-1 (GREM1) OTCK4IGV GREM1_HUMAN Increases Expression [9]
Histone H2B type 1-K (H2BC12) OTQ8V0KG H2B1K_HUMAN Decreases Expression [9]
Protein diaphanous homolog 2 (DIAPH2) OTBEYFEZ DIAP2_HUMAN Increases Expression [9]
Inward rectifier potassium channel 13 (KCNJ13) OTG1CNND KCJ13_HUMAN Decreases Expression [9]
Frizzled-7 (FZD7) OTTK3F6E FZD7_HUMAN Increases Expression [9]
Slit homolog 1 protein (SLIT1) OT35RBNT SLIT1_HUMAN Increases Expression [9]
Core histone macro-H2A.1 (MACROH2A1) OTV2DQDD H2AY_HUMAN Decreases Expression [9]
Large neutral amino acids transporter small subunit 3 (SLC43A1) OTQJQY3S LAT3_HUMAN Increases Expression [9]
Forkhead box protein H1 (FOXH1) OTEXJ9SL FOXH1_HUMAN Increases Expression [9]
Leukocyte cell-derived chemotaxin 1 (CNMD) OTHND8EL CNMD_HUMAN Increases Expression [9]
Lysozyme-like protein 6 (LYZL6) OT6XS67M LYZL6_HUMAN Increases Expression [9]
Slit homolog 2 protein (SLIT2) OTLS2RJ4 SLIT2_HUMAN Increases Expression [9]
Nucleolar protein 4 (NOL4) OTWI587R NOL4_HUMAN Decreases Expression [9]
Dickkopf-related protein 1 (DKK1) OTRDLUSP DKK1_HUMAN Increases Expression [9]
Serine protease 23 (PRSS23) OT6DQAM1 PRS23_HUMAN Decreases Expression [9]
Neurexophilin-2 (NXPH2) OTHD8HPU NXPH2_HUMAN Decreases Expression [9]
Protocadherin-8 (PCDH8) OTDDOQM2 PCDH8_HUMAN Increases Expression [9]
Homeobox protein SIX3 (SIX3) OTP5E3VU SIX3_HUMAN Decreases Expression [9]
Claudin-7 (CLDN7) OTNE0XHQ CLD7_HUMAN Increases Expression [9]
C-X-C motif chemokine 14 (CXCL14) OTM189TA CXL14_HUMAN Increases Expression [9]
BAG family molecular chaperone regulator 2 (BAG2) OTI6LD27 BAG2_HUMAN Increases Expression [9]
Leucine-rich glioma-inactivated protein 1 (LGI1) OTPS77HO LGI1_HUMAN Increases Expression [9]
Urokinase-type plasminogen activator (PLAU) OTX0QGKK UROK_HUMAN Increases Expression [9]
Adenosine deaminase (ADA) OTOX2872 ADA_HUMAN Decreases Expression [9]
Pro-neuropeptide Y (NPY) OT4ICV3P NPY_HUMAN Increases Expression [9]
Alpha-fetoprotein (AFP) OT9GG3ZI FETA_HUMAN Decreases Expression [9]
Endothelin-1 (EDN1) OTZCACEG EDN1_HUMAN Increases Expression [9]
Transcription factor AP-2-alpha (TFAP2A) OTMYT3NK AP2A_HUMAN Increases Expression [9]
Keratin, type I cytoskeletal 18 (KRT18) OTVLQFIP K1C18_HUMAN Increases Expression [9]
Calbindin (CALB1) OTM7IXDG CALB1_HUMAN Increases Expression [9]
Neurofilament light polypeptide (NEFL) OTQESJV4 NFL_HUMAN Increases Expression [9]
Annexin A2 (ANXA2) OTFNS0CC ANXA2_HUMAN Increases Expression [9]
Collagen alpha-2(I) chain (COL1A2) OTY7G382 CO1A2_HUMAN Increases Expression [9]
Inhibin beta A chain (INHBA) OTSP64PQ INHBA_HUMAN Increases Expression [9]
Fibroblast growth factor 4 (FGF4) OTNVV3ZG FGF4_HUMAN Increases Expression [9]
Tumor-associated calcium signal transducer 2 (TACSTD2) OTLSZR00 TACD2_HUMAN Increases Expression [9]
Apelin receptor early endogenous ligand (APELA) OTYY0P69 ELA_HUMAN Increases Expression [9]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Decreases Expression [9]
Chromogranin-A (CHGA) OTXYX5JH CMGA_HUMAN Increases Expression [9]
Tissue factor pathway inhibitor (TFPI) OTA0FX16 TFPI1_HUMAN Increases Expression [9]
Thyroid hormone receptor beta (THRB) OTBBIRHZ THB_HUMAN Increases Expression [9]
Hyaluronan and proteoglycan link protein 1 (HAPLN1) OTXWR9TJ HPLN1_HUMAN Increases Expression [9]
Serine/threonine-protein kinase pim-1 (PIM1) OTWEKXTU PIM1_HUMAN Increases Expression [9]
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Increases Expression [9]
Protein Cripto (CRIPTO) OT46DZXJ TDGF1_HUMAN Increases Expression [9]
Phospholipase A2, membrane associated (PLA2G2A) OT1NY7BF PA2GA_HUMAN Increases Expression [9]
Protein C-ets-1 (ETS1) OT4LVGDN ETS1_HUMAN Increases Expression [9]
15-hydroxyprostaglandin dehydrogenase (HPGD) OTYZI6JB PGDH_HUMAN Increases Expression [9]
NAD(P)H dehydrogenase 1 (NQO1) OTZGGIVK NQO1_HUMAN Increases Expression [9]
Epithelial cell adhesion molecule (EPCAM) OTHBZK5X EPCAM_HUMAN Increases Expression [9]
Atrial natriuretic peptide receptor 3 (NPR3) OT6MQP3A ANPRC_HUMAN Increases Expression [9]
cAMP-dependent protein kinase catalytic subunit alpha (PRKACA) OTAKDCMR KAPCA_HUMAN Increases Expression [9]
Neuromodulin (GAP43) OT2OTGGV NEUM_HUMAN Increases Expression [9]
Vascular endothelial growth factor receptor 1 (FLT1) OTT0OGYS VGFR1_HUMAN Increases Expression [9]
Integrin beta-5 (ITGB5) OT21MF51 ITB5_HUMAN Decreases Expression [9]
Pituitary adenylate cyclase-activating polypeptide (ADCYAP1) OT0LQH93 PACA_HUMAN Increases Expression [9]
Alpha-1-acid glycoprotein 2 (ORM2) OTRJGZP8 A1AG2_HUMAN Decreases Expression [9]
Serine protease inhibitor Kazal-type 2 (SPINK2) OTSFBT0G ISK2_HUMAN Increases Expression [9]
Muscarinic acetylcholine receptor M3 (CHRM3) OTKSD095 ACM3_HUMAN Increases Expression [9]
Ephrin-A1 (EFNA1) OTU2NUA2 EFNA1_HUMAN Increases Expression [9]
Ephrin type-A receptor 1 (EPHA1) OTGJMRZ0 EPHA1_HUMAN Increases Expression [9]
CD9 antigen (CD9) OT2184XU CD9_HUMAN Increases Expression [9]
Bone morphogenetic protein 5 (BMP5) OTC0Y6E0 BMP5_HUMAN Increases Expression [9]
Cadherin-3 (CDH3) OTKNLQU7 CADH3_HUMAN Increases Expression [9]
Fibulin-1 (FBLN1) OT5MHHOP FBLN1_HUMAN Decreases Expression [9]
Paired box protein Pax-7 (PAX7) OTDMQRPO PAX7_HUMAN Increases Expression [9]
Paired box protein Pax-3 (PAX3) OTN5PJZV PAX3_HUMAN Increases Expression [9]
Trans-acting T-cell-specific transcription factor GATA-3 (GATA3) OTGP7D5Y GATA3_HUMAN Increases Expression [9]
Endothelin receptor type B (EDNRB) OTLLZV3P EDNRB_HUMAN Increases Expression [9]
Tenascin (TNC) OTK4FSHR TENA_HUMAN Decreases Expression [9]
Signal transducer CD24 (CD24) OT7CODJ4 CD24_HUMAN Increases Expression [9]
Endothelin-1 receptor (EDNRA) OTK9T5O3 EDNRA_HUMAN Increases Expression [9]
Rhombotin-2 (LMO2) OTCC370G RBTN2_HUMAN Decreases Expression [9]
Pentraxin-related protein PTX3 (PTX3) OTPXHRKU PTX3_HUMAN Decreases Expression [9]
