Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM21WBH)

• Drug Name: MK-2461 Drug Info
• Synonyms: MK 2461

Indication

Disease Entry	ICD 11	Status	REF
Alzheimer disease	8A20	Phase 1/2	[1]

• Cross-matching ID:
  PubChem CID: 44137946
  ChEBI ID: CHEMBL1822792
  CAS Number: CAS 917879-39-1
  TTD Drug ID: DM21WBH

Molecule-Related Drug Atlas

Drug(s) Targeting Macrophage-stimulating protein receptor (RON)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Anti-RON receptor mabs	DMXACM2	Solid tumour/cancer	2A00-2F9Z	Investigative	[3]
ABC-7	DM2AIE9	Solid tumour/cancer	2A00-2F9Z	Investigative	[3]

Drug(s) Targeting Vascular endothelial growth factor receptor 3 (FLT-4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fruquintinib	DMHOSCQ	Colorectal cancer	2B91.Z	Approved	[4]
Tivozanib	DMUKC5L	Renal cell carcinoma	2C90	Approved	[5]
E-3810	DM42PFT	Solid tumour/cancer	2A00-2F9Z	Phase 3	[6]
Sulfatinib	DMPOTM4	Neuroendocrine cancer	2B72.1	Phase 3	[7]
PI-88	DMGZPX6	Hepatocellular carcinoma	2C12.02	Phase 3	[8]
Taberminogene vadenovec	DMW5PHL	Vascular restinosis	BE2Z	Phase 3	[9]
ABT-869	DMREDYP	Solid tumour/cancer	2A00-2F9Z	Phase 3	[10]
MGCD516	DM752PU	Solid tumour/cancer	2A00-2F9Z	Phase 2/3	[11]
Famitinib	DMSFWT7	Solid tumour/cancer	2A00-2F9Z	Phase 2	[12]
VATALANIB	DMY0UEQ	Solid tumour/cancer	2A00-2F9Z	Phase 2	[13]

Drug(s) Targeting Proto-oncogene c-Met (MET)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[14]
Cabozantinib	DMIYDT4	Medullary thyroid gland carcinoma		Approved	[15]
Amivantamab	DMZ7AMY	Non-small-cell lung cancer	2C25	Approved	[16]
Capmatinib	DMYCXKL	Non-small-cell lung cancer	2C25.Y	Approved	[17]
Tepotinib	DMUQ0E8	Non-small-cell lung cancer	2C25	Approved	[18]
RG3638	DMTQJE0	Gastric adenocarcinoma	2B72	Phase 3	[19]
Savolitinib	DMALFKX	Renal cell carcinoma	2C90	Phase 3	[20]
Beperminogene perplasmid	DM6RWBN	Critical limb ischemia	BD4Y	Phase 3	[21]
Tivantinib	DMNVP8Q	Hepatocellular carcinoma	2C12.02	Phase 3	[22]
MGCD516	DM752PU	Solid tumour/cancer	2A00-2F9Z	Phase 2/3	[19]

Drug(s) Targeting Fibroblast growth factor receptor 1 (FGFR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[23]
Intedanib	DMSTA36	Colorectal cancer	2B91.Z	Approved	[24]
Pemigatinib	DM819JF	Cholangiocarcinoma	2C12.10	Approved	[25]
Infigratinib	DMNKBEC	Cholangiocarcinoma	2C12.10	Approved	[26]
E-3810	DM42PFT	Solid tumour/cancer	2A00-2F9Z	Phase 3	[6]
Sulfatinib	DMPOTM4	Neuroendocrine cancer	2B72.1	Phase 3	[7]
ARQ-087	DM02BVQ	Intrahepatic cholangiocarcinoma	2C12.10	Phase 3	[27]
AZD4547	DM3827C	Solid tumour/cancer	2A00-2F9Z	Phase 2/3	[28]
Debio 1347	DMZW50O	Solid tumour/cancer	2A00-2F9Z	Phase 2	[20]
AM-001	DMGVQI8	Actinic keratosis	EK90.0	Phase 2	[29]

