Details of the Drug Combination

General Information of Drug Combination (ID: DCLDN0X)

• Drug Combination Name: PDX-101 + Vincristine
• Indication: Peripheral T-cell Lymphoma; Status: Phase 1 [1]
• Component Drugs:
  PDX-101 (DM6OC53): Small molecular drug
  Vincristine (DMINOX3): Small molecular drug

Molecular Interaction Atlas of This Drug Combination

Indication(s) of PDX-101

Disease Entry	ICD 11	Status	REF
Plasma cell myeloma	2A83.1	Approved	[2]
Primary cutaneous peripheral T-cell lymphoma not otherwise specified	N.A.	Approved	[2]
Primary cutaneous T-cell lymphoma	N.A.	Approved	[2]
Solid tumour/cancer	2A00-2F9Z	Phase 2	[3]
Haematological malignancy	2B33.Y	Phase 1	[4]
Peripheral T-cell lymphoma	2A90.C	Phase 1	[4]

PDX-101 Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Histone deacetylase (HDAC)	TTBH0VX	NOUNIPROTAC	Modulator	[12]

PDX-101 Interacts with 2 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[7]
UDP-glucuronosyltransferase 1A1 (UGT1A1)	DEYGVN4	UD11_HUMAN	Metabolism	[13]

PDX-101 Interacts with 566 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Aurora kinase A (AURKA)	OTMX0HYT	AURKA_HUMAN	Decreases Expression	[8]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Decreases Expression	[8]
Transforming acidic coiled-coil-containing protein 1 (TACC1)	OTGX20TE	TACC1_HUMAN	Increases Expression	[8]
Tyrosine-protein kinase ABL1 (ABL1)	OT09YVXH	ABL1_HUMAN	Decreases Expression	[8]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Decreases Expression	[8]
Cyclin-dependent kinase 1 (CDK1)	OTW1SC2N	CDK1_HUMAN	Decreases Expression	[8]
Histone H1.0 (H1-0)	OTRLJK4Z	H10_HUMAN	Increases Expression	[8]
Clusterin (CLU)	OTQGG0JM	CLUS_HUMAN	Increases Expression	[8]
Cyclin-dependent kinase 4 (CDK4)	OT7EP05T	CDK4_HUMAN	Decreases Expression	[8]
Ornithine decarboxylase (ODC1)	OTNDAGRR	DCOR_HUMAN	Increases Expression	[8]
G2/mitotic-specific cyclin-B1 (CCNB1)	OT19S7E5	CCNB1_HUMAN	Decreases Expression	[8]
Interferon gamma receptor 1 (IFNGR1)	OTCTQBWW	INGR1_HUMAN	Increases Expression	[8]
CTP synthase 1 (CTPS1)	OTZ9J6ZG	PYRG1_HUMAN	Decreases Expression	[8]
Cyclin-A2 (CCNA2)	OTPHHYZJ	CCNA2_HUMAN	Decreases Expression	[8]
Diamine acetyltransferase 1 (SAT1)	OT52AU22	SAT1_HUMAN	Increases Expression	[8]
DNA replication licensing factor MCM3 (MCM3)	OTOOHQPM	MCM3_HUMAN	Decreases Expression	[8]
DnaJ homolog subfamily B member 1 (DNAJB1)	OTCOSEVH	DNJB1_HUMAN	Increases Expression	[8]
Multifunctional protein CAD (CAD)	OTNCUYYE	PYR1_HUMAN	Decreases Expression	[8]
CCN family member 2 (CCN2)	OTC39NSU	CCN2_HUMAN	Increases Expression	[8]
M-phase inducer phosphatase 2 (CDC25B)	OT12MSRY	MPIP2_HUMAN	Decreases Expression	[8]
DNA replication licensing factor MCM7 (MCM7)	OT6FXC6K	MCM7_HUMAN	Decreases Expression	[8]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Increases Expression	[8]
Cyclin-dependent kinase inhibitor 2A (CDKN2A)	OTN0ZWAE	CDN2A_HUMAN	Decreases Expression	[8]
GTP-binding nuclear protein Ran (RAN)	OT2TER5M	RAN_HUMAN	Decreases Expression	[8]
Ras-related C3 botulinum toxin substrate 1 (RAC1)	OTKRO61U	RAC1_HUMAN	Decreases Expression	[8]
Eukaryotic translation initiation factor 4 gamma 2 (EIF4G2)	OTEO98CR	IF4G2_HUMAN	Decreases Expression	[8]
Dehydrogenase/reductase SDR family member 2, mitochondrial (DHRS2)	OTFHWIY8	DHRS2_HUMAN	Increases Expression	[8]
Kelch-like ECH-associated protein 1 (KEAP1)	OTFHOD0C	KEAP1_HUMAN	Decreases Expression	[8]
Importin subunit beta-1 (KPNB1)	OTBT2HFL	IMB1_HUMAN	Decreases Expression	[8]
Retrotransposon-derived protein PEG10 (PEG10)	OTWD2278	PEG10_HUMAN	Increases Expression	[8]
Histone H1.10 (H1-10)	OTBWDA4E	H1X_HUMAN	Increases Expression	[8]
Aurora kinase B (AURKB)	OTIY4VHU	AURKB_HUMAN	Decreases Expression	[8]
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)	OTUYHB84	MLP3B_HUMAN	Increases Expression	[8]
Inner centromere protein (INCENP)	OT9HFRYK	INCE_HUMAN	Decreases Expression	[8]
Nucleolar RNA helicase 2 (DDX21)	OTV73GMZ	DDX21_HUMAN	Decreases Expression	[8]
Bcl-2-associated transcription factor 1 (BCLAF1)	OT7T8H6A	BCLF1_HUMAN	Decreases Expression	[8]
Protein RCC2 (RCC2)	OTUJVTLS	RCC2_HUMAN	Decreases Expression	[8]
Targeting protein for Xklp2 (TPX2)	OTWLJYH0	TPX2_HUMAN	Decreases Expression	[8]
Proliferation-associated protein 2G4 (PA2G4)	OT7IG7HT	PA2G4_HUMAN	Decreases Expression	[8]
Rho guanine nucleotide exchange factor 37 (ARHGEF37)	OTXQSCDO	ARH37_HUMAN	Decreases Expression	[9]
Homeobox protein HMX2 (HMX2)	OTBRXY6D	HMX2_HUMAN	Increases Expression	[9]
Developmental pluripotency-associated 5 protein (DPPA5)	OTLZC371	DPPA5_HUMAN	Increases Expression	[9]
RNA binding protein fox-1 homolog 3 (RBFOX3)	OTL0F3D6	RFOX3_HUMAN	Decreases Expression	[9]
Transmembrane protein 221 (TMEM221)	OTNSYQ3L	TM221_HUMAN	Decreases Expression	[9]
Coiled-coil domain-containing protein 69 (CCDC69)	OT43MI0R	CCD69_HUMAN	Increases Expression	[9]
Rab GTPase-activating protein 1-like, isoform 10 (RABGAP1L)	OT7QO47I	RBG10_HUMAN	Increases Expression	[9]
Suppressyn (ERVH48-1)	OT303JGE	SUPYN_HUMAN	Increases Expression	[9]
PDZ and LIM domain protein 1 (PDLIM1)	OT4EGCPG	PDLI1_HUMAN	Increases Expression	[9]
Bone morphogenetic protein receptor type-1B (BMPR1B)	OTGFN0OD	BMR1B_HUMAN	Decreases Expression	[9]
Beta-1,3-N-acetylglucosaminyltransferase manic fringe (MFNG)	OTUX45ZF	MFNG_HUMAN	Decreases Expression	[9]
Podocalyxin (PODXL)	OTPNQXF3	PODXL_HUMAN	Increases Expression	[9]
Astrotactin-1 (ASTN1)	OT23FQIB	ASTN1_HUMAN	Decreases Expression	[9]
Suppressor of cytokine signaling 3 (SOCS3)	OTY183WJ	SOCS3_HUMAN	Decreases Expression	[9]
Neurocan core protein (NCAN)	OT8OO6ZE	NCAN_HUMAN	Decreases Expression	[9]
Neuropilin-1 (NRP1)	OTCGULYV	NRP1_HUMAN	Increases Expression	[9]
Semaphorin-3E (SEMA3E)	OTD4S36H	SEM3E_HUMAN	Increases Expression	[9]
Synaptojanin-2 (SYNJ2)	OTLRHXP1	SYNJ2_HUMAN	Decreases Expression	[9]
DNA-directed RNA polymerase III subunit RPC7 (POLR3G)	OTU3TGQ9	RPC7_HUMAN	Increases Expression	[9]
Cytochrome P450 26A1 (CYP26A1)	OTL1DFWV	CP26A_HUMAN	Increases Expression	[9]
Disintegrin and metalloproteinase domain-containing protein 12 (ADAM12)	OTZKOTDB	ADA12_HUMAN	Decreases Expression	[9]
Phospholipid-transporting ATPase IC (ATP8B1)	OTALGS63	AT8B1_HUMAN	Increases Expression	[9]
Zinc finger protein SNAI2 (SNAI2)	OT7Y8EJ2	SNAI2_HUMAN	Increases Expression	[9]
Integral membrane protein 2A (ITM2A)	OT590V63	ITM2A_HUMAN	Increases Expression	[9]
Plexin-C1 (PLXNC1)	OTJ5XKYY	PLXC1_HUMAN	Decreases Expression	[9]
Gremlin-1 (GREM1)	OTCK4IGV	GREM1_HUMAN	Increases Expression	[9]
Histone H2B type 1-K (H2BC12)	OTQ8V0KG	H2B1K_HUMAN	Decreases Expression	[9]
Protein diaphanous homolog 2 (DIAPH2)	OTBEYFEZ	DIAP2_HUMAN	Increases Expression	[9]
Inward rectifier potassium channel 13 (KCNJ13)	OTG1CNND	KCJ13_HUMAN	Decreases Expression	[9]
Frizzled-7 (FZD7)	OTTK3F6E	FZD7_HUMAN	Increases Expression	[9]
Slit homolog 1 protein (SLIT1)	OT35RBNT	SLIT1_HUMAN	Increases Expression	[9]
Core histone macro-H2A.1 (MACROH2A1)	OTV2DQDD	H2AY_HUMAN	Decreases Expression	[9]
