Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM0FB1J)

• Drug Name: Sertraline Drug Info
• Synonyms: Lustral; SRE; Sertralina; Sertralinum; Sertralina [Spanish]; Sertraline [Zoloft]; Sertralinum [Latin]; CP 51974; Cp 51974; Apo-Sertraline; Lustral (TN); Sertraline (INN); Sertraline (Zoloft); Sertraline [INN:BAN]; Zoloft (TN); (+)-Sertraline; (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine; (1S-cis)-1,2,3,4-Tetrahydro-4-(3,4-dichlorophenyl)-N-methyl-1-naphthalenamine; (1S-cis)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine

Indication

Disease Entry	ICD 11	Status	REF
Coronary heart disease	BA80.Z	Approved	[1]
Depression	6A70-6A7Z	Approved	[2]
Epilepsy	8A60-8A68	Approved	[1]
Obsessive compulsive disorder	6B20	Approved	[1]
Panic disorder	6B01	Approved	[1]
Post-traumatic stress disorder	6B40	Approved	[1]

• Therapeutic Class: Antidepressants
• Cross-matching ID:
  PubChem CID: 68617
  ChEBI ID: CHEBI:9123
  CAS Number: CAS 79617-96-2
  TTD Drug ID: DM0FB1J
  VARIDT Drug ID: DR00440
  INTEDE Drug ID: DR1477
  ACDINA Drug ID: D00620

Molecule-Related Drug Atlas

Drug(s) Targeting Serotonin transporter (SERT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[18]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[19]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[20]
Vortioxetine	DM6F1PU	Major depressive disorder	6A70.3	Approved	[21]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[22]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[23]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[20]
Nortriptyline	DM4KDYJ	Depression	6A70-6A7Z	Approved	[20]
Trazodone	DMK1GBJ	Depression	6A70-6A7Z	Approved	[20]
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[20]

Drug(s) Transported By P-glycoprotein 1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[24]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[25]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[26]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[27]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[26]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[26]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[28]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[26]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[29]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[30]

Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[31]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[32]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[33]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[34]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[35]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[36]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[37]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[38]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[32]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[39]

Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[40]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[41]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[42]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[44]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[45]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[37]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[46]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[47]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[48]

Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[49]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[50]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[51]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[35]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[39]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[52]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[53]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[54]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[55]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[56]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Paliperidone	DM7NPJS	Psychotic disorder	6A20-6A25	Approved	[100]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[101]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[102]
Oxatomide	DM1F42Z	Hay fever	CA08.00	Approved	[103]
Cinacalcet	DMCX0K3	Hyperparathyroidism	5A51	Approved	[104]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[105]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[106]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[107]
Buprenorphine	DMPRI8G	Opioid dependence	6C43.2Z	Approved	[108]

Drug(s) Metabolized By Cytochrome P450 2E1 (CYP2E1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[57]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[58]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[59]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[60]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[61]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[46]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[62]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[63]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[64]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[65]

Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[66]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[67]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[68]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[62]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[69]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[62]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[70]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[71]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[73]

Drug(s) Metabolized By Cytochrome P450 2B6 (CYP2B6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[74]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[62]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[75]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[68]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[77]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[78]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[79]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[80]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[81]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[89]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[90]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[91]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[92]
Clopidogrel	DMOL54H	Acute coronary syndrome	BA41	Approved	[93]
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[94]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[95]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[96]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[97]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[98]

Drug(s) Metabolized By Mephenytoin 4-hydroxylase (CYP2C19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[82]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[66]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[83]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[84]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[62]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[85]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[86]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[73]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[87]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[88]

Drug(s) Affected By Cytochrome P450 2C19 (CYP2C19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[109]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[110]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[111]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[112]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[105]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[106]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[113]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[106]
Desipramine	DMT2FDC	Attention deficit hyperactivity disorder	6A05.Z	Approved	[110]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[114]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[115]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[116]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[117]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[118]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[119]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[120]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[121]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[122]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[120]
Levetiracetam	DMTGDN8	Epilepsy	8A60-8A68	Approved	[117]

Drug(s) Affected By Phytanoyl-CoA dioxygenase, peroxisomal (PHYH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[12]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[123]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[12]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[124]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[12]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[12]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[125]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[126]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[127]

