Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM0FB1J)

• Drug Name: Sertraline Drug Info
• Synonyms: Lustral; SRE; Sertralina; Sertralinum; Sertralina [Spanish]; Sertraline [Zoloft]; Sertralinum [Latin]; CP 51974; Cp 51974; Apo-Sertraline; Lustral (TN); Sertraline (INN); Sertraline (Zoloft); Sertraline [INN:BAN]; Zoloft (TN); (+)-Sertraline; (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine; (1S-cis)-1,2,3,4-Tetrahydro-4-(3,4-dichlorophenyl)-N-methyl-1-naphthalenamine; (1S-cis)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine

Indication

Disease Entry	ICD 11	Status	REF
Coronary heart disease	BA80.Z	Approved	[1]
Depression	6A70-6A7Z	Approved	[2]
Epilepsy	8A60-8A68	Approved	[1]
Obsessive compulsive disorder	6B20	Approved	[1]
Panic disorder	6B01	Approved	[1]
Post-traumatic stress disorder	6B40	Approved	[1]

• Therapeutic Class: Antidepressants
• Cross-matching ID:
  PubChem CID: 68617
  ChEBI ID: CHEMBL809
  CAS Number: CAS 79617-96-2
  TTD Drug ID: DM0FB1J
  VARIDT Drug ID: DR00440
  INTEDE Drug ID: DR1477
  ACDINA Drug ID: D00620

Molecule-Related Drug Atlas

Drug(s) Targeting Serotonin transporter (SERT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[17]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[18]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[19]
Vortioxetine	DM6F1PU	Major depressive disorder	6A70.3	Approved	[20]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[21]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[22]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[19]
Nortriptyline	DM4KDYJ	Depression	6A70-6A7Z	Approved	[19]
Trazodone	DMK1GBJ	Depression	6A70-6A7Z	Approved	[19]
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[19]

Drug(s) Transported By P-glycoprotein 1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[23]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[24]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[25]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[26]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[25]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[25]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[27]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[25]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[28]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[29]

Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[30]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[31]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[32]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[33]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[34]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[35]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[36]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[37]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[31]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[38]

Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[39]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[40]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[41]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[42]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[43]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[44]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[36]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[45]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[46]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[47]

Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[49]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[50]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[34]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[51]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[52]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[53]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[54]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[55]

Drug(s) Metabolized By Cytochrome P450 2E1 (CYP2E1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[56]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[60]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[45]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[61]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[62]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[63]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[64]

Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[65]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[66]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[61]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[68]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[61]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[69]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[70]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]

Drug(s) Metabolized By Cytochrome P450 2B6 (CYP2B6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[73]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[61]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[74]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[75]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[76]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[77]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[78]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[79]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[80]

Drug(s) Metabolized By Mephenytoin 4-hydroxylase (CYP2C19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[81]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[65]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[82]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[83]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[61]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[84]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[86]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[87]

Drug(s) Affected By Cytochrome P450 2C19 (CYP2C19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[88]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[89]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[90]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[91]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[92]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[93]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[94]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[93]
Desipramine	DMT2FDC	Attention deficit hyperactivity disorder	6A05.Z	Approved	[89]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[95]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[96]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[97]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[98]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[99]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[100]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[101]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[102]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[103]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[101]
Levetiracetam	DMTGDN8	Epilepsy	8A60-8A68	Approved	[98]

Drug(s) Affected By Phytanoyl-CoA dioxygenase, peroxisomal (PHYH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[12]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[104]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[12]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[12]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[12]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[106]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[107]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[108]

Drug(s) Affected By Nuclear protein 1 (NUPR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[109]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[110]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[111]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[12]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[12]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[12]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[113]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[110]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[110]

Drug(s) Affected By Alpha-1-antichymotrypsin (SERPINA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[114]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[111]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[12]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[12]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[115]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[12]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[116]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[116]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[12]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[117]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[118]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[119]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[111]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[12]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[120]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[12]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[12]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[121]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[122]

Drug(s) Affected By Inhibin beta E chain (INHBE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[111]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[12]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[12]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[12]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[123]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[110]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[12]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[124]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[110]

Drug(s) Affected By Acid ceramidase (ASAH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[125]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[110]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[126]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[12]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[12]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[110]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[12]

Drug(s) Affected By Nuclear receptor subfamily 0 group B member 2 (NR0B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[128]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[129]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[130]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[131]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[12]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[110]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[132]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[12]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[133]

Drug(s) Affected By Lysophospholipase D GDPD3 (GDPD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[111]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[12]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[110]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[110]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[12]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[134]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[135]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[135]
Haloperidol	DM96SE0	Delirium		Approved	[110]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[136]

Drug(s) Affected By Fibronectin type III domain-containing protein 4 (FNDC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[12]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[12]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[12]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[110]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[12]
Haloperidol	DM96SE0	Delirium		Approved	[110]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[106]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[137]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[12]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[12]