Large neutral amino acids transporter small subunit 3 (SLC43A1)	OTQJQY3S	LAT3_HUMAN	Increases Expression	[9]
Forkhead box protein H1 (FOXH1)	OTEXJ9SL	FOXH1_HUMAN	Increases Expression	[9]
Leukocyte cell-derived chemotaxin 1 (CNMD)	OTHND8EL	CNMD_HUMAN	Increases Expression	[9]
Lysozyme-like protein 6 (LYZL6)	OT6XS67M	LYZL6_HUMAN	Increases Expression	[9]
Slit homolog 2 protein (SLIT2)	OTLS2RJ4	SLIT2_HUMAN	Increases Expression	[9]
Nucleolar protein 4 (NOL4)	OTWI587R	NOL4_HUMAN	Decreases Expression	[9]
Dickkopf-related protein 1 (DKK1)	OTRDLUSP	DKK1_HUMAN	Increases Expression	[9]
Serine protease 23 (PRSS23)	OT6DQAM1	PRS23_HUMAN	Decreases Expression	[9]
Neurexophilin-2 (NXPH2)	OTHD8HPU	NXPH2_HUMAN	Decreases Expression	[9]
Protocadherin-8 (PCDH8)	OTDDOQM2	PCDH8_HUMAN	Increases Expression	[9]
Homeobox protein SIX3 (SIX3)	OTP5E3VU	SIX3_HUMAN	Decreases Expression	[9]
Claudin-7 (CLDN7)	OTNE0XHQ	CLD7_HUMAN	Increases Expression	[9]
C-X-C motif chemokine 14 (CXCL14)	OTM189TA	CXL14_HUMAN	Increases Expression	[9]
BAG family molecular chaperone regulator 2 (BAG2)	OTI6LD27	BAG2_HUMAN	Increases Expression	[9]
Leucine-rich glioma-inactivated protein 1 (LGI1)	OTPS77HO	LGI1_HUMAN	Increases Expression	[9]
Urokinase-type plasminogen activator (PLAU)	OTX0QGKK	UROK_HUMAN	Increases Expression	[9]
Adenosine deaminase (ADA)	OTOX2872	ADA_HUMAN	Decreases Expression	[9]
Pro-neuropeptide Y (NPY)	OT4ICV3P	NPY_HUMAN	Increases Expression	[9]
Alpha-fetoprotein (AFP)	OT9GG3ZI	FETA_HUMAN	Decreases Expression	[9]
Endothelin-1 (EDN1)	OTZCACEG	EDN1_HUMAN	Increases Expression	[9]
Transcription factor AP-2-alpha (TFAP2A)	OTMYT3NK	AP2A_HUMAN	Increases Expression	[9]
Keratin, type I cytoskeletal 18 (KRT18)	OTVLQFIP	K1C18_HUMAN	Increases Expression	[9]
Calbindin (CALB1)	OTM7IXDG	CALB1_HUMAN	Increases Expression	[9]
Neurofilament light polypeptide (NEFL)	OTQESJV4	NFL_HUMAN	Increases Expression	[9]
Annexin A2 (ANXA2)	OTFNS0CC	ANXA2_HUMAN	Increases Expression	[9]
Collagen alpha-2(I) chain (COL1A2)	OTY7G382	CO1A2_HUMAN	Increases Expression	[9]
Inhibin beta A chain (INHBA)	OTSP64PQ	INHBA_HUMAN	Increases Expression	[9]
Fibroblast growth factor 4 (FGF4)	OTNVV3ZG	FGF4_HUMAN	Increases Expression	[9]
Tumor-associated calcium signal transducer 2 (TACSTD2)	OTLSZR00	TACD2_HUMAN	Increases Expression	[9]
Apelin receptor early endogenous ligand (APELA)	OTYY0P69	ELA_HUMAN	Increases Expression	[9]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Decreases Expression	[9]
Chromogranin-A (CHGA)	OTXYX5JH	CMGA_HUMAN	Increases Expression	[9]
Tissue factor pathway inhibitor (TFPI)	OTA0FX16	TFPI1_HUMAN	Increases Expression	[9]
Thyroid hormone receptor beta (THRB)	OTBBIRHZ	THB_HUMAN	Increases Expression	[9]
Hyaluronan and proteoglycan link protein 1 (HAPLN1)	OTXWR9TJ	HPLN1_HUMAN	Increases Expression	[9]
Serine/threonine-protein kinase pim-1 (PIM1)	OTWEKXTU	PIM1_HUMAN	Increases Expression	[9]
Cadherin-1 (CDH1)	OTFJMXPM	CADH1_HUMAN	Increases Expression	[9]
Protein Cripto (CRIPTO)	OT46DZXJ	TDGF1_HUMAN	Increases Expression	[9]
Phospholipase A2, membrane associated (PLA2G2A)	OT1NY7BF	PA2GA_HUMAN	Increases Expression	[9]
Protein C-ets-1 (ETS1)	OT4LVGDN	ETS1_HUMAN	Increases Expression	[9]
15-hydroxyprostaglandin dehydrogenase (HPGD)	OTYZI6JB	PGDH_HUMAN	Increases Expression	[9]
NAD(P)H dehydrogenase 1 (NQO1)	OTZGGIVK	NQO1_HUMAN	Increases Expression	[9]
Epithelial cell adhesion molecule (EPCAM)	OTHBZK5X	EPCAM_HUMAN	Increases Expression	[9]
Atrial natriuretic peptide receptor 3 (NPR3)	OT6MQP3A	ANPRC_HUMAN	Increases Expression	[9]
cAMP-dependent protein kinase catalytic subunit alpha (PRKACA)	OTAKDCMR	KAPCA_HUMAN	Increases Expression	[9]
Neuromodulin (GAP43)	OT2OTGGV	NEUM_HUMAN	Increases Expression	[9]
Vascular endothelial growth factor receptor 1 (FLT1)	OTT0OGYS	VGFR1_HUMAN	Increases Expression	[9]
Integrin beta-5 (ITGB5)	OT21MF51	ITB5_HUMAN	Decreases Expression	[9]
Pituitary adenylate cyclase-activating polypeptide (ADCYAP1)	OT0LQH93	PACA_HUMAN	Increases Expression	[9]
Alpha-1-acid glycoprotein 2 (ORM2)	OTRJGZP8	A1AG2_HUMAN	Decreases Expression	[9]
Serine protease inhibitor Kazal-type 2 (SPINK2)	OTSFBT0G	ISK2_HUMAN	Increases Expression	[9]
Muscarinic acetylcholine receptor M3 (CHRM3)	OTKSD095	ACM3_HUMAN	Increases Expression	[9]
Ephrin-A1 (EFNA1)	OTU2NUA2	EFNA1_HUMAN	Increases Expression	[9]
Ephrin type-A receptor 1 (EPHA1)	OTGJMRZ0	EPHA1_HUMAN	Increases Expression	[9]
CD9 antigen (CD9)	OT2184XU	CD9_HUMAN	Increases Expression	[9]
Bone morphogenetic protein 5 (BMP5)	OTC0Y6E0	BMP5_HUMAN	Increases Expression	[9]
Cadherin-3 (CDH3)	OTKNLQU7	CADH3_HUMAN	Increases Expression	[9]
Fibulin-1 (FBLN1)	OT5MHHOP	FBLN1_HUMAN	Decreases Expression	[9]
Paired box protein Pax-7 (PAX7)	OTDMQRPO	PAX7_HUMAN	Increases Expression	[9]
Paired box protein Pax-3 (PAX3)	OTN5PJZV	PAX3_HUMAN	Increases Expression	[9]
Trans-acting T-cell-specific transcription factor GATA-3 (GATA3)	OTGP7D5Y	GATA3_HUMAN	Increases Expression	[9]
Endothelin receptor type B (EDNRB)	OTLLZV3P	EDNRB_HUMAN	Increases Expression	[9]
Tenascin (TNC)	OTK4FSHR	TENA_HUMAN	Decreases Expression	[9]
Signal transducer CD24 (CD24)	OT7CODJ4	CD24_HUMAN	Increases Expression	[9]
Endothelin-1 receptor (EDNRA)	OTK9T5O3	EDNRA_HUMAN	Increases Expression	[9]
Rhombotin-2 (LMO2)	OTCC370G	RBTN2_HUMAN	Decreases Expression	[9]
Pentraxin-related protein PTX3 (PTX3)	OTPXHRKU	PTX3_HUMAN	Decreases Expression	[9]
HLA class II histocompatibility antigen, DM beta chain (HLA-DMB)	OT17HGXJ	DMB_HUMAN	Decreases Expression	[9]
Homeobox protein MSX-1 (MSX1)	OT5U41ZP	MSX1_HUMAN	Increases Expression	[9]
Gamma-aminobutyric acid receptor subunit beta-3 (GABRB3)	OT80C3D4	GBRB3_HUMAN	Increases Expression	[9]
Ephrin type-A receptor 3 (EPHA3)	OTZJF3ML	EPHA3_HUMAN	Increases Expression	[9]
Ephrin type-B receptor 2 (EPHB2)	OT8VZ6C5	EPHB2_HUMAN	Decreases Expression	[9]
G1/S-specific cyclin-D2 (CCND2)	OTDULQF9	CCND2_HUMAN	Decreases Expression	[9]
Fibroblast growth factor 9 (FGF9)	OT2SKDGM	FGF9_HUMAN	Decreases Expression	[9]
Gastrin/cholecystokinin type B receptor (CCKBR)	OTQSNXOI	GASR_HUMAN	Decreases Expression	[9]
Neuronal acetylcholine receptor subunit alpha-3 (CHRNA3)	OTCZQY1U	ACHA3_HUMAN	Increases Expression	[9]
Homeobox protein MSX-2 (MSX2)	OT1WDKE1	MSX2_HUMAN	Increases Expression	[9]
Metalloproteinase inhibitor 3 (TIMP3)	OTDGQAD1	TIMP3_HUMAN	Decreases Expression	[9]
Vascular endothelial growth factor receptor 2 (KDR)	OT15797V	VGFR2_HUMAN	Increases Expression	[9]
Amiloride-sensitive sodium channel subunit alpha (SCNN1A)	OTE2KVZV	SCNNA_HUMAN	Increases Expression	[9]
C-X-C motif chemokine 5 (CXCL5)	OTZOUPCA	CXCL5_HUMAN	Increases Expression	[9]
Lysophosphatidic acid receptor 6 (LPAR6)	OT4BY3W4	LPAR6_HUMAN	Increases Expression	[9]
Peptidyl-prolyl cis-trans isomerase C (PPIC)	OTY5Q42N	PPIC_HUMAN	Increases Expression	[9]
Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial (ACADSB)	OTDO6HBG	ACDSB_HUMAN	Increases Expression	[9]
Cytosolic phospholipase A2 (PLA2G4A)	OTE70SOT	PA24A_HUMAN	Increases Expression	[9]