Drug(s) Affected By Nuclear protein 1 (NUPR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[128]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[129]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[130]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[12]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[12]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[131]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[12]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[132]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[129]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[129]

Drug(s) Affected By Alpha-1-antichymotrypsin (SERPINA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[133]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[130]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[12]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[12]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[134]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[12]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[135]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[12]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[136]

Drug(s) Affected By Serine protease hepsin (HPN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[137]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[12]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[12]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[131]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[12]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[129]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[12]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[125]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]

Drug(s) Affected By Fatty acid-binding protein, liver (FABP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[140]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[130]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[12]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[123]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[12]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[131]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[12]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[141]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[129]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[12]

Drug(s) Affected By Asparagine synthetase (ASNS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[142]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[143]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[12]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[144]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[145]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[129]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[12]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[146]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[124]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[145]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[147]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[148]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[130]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[12]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[149]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[12]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[131]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[12]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[151]

Drug(s) Affected By Lanosterol synthase (LSS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[152]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[12]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[12]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[131]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[12]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[153]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[154]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[129]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[12]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[12]

Drug(s) Affected By Inhibin beta E chain (INHBE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[130]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[12]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[12]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[131]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[12]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[154]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[129]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[12]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[155]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[129]

Drug(s) Affected By Transgelin (TAGLN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[156]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[130]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[12]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[157]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[12]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[131]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[12]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[130]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[159]

Drug(s) Affected By Acid ceramidase (ASAH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[160]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[129]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[161]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[12]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[129]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[131]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[12]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[162]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[129]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[12]

Drug(s) Affected By Nuclear receptor subfamily 0 group B member 2 (NR0B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[163]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[164]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[152]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[12]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[129]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[166]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[131]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[12]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[167]

Drug(s) Affected By Lysophospholipase D GDPD3 (GDPD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[130]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[12]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[129]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[129]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[12]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[168]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[169]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[169]
Haloperidol	DM96SE0	Delirium		Approved	[129]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[170]

Drug(s) Affected By Fibronectin type III domain-containing protein 4 (FNDC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[12]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[12]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[12]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[129]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[12]
Haloperidol	DM96SE0	Delirium		Approved	[129]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[125]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[12]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[12]

Drug(s) Affected By Protein DEPP1 (DEPP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[129]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[171]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[12]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[12]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[131]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[12]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[129]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[129]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[12]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[173]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[174]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[175]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[176]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[177]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[178]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[164]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[179]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[180]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[181]

Drug(s) Affected By Signal transducer and activator of transcription 3 (STAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[114]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[182]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[183]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[184]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[185]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[149]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[186]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[187]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[188]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[134]

Drug(s) Affected By Aromatase (CYP19A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[189]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[190]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[164]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[16]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[123]
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[191]
Bifonazole	DM3KN7V	Fungal infection	1F29-1F2F	Approved	[192]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[193]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[16]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[153]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 13 (MAP3K13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[131]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[124]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[125]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[194]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[195]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[196]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[197]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[198]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[199]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[200]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 beta (GADD45B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[128]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[201]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[202]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[124]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[155]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[203]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[204]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[169]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[169]

Drug(s) Affected By Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[205]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[206]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[207]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[208]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[207]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[209]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[210]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[207]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[211]

Drug(s) Affected By Protein phosphatase 1 regulatory subunit 15A (PPP1R15A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[142]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[212]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[213]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[131]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[146]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[214]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[168]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[215]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[216]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[217]

Drug(s) Affected By Dual specificity protein phosphatase 14 (DUSP14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[212]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[218]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[219]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[124]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[204]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[220]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[221]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[170]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[218]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[222]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[201]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[131]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[124]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[223]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[170]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[224]
Bortezomib	DMNO38U	Leukemia		Approved	[225]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[195]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[226]

Drug(s) Affected By Epidermal growth factor receptor (EGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BIBW 2992	DMTKD7Q	Non-small-cell lung cancer	2C25.Y	Approved	[227]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[228]
Erlotinib	DMCMBHA	Adrenal gland neoplasm		Approved	[229]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[230]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[231]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[232]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[233]
Selenium	DM25CGV	N. A.	N. A.	Approved	[234]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[235]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[236]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[237]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[238]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[239]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[239]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[240]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[241]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[242]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[243]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[244]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[245]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[246]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[240]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[247]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[248]
Selenium	DM25CGV	N. A.	N. A.	Approved	[249]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[250]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[251]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[252]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[123]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[253]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[254]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[255]
Fructose	DM43AN2	Vomiting	MD90	Approved	[114]
Ketoprofen	DMRKXPT	Bursitis		Approved	[114]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[256]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[257]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[258]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[259]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[133]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[260]