HLA class II histocompatibility antigen, DM beta chain (HLA-DMB) OT17HGXJ DMB_HUMAN Decreases Expression [9]
Homeobox protein MSX-1 (MSX1) OT5U41ZP MSX1_HUMAN Increases Expression [9]
Gamma-aminobutyric acid receptor subunit beta-3 (GABRB3) OT80C3D4 GBRB3_HUMAN Increases Expression [9]
Ephrin type-A receptor 3 (EPHA3) OTZJF3ML EPHA3_HUMAN Increases Expression [9]
Ephrin type-B receptor 2 (EPHB2) OT8VZ6C5 EPHB2_HUMAN Decreases Expression [9]
G1/S-specific cyclin-D2 (CCND2) OTDULQF9 CCND2_HUMAN Decreases Expression [9]
Fibroblast growth factor 9 (FGF9) OT2SKDGM FGF9_HUMAN Decreases Expression [9]
Gastrin/cholecystokinin type B receptor (CCKBR) OTQSNXOI GASR_HUMAN Decreases Expression [9]
Neuronal acetylcholine receptor subunit alpha-3 (CHRNA3) OTCZQY1U ACHA3_HUMAN Increases Expression [9]
Homeobox protein MSX-2 (MSX2) OT1WDKE1 MSX2_HUMAN Increases Expression [9]
Metalloproteinase inhibitor 3 (TIMP3) OTDGQAD1 TIMP3_HUMAN Decreases Expression [9]
Vascular endothelial growth factor receptor 2 (KDR) OT15797V VGFR2_HUMAN Increases Expression [9]
Amiloride-sensitive sodium channel subunit alpha (SCNN1A) OTE2KVZV SCNNA_HUMAN Increases Expression [9]
C-X-C motif chemokine 5 (CXCL5) OTZOUPCA CXCL5_HUMAN Increases Expression [9]
Lysophosphatidic acid receptor 6 (LPAR6) OT4BY3W4 LPAR6_HUMAN Increases Expression [9]
Peptidyl-prolyl cis-trans isomerase C (PPIC) OTY5Q42N PPIC_HUMAN Increases Expression [9]
Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial (ACADSB) OTDO6HBG ACDSB_HUMAN Increases Expression [9]
Cytosolic phospholipase A2 (PLA2G4A) OTE70SOT PA24A_HUMAN Increases Expression [9]
DNA-binding protein inhibitor ID-4 (ID4) OTPMJ39I ID4_HUMAN Increases Expression [9]
Protein ERGIC-53 (LMAN1) OTYHKDEO LMAN1_HUMAN Decreases Expression [9]
Beta-arrestin-1 (ARRB1) OT2NJS37 ARRB1_HUMAN Increases Expression [9]
Isocitrate dehydrogenase subunit alpha, mitochondrial (IDH3A) OT5QQB5L IDH3A_HUMAN Increases Expression [9]
Homeobox protein MOX-1 (MEOX1) OTJEMT2D MEOX1_HUMAN Increases Expression [9]
Cysteine-rich protein 1 (CRIP1) OT0EICG3 CRIP1_HUMAN Increases Expression [9]
Serpin B9 (SERPINB9) OTJ811IF SPB9_HUMAN Increases Expression [9]
LIM/homeobox protein Lhx2 (LHX2) OTK61NP8 LHX2_HUMAN Decreases Expression [9]
Probable global transcription activator SNF2L2 (SMARCA2) OTSGJ8SV SMCA2_HUMAN Increases Expression [9]
Beta-crystallin A4 (CRYBA4) OTQJ5XGE CRBA4_HUMAN Decreases Expression [9]
GDNF family receptor alpha-1 (GFRA1) OT3WBVYB GFRA1_HUMAN Decreases Expression [9]
Transcription factor SOX-8 (SOX8) OTEJXYZM SOX8_HUMAN Increases Expression [9]
Sestrin-3 (SESN3) OTJRY1Y5 SESN3_HUMAN Increases Expression [9]
Neurexin-2-beta (NRXN2) OTB04QSU NRX2B_HUMAN Decreases Expression [9]
Histone H2B type 1-D (H2BC5) OTXDTDHN H2B1D_HUMAN Decreases Expression [9]
Synaptosomal-associated protein 25 (SNAP25) OTUIQ81Q SNP25_HUMAN Increases Expression [9]
Protein S100-A10 (S100A10) OTI71243 S10AA_HUMAN Increases Expression [9]
Somatostatin (SST) OTY75GQH SMS_HUMAN Increases Expression [9]
Neurocalcin-delta (NCALD) OTJZ8UEL NCALD_HUMAN Decreases Expression [9]
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 (GNG11) OTHIXBGW GBG11_HUMAN Increases Expression [9]
Rho-related GTP-binding protein RhoB (RHOB) OTHQFQF7 RHOB_HUMAN Increases Expression [9]
Iroquois-class homeodomain protein IRX-1 (IRX1) OT0ZN9EJ IRX1_HUMAN Increases Expression [9]
Reelin (RELN) OTLKMW1O RELN_HUMAN Increases Expression [9]
Nucleobindin-2 (NUCB2) OTHO6JWN NUCB2_HUMAN Decreases Expression [9]
Serine beta-lactamase-like protein LACTB, mitochondrial (LACTB) OTRWGNBF LACTB_HUMAN Increases Expression [9]
Norrin (NDP) OTGDJ4US NDP_HUMAN Decreases Expression [9]
POU domain, class 5, transcription factor 1 (POU5F1) OTDHHN7O PO5F1_HUMAN Increases Expression [9]
Hematopoietically-expressed homeobox protein HHEX (HHEX) OTLIUVYX HHEX_HUMAN Increases Expression [9]
Putative POU domain, class 5, transcription factor 1B (POU5F1B) OT0FKQ51 P5F1B_HUMAN Increases Expression [9]
Protein CBFA2T1 (RUNX1T1) OT30DED5 MTG8_HUMAN Increases Expression [9]
Forkhead box protein O1 (FOXO1) OTPJRB6D FOXO1_HUMAN Increases Expression [9]
Contactin-1 (CNTN1) OT7RNPEY CNTN1_HUMAN Increases Expression [9]
Noggin (NOG) OTGRHHPG NOGG_HUMAN Increases Expression [9]
N-myc-interactor (NMI) OTYVG3NM NMI_HUMAN Increases Expression [9]
Frizzled-5 (FZD5) OTXFFY56 FZD5_HUMAN Decreases Expression [9]
Cadherin-18 (CDH18) OTC06P9H CAD18_HUMAN Increases Expression [9]
Krueppel-like factor 5 (KLF5) OT1ABI9N KLF5_HUMAN Increases Expression [9]
Septin-6 (SEPTIN6) OTIV9RTK SEPT6_HUMAN Increases Expression [9]
Transcription factor E2F2 (E2F2) OTO75RM7 E2F2_HUMAN Decreases Expression [9]
Polypeptide N-acetylgalactosaminyltransferase 3 (GALNT3) OT7M67WT GALT3_HUMAN Increases Expression [9]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Increases Expression [9]
Uncharacterized protein KIAA0040 (KIAA0040) OT27EBY3 K0040_HUMAN Increases Expression [9]
Ephrin type-A receptor 7 (EPHA7) OT3VC211 EPHA7_HUMAN Increases Expression [9]
Angiopoietin-1 (ANGPT1) OTVZ1NG3 ANGP1_HUMAN Increases Expression [9]
Myosin light chain kinase, smooth muscle (MYLK) OT78QB4A MYLK_HUMAN Decreases Expression [9]
Metallophosphoesterase MPPED2 (MPPED2) OT7XLMJ6 MPPD2_HUMAN Decreases Expression [9]
Laminin subunit alpha-4 (LAMA4) OTHI7TA0 LAMA4_HUMAN Increases Expression [9]
Gamma-interferon-inducible protein 16 (IFI16) OT4SPU0U IF16_HUMAN Increases Expression [9]
Cytochrome P450 1B1 (CYP1B1) OTYXFLSD CP1B1_HUMAN Increases Expression [9]
Reticulon-1 (RTN1) OTCX1SMK RTN1_HUMAN Decreases Expression [9]
Tumor protein D53 (TPD52L1) OTSA6U0I TPD53_HUMAN Increases Expression [9]
Complement component receptor 1-like protein (CR1L) OTX3KR7U CR1L_HUMAN Increases Expression [9]
Cell cycle control protein 50B (TMEM30B) OTNSBH84 CC50B_HUMAN Increases Expression [9]
Protein shisa-like-1 (SHISAL1) OTOIUVC4 SHSL1_HUMAN Decreases Expression [9]
Protein PTHB1 (BBS9) OT23V9YF PTHB1_HUMAN Increases Expression [9]