Drug(s) Affected By Protein DEPP1 (DEPP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[110]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[138]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[12]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[12]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[12]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[110]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[110]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[12]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 13 (MAP3K13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[106]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[140]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[141]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[142]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[143]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[144]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[145]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[146]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 beta (GADD45B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[109]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[130]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[147]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[124]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[149]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[150]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[135]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[135]

Drug(s) Affected By Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[152]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[153]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[154]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[153]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[155]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[156]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[153]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[157]

Drug(s) Affected By Protein phosphatase 1 regulatory subunit 15A (PPP1R15A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[158]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[159]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[160]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[161]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[162]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[134]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[163]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[164]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[165]

Drug(s) Affected By Dual specificity protein phosphatase 14 (DUSP14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[159]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[166]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[150]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[168]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[169]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[136]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[166]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[170]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[147]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[171]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[136]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[137]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[172]
Bortezomib	DMNO38U	Leukemia		Approved	[173]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[141]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[174]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[175]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[176]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[177]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[177]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[178]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[180]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[181]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[182]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[183]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[184]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[178]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[185]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[186]
Selenium	DM25CGV	N. A.	N. A.	Approved	[187]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[188]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[189]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[190]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[104]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[191]

Drug(s) Affected By Albumin (ALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[142]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[95]
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[192]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[193]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[194]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[195]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[196]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[197]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[198]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[199]

Drug(s) Affected By Platelet basic protein (PPBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[200]
Nortriptyline	DM4KDYJ	Depression	6A70-6A7Z	Approved	[201]
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[201]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[202]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[158]
Amlodipine	DMBDAZV	Angina pectoris	BA40	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[137]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[204]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[205]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[206]

Drug(s) Affected By Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[207]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[208]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[209]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[210]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[211]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[155]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[212]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[213]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[214]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[215]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[216]
Fructose	DM43AN2	Vomiting	MD90	Approved	[95]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[217]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[218]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[219]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[220]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[221]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[222]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[223]

Drug(s) Affected By Transcription factor AP-2-alpha (TFAP2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[224]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[225]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[226]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[124]
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[227]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[168]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[228]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[165]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[165]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[165]

Drug(s) Affected By Heat shock cognate 71 kDa protein (HSPA8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[229]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[207]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[230]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[231]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[232]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[233]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[234]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[235]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[236]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[169]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-2 (ATF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[220]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[120]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[237]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[106]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[239]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[137]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[240]
Bortezomib	DMNO38U	Leukemia		Approved	[173]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[141]

Drug(s) Affected By Heat shock 70 kDa protein 6 (HSPA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[158]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[241]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[242]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[161]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[210]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[243]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[235]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[169]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[106]

Drug(s) Affected By Transcription factor JunD (JUND)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[218]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[244]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[246]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[247]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[186]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[248]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[249]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-4 (ATF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[250]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Selenium	DM25CGV	N. A.	N. A.	Approved	[251]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[244]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[155]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[156]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[247]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[252]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[237]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[171]

Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[253]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[248]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[254]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[255]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[256]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[191]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[257]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[258]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[199]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[158]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[254]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[259]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[244]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[260]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[261]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[262]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[263]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[264]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[210]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[265]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[266]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[267]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[268]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[269]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[270]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[271]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[272]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[273]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[274]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[275]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[266]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[276]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[277]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[278]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[265]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[95]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[279]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[268]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[269]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[158]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[280]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[250]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[153]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[241]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[281]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[282]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[160]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[283]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 8 (MAP3K8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[284]
Selenium	DM25CGV	N. A.	N. A.	Approved	[251]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[120]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[199]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[285]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[169]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[136]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[140]

Drug(s) Affected By Translocon-associated protein subunit beta (SSR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[106]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[286]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[143]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[287]
AHPN	DM8G6O4	Discovery agent	N.A.	Investigative	[288]

Drug(s) Affected By Protein transport protein Sec61 subunit gamma (SEC61G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[106]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[108]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[284]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[289]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[290]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[291]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[292]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[293]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[294]

Drug(s) Affected By E3 ubiquitin-protein ligase RBX1 (RBX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[249]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[140]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[108]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[295]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[141]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[289]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[296]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[291]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[292]

Drug(s) Affected By S-phase kinase-associated protein 1 (SKP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[136]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[137]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[108]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[297]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[295]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[298]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[299]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[142]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[300]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[292]

Drug(s) Affected By Nuclear factor NF-kappa-B p100 subunit (NFKB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[279]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[147]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[199]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[301]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[302]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[106]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[107]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[108]

Drug(s) Affected By Transcription factor RelB (RELB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[303]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[284]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[104]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[304]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[246]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[175]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[163]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[135]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[135]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[106]