Drug(s) Affected By Alpha-crystallin A chain (CRYAA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[261]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[222]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[262]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[263]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[197]

Drug(s) Affected By Albumin (ALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[196]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[114]
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[264]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[265]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[266]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[267]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[268]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[269]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[270]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[153]

Drug(s) Affected By Platelet basic protein (PPBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[271]
Nortriptyline	DM4KDYJ	Depression	6A70-6A7Z	Approved	[272]
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[272]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[273]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[142]
Amlodipine	DMBDAZV	Angina pectoris	BA40	Approved	[274]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[275]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[276]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[277]

Drug(s) Affected By Platelet factor 4 (PF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[271]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[123]
Fructose	DM43AN2	Vomiting	MD90	Approved	[278]
Nortriptyline	DM4KDYJ	Depression	6A70-6A7Z	Approved	[272]
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[272]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[279]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[276]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[280]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[281]
Ardeparin	DMYRX8B	Deep vein thrombosis	BD71	Approved	[282]

Drug(s) Affected By Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[143]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[283]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[131]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[284]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[285]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[286]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[209]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[287]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[288]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[289]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[290]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[291]
Fructose	DM43AN2	Vomiting	MD90	Approved	[114]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[292]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[293]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[294]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[295]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[296]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[297]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[298]

Drug(s) Affected By Transcription factor AP-2-alpha (TFAP2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[299]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[300]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[301]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[155]
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[302]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[220]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[138]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[217]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[217]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[217]

Drug(s) Affected By Monocyte differentiation antigen CD14 (CD14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[153]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[146]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[303]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[214]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[304]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[305]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[169]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[306]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[125]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[307]

Drug(s) Affected By Heat shock 70 kDa protein 1A (HSPA1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[308]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[142]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[309]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[310]
Selenium	DM25CGV	N. A.	N. A.	Approved	[137]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[311]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[123]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[131]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[312]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[285]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[313]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[314]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[315]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[316]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[114]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[128]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[317]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[318]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[319]
Flucytosine	DM13VTW	Cryptococcal meningitis		Approved	[320]

Drug(s) Affected By Heat shock cognate 71 kDa protein (HSPA8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[321]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[143]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[233]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[311]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[322]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[323]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[324]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[325]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[326]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[221]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-2 (ATF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[295]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[149]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[327]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[328]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[125]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[329]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[330]
Bortezomib	DMNO38U	Leukemia		Approved	[225]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[195]

Drug(s) Affected By P-selectin (SELP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[124]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[331]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[332]
Amlodipine	DMBDAZV	Angina pectoris	BA40	Approved	[274]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Asasantin	DMCZIHT	Cerebrovascular ischaemia	8B1Z	Approved	[333]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[334]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[335]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[276]
Ardeparin	DMYRX8B	Deep vein thrombosis	BD71	Approved	[336]

Drug(s) Affected By Platelet endothelial cell adhesion molecule (PECAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[258]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[124]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[337]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[136]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[338]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[339]
Asasantin	DMCZIHT	Cerebrovascular ischaemia	8B1Z	Approved	[333]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[340]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[341]
Vitamin B3	DMQVRZH	Chronic renal failure	GB61.Z	Approved	[342]

Drug(s) Affected By E-selectin (SELE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[343]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[344]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[345]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[346]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[347]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[348]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[349]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[350]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[351]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[352]

Drug(s) Affected By Stathmin (STMN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[143]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[311]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[353]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[146]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[323]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[354]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[169]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[169]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[221]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[125]

Drug(s) Affected By Heat shock 70 kDa protein 6 (HSPA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[142]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[310]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[355]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[146]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[285]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[356]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[325]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[221]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[125]

Drug(s) Affected By Transcription factor JunD (JUND)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[293]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[241]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[144]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[131]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[357]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[358]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[359]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[248]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[360]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[361]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-4 (ATF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[362]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[241]
Selenium	DM25CGV	N. A.	N. A.	Approved	[137]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[144]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[209]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[210]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[359]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[363]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[327]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[223]

Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[364]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[360]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[365]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[241]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[366]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[367]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[253]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[368]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[369]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[153]

Drug(s) Affected By Ribosomal protein S6 kinase beta-1 (RPS6KB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[370]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[371]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[372]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[251]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[373]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[374]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[375]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[376]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[377]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[378]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[142]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[365]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[379]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[144]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[380]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[381]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[382]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[383]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[384]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[285]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[385]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[386]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[387]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[388]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[389]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[390]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[391]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[392]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[393]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[394]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[395]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[386]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[396]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[397]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[398]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[385]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[114]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[182]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[388]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[389]

Drug(s) Affected By Dual specificity protein phosphatase 1 (DUSP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[128]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[399]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[400]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[219]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[131]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[132]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[401]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[215]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[204]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[169]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[142]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[402]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[362]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[207]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[310]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[403]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[404]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[213]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[131]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[405]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 8 (MAP3K8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[140]
Selenium	DM25CGV	N. A.	N. A.	Approved	[137]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[149]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[131]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[153]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[162]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[406]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[221]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[170]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[194]

Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[407]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[408]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[371]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[409]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[250]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[410]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[411]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[412]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[413]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[410]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[414]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[415]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[416]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[417]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[418]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[419]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[420]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[421]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[422]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[423]

Drug(s) Affected By Translocon-associated protein subunit beta (SSR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[125]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[424]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[197]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[425]
AHPN	DM8G6O4	Discovery agent	N.A.	Investigative	[426]

Drug(s) Affected By Caspase-4 (CASP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[182]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[294]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[140]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[427]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[428]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[429]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[220]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[430]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[406]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[125]

Drug(s) Affected By Ribosomal protein S6 kinase alpha-3 (RPS6KA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[131]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[375]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[169]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[169]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[125]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[127]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[431]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[432]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[433]

Drug(s) Affected By Caspase-7 (CASP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[434]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[435]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[436]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[437]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[437]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[201]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[253]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[438]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[439]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[440]

Drug(s) Affected By Protein transport protein Sec61 subunit gamma (SEC61G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[204]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[125]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[127]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[140]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[441]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[442]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[443]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[263]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[444]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[445]

Drug(s) Affected By E3 ubiquitin-protein ligase RBX1 (RBX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[124]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[361]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[194]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[127]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[446]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[195]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[441]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[281]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[443]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[263]

Drug(s) Affected By S-phase kinase-associated protein 1 (SKP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[170]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[127]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[447]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[446]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[448]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[449]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[196]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[450]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[263]

Drug(s) Affected By Nuclear factor NF-kappa-B p100 subunit (NFKB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[182]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[201]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[131]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[153]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[124]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[412]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[451]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[125]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[126]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[127]

Drug(s) Affected By Transcription factor RelB (RELB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[452]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[140]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[123]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[453]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[358]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[237]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[215]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[169]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[169]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[125]

Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[160]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[454]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[455]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[456]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[457]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[285]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[160]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[458]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[459]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[460]

Drug(s) Affected By Potassium voltage-gated channel subfamily H member 2 (KCNH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metoclopramide	DMFA5MY	Nausea	MD90	Approved	[461]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[462]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[463]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[464]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[464]
Disopyramide	DM5SYZP	Long QT syndrome	BC65.0	Approved	[465]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[466]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[467]
Dofetilide	DMPN1TW	Sinus rhythm disorder	BC9Y	Approved	[468]
Flecainide	DMSQDLE	Tachyarrhythmias	BC71	Approved	[464]

Drug(s) Affected By Acetyl-CoA carboxylase 1 (ACACA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[233]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[207]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[457]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[153]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[469]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[470]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[471]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[472]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[473]

Drug(s) Affected By Dual specificity protein phosphatase 8 (DUSP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[137]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[237]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[215]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[221]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[170]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Febuxostat	DMDEXQ0	Hyperuricaemia	5C55.Y	Approved	[474]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[475]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[195]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[476]

Drug(s) Affected By Sequestosome-1 (SQSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[408]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[477]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[161]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[478]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[144]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[201]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[131]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[146]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[479]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[359]

Drug(s) Affected By Cullin-1 (CUL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[375]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[412]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[127]
Bortezomib	DMNO38U	Leukemia		Approved	[480]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[195]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[196]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[375]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[481]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[197]