Uncharacterized protein C8orf34 (C8ORF34) OTXCTHDG CH034_HUMAN Increases Expression [9]
F-box only protein 43 (FBXO43) OT6ST2A4 FBX43_HUMAN Decreases Expression [9]
Extracellular tyrosine-protein kinase PKDCC (PKDCC) OTVXJR26 PKDCC_HUMAN Increases Expression [9]
Seizure protein 6 homolog (SEZ6) OTCD8K5D SEZ6_HUMAN Increases Expression [9]
Pleckstrin homology-like domain family A member 2 (PHLDA2) OTMV9DPP PHLA2_HUMAN Increases Expression [9]
Fibulin-7 (FBLN7) OT1XRDP6 FBLN7_HUMAN Decreases Expression [9]
Protein BEX5 (BEX5) OTZ2RB6L BEX5_HUMAN Increases Expression [9]
Collectin-12 (COLEC12) OTIQTK9G COL12_HUMAN Increases Expression [9]
Solute carrier family 35 member D3 (SLC35D3) OTHKRBGM S35D3_HUMAN Increases Expression [9]
Centrosomal protein of 85 kDa-like (CEP85L) OTSHJFOT CE85L_HUMAN Increases Expression [9]
Protein FAM162B (FAM162B) OTZ31RP5 F162B_HUMAN Increases Expression [9]
Transcription factor HES-5 (HES5) OTW7JEHV HES5_HUMAN Decreases Expression [9]
Protein FAM222A (FAM222A) OTRD9AUH F222A_HUMAN Decreases Expression [9]
Scm-like with four MBT domains protein 2 (SFMBT2) OTZQT61Q SMBT2_HUMAN Increases Expression [9]
LIM/homeobox protein Lhx8 (LHX8) OT0DFL7C LHX8_HUMAN Increases Expression [9]
TMF-regulated nuclear protein 1 (TRNP1) OTYYV8LN TRNP1_HUMAN Increases Expression [9]
Lactase-like protein (LCTL) OTN36T21 LCTL_HUMAN Decreases Expression [9]
Interleukin-20 receptor subunit beta (IL20RB) OTHFXK95 I20RB_HUMAN Increases Expression [9]
Transmembrane protein 64 (TMEM64) OTO9IDFD TMM64_HUMAN Increases Expression [9]
Metastasis-associated in colon cancer protein 1 (MACC1) OTV3DLX0 MACC1_HUMAN Increases Expression [9]
Zinc finger protein basonuclin-2 (BNC2) OTU22H9Z BNC2_HUMAN Increases Expression [9]
Solute carrier organic anion transporter family member 4C1 (SLCO4C1) OTVILUUN SO4C1_HUMAN Increases Expression [9]
Leucine-rich repeat-containing protein 55 (LRRC55) OT8LQI1W LRC55_HUMAN Decreases Expression [9]
UPF0606 protein KIAA1549L (KIAA1549L) OT80HUVY K154L_HUMAN Decreases Expression [9]
Monocarboxylate transporter 14 (SLC16A14) OTUGDEUV MOT14_HUMAN Decreases Expression [9]
E3 ubiquitin-protein ligase RNF144B (RNF144B) OTN7FCDE R144B_HUMAN Increases Expression [9]
Developmental pluripotency-associated protein 2 (DPPA2) OT8Y55RY DPPA2_HUMAN Increases Expression [9]
Uncharacterized protein C11orf96 (C11ORF96) OTEQU0V7 CK096_HUMAN Increases Expression [9]
Sodium/hydrogen exchanger 9B2 (SLC9B2) OTZVOY8T SL9B2_HUMAN Decreases Expression [9]
Leucine-rich repeat transmembrane neuronal protein 1 (LRRTM1) OTKI3IU9 LRRT1_HUMAN Increases Expression [9]
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (MAGI2) OTXDDKZS MAGI2_HUMAN Increases Expression [9]
Inter-alpha-trypsin inhibitor heavy chain H5 (ITIH5) OTP46PZM ITIH5_HUMAN Increases Expression [9]
Catechol O-methyltransferase domain-containing protein 1 (COMTD1) OTLQJTBI CMTD1_HUMAN Increases Expression [9]
Protein phosphatase 1 regulatory subunit 3B (PPP1R3B) OTVCRXEZ PPR3B_HUMAN Increases Expression [9]
Podoplanin (PDPN) OTBUV19I PDPN_HUMAN Increases Expression [9]
Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PPARGC1B) OTN6FKCB PRGC2_HUMAN Increases Expression [9]
Neuron navigator 3 (NAV3) OT97M1TR NAV3_HUMAN Increases Expression [9]
Procollagen galactosyltransferase 2 (COLGALT2) OTV9EDZB GT252_HUMAN Decreases Expression [9]
Ras and EF-hand domain-containing protein (RASEF) OTGSAM2E RASEF_HUMAN Increases Expression [9]
Solute carrier family 38 member 6 (SLC38A6) OTIC8SHQ S38A6_HUMAN Increases Expression [9]
Protein SIX6OS1 (C14ORF39) OTFKQ6HO S6OS1_HUMAN Decreases Expression [9]
Rho GTPase-activating protein 24 (ARHGAP24) OTCQCEZS RHG24_HUMAN Increases Expression [9]
Protein FAM43A (FAM43A) OT5RPQRE FA43A_HUMAN Increases Expression [9]
ELMO domain-containing protein 1 (ELMOD1) OT0WRVJC ELMD1_HUMAN Increases Expression [9]
Mucin-15 (MUC15) OT3PQT6L MUC15_HUMAN Increases Expression [9]
Chemokine-like protein TAFA-2 (TAFA2) OTU6WP6J TAFA2_HUMAN Increases Expression [9]
Protein phosphatase Mn(2+)-dependent 1K (PPM1K) OTNZ4N4E PPM1K_HUMAN Increases Expression [9]
Thioredoxin domain-containing protein 3 (NME8) OT4RULP5 TXND3_HUMAN Increases Expression [9]
Leucine-rich repeat-containing protein 17 (LRRC17) OT3NZSX3 LRC17_HUMAN Increases Expression [9]
Inactive phospholipase D5 (PLD5) OTEVPYNY PLD5_HUMAN Decreases Expression [9]
BMP-binding endothelial regulator protein (BMPER) OTBYON4H BMPER_HUMAN Increases Expression [9]
Tandem C2 domains nuclear protein (TC2N) OT6482WN TAC2N_HUMAN Increases Expression [9]
Tetratricopeptide repeat protein 29 (TTC29) OT37KCUL TTC29_HUMAN Increases Expression [9]
Neuropilin and tolloid-like protein 2 (NETO2) OT0YAMC0 NETO2_HUMAN Decreases Expression [9]
Beta-galactosidase-1-like protein 3 (GLB1L3) OTWAWGX4 GLBL3_HUMAN Increases Expression [9]
Zinc finger protein GLIS3 (GLIS3) OTBC960E GLIS3_HUMAN Decreases Expression [9]
Interleukin-17 receptor D (IL17RD) OTKD9XST I17RD_HUMAN Decreases Expression [9]
Delta and Notch-like epidermal growth factor-related receptor (DNER) OT2GH2E5 DNER_HUMAN Increases Expression [9]
Semaphorin-6D (SEMA6D) OTU0UAZS SEM6D_HUMAN Decreases Expression [9]
LIM domain only protein 3 (LMO3) OTR7AJHN LMO3_HUMAN Decreases Expression [9]
DEP domain-containing mTOR-interacting protein (DEPTOR) OTCBP1BT DPTOR_HUMAN Increases Expression [9]
E3 ubiquitin-protein ligase RNF217 (RNF217) OTAX91ES RN217_HUMAN Increases Expression [9]
Ciliary microtubule-associated protein 3 (CIMAP3) OT8RL1WO CMAP3_HUMAN Increases Expression [9]
Mucolipin-3 (MCOLN3) OTCRPRVS MCLN3_HUMAN Increases Expression [9]
Grainyhead-like protein 3 homolog (GRHL3) OT1V4ZEH GRHL3_HUMAN Increases Expression [9]
DENN domain-containing protein 1A (DENND1A) OTONDAA0 DEN1A_HUMAN Decreases Expression [9]
Pleckstrin homology-like domain family A member 1 (PHLDA1) OTFTWMIQ PHLA1_HUMAN Increases Expression [9]