DNA-binding protein inhibitor ID-4 (ID4)	OTPMJ39I	ID4_HUMAN	Increases Expression	[9]
Protein ERGIC-53 (LMAN1)	OTYHKDEO	LMAN1_HUMAN	Decreases Expression	[9]
Beta-arrestin-1 (ARRB1)	OT2NJS37	ARRB1_HUMAN	Increases Expression	[9]
Isocitrate dehydrogenase subunit alpha, mitochondrial (IDH3A)	OT5QQB5L	IDH3A_HUMAN	Increases Expression	[9]
Homeobox protein MOX-1 (MEOX1)	OTJEMT2D	MEOX1_HUMAN	Increases Expression	[9]
Cysteine-rich protein 1 (CRIP1)	OT0EICG3	CRIP1_HUMAN	Increases Expression	[9]
Serpin B9 (SERPINB9)	OTJ811IF	SPB9_HUMAN	Increases Expression	[9]
LIM/homeobox protein Lhx2 (LHX2)	OTK61NP8	LHX2_HUMAN	Decreases Expression	[9]
Probable global transcription activator SNF2L2 (SMARCA2)	OTSGJ8SV	SMCA2_HUMAN	Increases Expression	[9]
Beta-crystallin A4 (CRYBA4)	OTQJ5XGE	CRBA4_HUMAN	Decreases Expression	[9]
GDNF family receptor alpha-1 (GFRA1)	OT3WBVYB	GFRA1_HUMAN	Decreases Expression	[9]
Transcription factor SOX-8 (SOX8)	OTEJXYZM	SOX8_HUMAN	Increases Expression	[9]
Sestrin-3 (SESN3)	OTJRY1Y5	SESN3_HUMAN	Increases Expression	[9]
Neurexin-2-beta (NRXN2)	OTB04QSU	NRX2B_HUMAN	Decreases Expression	[9]
Histone H2B type 1-D (H2BC5)	OTXDTDHN	H2B1D_HUMAN	Decreases Expression	[9]
Synaptosomal-associated protein 25 (SNAP25)	OTUIQ81Q	SNP25_HUMAN	Increases Expression	[9]
Protein S100-A10 (S100A10)	OTI71243	S10AA_HUMAN	Increases Expression	[9]
Somatostatin (SST)	OTY75GQH	SMS_HUMAN	Increases Expression	[9]
Neurocalcin-delta (NCALD)	OTJZ8UEL	NCALD_HUMAN	Decreases Expression	[9]
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 (GNG11)	OTHIXBGW	GBG11_HUMAN	Increases Expression	[9]
Rho-related GTP-binding protein RhoB (RHOB)	OTHQFQF7	RHOB_HUMAN	Increases Expression	[9]
Iroquois-class homeodomain protein IRX-1 (IRX1)	OT0ZN9EJ	IRX1_HUMAN	Increases Expression	[9]
Reelin (RELN)	OTLKMW1O	RELN_HUMAN	Increases Expression	[9]
Nucleobindin-2 (NUCB2)	OTHO6JWN	NUCB2_HUMAN	Decreases Expression	[9]
Serine beta-lactamase-like protein LACTB, mitochondrial (LACTB)	OTRWGNBF	LACTB_HUMAN	Increases Expression	[9]
Norrin (NDP)	OTGDJ4US	NDP_HUMAN	Decreases Expression	[9]
POU domain, class 5, transcription factor 1 (POU5F1)	OTDHHN7O	PO5F1_HUMAN	Increases Expression	[9]
Hematopoietically-expressed homeobox protein HHEX (HHEX)	OTLIUVYX	HHEX_HUMAN	Increases Expression	[9]
Putative POU domain, class 5, transcription factor 1B (POU5F1B)	OT0FKQ51	P5F1B_HUMAN	Increases Expression	[9]
Protein CBFA2T1 (RUNX1T1)	OT30DED5	MTG8_HUMAN	Increases Expression	[9]
Forkhead box protein O1 (FOXO1)	OTPJRB6D	FOXO1_HUMAN	Increases Expression	[9]
Contactin-1 (CNTN1)	OT7RNPEY	CNTN1_HUMAN	Increases Expression	[9]
Noggin (NOG)	OTGRHHPG	NOGG_HUMAN	Increases Expression	[9]
N-myc-interactor (NMI)	OTYVG3NM	NMI_HUMAN	Increases Expression	[9]
Frizzled-5 (FZD5)	OTXFFY56	FZD5_HUMAN	Decreases Expression	[9]
Cadherin-18 (CDH18)	OTC06P9H	CAD18_HUMAN	Increases Expression	[9]
Krueppel-like factor 5 (KLF5)	OT1ABI9N	KLF5_HUMAN	Increases Expression	[9]
Septin-6 (SEPTIN6)	OTIV9RTK	SEPT6_HUMAN	Increases Expression	[9]
Transcription factor E2F2 (E2F2)	OTO75RM7	E2F2_HUMAN	Decreases Expression	[9]
Polypeptide N-acetylgalactosaminyltransferase 3 (GALNT3)	OT7M67WT	GALT3_HUMAN	Increases Expression	[9]
Caspase-8 (CASP8)	OTA8TVI8	CASP8_HUMAN	Increases Expression	[9]
Uncharacterized protein KIAA0040 (KIAA0040)	OT27EBY3	K0040_HUMAN	Increases Expression	[9]
Ephrin type-A receptor 7 (EPHA7)	OT3VC211	EPHA7_HUMAN	Increases Expression	[9]
Angiopoietin-1 (ANGPT1)	OTVZ1NG3	ANGP1_HUMAN	Increases Expression	[9]
Myosin light chain kinase, smooth muscle (MYLK)	OT78QB4A	MYLK_HUMAN	Decreases Expression	[9]
Metallophosphoesterase MPPED2 (MPPED2)	OT7XLMJ6	MPPD2_HUMAN	Decreases Expression	[9]
Laminin subunit alpha-4 (LAMA4)	OTHI7TA0	LAMA4_HUMAN	Increases Expression	[9]
Gamma-interferon-inducible protein 16 (IFI16)	OT4SPU0U	IF16_HUMAN	Increases Expression	[9]
Cytochrome P450 1B1 (CYP1B1)	OTYXFLSD	CP1B1_HUMAN	Increases Expression	[9]
Reticulon-1 (RTN1)	OTCX1SMK	RTN1_HUMAN	Decreases Expression	[9]
Tumor protein D53 (TPD52L1)	OTSA6U0I	TPD53_HUMAN	Increases Expression	[9]
Complement component receptor 1-like protein (CR1L)	OTX3KR7U	CR1L_HUMAN	Increases Expression	[9]
Cell cycle control protein 50B (TMEM30B)	OTNSBH84	CC50B_HUMAN	Increases Expression	[9]
Protein shisa-like-1 (SHISAL1)	OTOIUVC4	SHSL1_HUMAN	Decreases Expression	[9]
Protein PTHB1 (BBS9)	OT23V9YF	PTHB1_HUMAN	Increases Expression	[9]
Uncharacterized protein C8orf34 (C8ORF34)	OTXCTHDG	CH034_HUMAN	Increases Expression	[9]
F-box only protein 43 (FBXO43)	OT6ST2A4	FBX43_HUMAN	Decreases Expression	[9]
Extracellular tyrosine-protein kinase PKDCC (PKDCC)	OTVXJR26	PKDCC_HUMAN	Increases Expression	[9]
Seizure protein 6 homolog (SEZ6)	OTCD8K5D	SEZ6_HUMAN	Increases Expression	[9]
Pleckstrin homology-like domain family A member 2 (PHLDA2)	OTMV9DPP	PHLA2_HUMAN	Increases Expression	[9]
Fibulin-7 (FBLN7)	OT1XRDP6	FBLN7_HUMAN	Decreases Expression	[9]
Protein BEX5 (BEX5)	OTZ2RB6L	BEX5_HUMAN	Increases Expression	[9]
Collectin-12 (COLEC12)	OTIQTK9G	COL12_HUMAN	Increases Expression	[9]
Solute carrier family 35 member D3 (SLC35D3)	OTHKRBGM	S35D3_HUMAN	Increases Expression	[9]
Centrosomal protein of 85 kDa-like (CEP85L)	OTSHJFOT	CE85L_HUMAN	Increases Expression	[9]
Protein FAM162B (FAM162B)	OTZ31RP5	F162B_HUMAN	Increases Expression	[9]
Transcription factor HES-5 (HES5)	OTW7JEHV	HES5_HUMAN	Decreases Expression	[9]
Protein FAM222A (FAM222A)	OTRD9AUH	F222A_HUMAN	Decreases Expression	[9]
Scm-like with four MBT domains protein 2 (SFMBT2)	OTZQT61Q	SMBT2_HUMAN	Increases Expression	[9]
LIM/homeobox protein Lhx8 (LHX8)	OT0DFL7C	LHX8_HUMAN	Increases Expression	[9]
TMF-regulated nuclear protein 1 (TRNP1)	OTYYV8LN	TRNP1_HUMAN	Increases Expression	[9]
Lactase-like protein (LCTL)	OTN36T21	LCTL_HUMAN	Decreases Expression	[9]
Interleukin-20 receptor subunit beta (IL20RB)	OTHFXK95	I20RB_HUMAN	Increases Expression	[9]
Transmembrane protein 64 (TMEM64)	OTO9IDFD	TMM64_HUMAN	Increases Expression	[9]
Metastasis-associated in colon cancer protein 1 (MACC1)	OTV3DLX0	MACC1_HUMAN	Increases Expression	[9]
Zinc finger protein basonuclin-2 (BNC2)	OTU22H9Z	BNC2_HUMAN	Increases Expression	[9]
Solute carrier organic anion transporter family member 4C1 (SLCO4C1)	OTVILUUN	SO4C1_HUMAN	Increases Expression	[9]
Leucine-rich repeat-containing protein 55 (LRRC55)	OT8LQI1W	LRC55_HUMAN	Decreases Expression	[9]
UPF0606 protein KIAA1549L (KIAA1549L)	OT80HUVY	K154L_HUMAN	Decreases Expression	[9]
Monocarboxylate transporter 14 (SLC16A14)	OTUGDEUV	MOT14_HUMAN	Decreases Expression	[9]
E3 ubiquitin-protein ligase RNF144B (RNF144B)	OTN7FCDE	R144B_HUMAN	Increases Expression	[9]
Developmental pluripotency-associated protein 2 (DPPA2)	OT8Y55RY	DPPA2_HUMAN	Increases Expression	[9]
Uncharacterized protein C11orf96 (C11ORF96)	OTEQU0V7	CK096_HUMAN	Increases Expression	[9]
Sodium/hydrogen exchanger 9B2 (SLC9B2)	OTZVOY8T	SL9B2_HUMAN	Decreases Expression	[9]
Leucine-rich repeat transmembrane neuronal protein 1 (LRRTM1)	OTKI3IU9	LRRT1_HUMAN	Increases Expression	[9]
