Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1WEHC)

Drug Name

Buparlisib Drug Info

Synonyms

BKM120

Indication

Disease Entry	ICD 11	Status	REF
Breast cancer	2C60-2C65	Phase 3	[1]

Cross-matching ID

PubChem CID: 16654980
ChEBI ID: CHEMBL2017974
CAS Number: CAS 944396-07-0
TTD Drug ID: DM1WEHC

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

Approved Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting PI3-kinase beta (PIK3CB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PQR309	DMMCYZ8	Squamous head and neck cell carcinom	2D60.0	Phase 2	[6]
PA-799	DMLSYJQ	Colorectal cancer	2B91.Z	Phase 1/2	[7]
AZD8186	DMWYF1H	Solid tumour/cancer	2A00-2F9Z	Phase 1	[8]
GSK2636771	DMCBGLW	Prostate cancer	2C82.0	Phase 1	[9]
BAY 1082439	DMLRGX1	Solid tumour/cancer	2A00-2F9Z	Phase 1	[10]
AZD6482	DMVP4E5	Thrombosis	DB61-GB90	Terminated	[11]
PP121	DMU8KTO	Discovery agent	N.A.	Investigative	[12]
PIK-75	DM9BQTX	Discovery agent	N.A.	Investigative	[13]
KU-0060648	DMQWS6U	Discovery agent	N.A.	Investigative	[14]
PI-3065	DMCQUWI	Discovery agent	N.A.	Investigative	[15]
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Drug(s) Targeting PI3-kinase delta (PIK3CD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BAY 80-6946	DMLOS5R	Follicular lymphoma	2A80	Approved	[16]
Idelalisib	DM602WT	Chronic lymphocytic leukaemia	2A82.0	Approved	[17]
Umbralisib	DMYRBO1	Follicular lymphoma	2A80	Approved	[18]
IPI-145	DMWA24P	Follicular lymphoma	2A80	Approved	[19]
Leniolisib	DMWAD93	Stomach cancer	2B72	Approved	[20]
INCB50465	DMZJP2T	Diffuse large B-cell lymphoma	2A81	Phase 2	[21]
ME-401	DMK0UOY	Follicular lymphoma	2A80	Phase 2	[21]
RP6530	DMYILGK	Chronic lymphocytic leukaemia	2A82.0	Phase 2	[21]
Parsaclisib	DMYBIFS	Follicular lymphoma	2A80	Phase 2	[22]
AZD8154	DMK13L1	Asthma	CA23	Phase 2	[23]
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Drug(s) Targeting PI3-kinase alpha (PIK3CA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BAY 80-6946	DMLOS5R	Follicular lymphoma	2A80	Approved	[16]
Alpelisib	DMEXMYK	Breast cancer	2C60-2C65	Approved	[24]
GDC-0032	DMT4QHD	Breast cancer	2C60-2C65	Phase 3	[25]
LY3023414	DMD9KYF	Prostate cancer	2C82.0	Phase 2	[26]
PA-799	DMLSYJQ	Colorectal cancer	2B91.Z	Phase 1/2	[7]
MLN1117	DMCVBQD	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[27]
PWT-33597	DMJY15D	Solid tumour/cancer	2A00-2F9Z	Phase 1	[10]
BLY719	DMYHNV3	Solid tumour/cancer	2A00-2F9Z	Phase 1	[28]
HHCYH33	DMRQ4L6	Breast cancer	2C60-2C65	Phase 1	[29]
LY3849524	DM8I68X	Breast cancer	2C60-2C65	Phase 1	[30]
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Drug(s) Targeting PI3-kinase gamma (PIK3CG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BAY 80-6946	DMLOS5R	Follicular lymphoma	2A80	Approved	[31]
IPI-145	DMWA24P	Follicular lymphoma	2A80	Approved	[19]
Enzastaurin	DM5H0R9	Diffuse large B-cell lymphoma	2A81	Phase 3	[21]
Rigosertib	DMOSTXF	Myelodysplastic syndrome	2A37	Phase 3	[32]
GDC-0032	DMT4QHD	Breast cancer	2C60-2C65	Phase 3	[21]
PQR309	DMMCYZ8	Squamous head and neck cell carcinom	2D60.0	Phase 2	[33]
SAR245409	DMQM7IL	Solid tumour/cancer	2A00-2F9Z	Phase 2	[34]
XL147	DMML7BE	Solid tumour/cancer	2A00-2F9Z	Phase 2	[34]
SF1126	DML10K3	Head and neck cancer	2D42	Phase 2	[35]
PF-05212384	DMBL3VD	Solid tumour/cancer	2A00-2F9Z	Phase 2	[36]
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Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[37]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[38]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[39]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[40]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[41]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[42]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[43]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[44]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[46]
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Drug(s) Affected By Forkhead box protein O3 (FOXO3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[47]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[48]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[51]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[52]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[53]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[54]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
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Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[57]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[58]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[40]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[60]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[61]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[60]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[62]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[63]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[64]
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Drug(s) Affected By Proto-oncogene tyrosine-protein kinase Src (SRC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bosutinib	DMTI8YE	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[65]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[69]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[70]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[71]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[72]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[73]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[74]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[75]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[76]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[77]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[78]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[79]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[80]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[81]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[82]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[83]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[84]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[75]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[85]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[86]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[87]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[74]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[88]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[89]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[77]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[78]
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Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[90]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[91]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[92]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[93]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[94]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[95]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[96]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[97]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[94]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[98]
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Drug(s) Affected By Small ribosomal subunit protein eS6 (RPS6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[99]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[100]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[101]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[102]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[103]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[104]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[105]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[106]
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
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Drug(s) Affected By Baculoviral IAP repeat-containing protein 3 (BIRC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[108]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[109]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[110]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[40]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[111]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[112]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[113]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[114]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[115]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[116]
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Drug(s) Affected By Baculoviral IAP repeat-containing protein 2 (BIRC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[108]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[109]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[118]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[119]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[120]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[4]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[116]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[121]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[122]
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Drug(s) Affected By Bcl2-associated agonist of cell death (BAD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[123]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[109]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[89]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[124]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[125]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[126]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[112]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[128]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[129]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
PI3-kinase alpha (PIK3CA)	TTEUNMR	PK3CA_HUMAN	Inhibitor	[2]
PI3-kinase beta (PIK3CB)	TTTHBCA	PK3CB_HUMAN	Inhibitor	[2]
PI3-kinase delta (PIK3CD)	TTGBPJE	PK3CD_HUMAN	Inhibitor	[2]
PI3-kinase gamma (PIK3CG)	TTHBTOP	PK3CG_HUMAN	Inhibitor	[2]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Baculoviral IAP repeat-containing protein 2 (BIRC2)	OTFXFREP	BIRC2_HUMAN	Gene/Protein Processing	[3]
Baculoviral IAP repeat-containing protein 3 (BIRC3)	OT3E95KB	BIRC3_HUMAN	Gene/Protein Processing	[3]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Gene/Protein Processing	[4]
Bcl2-associated agonist of cell death (BAD)	OT63ERYM	BAD_HUMAN	Gene/Protein Processing	[3]
E3 ubiquitin-protein ligase XIAP	OT24GP9B	XIAP_HUMAN	Gene/Protein Processing	[3]
Forkhead box protein O3 (FOXO3)	OTHXQG4P	FOXO3_HUMAN	Gene/Protein Processing	[4]
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Post-Translational Modifications	[5]
Mitogen-activated protein kinase 3 (MAPK3)	OTCYKGKO	MK03_HUMAN	Post-Translational Modifications	[5]
Mitogen-activated protein kinase 8 (MAPK8)	OTEREYS5	MK08_HUMAN	Post-Translational Modifications	[5]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Protein Interaction/Cellular Processes	[5]