Drug(s) Targeting NT-3 growth factor receptor (TrkC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Entrectinib	DMMPTLH	Non-small-cell lung cancer	2C25	Approved	[30]
Larotrectinib	DM26CQR	Solid tumour/cancer	2A00-2F9Z	Approved	[31]
Altiratinib	DMUJCBT	Solid tumour/cancer	2A00-2F9Z	Phase 1	[32]
PMID28270021-Compound-WO2016054807Example1	DMD5QEL	Chronic pain	MG30	Patented	[33]
PMID28270010-Compound-Figure24-b	DM0QHLK	N. A.	N. A.	Patented	[32]
Pyrrolo[2,3-d]pyrimidine derivative 4	DME0WSR	Chronic pain	MG30	Patented	[33]
3-amino-5-benzyl-substituted indazole derivative 1	DMFDURZ	Chronic pain	MG30	Patented	[33]
PMID28270010-Compound-Figure5-1	DM2YAPJ	N. A.	N. A.	Patented	[32]
PMID28270021-Compound-WO2015042088Example4	DM6KXOQ	Chronic pain	MG30	Patented	[33]
PMID28270010-Compound-Figure5-2	DMK3GRZ	N. A.	N. A.	Patented	[32]

Drug(s) Targeting Tyrosine-protein kinase Mer (MERTK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ONO-7475	DMV6GX7	Acute leukaemia	2A60	Phase 1/2	[20]
ONO-7475	DMV6GX7	Acute leukaemia	2A60	Phase 1/2	[34]
RXDX-106	DM6NVTR	Solid tumour/cancer	2A00-2F9Z	Phase 1	[35]
MRX-2843	DMM5N8P	Solid tumour/cancer	2A00-2F9Z	Phase 1	[36]
PF-07265807	DMSMNRQ	Solid tumour/cancer	2A00-2F9Z	Phase 1	[37]
INCB81776	DMFOXGB	Solid tumour/cancer	2A00-2F9Z	Phase 1	[38]
LDC1267	DMH7R6L	Discovery agent	N.A.	Investigative	[39]
G749	DMC7HIS	Discovery agent	N.A.	Investigative	[40]
UNC2025	DMCU59W	Glioblastoma of brain	2A00.00	Investigative	[41]
UNC569	DMJL6ZM	Acute lymphoblastic leukaemia	2A85	Investigative	[42]

Drug(s) Targeting Fibroblast growth factor receptor 2 (FGFR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pemigatinib	DM819JF	Cholangiocarcinoma	2C12.10	Approved	[25]
Interferon Alfa-2a, Recombinant	DMUTZ8S	Chronic HCV-1 infection	1E51.1	Approved	[43]
Palifermin	DM9JOYP	Oral mucositis	DA01.11	Approved	[44]
E-3810	DM42PFT	Solid tumour/cancer	2A00-2F9Z	Phase 3	[6]
Trafermin	DMLKI2B	Periodontitis	DA0C	Phase 3	[45]
Debio 1347	DMZW50O	Solid tumour/cancer	2A00-2F9Z	Phase 2	[20]
LY2874455	DMZ0DMY	Solid tumour/cancer	2A00-2F9Z	Phase 2	[46]
AEE-788	DMEOS5K	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[47]
BAY1179470	DM7L91K	Solid tumour/cancer	2A00-2F9Z	Phase 1	[48]
Alofanib	DMIEKTF	Gastric adenocarcinoma	2B72	Phase 1	[49]

Drug(s) Targeting Platelet-derived growth factor receptor beta (PDGFRB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[50]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[51]
Becaplermin	DM1R5X4	Diabetic complication	5A2Y	Approved	[52]
E-3810	DM42PFT	Solid tumour/cancer	2A00-2F9Z	Phase 3	[6]
Famitinib	DMSFWT7	Solid tumour/cancer	2A00-2F9Z	Phase 2	[12]
XL-820	DMMHX9K	Solid tumour/cancer	2A00-2F9Z	Phase 2	[53]
SNN-0031	DM2X3BR	Brain injury	NA07.Z	Phase 1/2	[54]
TAK-593	DMNFZOT	Solid tumour/cancer	2A00-2F9Z	Phase 1	[55]
Pyridine derivative 18	DMBZMYT	N. A.	N. A.	Patented	[56]
PMID25656651-Compound-21a	DMCKAON	N. A.	N. A.	Patented	[57]

