Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM3R8YL)

Drug Name
Erythropoietin Drug Info
Synonyms NuPIAO; Erythropoietin (second generation, anemia/blood cell mobilization); Erythropoietin (second generation, anemia/blood cell mobilization), 3SBio
Indication
Disease Entry ICD 11 Status REF
Periventricular leukomalacia Approved [1]
Traumatic brain injury NA07.Z Approved [2]
Anemia 3A00-3A9Z Investigative [3]
Cross-matching ID
PubChem CID
11751549
ChEBI ID
CHEMBL995
CAS Number
CAS 124750-99-8
TTD Drug ID
DM3R8YL

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Erythropoietin Receptor (EPOR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Darbepoetin alfa DMMJTYW Anemia 3A00-3A9Z Approved [13]
Epoetin alfa DMKWB73 Anemia 3A00-3A9Z Approved [14]
Methoxy polyethylene glycol-epoetin beta DMK1LZD Kidney transplant rejection NE84 Approved [15]
RHuEPO DMALNG0 Solid tumour/cancer 2A00-2F9Z Approved [4]
ErepoXen DM9YI2C Anemia 3A00-3A9Z Phase 3 [16]
Epoetin zeta DM9QPOU Anemia 3A00-3A9Z Phase 3 [17]
Hematide DMUE843 Anemia 3A00-3A9Z Phase 3 [18]
Cibinetide DMCFLRH Depression 6A70-6A7Z Phase 2 [19]
GlycoPEGylated erythropoietin DM5JKCL Solid tumour/cancer 2A00-2F9Z Discontinued in Phase 2 [20]
Albupoietin DMXK4CI Anemia 3A00-3A9Z Terminated [21]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bile salt export pump (ABCB11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [22]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [23]
Glipizide DMZA5PQ Diabetic complication 5A2Y Approved [23]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [24]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [22]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [23]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [25]
Gefitinib DM15F0X Colon adenocarcinoma Approved [22]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [6]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [22]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Renin (REN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [26]
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [27]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [28]
Reboxetine DM26PRD Depression 6A70-6A7Z Approved [29]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [30]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [31]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [32]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [33]
Epinephrine DM3KJBC Acute asthma CA23 Approved [34]
Chlorthalidone DM4DMBT Edema MG29 Approved [35]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [36]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [37]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [38]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [39]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [40]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [41]
Prednisone DM2HG4X Acute asthma CA23 Approved [42]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [43]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [44]
Methotrexate DM2TEOL Anterior urethra cancer Approved [45]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein AMBP (AMBP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [46]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [47]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [48]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [49]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [51]
Benazepril DMH1M9B Hypertension BA00-BA04 Approved [9]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [52]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [53]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [54]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Albumin (ALB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [55]
Sulfamethoxazole DMB08GE Acute otitis media AB00 Approved [37]
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [56]
Diazepam DM08E9O Alcohol withdrawal Approved [57]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [58]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [59]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [60]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [61]
Methotrexate DM2TEOL Anterior urethra cancer Approved [62]
Quercetin DM3NC4M Obesity 5B81 Approved [63]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [64]
Selenium DM25CGV N. A. N. A. Approved [65]
Methotrexate DM2TEOL Anterior urethra cancer Approved [66]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [67]
Epinephrine DM3KJBC Acute asthma CA23 Approved [68]
Quercetin DM3NC4M Obesity 5B81 Approved [69]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [70]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [71]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [72]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [73]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Endoglin (ENG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [76]
Testosterone enanthate DMB6871 N. A. N. A. Approved [77]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [51]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [78]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [79]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [80]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [52]
Ximelegatran DMU8ANS Myocardial infarction BA41-BA43 Approved [81]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear respiratory factor 1 (NRF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [82]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [83]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [84]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [85]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [86]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [87]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [52]
Arsenic DMTL2Y1 N. A. N. A. Approved [88]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [54]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [89]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Solute carrier family 22 member 12 (SLC22A12)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pyrazinamide DM4IF32 Meningeal tuberculosis Approved [90]
Benzbromarone DMC3YUA Gout FA25 Approved [11]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [51]
Probenecid DMMFWOJ Acute gonococcal cervicitis Approved [90]
Arsenic DMTL2Y1 N. A. N. A. Approved [91]
Oxypurinol DMURH4X Heart failure BD10-BD13 Phase 2/3 [92]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [93]
[3H]estrone-3-sulphate DMGPF0N Discovery agent N.A. Investigative [94]
⏷ Show the Full List of 8 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Erythropoietin Receptor (EPOR) TTAUX24 EPOR_HUMAN Stimulator [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Albumin (ALB) OTVMM513 ALBU_HUMAN Protein Interaction/Cellular Processes [5]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Gene/Protein Processing [6]
Endoglin (ENG) OTL2LSMI EGLN_HUMAN Gene/Protein Processing [7]
Nuclear respiratory factor 1 (NRF1) OTOXWNV8 NRF1_HUMAN Gene/Protein Processing [8]
Protein AMBP (AMBP) OTLU8GU8 AMBP_HUMAN Gene/Protein Processing [9]
Renin (REN) OT52GZR2 RENI_HUMAN Gene/Protein Processing [10]
Solute carrier family 22 member 12 (SLC22A12) OT72ZAWS S22AC_HUMAN Gene/Protein Processing [11]
Superoxide dismutase , mitochondrial (SOD2) OTIWXGZ9 SODM_HUMAN Gene/Protein Processing [8]
Transforming growth factor beta-1 proprotein (TGFB1) OTV5XHVH TGFB1_HUMAN Gene/Protein Processing [7]
Vascular endothelial growth factor A, long form OTIM9MZ3 VEGFA_HUMAN Gene/Protein Processing [12]

References

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83 AMPK activator acadesine fails to alleviate isoniazid-caused mitochondrial instability in HepG2 cells. J Appl Toxicol. 2017 Oct;37(10):1219-1224. doi: 10.1002/jat.3483. Epub 2017 May 29.
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85 Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
86 Plasmatic concentration of organochlorine lindane acts as metabolic disruptors in HepG2 liver cell line by inducing mitochondrial disorder. Toxicol Appl Pharmacol. 2013 Oct 15;272(2):325-34.
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