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (MAGI2)	OTXDDKZS	MAGI2_HUMAN	Increases Expression	[9]
Inter-alpha-trypsin inhibitor heavy chain H5 (ITIH5)	OTP46PZM	ITIH5_HUMAN	Increases Expression	[9]
Catechol O-methyltransferase domain-containing protein 1 (COMTD1)	OTLQJTBI	CMTD1_HUMAN	Increases Expression	[9]
Protein phosphatase 1 regulatory subunit 3B (PPP1R3B)	OTVCRXEZ	PPR3B_HUMAN	Increases Expression	[9]
Podoplanin (PDPN)	OTBUV19I	PDPN_HUMAN	Increases Expression	[9]
Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PPARGC1B)	OTN6FKCB	PRGC2_HUMAN	Increases Expression	[9]
Neuron navigator 3 (NAV3)	OT97M1TR	NAV3_HUMAN	Increases Expression	[9]
Procollagen galactosyltransferase 2 (COLGALT2)	OTV9EDZB	GT252_HUMAN	Decreases Expression	[9]
Ras and EF-hand domain-containing protein (RASEF)	OTGSAM2E	RASEF_HUMAN	Increases Expression	[9]
Solute carrier family 38 member 6 (SLC38A6)	OTIC8SHQ	S38A6_HUMAN	Increases Expression	[9]
Protein SIX6OS1 (C14ORF39)	OTFKQ6HO	S6OS1_HUMAN	Decreases Expression	[9]
Rho GTPase-activating protein 24 (ARHGAP24)	OTCQCEZS	RHG24_HUMAN	Increases Expression	[9]
Protein FAM43A (FAM43A)	OT5RPQRE	FA43A_HUMAN	Increases Expression	[9]
ELMO domain-containing protein 1 (ELMOD1)	OT0WRVJC	ELMD1_HUMAN	Increases Expression	[9]
Mucin-15 (MUC15)	OT3PQT6L	MUC15_HUMAN	Increases Expression	[9]
Chemokine-like protein TAFA-2 (TAFA2)	OTU6WP6J	TAFA2_HUMAN	Increases Expression	[9]
Protein phosphatase Mn(2+)-dependent 1K (PPM1K)	OTNZ4N4E	PPM1K_HUMAN	Increases Expression	[9]
Thioredoxin domain-containing protein 3 (NME8)	OT4RULP5	TXND3_HUMAN	Increases Expression	[9]
Leucine-rich repeat-containing protein 17 (LRRC17)	OT3NZSX3	LRC17_HUMAN	Increases Expression	[9]
Inactive phospholipase D5 (PLD5)	OTEVPYNY	PLD5_HUMAN	Decreases Expression	[9]
BMP-binding endothelial regulator protein (BMPER)	OTBYON4H	BMPER_HUMAN	Increases Expression	[9]
Tandem C2 domains nuclear protein (TC2N)	OT6482WN	TAC2N_HUMAN	Increases Expression	[9]
Tetratricopeptide repeat protein 29 (TTC29)	OT37KCUL	TTC29_HUMAN	Increases Expression	[9]
Neuropilin and tolloid-like protein 2 (NETO2)	OT0YAMC0	NETO2_HUMAN	Decreases Expression	[9]
Beta-galactosidase-1-like protein 3 (GLB1L3)	OTWAWGX4	GLBL3_HUMAN	Increases Expression	[9]
Zinc finger protein GLIS3 (GLIS3)	OTBC960E	GLIS3_HUMAN	Decreases Expression	[9]
Interleukin-17 receptor D (IL17RD)	OTKD9XST	I17RD_HUMAN	Decreases Expression	[9]
Delta and Notch-like epidermal growth factor-related receptor (DNER)	OT2GH2E5	DNER_HUMAN	Increases Expression	[9]
Semaphorin-6D (SEMA6D)	OTU0UAZS	SEM6D_HUMAN	Decreases Expression	[9]
LIM domain only protein 3 (LMO3)	OTR7AJHN	LMO3_HUMAN	Decreases Expression	[9]
DEP domain-containing mTOR-interacting protein (DEPTOR)	OTCBP1BT	DPTOR_HUMAN	Increases Expression	[9]
E3 ubiquitin-protein ligase RNF217 (RNF217)	OTAX91ES	RN217_HUMAN	Increases Expression	[9]
Ciliary microtubule-associated protein 3 (CIMAP3)	OT8RL1WO	CMAP3_HUMAN	Increases Expression	[9]
Mucolipin-3 (MCOLN3)	OTCRPRVS	MCLN3_HUMAN	Increases Expression	[9]
Grainyhead-like protein 3 homolog (GRHL3)	OT1V4ZEH	GRHL3_HUMAN	Increases Expression	[9]
DENN domain-containing protein 1A (DENND1A)	OTONDAA0	DEN1A_HUMAN	Decreases Expression	[9]
Pleckstrin homology-like domain family A member 1 (PHLDA1)	OTFTWMIQ	PHLA1_HUMAN	Increases Expression	[9]
Secretogranin-3 (SCG3)	OTUYSV2S	SCG3_HUMAN	Increases Expression	[9]
Myosin-IIIb (MYO3B)	OTVD4TNG	MYO3B_HUMAN	Increases Expression	[9]
E3 ubiquitin-protein ligase MYLIP (MYLIP)	OTL0PFGV	MYLIP_HUMAN	Increases Expression	[9]
Transcription factor AP-2-beta (TFAP2B)	OTR1T8E9	AP2B_HUMAN	Increases Expression	[9]
Piezo-type mechanosensitive ion channel component 1 (PIEZO1)	OTBG1FU4	PIEZ1_HUMAN	Decreases Expression	[9]
Transcription factor AP-2 gamma (TFAP2C)	OTUDIW05	AP2C_HUMAN	Increases Expression	[9]
Deleted in azoospermia-like (DAZL)	OTZMTD4R	DAZL_HUMAN	Decreases Expression	[9]
Stathmin-2 (STMN2)	OT0FUHLH	STMN2_HUMAN	Increases Expression	[9]
Sodium-coupled neutral amino acid transporter 4 (SLC38A4)	OTV5OHBT	S38A4_HUMAN	Increases Expression	[9]
Copine-4 (CPNE4)	OTTAGM5L	CPNE4_HUMAN	Increases Expression	[9]
Serine/threonine-protein kinase Sgk3 (SGK3)	OTQ6QO99	SGK3_HUMAN	Increases Expression	[9]
Collagen triple helix repeat-containing protein 1 (CTHRC1)	OTV88X2G	CTHR1_HUMAN	Increases Expression	[9]
Ras-related protein Rab-3C (RAB3C)	OTFTJNGA	RAB3C_HUMAN	Increases Expression	[9]
BLOC-1-related complex subunit 8 (BORCS8)	OTVRSVCB	BORC8_HUMAN	Increases Expression	[9]
Serine dehydratase-like (SDSL)	OTGZEAGJ	SDSL_HUMAN	Decreases Expression	[9]
Calmodulin-like protein 4 (CALML4)	OT6DD5EW	CALL4_HUMAN	Decreases Expression	[9]
4-hydroxyphenylpyruvate dioxygenase-like protein (HPDL)	OTW7D1SV	HPDL_HUMAN	Increases Expression	[9]
Microtubule-associated protein 6 (MAP6)	OTPUI00F	MAP6_HUMAN	Decreases Expression	[9]
TOX high mobility group box family member 2 (TOX2)	OT7RZRVK	TOX2_HUMAN	Decreases Expression	[9]
Collagen alpha-1(XXI) chain (COL21A1)	OT7GS82E	COLA1_HUMAN	Increases Expression	[9]
Noelin-3 (OLFM3)	OTBHPDTL	NOE3_HUMAN	Increases Expression	[9]
Secretoglobin family 3A member 2 (SCGB3A2)	OTB63PHR	SG3A2_HUMAN	Increases Expression	[9]
DEP domain-containing protein 7 (DEPDC7)	OT62C942	DEPD7_HUMAN	Increases Expression	[9]
MAP7 domain-containing protein 2 (MAP7D2)	OTN85925	MA7D2_HUMAN	Decreases Expression	[9]
Glutamate decarboxylase 1 (GAD1)	OT52Z39J	DCE1_HUMAN	Increases Expression	[9]
Protein kinase C-binding protein NELL2 (NELL2)	OTS4MJZ7	NELL2_HUMAN	Decreases Expression	[9]
Sphingosine 1-phosphate receptor 3 (S1PR3)	OTXBIYO8	S1PR3_HUMAN	Decreases Expression	[9]
Neuroserpin (SERPINI1)	OTUJHIJW	NEUS_HUMAN	Increases Expression	[9]
Pituitary homeobox 2 (PITX2)	OTWMXAOY	PITX2_HUMAN	Increases Expression	[9]
Forkhead box protein C2 (FOXC2)	OT83P1E0	FOXC2_HUMAN	Increases Expression	[9]
Retinoic acid receptor responder protein 2 (RARRES2)	OT1BJE8K	RARR2_HUMAN	Increases Expression	[9]
Semaphorin-3C (SEMA3C)	OTEGUY7F	SEM3C_HUMAN	Increases Expression	[9]
Microtubule-associated proteins 1A/1B light chain 3C (MAP1LC3C)	OTM4ECDK	MLP3C_HUMAN	Increases Expression	[9]
Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase (B3GNT5)	OTA0DE43	B3GN5_HUMAN	Decreases Expression	[9]
Anoctamin-3 (ANO3)	OTM34U6Q	ANO3_HUMAN	Increases Expression	[9]
Iroquois-class homeodomain protein IRX-2 (IRX2)	OTBHXXQ2	IRX2_HUMAN	Increases Expression	[9]
PR domain zinc finger protein 14 (PRDM14)	OTWZKY4L	PRD14_HUMAN	Increases Expression	[9]
AP-5 complex subunit mu-1 (AP5M1)	OTDLWEBL	AP5M1_HUMAN	Increases Expression	[9]
B-cell lymphoma/leukemia 11A (BCL11A)	OTI6ZBP6	BC11A_HUMAN	Increases Expression	[9]
Serine/threonine-protein kinase TAO3 (TAOK3)	OTYBATSH	TAOK3_HUMAN	Increases Expression	[9]
Leucine-rich repeat neuronal protein 3 (LRRN3)	OT7X0AA7	LRRN3_HUMAN	Increases Expression	[9]
SPARC-related modular calcium-binding protein 1 (SMOC1)	OTJG2JQY	SMOC1_HUMAN	Decreases Expression	[9]
Nuclear body protein SP140-like protein (SP140L)	OTL30JKT	SP14L_HUMAN	Increases Expression	[9]