Drug(s) Targeting Fms-like tyrosine kinase 3 (FLT-3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[58]
Ponatinib	DMYGJQO	Acute lymphoblastic leukaemia	2A85	Approved	[14]
Intedanib	DMSTA36	Colorectal cancer	2B91.Z	Approved	[24]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[47]
Gilteritinib	DMTI0ZO	Acute myeloid leukaemia	2A60	Approved	[31]
Pexidartinib	DMS2J0Z	Tenosynovial giant cell tumour	2F7B	Approved	[59]
Pacritinib	DM1T6ZN	Myelofibrosis	2A20.2	Approved	[58]
Quizartinib	DM8Y4JS	Acute myeloid leukaemia	2A60	Approved	[20]
Lestaurtinib	DMQ2AIJ	Acute myeloid leukaemia	2A60	Approved (orphan drug)	[60]
Famitinib	DMSFWT7	Solid tumour/cancer	2A00-2F9Z	Phase 2	[12]

Drug(s) Targeting VEGFR1 messenger RNA (VEGFR1 mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[61]
VATALANIB	DMY0UEQ	Solid tumour/cancer	2A00-2F9Z	Phase 2	[62]
Sirna-027	DMZTQD8	Exudative age-related macular degeneration	9B78.3Z	Phase 1/2	[63]
PMID22765894C8h	DMH5RFU	Discovery agent	N.A.	Investigative	[64]
2-(1H-indazol-3-yl)-1H-benzo[d]imidazole	DM0CSH8	Discovery agent	N.A.	Investigative	[65]
AAL-993	DM35RFH	Discovery agent	N.A.	Investigative	[62]
PMID17935989C25	DML8ZBR	Discovery agent	N.A.	Investigative	[66]
2-(5-Phenyl-oxazol-2-ylamino)-benzonitrile	DMX6QMT	Discovery agent	N.A.	Investigative	[13]
4-Chloro-N-(3-chloro-benzoyl)-benzenesulfonamide	DMI3OR9	Discovery agent	N.A.	Investigative	[67]
(2-Methoxy-phenyl)-(5-phenyl-oxazol-2-yl)-amine	DMQWD75	Discovery agent	N.A.	Investigative	[13]

Drug(s) Targeting Vascular endothelial growth factor receptor 2 (KDR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[50]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[23]
Regorafenib	DMHSY1I	Gastrointestinal stromal tumour	2B5B	Approved	[14]
Sunitinib	DMCBJSR	Acute undifferentiated leukemia		Approved	[68]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[69]
Vandetanib	DMRICNP	Solid tumour/cancer	2A00-2F9Z	Approved	[47]
Pazopanib HCl	DM6U9CQ	Renal cell carcinoma	2C90	Approved	[70]
Fruquintinib	DMHOSCQ	Colorectal cancer	2B91.Z	Approved	[4]
Cabozantinib	DMIYDT4	Medullary thyroid gland carcinoma		Approved	[15]
Tivozanib	DMUKC5L	Renal cell carcinoma	2C90	Approved	[5]

Drug(s) Targeting BDNF/NT-3 growth factors receptor (TrkB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Entrectinib	DMMPTLH	Non-small-cell lung cancer	2C25	Approved	[30]
Larotrectinib	DM26CQR	Solid tumour/cancer	2A00-2F9Z	Approved	[31]
PMID28270021-Compound-WO2016054807Example1	DMD5QEL	Chronic pain	MG30	Patented	[33]
PMID28270010-Compound-Figure24-b	DM0QHLK	N. A.	N. A.	Patented	[32]
Pyrrolo[2,3-d]pyrimidine derivative 4	DME0WSR	Chronic pain	MG30	Patented	[33]
3-amino-5-benzyl-substituted indazole derivative 1	DMFDURZ	Chronic pain	MG30	Patented	[33]
PMID28270010-Compound-Figure5-1	DM2YAPJ	N. A.	N. A.	Patented	[32]
PMID28270021-Compound-WO2015042088Example4	DM6KXOQ	Chronic pain	MG30	Patented	[33]
PMID28270010-Compound-Figure5-2	DMK3GRZ	N. A.	N. A.	Patented	[32]
PMID28270010-Compound-Figure5-3	DMSOT1R	N. A.	N. A.	Patented	[32]