Secretogranin-3 (SCG3) OTUYSV2S SCG3_HUMAN Increases Expression [9]
Myosin-IIIb (MYO3B) OTVD4TNG MYO3B_HUMAN Increases Expression [9]
E3 ubiquitin-protein ligase MYLIP (MYLIP) OTL0PFGV MYLIP_HUMAN Increases Expression [9]
Transcription factor AP-2-beta (TFAP2B) OTR1T8E9 AP2B_HUMAN Increases Expression [9]
Piezo-type mechanosensitive ion channel component 1 (PIEZO1) OTBG1FU4 PIEZ1_HUMAN Decreases Expression [9]
Transcription factor AP-2 gamma (TFAP2C) OTUDIW05 AP2C_HUMAN Increases Expression [9]
Deleted in azoospermia-like (DAZL) OTZMTD4R DAZL_HUMAN Decreases Expression [9]
Stathmin-2 (STMN2) OT0FUHLH STMN2_HUMAN Increases Expression [9]
Sodium-coupled neutral amino acid transporter 4 (SLC38A4) OTV5OHBT S38A4_HUMAN Increases Expression [9]
Copine-4 (CPNE4) OTTAGM5L CPNE4_HUMAN Increases Expression [9]
Serine/threonine-protein kinase Sgk3 (SGK3) OTQ6QO99 SGK3_HUMAN Increases Expression [9]
Collagen triple helix repeat-containing protein 1 (CTHRC1) OTV88X2G CTHR1_HUMAN Increases Expression [9]
Ras-related protein Rab-3C (RAB3C) OTFTJNGA RAB3C_HUMAN Increases Expression [9]
BLOC-1-related complex subunit 8 (BORCS8) OTVRSVCB BORC8_HUMAN Increases Expression [9]
Serine dehydratase-like (SDSL) OTGZEAGJ SDSL_HUMAN Decreases Expression [9]
Calmodulin-like protein 4 (CALML4) OT6DD5EW CALL4_HUMAN Decreases Expression [9]
4-hydroxyphenylpyruvate dioxygenase-like protein (HPDL) OTW7D1SV HPDL_HUMAN Increases Expression [9]
Microtubule-associated protein 6 (MAP6) OTPUI00F MAP6_HUMAN Decreases Expression [9]
TOX high mobility group box family member 2 (TOX2) OT7RZRVK TOX2_HUMAN Decreases Expression [9]
Collagen alpha-1(XXI) chain (COL21A1) OT7GS82E COLA1_HUMAN Increases Expression [9]
Noelin-3 (OLFM3) OTBHPDTL NOE3_HUMAN Increases Expression [9]
Secretoglobin family 3A member 2 (SCGB3A2) OTB63PHR SG3A2_HUMAN Increases Expression [9]
DEP domain-containing protein 7 (DEPDC7) OT62C942 DEPD7_HUMAN Increases Expression [9]
MAP7 domain-containing protein 2 (MAP7D2) OTN85925 MA7D2_HUMAN Decreases Expression [9]
Glutamate decarboxylase 1 (GAD1) OT52Z39J DCE1_HUMAN Increases Expression [9]
Protein kinase C-binding protein NELL2 (NELL2) OTS4MJZ7 NELL2_HUMAN Decreases Expression [9]
Sphingosine 1-phosphate receptor 3 (S1PR3) OTXBIYO8 S1PR3_HUMAN Decreases Expression [9]
Neuroserpin (SERPINI1) OTUJHIJW NEUS_HUMAN Increases Expression [9]
Pituitary homeobox 2 (PITX2) OTWMXAOY PITX2_HUMAN Increases Expression [9]
Forkhead box protein C2 (FOXC2) OT83P1E0 FOXC2_HUMAN Increases Expression [9]
Retinoic acid receptor responder protein 2 (RARRES2) OT1BJE8K RARR2_HUMAN Increases Expression [9]
Semaphorin-3C (SEMA3C) OTEGUY7F SEM3C_HUMAN Increases Expression [9]
Microtubule-associated proteins 1A/1B light chain 3C (MAP1LC3C) OTM4ECDK MLP3C_HUMAN Increases Expression [9]
Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase (B3GNT5) OTA0DE43 B3GN5_HUMAN Decreases Expression [9]
Anoctamin-3 (ANO3) OTM34U6Q ANO3_HUMAN Increases Expression [9]
Iroquois-class homeodomain protein IRX-2 (IRX2) OTBHXXQ2 IRX2_HUMAN Increases Expression [9]
PR domain zinc finger protein 14 (PRDM14) OTWZKY4L PRD14_HUMAN Increases Expression [9]
AP-5 complex subunit mu-1 (AP5M1) OTDLWEBL AP5M1_HUMAN Increases Expression [9]
B-cell lymphoma/leukemia 11A (BCL11A) OTI6ZBP6 BC11A_HUMAN Increases Expression [9]
Serine/threonine-protein kinase TAO3 (TAOK3) OTYBATSH TAOK3_HUMAN Increases Expression [9]
Leucine-rich repeat neuronal protein 3 (LRRN3) OT7X0AA7 LRRN3_HUMAN Increases Expression [9]
SPARC-related modular calcium-binding protein 1 (SMOC1) OTJG2JQY SMOC1_HUMAN Decreases Expression [9]
Nuclear body protein SP140-like protein (SP140L) OTL30JKT SP14L_HUMAN Increases Expression [9]
Chondrolectin (CHODL) OTVCNOUQ CHODL_HUMAN Increases Expression [9]
Homeobox protein NANOG (NANOG) OTUEY1FM NANOG_HUMAN Increases Expression [9]
Adhesion G protein-coupled receptor L3 (ADGRL3) OT81Q8LY AGRL3_HUMAN Decreases Expression [9]
Roundabout homolog 2 (ROBO2) OTFJ9FQW ROBO2_HUMAN Decreases Expression [9]
Band 4.1-like protein 5 (EPB41L5) OTPPQPLU E41L5_HUMAN Increases Expression [9]
Olfactomedin-like protein 3 (OLFML3) OTDN45FN OLFL3_HUMAN Increases Expression [9]
Homer protein homolog 2 (HOMER2) OT4JGKJF HOME2_HUMAN Decreases Expression [9]
Muscleblind-like protein 3 (MBNL3) OT2T2YOK MBNL3_HUMAN Increases Expression [9]
Very long chain fatty acid elongase 2 (ELOVL2) OTDAF6U3 ELOV2_HUMAN Decreases Expression [9]
Dapper homolog 1 (DACT1) OT19Z704 DACT1_HUMAN Increases Expression [9]
Neuroligin-3 (NLGN3) OTKDEC1Q NLGN3_HUMAN Decreases Expression [9]
Myoferlin (MYOF) OTRFC3IJ MYOF_HUMAN Increases Expression [9]
Peroxisomal sarcosine oxidase (PIPOX) OTWTCOTN SOX_HUMAN Increases Expression [9]
Docking protein 5 (DOK5) OT2XWUPN DOK5_HUMAN Increases Expression [9]
Contactin-3 (CNTN3) OTC1274J CNTN3_HUMAN Decreases Expression [9]
Protocadherin-10 (PCDH10) OT2GIT0E PCD10_HUMAN Increases Expression [9]
Centrosomal protein of 126 kDa (CEP126) OTUMFEME CE126_HUMAN Increases Expression [9]
Hairy/enhancer-of-split related with YRPW motif protein 2 (HEY2) OTU4J3ZI HEY2_HUMAN Increases Expression [9]
Homeobox expressed in ES cells 1 (HESX1) OT5E2Z4G HESX1_HUMAN Decreases Expression [9]
Forkhead box protein D3 (FOXD3) OTXYV6GO FOXD3_HUMAN Increases Expression [9]
TRAF2 and NCK-interacting protein kinase (TNIK) OTDZBJ4K TNIK_HUMAN Increases Expression [9]
POU domain, class 2, transcription factor 3 (POU2F3) OTIOOJWD PO2F3_HUMAN Increases Expression [9]
Paraneoplastic antigen Ma2 (PNMA2) OTF5YBQG PNMA2_HUMAN Decreases Expression [9]
Protein HEG homolog 1 (HEG1) OT3CUXA7 HEG1_HUMAN Decreases Expression [9]
RING finger protein 150 (RNF150) OTAMSBK5 RN150_HUMAN Increases Expression [9]
Sex comb on midleg-like protein 1 (SCML1) OT7V5DAR SCML1_HUMAN Increases Expression [9]
LIM and calponin homology domains-containing protein 1 (LIMCH1) OTYPC4XA LIMC1_HUMAN Decreases Expression [9]
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A) OT74EK7Z PDE10_HUMAN Decreases Expression [9]