Chondrolectin (CHODL)	OTVCNOUQ	CHODL_HUMAN	Increases Expression	[9]
Homeobox protein NANOG (NANOG)	OTUEY1FM	NANOG_HUMAN	Increases Expression	[9]
Adhesion G protein-coupled receptor L3 (ADGRL3)	OT81Q8LY	AGRL3_HUMAN	Decreases Expression	[9]
Roundabout homolog 2 (ROBO2)	OTFJ9FQW	ROBO2_HUMAN	Decreases Expression	[9]
Band 4.1-like protein 5 (EPB41L5)	OTPPQPLU	E41L5_HUMAN	Increases Expression	[9]
Olfactomedin-like protein 3 (OLFML3)	OTDN45FN	OLFL3_HUMAN	Increases Expression	[9]
Homer protein homolog 2 (HOMER2)	OT4JGKJF	HOME2_HUMAN	Decreases Expression	[9]
Muscleblind-like protein 3 (MBNL3)	OT2T2YOK	MBNL3_HUMAN	Increases Expression	[9]
Very long chain fatty acid elongase 2 (ELOVL2)	OTDAF6U3	ELOV2_HUMAN	Decreases Expression	[9]
Dapper homolog 1 (DACT1)	OT19Z704	DACT1_HUMAN	Increases Expression	[9]
Neuroligin-3 (NLGN3)	OTKDEC1Q	NLGN3_HUMAN	Decreases Expression	[9]
Myoferlin (MYOF)	OTRFC3IJ	MYOF_HUMAN	Increases Expression	[9]
Peroxisomal sarcosine oxidase (PIPOX)	OTWTCOTN	SOX_HUMAN	Increases Expression	[9]
Docking protein 5 (DOK5)	OT2XWUPN	DOK5_HUMAN	Increases Expression	[9]
Contactin-3 (CNTN3)	OTC1274J	CNTN3_HUMAN	Decreases Expression	[9]
Protocadherin-10 (PCDH10)	OT2GIT0E	PCD10_HUMAN	Increases Expression	[9]
Centrosomal protein of 126 kDa (CEP126)	OTUMFEME	CE126_HUMAN	Increases Expression	[9]
Hairy/enhancer-of-split related with YRPW motif protein 2 (HEY2)	OTU4J3ZI	HEY2_HUMAN	Increases Expression	[9]
Homeobox expressed in ES cells 1 (HESX1)	OT5E2Z4G	HESX1_HUMAN	Decreases Expression	[9]
Forkhead box protein D3 (FOXD3)	OTXYV6GO	FOXD3_HUMAN	Increases Expression	[9]
TRAF2 and NCK-interacting protein kinase (TNIK)	OTDZBJ4K	TNIK_HUMAN	Increases Expression	[9]
POU domain, class 2, transcription factor 3 (POU2F3)	OTIOOJWD	PO2F3_HUMAN	Increases Expression	[9]
Paraneoplastic antigen Ma2 (PNMA2)	OTF5YBQG	PNMA2_HUMAN	Decreases Expression	[9]
Protein HEG homolog 1 (HEG1)	OT3CUXA7	HEG1_HUMAN	Decreases Expression	[9]
RING finger protein 150 (RNF150)	OTAMSBK5	RN150_HUMAN	Increases Expression	[9]
Sex comb on midleg-like protein 1 (SCML1)	OT7V5DAR	SCML1_HUMAN	Increases Expression	[9]
LIM and calponin homology domains-containing protein 1 (LIMCH1)	OTYPC4XA	LIMC1_HUMAN	Decreases Expression	[9]
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A)	OT74EK7Z	PDE10_HUMAN	Decreases Expression	[9]
C-C motif chemokine 26 (CCL26)	OT2B7HR9	CCL26_HUMAN	Increases Expression	[9]
Band 4.1-like protein 3 (EPB41L3)	OTS6CHG2	E41L3_HUMAN	Increases Expression	[9]
Retinal homeobox protein Rx (RAX)	OTJ3YCE7	RX_HUMAN	Decreases Expression	[9]
Beta/gamma crystallin domain-containing protein 1 (CRYBG1)	OTIPDI15	CRBG1_HUMAN	Increases Expression	[9]
Neuropeptide FF receptor 2 (NPFFR2)	OTVI4Q85	NPFF2_HUMAN	Increases Expression	[9]
Glypican-6 (GPC6)	OTNJBESF	GPC6_HUMAN	Decreases Expression	[9]
Adhesion G-protein coupled receptor G1 (ADGRG1)	OTQBB8NT	AGRG1_HUMAN	Decreases Expression	[9]
Solute carrier organic anion transporter family member 1B1 (SLCO1B1)	OTNEN8QK	SO1B1_HUMAN	Increases Expression	[9]
Dual specificity protein phosphatase 10 (DUSP10)	OTNG467B	DUS10_HUMAN	Increases Expression	[9]
KAT8 regulatory NSL complex subunit 1-like protein (KANSL1L)	OTOAH2RR	KAL1L_HUMAN	Decreases Expression	[10]
Cilia- and flagella-associated protein 119 (CFAP119)	OT7PL1Q6	CF119_HUMAN	Increases Expression	[10]
Leucine-rich repeat-containing protein 10B (LRRC10B)	OT9NKWFW	LR10B_HUMAN	Decreases Expression	[10]
Collagen alpha-6(VI) chain (COL6A6)	OT4MVGRW	CO6A6_HUMAN	Decreases Expression	[10]
Sulfotransferase 1C2 (SULT1C2)	OT07MMZS	ST1C2_HUMAN	Decreases Expression	[10]
Acetyl-CoA carboxylase 2 (ACACB)	OT96UIP1	ACACB_HUMAN	Decreases Expression	[10]
Homeobox protein CDX-4 (CDX4)	OTD1SQKM	CDX4_HUMAN	Decreases Expression	[10]
Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3)	OTPGHZB9	IFIT3_HUMAN	Decreases Expression	[10]
Ras-related protein Rab-7L1 (RAB29)	OTDZT6LP	RAB7L_HUMAN	Increases Expression	[10]
Synemin (SYNM)	OTOI8TRJ	SYNEM_HUMAN	Decreases Expression	[10]
A disintegrin and metalloproteinase with thrombospondin motifs 3 (ADAMTS3)	OT2U6VF5	ATS3_HUMAN	Decreases Expression	[10]
Angiopoietin-2 (ANGPT2)	OTEQK65P	ANGP2_HUMAN	Decreases Expression	[10]
Cochlin (COCH)	OTBEHD89	COCH_HUMAN	Decreases Expression	[10]
Maltase-glucoamylase (MGAM)	OTVLMDUE	MGA_HUMAN	Decreases Expression	[10]
Protocadherin-7 (PCDH7)	OTP091X8	PCDH7_HUMAN	Decreases Expression	[10]
Protein tyrosine phosphatase type IVA 3 (PTP4A3)	OTXMMWUN	TP4A3_HUMAN	Decreases Expression	[10]
Src kinase-associated phosphoprotein 2 (SKAP2)	OTSF44KP	SKAP2_HUMAN	Increases Expression	[10]
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial (GCAT)	OT6WZPWV	KBL_HUMAN	Decreases Expression	[10]
UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 (B3GALNT1)	OT8GFSQL	B3GL1_HUMAN	Decreases Expression	[10]
Stanniocalcin-2 (STC2)	OT86YP8G	STC2_HUMAN	Decreases Expression	[10]
Kelch-like protein 18 (KLHL18)	OTX7NOSM	KLH18_HUMAN	Increases Expression	[10]
RCC1 and BTB domain-containing protein 2 (RCBTB2)	OTECBF4R	RCBT2_HUMAN	Decreases Expression	[10]
ATP-binding cassette sub-family C member 6 (ABCC6)	OTZT0LKT	MRP6_HUMAN	Decreases Expression	[10]
Coagulation factor XIII A chain (F13A1)	OTO8O184	F13A_HUMAN	Increases Expression	[10]
Coagulation factor X (F10)	OT2BLK17	FA10_HUMAN	Decreases Expression	[10]
Plasminogen (PLG)	OTWWIPPY	PLMN_HUMAN	Decreases Expression	[10]
Alpha-1-antitrypsin (SERPINA1)	OTACYW9J	A1AT_HUMAN	Decreases Expression	[10]
HLA class I histocompatibility antigen, B alpha chain (HLA-B)	OTNXFWY2	HLAB_HUMAN	Increases Expression	[10]
Hemoglobin subunit epsilon (HBE1)	OTJPKMX4	HBE_HUMAN	Decreases Expression	[10]
Apolipoprotein C-I (APOC1)	OTA58CED	APOC1_HUMAN	Decreases Expression	[10]
Hemopexin (HPX)	OT14T7Q1	HEMO_HUMAN	Decreases Expression	[10]
Platelet-derived growth factor subunit A (PDGFA)	OTCMZ0W8	PDGFA_HUMAN	Decreases Expression	[10]
Trefoil factor 1 (TFF1)	OTCYQH4F	TFF1_HUMAN	Decreases Expression	[10]
Fructose-bisphosphate aldolase B (ALDOB)	OT7FR69A	ALDOB_HUMAN	Decreases Expression	[10]
Thyroxine-binding globulin (SERPINA7)	OTUYVTSU	THBG_HUMAN	Decreases Expression	[10]
Fatty acid-binding protein, liver (FABP1)	OTR34ETM	FABPL_HUMAN	Decreases Expression	[10]
Asialoglycoprotein receptor 1 (ASGR1)	OTS99MJO	ASGR1_HUMAN	Decreases Expression	[10]
Asparagine synthetase (ASNS)	OT8R922G	ASNS_HUMAN	Decreases Expression	[10]
Homeobox protein Hox-D4 (HOXD4)	OTQR4WCG	HXD4_HUMAN	Increases Expression	[10]
Annexin A4 (ANXA4)	OTUCRYXL	ANXA4_HUMAN	Decreases Expression	[10]
Cystic fibrosis transmembrane conductance regulator (CFTR)	OT6B22QH	CFTR_HUMAN	Decreases Expression	[10]
Tartrate-resistant acid phosphatase type 5 (ACP5)	OTBV4498	PPA5_HUMAN	Decreases Expression	[10]
Folate receptor alpha (FOLR1)	OT0QZ0H6	FOLR1_HUMAN	Decreases Expression	[10]
Integrin alpha-2 (ITGA2)	OTPFL017	ITA2_HUMAN	Increases Expression	[10]
HLA class II histocompatibility antigen, DP alpha 1 chain (HLA-DPA1)	OT7OG7Y2	DPA1_HUMAN	Decreases Expression	[10]