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References

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14	1-substituted (Dibenzo[b,d]thiophen-4-yl)-2-morpholino-4H-chromen-4-ones endowed with dual DNA-PK/PI3-K inhibitory activity. J Med Chem. 2013 Aug 22;56(16):6386-401.
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20	Effective "activated PI3K syndrome"-targeted therapy with the PI3K inhibitor leniolisib. Blood. 2017 Nov 23;130(21):2307-2316.
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22	Parsaclisib, a potent and highly selective PI3K inhibitor, in patients with relapsed or refractory B-cell malignancies. Blood. 2019 Apr 18;133(16):1742-1752.
23	Discovery of AZD8154, a Dual PI3Kgamma-delta Inhibitor for the Treatment of Asthma. J Med Chem. 2021 Jun 24;64(12):8053-8075.
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31	BAY 80-6946 is a highly selective intravenous PI3K inhibitor with potent p110 and p110 activities in tumor cell lines and xenograft models.Mol Cancer Ther.2013 Nov;12(11):2319-30.
32	Phase I study of oral rigosertib (ON 01910.Na), a dual inhibitor of the PI3K and Plk1 pathways, in adult patients with advanced solid malignancies. Clin Cancer Res. 2014 Mar 15;20(6):1656-65.
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35	An integrin-targeted, pan-isoform, phosphoinositide-3 kinase inhibitor, SF1126, has activity against multiple myeloma in vivo.Cancer Chemother Pharmacol.2013 Apr;71(4):867-81.
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37	mTOR inhibition reverses acquired endocrine therapy resistance of breast cancer cells at the cell proliferation and gene-expression levels. Cancer Sci. 2008 Oct;99(10):1992-2003. doi: 10.1111/j.1349-7006.2008.00955.x.
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