C-C motif chemokine 26 (CCL26) OT2B7HR9 CCL26_HUMAN Increases Expression [9]
Band 4.1-like protein 3 (EPB41L3) OTS6CHG2 E41L3_HUMAN Increases Expression [9]
Retinal homeobox protein Rx (RAX) OTJ3YCE7 RX_HUMAN Decreases Expression [9]
Beta/gamma crystallin domain-containing protein 1 (CRYBG1) OTIPDI15 CRBG1_HUMAN Increases Expression [9]
Neuropeptide FF receptor 2 (NPFFR2) OTVI4Q85 NPFF2_HUMAN Increases Expression [9]
Glypican-6 (GPC6) OTNJBESF GPC6_HUMAN Decreases Expression [9]
Adhesion G-protein coupled receptor G1 (ADGRG1) OTQBB8NT AGRG1_HUMAN Decreases Expression [9]
Solute carrier organic anion transporter family member 1B1 (SLCO1B1) OTNEN8QK SO1B1_HUMAN Increases Expression [9]
Dual specificity protein phosphatase 10 (DUSP10) OTNG467B DUS10_HUMAN Increases Expression [9]
KAT8 regulatory NSL complex subunit 1-like protein (KANSL1L) OTOAH2RR KAL1L_HUMAN Decreases Expression [10]
Cilia- and flagella-associated protein 119 (CFAP119) OT7PL1Q6 CF119_HUMAN Increases Expression [10]
Leucine-rich repeat-containing protein 10B (LRRC10B) OT9NKWFW LR10B_HUMAN Decreases Expression [10]
Collagen alpha-6(VI) chain (COL6A6) OT4MVGRW CO6A6_HUMAN Decreases Expression [10]
Sulfotransferase 1C2 (SULT1C2) OT07MMZS ST1C2_HUMAN Decreases Expression [10]
Acetyl-CoA carboxylase 2 (ACACB) OT96UIP1 ACACB_HUMAN Decreases Expression [10]
Homeobox protein CDX-4 (CDX4) OTD1SQKM CDX4_HUMAN Decreases Expression [10]
Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) OTPGHZB9 IFIT3_HUMAN Decreases Expression [10]
Ras-related protein Rab-7L1 (RAB29) OTDZT6LP RAB7L_HUMAN Increases Expression [10]
Synemin (SYNM) OTOI8TRJ SYNEM_HUMAN Decreases Expression [10]
A disintegrin and metalloproteinase with thrombospondin motifs 3 (ADAMTS3) OT2U6VF5 ATS3_HUMAN Decreases Expression [10]
Angiopoietin-2 (ANGPT2) OTEQK65P ANGP2_HUMAN Decreases Expression [10]
Cochlin (COCH) OTBEHD89 COCH_HUMAN Decreases Expression [10]
Maltase-glucoamylase (MGAM) OTVLMDUE MGA_HUMAN Decreases Expression [10]
Protocadherin-7 (PCDH7) OTP091X8 PCDH7_HUMAN Decreases Expression [10]
Protein tyrosine phosphatase type IVA 3 (PTP4A3) OTXMMWUN TP4A3_HUMAN Decreases Expression [10]
Src kinase-associated phosphoprotein 2 (SKAP2) OTSF44KP SKAP2_HUMAN Increases Expression [10]
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial (GCAT) OT6WZPWV KBL_HUMAN Decreases Expression [10]
UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 (B3GALNT1) OT8GFSQL B3GL1_HUMAN Decreases Expression [10]
Stanniocalcin-2 (STC2) OT86YP8G STC2_HUMAN Decreases Expression [10]
Kelch-like protein 18 (KLHL18) OTX7NOSM KLH18_HUMAN Increases Expression [10]
RCC1 and BTB domain-containing protein 2 (RCBTB2) OTECBF4R RCBT2_HUMAN Decreases Expression [10]
ATP-binding cassette sub-family C member 6 (ABCC6) OTZT0LKT MRP6_HUMAN Decreases Expression [10]
Coagulation factor XIII A chain (F13A1) OTO8O184 F13A_HUMAN Increases Expression [10]
Coagulation factor X (F10) OT2BLK17 FA10_HUMAN Decreases Expression [10]
Plasminogen (PLG) OTWWIPPY PLMN_HUMAN Decreases Expression [10]
Alpha-1-antitrypsin (SERPINA1) OTACYW9J A1AT_HUMAN Decreases Expression [10]
HLA class I histocompatibility antigen, B alpha chain (HLA-B) OTNXFWY2 HLAB_HUMAN Increases Expression [10]
Hemoglobin subunit epsilon (HBE1) OTJPKMX4 HBE_HUMAN Decreases Expression [10]
Apolipoprotein C-I (APOC1) OTA58CED APOC1_HUMAN Decreases Expression [10]
Hemopexin (HPX) OT14T7Q1 HEMO_HUMAN Decreases Expression [10]
Platelet-derived growth factor subunit A (PDGFA) OTCMZ0W8 PDGFA_HUMAN Decreases Expression [10]
Trefoil factor 1 (TFF1) OTCYQH4F TFF1_HUMAN Decreases Expression [10]
Fructose-bisphosphate aldolase B (ALDOB) OT7FR69A ALDOB_HUMAN Decreases Expression [10]
Thyroxine-binding globulin (SERPINA7) OTUYVTSU THBG_HUMAN Decreases Expression [10]
Fatty acid-binding protein, liver (FABP1) OTR34ETM FABPL_HUMAN Decreases Expression [10]
Asialoglycoprotein receptor 1 (ASGR1) OTS99MJO ASGR1_HUMAN Decreases Expression [10]
Asparagine synthetase (ASNS) OT8R922G ASNS_HUMAN Decreases Expression [10]
Homeobox protein Hox-D4 (HOXD4) OTQR4WCG HXD4_HUMAN Increases Expression [10]
Annexin A4 (ANXA4) OTUCRYXL ANXA4_HUMAN Decreases Expression [10]
Cystic fibrosis transmembrane conductance regulator (CFTR) OT6B22QH CFTR_HUMAN Decreases Expression [10]
Tartrate-resistant acid phosphatase type 5 (ACP5) OTBV4498 PPA5_HUMAN Decreases Expression [10]
Folate receptor alpha (FOLR1) OT0QZ0H6 FOLR1_HUMAN Decreases Expression [10]
Integrin alpha-2 (ITGA2) OTPFL017 ITA2_HUMAN Increases Expression [10]
HLA class II histocompatibility antigen, DP alpha 1 chain (HLA-DPA1) OT7OG7Y2 DPA1_HUMAN Decreases Expression [10]
Aromatic-L-amino-acid decarboxylase (DDC) OT0TSW09 DDC_HUMAN Decreases Expression [10]
Carbonic anhydrase 4 (CA4) OT3K93LZ CAH4_HUMAN Decreases Expression [10]
Sodium-dependent noradrenaline transporter (SLC6A2) OTMHQJMP SC6A2_HUMAN Increases Expression [10]
Interleukin-4 receptor subunit alpha (IL4R) OTTXOTCW IL4RA_HUMAN Decreases Expression [10]
Atypical chemokine receptor 3 (ACKR3) OTA6GA4F ACKR3_HUMAN Increases Expression [10]
Integrin alpha-3 (ITGA3) OTBCH21D ITA3_HUMAN Decreases Expression [10]
Tyrosine-protein phosphatase non-receptor type 3 (PTPN3) OTSLZBVY PTN3_HUMAN Decreases Expression [10]
Leukocyte elastase inhibitor (SERPINB1) OT5RDUFO ILEU_HUMAN Decreases Expression [10]
Homeobox protein Hox-D3 (HOXD3) OTBUZ35T HXD3_HUMAN Increases Expression [10]
Fibrillin-1 (FBN1) OTYCJT63 FBN1_HUMAN Decreases Expression [10]
Glutamate receptor ionotropic, kainate 1 (GRIK1) OTO19X5C GRIK1_HUMAN Increases Expression [10]
Pre-B-cell leukemia transcription factor 2 (PBX2) OTEBYCAW PBX2_HUMAN Decreases Expression [10]
ETS translocation variant 5 (ETV5) OTE2OBM4 ETV5_HUMAN Decreases Expression [10]
Mitogen-activated protein kinase kinase kinase 8 (MAP3K8) OTOZTA1F M3K8_HUMAN Increases Expression [10]
Glutamate receptor 3 (GRIA3) OT34CNBR GRIA3_HUMAN Increases Expression [10]