Aromatic-L-amino-acid decarboxylase (DDC)	OT0TSW09	DDC_HUMAN	Decreases Expression	[10]
Carbonic anhydrase 4 (CA4)	OT3K93LZ	CAH4_HUMAN	Decreases Expression	[10]
Sodium-dependent noradrenaline transporter (SLC6A2)	OTMHQJMP	SC6A2_HUMAN	Increases Expression	[10]
Interleukin-4 receptor subunit alpha (IL4R)	OTTXOTCW	IL4RA_HUMAN	Decreases Expression	[10]
Atypical chemokine receptor 3 (ACKR3)	OTA6GA4F	ACKR3_HUMAN	Increases Expression	[10]
Integrin alpha-3 (ITGA3)	OTBCH21D	ITA3_HUMAN	Decreases Expression	[10]
Tyrosine-protein phosphatase non-receptor type 3 (PTPN3)	OTSLZBVY	PTN3_HUMAN	Decreases Expression	[10]
Leukocyte elastase inhibitor (SERPINB1)	OT5RDUFO	ILEU_HUMAN	Decreases Expression	[10]
Homeobox protein Hox-D3 (HOXD3)	OTBUZ35T	HXD3_HUMAN	Increases Expression	[10]
Fibrillin-1 (FBN1)	OTYCJT63	FBN1_HUMAN	Decreases Expression	[10]
Glutamate receptor ionotropic, kainate 1 (GRIK1)	OTO19X5C	GRIK1_HUMAN	Increases Expression	[10]
Pre-B-cell leukemia transcription factor 2 (PBX2)	OTEBYCAW	PBX2_HUMAN	Decreases Expression	[10]
ETS translocation variant 5 (ETV5)	OTE2OBM4	ETV5_HUMAN	Decreases Expression	[10]
Mitogen-activated protein kinase kinase kinase 8 (MAP3K8)	OTOZTA1F	M3K8_HUMAN	Increases Expression	[10]
Glutamate receptor 3 (GRIA3)	OT34CNBR	GRIA3_HUMAN	Increases Expression	[10]
Cathepsin O (CTSO)	OTFL6VRO	CATO_HUMAN	Decreases Expression	[10]
Cathepsin K (CTSK)	OTT3YX5O	CATK_HUMAN	Decreases Expression	[10]
G protein-coupled receptor kinase 6 (GRK6)	OT4LZTP9	GRK6_HUMAN	Decreases Expression	[10]
Stromal cell-derived factor 1 (CXCL12)	OT2QX5LL	SDF1_HUMAN	Decreases Expression	[10]
Flavin-containing monooxygenase 5 (FMO5)	OTTILF8T	FMO5_HUMAN	Decreases Expression	[10]
Inositol polyphosphate 1-phosphatase (INPP1)	OTHSJCRQ	INPP_HUMAN	Decreases Expression	[10]
Retinoic acid receptor responder protein 1 (RARRES1)	OTETUPP5	TIG1_HUMAN	Decreases Expression	[10]
Type I iodothyronine deiodinase (DIO1)	OTFYLYJ0	IOD1_HUMAN	Decreases Expression	[10]
5-formyltetrahydrofolate cyclo-ligase (MTHFS)	OTZ39JNR	MTHFS_HUMAN	Decreases Expression	[10]
Arylsulfatase D (ARSD)	OTAHW9M8	ARSD_HUMAN	Decreases Expression	[10]
G-protein coupled receptor 143 (GPR143)	OTWUA2AV	GP143_HUMAN	Decreases Expression	[10]
Pancreatic lipase-related protein 2 (PNLIPRP2)	OTJG6BA7	LIPR2_HUMAN	Decreases Expression	[10]
Tyrosine-protein phosphatase non-receptor type 5 (PTPN5)	OT2H1KDK	PTN5_HUMAN	Decreases Expression	[10]
Proteinase-activated receptor 2 (F2RL1)	OTMRMJ8N	PAR2_HUMAN	Decreases Expression	[10]
Hormonally up-regulated neu tumor-associated kinase (HUNK)	OTZR4GBH	HUNK_HUMAN	Decreases Expression	[10]
F-box/WD repeat-containing protein 4 (FBXW4)	OTEGSZOX	FBXW4_HUMAN	Decreases Expression	[10]
Clarin-1 (CLRN1)	OT1ADI7Q	CLRN1_HUMAN	Increases Expression	[10]
Beta-defensin 1 (DEFB1)	OT5SV0E4	DEFB1_HUMAN	Decreases Expression	[10]
DDB1- and CUL4-associated factor 7 (DCAF7)	OT3W5DYL	DCAF7_HUMAN	Increases Expression	[10]
Inward rectifier potassium channel 2 (KCNJ2)	OT2OQEZS	KCNJ2_HUMAN	Decreases Expression	[10]
POU domain, class 6, transcription factor 2 (POU6F2)	OTNSW95F	PO6F2_HUMAN	Increases Expression	[10]
Protein crumbs homolog 1 (CRB1)	OTXYUNG0	CRUM1_HUMAN	Increases Expression	[10]
Fibulin-2 (FBLN2)	OTEHR7N7	FBLN2_HUMAN	Decreases Expression	[10]
Cyclin-dependent kinase 3 (CDK3)	OT2GP6RL	CDK3_HUMAN	Decreases Expression	[10]
AMP deaminase 3 (AMPD3)	OT5SP1KJ	AMPD3_HUMAN	Decreases Expression	[10]
Trefoil factor 2 (TFF2)	OTRXB19X	TFF2_HUMAN	Decreases Expression	[10]
1,4-alpha-glucan-branching enzyme (GBE1)	OTK2N05B	GLGB_HUMAN	Decreases Expression	[10]
Aldehyde oxidase (AOX1)	OT2FZP6H	AOXA_HUMAN	Decreases Expression	[10]
Sulfotransferase 2A1 (SULT2A1)	OT0ISKQ4	ST2A1_HUMAN	Decreases Expression	[10]
Filensin (BFSP1)	OTXZ3YIU	BFSP1_HUMAN	Decreases Expression	[10]
Semaphorin-3B (SEMA3B)	OTCZCPMS	SEM3B_HUMAN	Decreases Expression	[10]
Semaphorin-3F (SEMA3F)	OTQFMS8S	SEM3F_HUMAN	Decreases Expression	[10]
Caprin-1 (CAPRIN1)	OTEJAMS3	CAPR1_HUMAN	Decreases Expression	[10]
Sarcospan (SSPN)	OTYG2SL7	SSPN_HUMAN	Decreases Expression	[10]
Cytohesin-1 (CYTH1)	OTYH9NRJ	CYH1_HUMAN	Decreases Expression	[10]
NT-3 growth factor receptor (NTRK3)	OTII30MY	NTRK3_HUMAN	Increases Expression	[10]
Melanoma antigen recognized by T-cells 1 (MLANA)	OT1N2S2K	MAR1_HUMAN	Decreases Expression	[10]
Interphotoreceptor matrix proteoglycan 1 (IMPG1)	OT12HBL0	IMPG1_HUMAN	Increases Expression	[10]
Protein Shroom1 (SHROOM1)	OTUP99ZD	SHRM1_HUMAN	Decreases Expression	[10]
Transmembrane protein 44 (TMEM44)	OTRUF467	TMM44_HUMAN	Decreases Expression	[10]
Hexokinase HKDC1 (HKDC1)	OTTHDMBM	HKDC1_HUMAN	Decreases Expression	[10]
Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2 (ITPRIPL2)	OTSSP13W	IPIL2_HUMAN	Decreases Expression	[10]
Membrane protein FAM174B (FAM174B)	OT1SCOTY	F174B_HUMAN	Decreases Expression	[10]
OCIA domain-containing protein 2 (OCIAD2)	OTSWB4SZ	OCAD2_HUMAN	Decreases Expression	[10]
UMP-CMP kinase 2, mitochondrial (CMPK2)	OTOG90R0	CMPK2_HUMAN	Decreases Expression	[10]
FRAS1-related extracellular matrix protein 1 (FREM1)	OTMHRV87	FREM1_HUMAN	Decreases Expression	[10]
Calcium homeostasis modulator protein 6 (CALHM6)	OTLX9B4Y	CAHM6_HUMAN	Decreases Expression	[10]
Putative hydroxypyruvate isomerase (HYI)	OTFPNOTN	HYI_HUMAN	Decreases Expression	[10]
Probable gluconokinase (IDNK)	OT5ZC54L	GNTK_HUMAN	Decreases Expression	[10]
Dynein regulatory complex protein 8 (EFCAB2)	OTXEFI4O	DRC8_HUMAN	Decreases Expression	[10]
Little elongation complex subunit 2 (ICE2)	OTJ3BXND	ICE2_HUMAN	Increases Expression	[10]
Polypeptide N-acetylgalactosaminyltransferase 17 (GALNT17)	OTMF0W2U	GLT17_HUMAN	Decreases Expression	[10]
Serine/threonine-protein phosphatase 4 regulatory subunit 4 (PPP4R4)	OTKZDDIF	PP4R4_HUMAN	Increases Expression	[10]
Transmembrane protein 220 (TMEM220)	OTGTRDNX	TM220_HUMAN	Decreases Expression	[10]
Sushi domain-containing protein 1 (SUSD1)	OTR3UGLY	SUSD1_HUMAN	Decreases Expression	[10]
Thiol S-methyltransferase TMT1B (TMT1B)	OTP0QOAL	TMT1B_HUMAN	Decreases Expression	[10]
Gliomedin (GLDN)	OTA8TQU9	GLDN_HUMAN	Increases Expression	[10]
Refilin-A (RFLNA)	OT6GS3XQ	RFLA_HUMAN	Decreases Expression	[10]
Protein CFAP20DC (CFAP20DC)	OTVOREMP	CF20D_HUMAN	Increases Expression	[10]
Fibrillin-3 (FBN3)	OTEWLXTH	FBN3_HUMAN	Decreases Expression	[10]
Cytoplasmic FMR1-interacting protein 1 (CYFIP1)	OTOBEH24	CYFP1_HUMAN	Decreases Expression	[10]
Carbohydrate sulfotransferase 15 (CHST15)	OTNTM2SP	CHSTF_HUMAN	Increases Expression	[10]
Neuronal growth regulator 1 (NEGR1)	OT57ECW9	NEGR1_HUMAN	Increases Expression	[10]
Microtubule organization protein AKNA (AKNA)	OTQ6E2C8	AKNA_HUMAN	Decreases Expression	[10]
E3 ubiquitin-protein ligase RNF180 (RNF180)	OT2GKIKE	RN180_HUMAN	Decreases Expression	[10]
Hyaluronan and proteoglycan link protein 4 (HAPLN4)	OTZQOG9A	HPLN4_HUMAN	Decreases Expression	[10]
Proline-rich membrane anchor 1 (PRIMA1)	OT9ITT3P	PRIMA_HUMAN	Decreases Expression	[10]
Enoyl-CoA hydratase domain-containing protein 2, mitochondrial (ECHDC2)	OTL0DWCO	ECHD2_HUMAN	Decreases Expression	[10]