Drug(s) Affected By Acetyl-CoA carboxylase 1 (ACACA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[230]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[153]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[305]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[199]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[306]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[307]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[308]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[309]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[310]

Drug(s) Affected By Dual specificity protein phosphatase 8 (DUSP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[251]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[175]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[163]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[169]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[136]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[137]
Febuxostat	DMDEXQ0	Hyperuricaemia	5C55.Y	Approved	[311]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[312]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[141]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[313]

Drug(s) Affected By Cullin-1 (CUL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[314]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[301]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[137]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[108]
Bortezomib	DMNO38U	Leukemia		Approved	[315]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[141]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[142]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[314]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[316]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[143]

Drug(s) Affected By Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (HERPUD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[158]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[317]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[247]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[163]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[318]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[140]
Racecadotril	DMFOTZ7	Diarrhea	ME05.1	Approved	[319]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[320]

Drug(s) Affected By Serine/threonine-protein kinase STK11 (STK11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[251]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[321]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[137]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[322]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[323]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[170]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[324]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[325]
GDC-0980/RG7422	DMF3MV1	Non-hodgkin lymphoma	2B33.5	Phase 2	[326]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[327]

Drug(s) Affected By E3 ubiquitin-protein ligase synoviolin (SYVN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[106]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[108]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[170]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[328]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[296]
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[329]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[286]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[292]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[145]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[330]

Drug(s) Affected By Dual specificity protein phosphatase 16 (DUSP16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[331]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[161]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[175]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[169]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[106]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[137]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[332]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[333]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[142]

Drug(s) Affected By Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[334]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[147]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[335]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[247]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[336]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[337]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[338]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[339]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[340]

Drug(s) Affected By DnaJ homolog subfamily C member 5 (DNAJC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[341]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[140]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[174]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[170]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[289]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[296]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[174]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[342]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[343]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[343]

Drug(s) Affected By Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[153]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[284]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[153]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[344]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[153]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[155]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[156]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[252]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[157]

Drug(s) Affected By Serine/threonine-protein kinase TAO2 (TAOK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[104]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[169]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[137]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[297]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[345]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[346]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[296]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[292]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[347]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[143]

Drug(s) Affected By C-Jun-amino-terminal kinase-interacting protein 3 (MAPK8IP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[137]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[348]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[346]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[143]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[343]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[146]

Drug(s) Affected By Sodium-dependent serotonin transporter (SLC6A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[349]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[350]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[284]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[351]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[352]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[353]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[354]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[352]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[136]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Serotonin transporter (SERT)	TT3ROYC	SC6A4_HUMAN	Inhibitor	[3]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[4]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4) Main DME	DE4LYSA	CP3A4_HUMAN	Substrate	[5]
Cytochrome P450 2E1 (CYP2E1)	DEVDYN7	CP2E1_HUMAN	Substrate	[6]
Cytochrome P450 2D6 (CYP2D6)	DECB0K3	CP2D6_HUMAN	Substrate	[7]
Cytochrome P450 2C9 (CYP2C9)	DE5IED8	CP2C9_HUMAN	Substrate	[8]
Mephenytoin 4-hydroxylase (CYP2C19)	DEGTFWK	CP2CJ_HUMAN	Substrate	[9]
Cytochrome P450 1A2 (CYP1A2)	DEJGDUW	CP1A2_HUMAN	Substrate	[10]
Cytochrome P450 2B6 (CYP2B6) Main DME	DEPKLMQ	CP2B6_HUMAN	Substrate	[9]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Acetyl-CoA carboxylase 1 (ACACA)	OT5CQPZY	ACACA_HUMAN	Post-Translational Modifications	[11]
Acid ceramidase (ASAH1)	OT1DNGXL	ASAH1_HUMAN	Gene/Protein Processing	[12]
Albumin (ALB)	OTVMM513	ALBU_HUMAN	Protein Interaction/Cellular Processes	[13]
Alpha-1-antichymotrypsin (SERPINA3)	OT9BP2S0	AACT_HUMAN	Gene/Protein Processing	[12]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Gene/Protein Processing	[14]
C-Jun-amino-terminal kinase-interacting protein 3 (MAPK8IP3)	OT0X8ACY	JIP3_HUMAN	Gene/Protein Processing	[15]
Cullin-1 (CUL1)	OTXPE1UZ	CUL1_HUMAN	Gene/Protein Processing	[15]
Cyclic AMP-dependent transcription factor ATF-2 (ATF2)	OTNIZPEA	ATF2_HUMAN	Gene/Protein Processing	[15]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4)	OTRFV19J	ATF4_HUMAN	Gene/Protein Processing	[15]
Cytochrome P450 2C19 (CYP2C19)	OTFMJYYE	CP2CJ_HUMAN	Biotransformations	[16]

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