Cathepsin O (CTSO) OTFL6VRO CATO_HUMAN Decreases Expression [10]
Cathepsin K (CTSK) OTT3YX5O CATK_HUMAN Decreases Expression [10]
G protein-coupled receptor kinase 6 (GRK6) OT4LZTP9 GRK6_HUMAN Decreases Expression [10]
Stromal cell-derived factor 1 (CXCL12) OT2QX5LL SDF1_HUMAN Decreases Expression [10]
Flavin-containing monooxygenase 5 (FMO5) OTTILF8T FMO5_HUMAN Decreases Expression [10]
Inositol polyphosphate 1-phosphatase (INPP1) OTHSJCRQ INPP_HUMAN Decreases Expression [10]
Retinoic acid receptor responder protein 1 (RARRES1) OTETUPP5 TIG1_HUMAN Decreases Expression [10]
Type I iodothyronine deiodinase (DIO1) OTFYLYJ0 IOD1_HUMAN Decreases Expression [10]
5-formyltetrahydrofolate cyclo-ligase (MTHFS) OTZ39JNR MTHFS_HUMAN Decreases Expression [10]
Arylsulfatase D (ARSD) OTAHW9M8 ARSD_HUMAN Decreases Expression [10]
G-protein coupled receptor 143 (GPR143) OTWUA2AV GP143_HUMAN Decreases Expression [10]
Pancreatic lipase-related protein 2 (PNLIPRP2) OTJG6BA7 LIPR2_HUMAN Decreases Expression [10]
Tyrosine-protein phosphatase non-receptor type 5 (PTPN5) OT2H1KDK PTN5_HUMAN Decreases Expression [10]
Proteinase-activated receptor 2 (F2RL1) OTMRMJ8N PAR2_HUMAN Decreases Expression [10]
Hormonally up-regulated neu tumor-associated kinase (HUNK) OTZR4GBH HUNK_HUMAN Decreases Expression [10]
F-box/WD repeat-containing protein 4 (FBXW4) OTEGSZOX FBXW4_HUMAN Decreases Expression [10]
Clarin-1 (CLRN1) OT1ADI7Q CLRN1_HUMAN Increases Expression [10]
Beta-defensin 1 (DEFB1) OT5SV0E4 DEFB1_HUMAN Decreases Expression [10]
DDB1- and CUL4-associated factor 7 (DCAF7) OT3W5DYL DCAF7_HUMAN Increases Expression [10]
Inward rectifier potassium channel 2 (KCNJ2) OT2OQEZS KCNJ2_HUMAN Decreases Expression [10]
POU domain, class 6, transcription factor 2 (POU6F2) OTNSW95F PO6F2_HUMAN Increases Expression [10]
Protein crumbs homolog 1 (CRB1) OTXYUNG0 CRUM1_HUMAN Increases Expression [10]
Fibulin-2 (FBLN2) OTEHR7N7 FBLN2_HUMAN Decreases Expression [10]
Cyclin-dependent kinase 3 (CDK3) OT2GP6RL CDK3_HUMAN Decreases Expression [10]
AMP deaminase 3 (AMPD3) OT5SP1KJ AMPD3_HUMAN Decreases Expression [10]
Trefoil factor 2 (TFF2) OTRXB19X TFF2_HUMAN Decreases Expression [10]
1,4-alpha-glucan-branching enzyme (GBE1) OTK2N05B GLGB_HUMAN Decreases Expression [10]
Aldehyde oxidase (AOX1) OT2FZP6H AOXA_HUMAN Decreases Expression [10]
Sulfotransferase 2A1 (SULT2A1) OT0ISKQ4 ST2A1_HUMAN Decreases Expression [10]
Filensin (BFSP1) OTXZ3YIU BFSP1_HUMAN Decreases Expression [10]
Semaphorin-3B (SEMA3B) OTCZCPMS SEM3B_HUMAN Decreases Expression [10]
Semaphorin-3F (SEMA3F) OTQFMS8S SEM3F_HUMAN Decreases Expression [10]
Caprin-1 (CAPRIN1) OTEJAMS3 CAPR1_HUMAN Decreases Expression [10]
Sarcospan (SSPN) OTYG2SL7 SSPN_HUMAN Decreases Expression [10]
Cytohesin-1 (CYTH1) OTYH9NRJ CYH1_HUMAN Decreases Expression [10]
NT-3 growth factor receptor (NTRK3) OTII30MY NTRK3_HUMAN Increases Expression [10]
Melanoma antigen recognized by T-cells 1 (MLANA) OT1N2S2K MAR1_HUMAN Decreases Expression [10]
Interphotoreceptor matrix proteoglycan 1 (IMPG1) OT12HBL0 IMPG1_HUMAN Increases Expression [10]
Protein Shroom1 (SHROOM1) OTUP99ZD SHRM1_HUMAN Decreases Expression [10]
Transmembrane protein 44 (TMEM44) OTRUF467 TMM44_HUMAN Decreases Expression [10]
Hexokinase HKDC1 (HKDC1) OTTHDMBM HKDC1_HUMAN Decreases Expression [10]
Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2 (ITPRIPL2) OTSSP13W IPIL2_HUMAN Decreases Expression [10]
Membrane protein FAM174B (FAM174B) OT1SCOTY F174B_HUMAN Decreases Expression [10]
OCIA domain-containing protein 2 (OCIAD2) OTSWB4SZ OCAD2_HUMAN Decreases Expression [10]
UMP-CMP kinase 2, mitochondrial (CMPK2) OTOG90R0 CMPK2_HUMAN Decreases Expression [10]
FRAS1-related extracellular matrix protein 1 (FREM1) OTMHRV87 FREM1_HUMAN Decreases Expression [10]
Calcium homeostasis modulator protein 6 (CALHM6) OTLX9B4Y CAHM6_HUMAN Decreases Expression [10]
Putative hydroxypyruvate isomerase (HYI) OTFPNOTN HYI_HUMAN Decreases Expression [10]
Probable gluconokinase (IDNK) OT5ZC54L GNTK_HUMAN Decreases Expression [10]
Dynein regulatory complex protein 8 (EFCAB2) OTXEFI4O DRC8_HUMAN Decreases Expression [10]
Little elongation complex subunit 2 (ICE2) OTJ3BXND ICE2_HUMAN Increases Expression [10]
Polypeptide N-acetylgalactosaminyltransferase 17 (GALNT17) OTMF0W2U GLT17_HUMAN Decreases Expression [10]
Serine/threonine-protein phosphatase 4 regulatory subunit 4 (PPP4R4) OTKZDDIF PP4R4_HUMAN Increases Expression [10]
Transmembrane protein 220 (TMEM220) OTGTRDNX TM220_HUMAN Decreases Expression [10]
Sushi domain-containing protein 1 (SUSD1) OTR3UGLY SUSD1_HUMAN Decreases Expression [10]
Thiol S-methyltransferase TMT1B (TMT1B) OTP0QOAL TMT1B_HUMAN Decreases Expression [10]
Gliomedin (GLDN) OTA8TQU9 GLDN_HUMAN Increases Expression [10]
Refilin-A (RFLNA) OT6GS3XQ RFLA_HUMAN Decreases Expression [10]
Protein CFAP20DC (CFAP20DC) OTVOREMP CF20D_HUMAN Increases Expression [10]
Fibrillin-3 (FBN3) OTEWLXTH FBN3_HUMAN Decreases Expression [10]
Cytoplasmic FMR1-interacting protein 1 (CYFIP1) OTOBEH24 CYFP1_HUMAN Decreases Expression [10]
Carbohydrate sulfotransferase 15 (CHST15) OTNTM2SP CHSTF_HUMAN Increases Expression [10]
Neuronal growth regulator 1 (NEGR1) OT57ECW9 NEGR1_HUMAN Increases Expression [10]
Microtubule organization protein AKNA (AKNA) OTQ6E2C8 AKNA_HUMAN Decreases Expression [10]
E3 ubiquitin-protein ligase RNF180 (RNF180) OT2GKIKE RN180_HUMAN Decreases Expression [10]
Hyaluronan and proteoglycan link protein 4 (HAPLN4) OTZQOG9A HPLN4_HUMAN Decreases Expression [10]
Proline-rich membrane anchor 1 (PRIMA1) OT9ITT3P PRIMA_HUMAN Decreases Expression [10]
Enoyl-CoA hydratase domain-containing protein 2, mitochondrial (ECHDC2) OTL0DWCO ECHD2_HUMAN Decreases Expression [10]
L-seryl-tRNA(Sec) kinase (PSTK) OTA5UXAX PSTK_HUMAN Decreases Expression [10]
Protein mono-ADP-ribosyltransferase PARP9 (PARP9) OT7K4494 PARP9_HUMAN Decreases Expression [10]