Drug(s) Affected By Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (HERPUD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[142]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[482]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[131]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[359]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[215]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[204]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[483]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[194]
Racecadotril	DMFOTZ7	Diarrhea	ME05.1	Approved	[484]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[485]

Drug(s) Affected By Serine/threonine-protein kinase STK11 (STK11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[137]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[486]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[487]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[488]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[222]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[489]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[490]
GDC-0980/RG7422	DMF3MV1	Non-hodgkin lymphoma	2B33.5	Phase 2	[491]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[492]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[493]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[494]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[495]
Selenium	DM25CGV	N. A.	N. A.	Approved	[137]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[496]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[497]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[498]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[131]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[499]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[153]

Drug(s) Affected By E3 ubiquitin-protein ligase synoviolin (SYVN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[125]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[127]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[222]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[500]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[281]
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[501]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[424]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[263]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[199]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[502]

Drug(s) Affected By Dual specificity protein phosphatase 16 (DUSP16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[503]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[146]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[237]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[221]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[125]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[504]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[505]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[196]

Drug(s) Affected By Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[409]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[201]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[131]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[506]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[359]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[507]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[508]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[509]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[413]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[510]

Drug(s) Affected By DnaJ homolog subfamily C member 5 (DNAJC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[511]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[194]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[226]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[222]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[441]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[281]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[226]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[512]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[513]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[513]

Drug(s) Affected By Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[205]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[207]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[140]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[207]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[514]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[207]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[209]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[210]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[363]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[211]

Drug(s) Affected By Serine/threonine-protein kinase TAO2 (TAOK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[123]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[221]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[447]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[515]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[516]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[281]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[263]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[517]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[197]

Drug(s) Affected By C-Jun-amino-terminal kinase-interacting protein 3 (MAPK8IP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[433]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[516]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[197]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[513]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[200]

Drug(s) Affected By Dual specificity protein phosphatase 10 (DUSP10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[219]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[518]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[135]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[155]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[518]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[215]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[406]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[221]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[125]

Drug(s) Affected By Sodium-dependent serotonin transporter (SLC6A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[519]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[520]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[140]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[521]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[410]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[522]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[131]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[523]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[410]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[170]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Serotonin transporter (SERT)	TT3ROYC	SC6A4_HUMAN	Inhibitor	[3]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[4]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4) Main DME	DE4LYSA	CP3A4_HUMAN	Substrate	[5]
Cytochrome P450 2E1 (CYP2E1)	DEVDYN7	CP2E1_HUMAN	Substrate	[6]
Cytochrome P450 2D6 (CYP2D6)	DECB0K3	CP2D6_HUMAN	Substrate	[7]
Cytochrome P450 2C9 (CYP2C9)	DE5IED8	CP2C9_HUMAN	Substrate	[8]
Mephenytoin 4-hydroxylase (CYP2C19)	DEGTFWK	CP2CJ_HUMAN	Substrate	[9]
Cytochrome P450 1A2 (CYP1A2)	DEJGDUW	CP1A2_HUMAN	Substrate	[10]
Cytochrome P450 2B6 (CYP2B6) Main DME	DEPKLMQ	CP2B6_HUMAN	Substrate	[9]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Acetyl-CoA carboxylase 1 (ACACA)	OT5CQPZY	ACACA_HUMAN	Post-Translational Modifications	[11]
Acid ceramidase (ASAH1)	OT1DNGXL	ASAH1_HUMAN	Gene/Protein Processing	[12]
Albumin (ALB)	OTVMM513	ALBU_HUMAN	Protein Interaction/Cellular Processes	[13]
Alpha-1-antichymotrypsin (SERPINA3)	OT9BP2S0	AACT_HUMAN	Gene/Protein Processing	[12]
Alpha-crystallin A chain (CRYAA)	OTSN7JUR	CRYAA_HUMAN	Gene/Protein Processing	[14]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[15]
Aromatase (CYP19A1)	OTZ6XF74	CP19A_HUMAN	Gene/Protein Processing	[16]
Asparagine synthetase (ASNS)	OT8R922G	ASNS_HUMAN	Gene/Protein Processing	[12]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Gene/Protein Processing	[17]
C-Jun-amino-terminal kinase-interacting protein 3 (MAPK8IP3)	OT0X8ACY	JIP3_HUMAN	Gene/Protein Processing	[14]

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