L-seryl-tRNA(Sec) kinase (PSTK)	OTA5UXAX	PSTK_HUMAN	Decreases Expression	[10]
Protein mono-ADP-ribosyltransferase PARP9 (PARP9)	OT7K4494	PARP9_HUMAN	Decreases Expression	[10]
Solute carrier family 35 member F3 (SLC35F3)	OTAOBKBG	S35F3_HUMAN	Decreases Expression	[10]
Ribonuclease SLFN12 (SLFN12)	OTTBXM25	SLN12_HUMAN	Increases Expression	[10]
UPF0462 protein C4orf33 (C4ORF33)	OT3O3FC3	CD033_HUMAN	Increases Expression	[10]
Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 (PYROXD2)	OTJIX22S	PYRD2_HUMAN	Decreases Expression	[10]
T-cell activation inhibitor, mitochondrial (TCAIM)	OTOBD7YO	TCAIM_HUMAN	Decreases Expression	[10]
Choline transporter-like protein 3 (SLC44A3)	OTL0FT8L	CTL3_HUMAN	Decreases Expression	[10]
Dynein light chain Tctex-type 5 (DYNLT5)	OTDM1DWJ	DYLT5_HUMAN	Increases Expression	[10]
Proprotein convertase subtilisin/kexin type 9 (PCSK9)	OTI0DU9Y	PCSK9_HUMAN	Decreases Expression	[10]
Clarin-3 (CLRN3)	OTZDNL65	CLRN3_HUMAN	Decreases Expression	[10]
Putative methyltransferase NSUN7 (NSUN7)	OTDTL9UE	NSUN7_HUMAN	Decreases Expression	[10]
Phospholipid phosphatase 5 (PLPP5)	OTHT51D6	PLPP5_HUMAN	Decreases Expression	[10]
Interleukin-17D (IL17D)	OTMBLLRF	IL17D_HUMAN	Decreases Expression	[10]
E3 ubiquitin-protein ligase DTX3L (DTX3L)	OTCCO2QZ	DTX3L_HUMAN	Decreases Expression	[10]
CDK5 and ABL1 enzyme substrate 1 (CABLES1)	OTMN4XSX	CABL1_HUMAN	Decreases Expression	[10]
Serine/threonine-protein kinase 32A (STK32A)	OTONYLYO	ST32A_HUMAN	Decreases Expression	[10]
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 (ARAP3)	OTUWZTH7	ARAP3_HUMAN	Decreases Expression	[10]
Nanos homolog 1 (NANOS1)	OT3UNZZY	NANO1_HUMAN	Decreases Expression	[10]
Lysophosphatidic acid receptor 1 (LPAR1)	OTJNJQPF	LPAR1_HUMAN	Decreases Expression	[10]
Histone-lysine N-methyltransferase EZH1 (EZH1)	OTFLUU94	EZH1_HUMAN	Increases Expression	[10]
Peroxisomal membrane protein PEX13 (PEX13)	OTXUAYEW	PEX13_HUMAN	Increases Expression	[10]
Homogentisate 1,2-dioxygenase (HGD)	OTTKLQOO	HGD_HUMAN	Decreases Expression	[10]
Collagen alpha-1(XXVI) chain (COL26A1)	OTMS7RNF	COQA1_HUMAN	Decreases Expression	[10]
Dedicator of cytokinesis protein 10 (DOCK10)	OTI3MBLV	DOC10_HUMAN	Decreases Expression	[10]
Copine-2 (CPNE2)	OTPESEM5	CPNE2_HUMAN	Decreases Expression	[10]
Coiled-coil domain-containing protein 34 (CCDC34)	OTZ3AGSQ	CCD34_HUMAN	Increases Expression	[10]
Fatty acyl-CoA reductase 2 (FAR2)	OTRYY709	FACR2_HUMAN	Decreases Expression	[10]
Adenylate kinase 7 (AK7)	OTASZDJN	KAD7_HUMAN	Increases Expression	[10]
Sodium channel and clathrin linker 1 (SCLT1)	OT2ZSSP4	SCLT1_HUMAN	Increases Expression	[10]
Erythroid membrane-associated protein (ERMAP)	OTKXBB52	ERMAP_HUMAN	Decreases Expression	[10]
Tribbles homolog 3 (TRIB3)	OTG5OS7X	TRIB3_HUMAN	Decreases Expression	[10]
Glutathione peroxidase 7 (GPX7)	OTINT9Z4	GPX7_HUMAN	Decreases Expression	[10]
Mitogen-activated protein kinase kinase kinase 5 (MAP3K5)	OTQR6ENW	M3K5_HUMAN	Decreases Expression	[10]
Melanin-concentrating hormone receptor 1 (MCHR1)	OTT57EOE	MCHR1_HUMAN	Decreases Expression	[10]
Dual specificity protein phosphatase 9 (DUSP9)	OTZZWEQL	DUS9_HUMAN	Decreases Expression	[10]
NAD-capped RNA hydrolase NUDT12 (NUDT12)	OTBUY58C	NUD12_HUMAN	Increases Expression	[10]
Mitochondrial 2-oxodicarboxylate carrier (SLC25A21)	OTB78IF4	ODC_HUMAN	Decreases Expression	[10]
MARVEL domain-containing protein 1 (MARVELD1)	OT5CPOJE	MALD1_HUMAN	Decreases Expression	[10]
Spexin (SPX)	OTY3G4AR	SPXN_HUMAN	Decreases Expression	[10]
Acireductone dioxygenase (ADI1)	OT8IOD03	MTND_HUMAN	Decreases Expression	[10]
Caspase recruitment domain-containing protein 10 (CARD10)	OT2RPM4I	CAR10_HUMAN	Decreases Expression	[10]
Contactin-associated protein-like 4 (CNTNAP4)	OTKXR9AW	CNTP4_HUMAN	Decreases Expression	[10]
Glycosyltransferase 8 domain-containing protein 2 (GLT8D2)	OT4VS9YY	GL8D2_HUMAN	Decreases Expression	[10]
Cytosolic beta-glucosidase (GBA3)	OT86XWU2	GBA3_HUMAN	Decreases Expression	[10]
Lysine-specific demethylase 4C (KDM4C)	OT2RHV9S	KDM4C_HUMAN	Increases Expression	[10]
NIPA-like protein 2 (NIPAL2)	OTX9UREP	NPAL2_HUMAN	Decreases Expression	[10]
Sialate O-acetylesterase (SIAE)	OTDQUESH	SIAE_HUMAN	Increases Expression	[10]
Pleckstrin homology domain-containing family A member 2 (PLEKHA2)	OTY2AP6T	PKHA2_HUMAN	Decreases Expression	[10]
Beta-parvin (PARVB)	OT9OGVWX	PARVB_HUMAN	Decreases Expression	[10]
3',5'-cyclic-AMP phosphodiesterase 7B (PDE7B)	OTK3SHT2	PDE7B_HUMAN	Increases Expression	[10]
Cell death regulator Aven (AVEN)	OTGIN5YK	AVEN_HUMAN	Decreases Expression	[10]
Rho guanine nucleotide exchange factor 4 (ARHGEF4)	OTR2VG0W	ARHG4_HUMAN	Decreases Expression	[10]
Interleukin-17 receptor B (IL17RB)	OT0KDNSF	I17RB_HUMAN	Decreases Expression	[10]
Probable G-protein coupled receptor 27 (GPR27)	OTH4KQPI	GPR27_HUMAN	Decreases Expression	[10]
Transmembrane protein 51 (TMEM51)	OTZCW8XJ	TMM51_HUMAN	Decreases Expression	[10]
24-hydroxycholesterol 7-alpha-hydroxylase (CYP39A1)	OTBAJT4I	CP39A_HUMAN	Increases Expression	[10]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (PLCE1)	OTJISZOX	PLCE1_HUMAN	Decreases Expression	[10]
Doublecortin domain-containing protein 2 (DCDC2)	OTSUFH1H	DCDC2_HUMAN	Decreases Expression	[10]
Cadherin-9 (CDH9)	OTV9N5XK	CADH9_HUMAN	Decreases Expression	[10]
Long-chain-fatty-acid--CoA ligase 5 (ACSL5)	OT3L9XO3	ACSL5_HUMAN	Decreases Expression	[10]
Mammalian ependymin-related protein 1 (EPDR1)	OT5JW5RB	EPDR1_HUMAN	Decreases Expression	[10]
Cystine/glutamate transporter (SLC7A11)	OTKJ6PXW	XCT_HUMAN	Decreases Expression	[10]
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9 (FUT9)	OTLIJBQY	FUT9_HUMAN	Increases Expression	[10]
Sorting nexin-10 (SNX10)	OT05B7BT	SNX10_HUMAN	Decreases Expression	[10]
CCN family member 1 (CCN1)	OTKJBEMD	CCN1_HUMAN	Increases Expression	[11]
Bcl-2-like protein 11 (BCL2L11)	OTNQQWFJ	B2L11_HUMAN	Increases Expression	[14]
Insulin-like growth factor I (IGF1)	OTIIZR61	IGF1_HUMAN	Increases Expression	[11]
Interleukin-6 (IL6)	OTUOSCCU	IL6_HUMAN	Increases Expression	[11]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Increases Cleavage	[14]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Increases Expression	[11]
Nuclear factor NF-kappa-B p105 subunit (NFKB1)	OTNRRD8I	NFKB1_HUMAN	Increases Expression	[14]
NF-kappa-B inhibitor alpha (NFKBIA)	OTFT924M	IKBA_HUMAN	Increases Expression	[14]
RAC-alpha serine/threonine-protein kinase (AKT1)	OT8H2YY7	AKT1_HUMAN	Increases Phosphorylation	[11]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Increases Cleavage	[14]
Glycogen synthase kinase-3 beta (GSK3B)	OTL3L14B	GSK3B_HUMAN	Increases Phosphorylation	[11]
Caspase-7 (CASP7)	OTAPJ040	CASP7_HUMAN	Increases Cleavage	[15]
Caspase-9 (CASP9)	OTD4RFFG	CASP9_HUMAN	Increases Cleavage	[14]
Transforming growth factor beta-2 proprotein (TGFB2)	OTC0TXEP	TGFB2_HUMAN	Increases Expression	[11]
Transcription factor p65 (RELA)	OTUJP9CN	TF65_HUMAN	Increases Acetylation	[14]