Solute carrier family 35 member F3 (SLC35F3) OTAOBKBG S35F3_HUMAN Decreases Expression [10]
Ribonuclease SLFN12 (SLFN12) OTTBXM25 SLN12_HUMAN Increases Expression [10]
UPF0462 protein C4orf33 (C4ORF33) OT3O3FC3 CD033_HUMAN Increases Expression [10]
Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 (PYROXD2) OTJIX22S PYRD2_HUMAN Decreases Expression [10]
T-cell activation inhibitor, mitochondrial (TCAIM) OTOBD7YO TCAIM_HUMAN Decreases Expression [10]
Choline transporter-like protein 3 (SLC44A3) OTL0FT8L CTL3_HUMAN Decreases Expression [10]
Dynein light chain Tctex-type 5 (DYNLT5) OTDM1DWJ DYLT5_HUMAN Increases Expression [10]
Proprotein convertase subtilisin/kexin type 9 (PCSK9) OTI0DU9Y PCSK9_HUMAN Decreases Expression [10]
Clarin-3 (CLRN3) OTZDNL65 CLRN3_HUMAN Decreases Expression [10]
Putative methyltransferase NSUN7 (NSUN7) OTDTL9UE NSUN7_HUMAN Decreases Expression [10]
Phospholipid phosphatase 5 (PLPP5) OTHT51D6 PLPP5_HUMAN Decreases Expression [10]
Interleukin-17D (IL17D) OTMBLLRF IL17D_HUMAN Decreases Expression [10]
E3 ubiquitin-protein ligase DTX3L (DTX3L) OTCCO2QZ DTX3L_HUMAN Decreases Expression [10]
CDK5 and ABL1 enzyme substrate 1 (CABLES1) OTMN4XSX CABL1_HUMAN Decreases Expression [10]
Serine/threonine-protein kinase 32A (STK32A) OTONYLYO ST32A_HUMAN Decreases Expression [10]
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 (ARAP3) OTUWZTH7 ARAP3_HUMAN Decreases Expression [10]
Nanos homolog 1 (NANOS1) OT3UNZZY NANO1_HUMAN Decreases Expression [10]
Lysophosphatidic acid receptor 1 (LPAR1) OTJNJQPF LPAR1_HUMAN Decreases Expression [10]
Histone-lysine N-methyltransferase EZH1 (EZH1) OTFLUU94 EZH1_HUMAN Increases Expression [10]
Peroxisomal membrane protein PEX13 (PEX13) OTXUAYEW PEX13_HUMAN Increases Expression [10]
Homogentisate 1,2-dioxygenase (HGD) OTTKLQOO HGD_HUMAN Decreases Expression [10]
Collagen alpha-1(XXVI) chain (COL26A1) OTMS7RNF COQA1_HUMAN Decreases Expression [10]
Dedicator of cytokinesis protein 10 (DOCK10) OTI3MBLV DOC10_HUMAN Decreases Expression [10]
Copine-2 (CPNE2) OTPESEM5 CPNE2_HUMAN Decreases Expression [10]
Coiled-coil domain-containing protein 34 (CCDC34) OTZ3AGSQ CCD34_HUMAN Increases Expression [10]
Fatty acyl-CoA reductase 2 (FAR2) OTRYY709 FACR2_HUMAN Decreases Expression [10]
Adenylate kinase 7 (AK7) OTASZDJN KAD7_HUMAN Increases Expression [10]
Sodium channel and clathrin linker 1 (SCLT1) OT2ZSSP4 SCLT1_HUMAN Increases Expression [10]
Erythroid membrane-associated protein (ERMAP) OTKXBB52 ERMAP_HUMAN Decreases Expression [10]
Tribbles homolog 3 (TRIB3) OTG5OS7X TRIB3_HUMAN Decreases Expression [10]
Glutathione peroxidase 7 (GPX7) OTINT9Z4 GPX7_HUMAN Decreases Expression [10]
Mitogen-activated protein kinase kinase kinase 5 (MAP3K5) OTQR6ENW M3K5_HUMAN Decreases Expression [10]
Melanin-concentrating hormone receptor 1 (MCHR1) OTT57EOE MCHR1_HUMAN Decreases Expression [10]
Dual specificity protein phosphatase 9 (DUSP9) OTZZWEQL DUS9_HUMAN Decreases Expression [10]
NAD-capped RNA hydrolase NUDT12 (NUDT12) OTBUY58C NUD12_HUMAN Increases Expression [10]
Mitochondrial 2-oxodicarboxylate carrier (SLC25A21) OTB78IF4 ODC_HUMAN Decreases Expression [10]
MARVEL domain-containing protein 1 (MARVELD1) OT5CPOJE MALD1_HUMAN Decreases Expression [10]
Spexin (SPX) OTY3G4AR SPXN_HUMAN Decreases Expression [10]
Acireductone dioxygenase (ADI1) OT8IOD03 MTND_HUMAN Decreases Expression [10]
Caspase recruitment domain-containing protein 10 (CARD10) OT2RPM4I CAR10_HUMAN Decreases Expression [10]
Contactin-associated protein-like 4 (CNTNAP4) OTKXR9AW CNTP4_HUMAN Decreases Expression [10]
Glycosyltransferase 8 domain-containing protein 2 (GLT8D2) OT4VS9YY GL8D2_HUMAN Decreases Expression [10]
Cytosolic beta-glucosidase (GBA3) OT86XWU2 GBA3_HUMAN Decreases Expression [10]
Lysine-specific demethylase 4C (KDM4C) OT2RHV9S KDM4C_HUMAN Increases Expression [10]
NIPA-like protein 2 (NIPAL2) OTX9UREP NPAL2_HUMAN Decreases Expression [10]
Sialate O-acetylesterase (SIAE) OTDQUESH SIAE_HUMAN Increases Expression [10]
Pleckstrin homology domain-containing family A member 2 (PLEKHA2) OTY2AP6T PKHA2_HUMAN Decreases Expression [10]
Beta-parvin (PARVB) OT9OGVWX PARVB_HUMAN Decreases Expression [10]
3',5'-cyclic-AMP phosphodiesterase 7B (PDE7B) OTK3SHT2 PDE7B_HUMAN Increases Expression [10]
Cell death regulator Aven (AVEN) OTGIN5YK AVEN_HUMAN Decreases Expression [10]
Rho guanine nucleotide exchange factor 4 (ARHGEF4) OTR2VG0W ARHG4_HUMAN Decreases Expression [10]
Interleukin-17 receptor B (IL17RB) OT0KDNSF I17RB_HUMAN Decreases Expression [10]
Probable G-protein coupled receptor 27 (GPR27) OTH4KQPI GPR27_HUMAN Decreases Expression [10]
Transmembrane protein 51 (TMEM51) OTZCW8XJ TMM51_HUMAN Decreases Expression [10]
24-hydroxycholesterol 7-alpha-hydroxylase (CYP39A1) OTBAJT4I CP39A_HUMAN Increases Expression [10]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (PLCE1) OTJISZOX PLCE1_HUMAN Decreases Expression [10]
Doublecortin domain-containing protein 2 (DCDC2) OTSUFH1H DCDC2_HUMAN Decreases Expression [10]
Cadherin-9 (CDH9) OTV9N5XK CADH9_HUMAN Decreases Expression [10]
Long-chain-fatty-acid--CoA ligase 5 (ACSL5) OT3L9XO3 ACSL5_HUMAN Decreases Expression [10]
Mammalian ependymin-related protein 1 (EPDR1) OT5JW5RB EPDR1_HUMAN Decreases Expression [10]
Cystine/glutamate transporter (SLC7A11) OTKJ6PXW XCT_HUMAN Decreases Expression [10]
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9 (FUT9) OTLIJBQY FUT9_HUMAN Increases Expression [10]
Sorting nexin-10 (SNX10) OT05B7BT SNX10_HUMAN Decreases Expression [10]
CCN family member 1 (CCN1) OTKJBEMD CCN1_HUMAN Increases Expression [11]
Bcl-2-like protein 11 (BCL2L11) OTNQQWFJ B2L11_HUMAN Increases Expression [14]
Insulin-like growth factor I (IGF1) OTIIZR61 IGF1_HUMAN Increases Expression [11]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Increases Expression [11]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Cleavage [14]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Increases Expression [11]