Drug(s) Targeting Fibroblast growth factor receptor 3 (FGFR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pemigatinib	DM819JF	Cholangiocarcinoma	2C12.10	Approved	[25]
Trapidil	DMY67U8	Acute coronary syndrome	BA41	Phase 4	[71]
E-3810	DM42PFT	Solid tumour/cancer	2A00-2F9Z	Phase 3	[6]
TKI258	DMYLT67	Renal cell carcinoma	2C90	Phase 3	[47]
BMS-582664	DMDAN8H	Hepatocellular carcinoma	2C12.02	Phase 3	[47]
Debio 1347	DMZW50O	Solid tumour/cancer	2A00-2F9Z	Phase 2	[20]
B-701	DMOMDA4	Bladder cancer	2C94	Phase 2	[72]
Recifercept	DML8N3Y	Achondroplasia	LD24.00	Phase 2	[73]
AEE-788	DMEOS5K	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[47]
Anti-FGFR3	DM6QENU	Multiple myeloma	2A83	Phase 1	[74]

Drug(s) Affected By High affinity nerve growth factor receptor (NTRK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[76]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[77]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[78]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[79]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[80]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[81]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[82]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[83]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[84]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[85]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[86]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[87]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[88]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[89]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[90]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[91]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[92]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[93]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[94]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[95]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[86]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[96]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[97]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[98]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[85]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[99]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[100]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[88]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[89]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
BDNF/NT-3 growth factors receptor (TrkB)	TTKN7QR	NTRK2_HUMAN	Inhibitor	[1]
Fibroblast growth factor receptor 1 (FGFR1)	TTRLW2X	FGFR1_HUMAN	Inhibitor	[1]
Fibroblast growth factor receptor 2 (FGFR2)	TTGJVQM	FGFR2_HUMAN	Inhibitor	[1]
Fibroblast growth factor receptor 3 (FGFR3)	TTST7KB	FGFR3_HUMAN	Inhibitor	[1]
Fms-like tyrosine kinase 3 (FLT-3)	TTGJCWZ	FLT3_HUMAN	Inhibitor	[1]
Macrophage-stimulating protein receptor (RON)	TTBQ3OC	RON_HUMAN	Inhibitor	[1]
NT-3 growth factor receptor (TrkC)	TTXABCW	NTRK3_HUMAN	Inhibitor	[1]
Platelet-derived growth factor receptor beta (PDGFRB)	TTI7421	PGFRB_HUMAN	Inhibitor	[1]
Proto-oncogene c-Met (MET)	TTNDSF4	MET_HUMAN	Inhibitor	[1]
Tyrosine-protein kinase Mer (MERTK)	TTO7LKR	MERTK_HUMAN	Inhibitor	[1]
Vascular endothelial growth factor receptor 2 (KDR)	TTUTJGQ	VGFR2_HUMAN	Inhibitor	[1]
Vascular endothelial growth factor receptor 3 (FLT-4)	TTDCBX5	VGFR3_HUMAN	Inhibitor	[1]
VEGFR1 messenger RNA (VEGFR1 mRNA)	TT1VAUK	VGFR1_HUMAN	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
High affinity nerve growth factor receptor (NTRK1)	OTJORQAU	NTRK1_HUMAN	Gene/Protein Processing	[2]
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Post-Translational Modifications	[2]
Mitogen-activated protein kinase 3 (MAPK3)	OTCYKGKO	MK03_HUMAN	Post-Translational Modifications	[2]

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