Indication(s) of Vincristine

Disease Entry	ICD 11	Status	REF
Acute lymphoblastic leukaemia	2A85	Approved	[5]
Adult kidney Wilms tumor	N.A.	Approved	[6]
Beckwith-Wiedemann syndrome	N.A.	Approved	[6]
Burkitt lymphoma	N.A.	Approved	[6]
Central nervous system neoplasm	N.A.	Approved	[6]
Childhood acute lymphoblastic leukemia	N.A.	Approved	[6]
Childhood kidney Wilms tumor	N.A.	Approved	[6]
Hamartoma	N.A.	Approved	[6]
Kidney neoplasm	N.A.	Approved	[6]
Leukemia	N.A.	Approved	[6]
MALT lymphoma	N.A.	Approved	[6]
Nodal marginal zone lymphoma	2A85.0	Approved	[6]
Plasma cell myeloma	2A83.1	Approved	[6]
Primitive neuroectodermal tumor	N.A.	Approved	[6]
Splenic marginal zone lymphoma	N.A.	Approved	[6]
Testicular lymphoma	N.A.	Approved	[6]
Wilms tumor	N.A.	Approved	[6]
Classic Hodgkin lymphoma	N.A.	Investigative	[6]
Follicular lymphoma	2A80	Investigative	[6]
Neuroblastoma	2D11.2	Investigative	[6]

Vincristine Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Tubulin beta (TUBB)	TTYFKSZ	NOUNIPROTAC	Modulator	[16]

Vincristine Interacts with 4 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
Multidrug resistance-associated protein 1 (ABCC1)	DTSYQGK	MRP1_HUMAN	Substrate	[17]
Multidrug resistance-associated protein 2 (ABCC2)	DTFI42L	MRP2_HUMAN	Substrate	[18]
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[19]
Breast cancer resistance protein (ABCG2)	DTI7UX6	ABCG2_HUMAN	Substrate	[20]

Vincristine Interacts with 3 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[21]
Cytochrome P450 3A5 (CYP3A5)	DEIBDNY	CP3A5_HUMAN	Metabolism	[21]
Cytochrome P450 3A7 (CYP3A7)	DERD86B	CP3A7_HUMAN	Metabolism	[22]

References

• [1] ClinicalTrials.gov (NCT01839097) Phase 1 Dose Finding Study of Belinostat for Treatment of Patients With Peripheral T-cell Lymphoma (PTCL)
• [2] Belinostat FDA Label
• [3] A Phase II trial of Belinostat (PXD101) in patients with relapsed or refractory peripheral or cutaneous T-cell lymphoma. Br J Haematol. 2015 Mar;168(6):811-9.
• [4] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [5] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6785).
• [6] Vincristine FDA Label
• [7] Glucuronidation by UGT1A1 is the dominant pathway of the metabolic disposition of belinostat in liver cancer patients. PLoS One. 2013;8(1):e54522.
• [8] Gene expression-signature of belinostat in cell lines is specific for histone deacetylase inhibitor treatment, with a corresponding signature in xenografts. Anticancer Drugs. 2009 Sep;20(8):682-92.
• [9] A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
• [10] Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
• [11] Histone acetylation-mediated regulation of the Hippo pathway. PLoS One. 2013 May 6;8(5):e62478. doi: 10.1371/journal.pone.0062478. Print 2013.
• [12] Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
• [13] Effects of UGT1A1 genotype on the pharmacokinetics, pharmacodynamics, and toxicities of belinostat administered by 48-hour continuous infusion in patients with cancer. J Clin Pharmacol. 2016 Apr;56(4):461-73.
• [14] Interactions between bortezomib and romidepsin and belinostat in chronic lymphocytic leukemia cells. Clin Cancer Res. 2008 Jan 15;14(2):549-58. doi: 10.1158/1078-0432.CCR-07-1934.
• [15] Raloxifene induces autophagy-dependent cell death in breast cancer cells via the activation of AMP-activated protein kinase. Mol Cells. 2015;38(2):138-44. doi: 10.14348/molcells.2015.2193. Epub 2014 Dec 24.
• [16] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [17] Interaction of plant cannabinoids with the multidrug transporter ABCC1 (MRP1). Eur J Pharmacol. 2008 Sep 4;591(1-3):128-31.
• [18] Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64.
• [19] L-type calcium channel blockers reverse docetaxel and vincristine-induced multidrug resistance independent of ABCB1 expression in human lung cancer cell lines. Toxicol Lett. 2010 Feb 15;192(3):408-18.
• [20] Mutant Gly482 and Thr482 ABCG2 mediate high-level resistance to lipophilic antifolates. Cancer Chemother Pharmacol. 2006 Dec;58(6):826-34.
• [21] Association of CYP3A5 expression and vincristine neurotoxicity in pediatric malignancies in Turkish population. J Pediatr Hematol Oncol. 2017 Aug;39(6):458-462.
• [22] Drug Interactions Flockhart Table