Nuclear factor NF-kappa-B p105 subunit (NFKB1) OTNRRD8I NFKB1_HUMAN Increases Expression [14]
NF-kappa-B inhibitor alpha (NFKBIA) OTFT924M IKBA_HUMAN Increases Expression [14]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Increases Phosphorylation [11]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Cleavage [14]
Glycogen synthase kinase-3 beta (GSK3B) OTL3L14B GSK3B_HUMAN Increases Phosphorylation [11]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Increases Cleavage [15]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Increases Cleavage [14]
Transforming growth factor beta-2 proprotein (TGFB2) OTC0TXEP TGFB2_HUMAN Increases Expression [11]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Increases Acetylation [14]
------------------------------------------------------------------------------------
⏷ Show the Full List of 566 DOT(s)
Indication(s) of Idarubicin
Disease Entry ICD 11 Status REF
Acute myelogenous leukaemia 2A41 Approved [5]
Acute myeloid leukaemia 2A60 Approved [6]
Adult acute monocytic leukemia N.A. Approved [5]
Childhood acute megakaryoblastic leukemia N.A. Approved [5]
Leukemia N.A. Approved [5]
Idarubicin Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
DNA topoisomerase II (TOP2) TT0IHXV TOP2A_HUMAN; TOP2B_HUMAN Modulator [17]
------------------------------------------------------------------------------------
Idarubicin Interacts with 3 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
Multidrug resistance-associated protein 1 (ABCC1) DTSYQGK MRP1_HUMAN Substrate [18]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [19]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [19]
------------------------------------------------------------------------------------
Idarubicin Interacts with 2 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Metabolism [20]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Metabolism [20]
------------------------------------------------------------------------------------
Idarubicin Interacts with 9 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Estrogen receptor (ESR1) OTKLU61J ESR1_HUMAN Decreases Activity [16]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Increases Expression [21]
Androgen receptor (AR) OTUBKAZZ ANDR_HUMAN Increases Activity [16]
Natriuretic peptides B (NPPB) OTSN2IPY ANFB_HUMAN Increases Expression [22]
Peroxisome proliferator-activated receptor gamma (PPARG) OTHMARHO PPARG_HUMAN Decreases Activity [16]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Activity [23]
Peroxisome proliferator-activated receptor delta (PPARD) OTI4WTOP PPARD_HUMAN Decreases Activity [16]
Potassium voltage-gated channel subfamily H member 2 (KCNH2) OTZX881H KCNH2_HUMAN Decreases Activity [24]
Bile acid receptor (NR1H4) OTWZLPTB NR1H4_HUMAN Decreases Activity [16]
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⏷ Show the Full List of 9 DOT(s)

References

1 ClinicalTrials.gov (NCT00878722) Trial of PXD101 (Belinostat) in Combination With Idarubicin to Treat AML Not Suitable for Standard Intensive Therapy
2 Belinostat FDA Label
3 A Phase II trial of Belinostat (PXD101) in patients with relapsed or refractory peripheral or cutaneous T-cell lymphoma. Br J Haematol. 2015 Mar;168(6):811-9.
4 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5 Idarubicin FDA Label
6 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7083).
7 Glucuronidation by UGT1A1 is the dominant pathway of the metabolic disposition of belinostat in liver cancer patients. PLoS One. 2013;8(1):e54522.
8 Gene expression-signature of belinostat in cell lines is specific for histone deacetylase inhibitor treatment, with a corresponding signature in xenografts. Anticancer Drugs. 2009 Sep;20(8):682-92.
9 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
10 Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
11 Histone acetylation-mediated regulation of the Hippo pathway. PLoS One. 2013 May 6;8(5):e62478. doi: 10.1371/journal.pone.0062478. Print 2013.
12 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
13 Effects of UGT1A1 genotype on the pharmacokinetics, pharmacodynamics, and toxicities of belinostat administered by 48-hour continuous infusion in patients with cancer. J Clin Pharmacol. 2016 Apr;56(4):461-73.
14 Interactions between bortezomib and romidepsin and belinostat in chronic lymphocytic leukemia cells. Clin Cancer Res. 2008 Jan 15;14(2):549-58. doi: 10.1158/1078-0432.CCR-07-1934.
15 Raloxifene induces autophagy-dependent cell death in breast cancer cells via the activation of AMP-activated protein kinase. Mol Cells. 2015;38(2):138-44. doi: 10.14348/molcells.2015.2193. Epub 2014 Dec 24.
16 Quantitative high-throughput profiling of environmental chemicals and drugs that modulate farnesoid X receptor. Sci Rep. 2014 Sep 26;4:6437. doi: 10.1038/srep06437.
17 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
18 Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007.
19 Amonafide L-malate is not a substrate for multidrug resistance proteins in secondary acute myeloid leukemia. Leukemia. 2008 Nov;22(11):2110-5.
20 In vitro evaluation of cytochrome P450-mediated drug interactions between cytarabine, idarubicin, itraconazole and caspofungin. Hematology. 2004 Jun;9(3):217-21.
21 A Quantitative Approach to Screen for Nephrotoxic Compounds In Vitro. J Am Soc Nephrol. 2016 Apr;27(4):1015-28. doi: 10.1681/ASN.2015010060. Epub 2015 Aug 10.
22 The use of biochemical markers in cardiotoxicity monitoring in patients treated for leukemia. Neoplasma. 2005;52(5):430-4.
23 The induction of apoptosis by daunorubicin and idarubicin in human trisomic and diabetic fibroblasts. Cell Mol Biol Lett. 2008;13(2):182-94. doi: 10.2478/s11658-007-0045-7. Epub 2008 Apr 10.
24 Refining the human iPSC-cardiomyocyte arrhythmic risk assessment model. Toxicol Sci. 2013 Dec;136(2):581-94. doi: 10.1093/toxsci/kft205. Epub 2013 Sep 19.