Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM54O1Z)

• Drug Name: OLEIC ACID Drug Info
• Synonyms: oleic acid; 112-80-1; cis-9-Octadecenoic acid; cis-Oleic acid; Elaidoic acid; oleate; Glycon wo; Wecoline OO; Pamolyn 100; Glycon RO; (Z)-Octadec-9-enoic acid; Metaupon; Oelsauere; Vopcolene 27; Groco 5l; Groco 2; Groco 4; Groco 6; Tego-oleic 130; Emersol 211; Z-9-Octadecenoic acid; Industrene 206; Industrene 105; Pamolyn; Industrene 205; Oleinic acid; Emersol 213; Emersol 210; L'Acide oleique; cis-Octadec-9-enoic acid; Century cd fatty acid; Emersol 6321; Extraolein 90; Oleine 7503; 9-Octadecenoic acid (Z)-; Emersol 205; Emersol 233LL

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 445639
  ChEBI ID: CHEMBL8659
  CAS Number: CAS 112-80-1
  TTD Drug ID: DM54O1Z
  VARIDT Drug ID: DR00152

Molecule-Related Drug Atlas

Drug(s) Targeting Fatty acid-binding protein 4 (FABP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID27109571-Compound-27	DMXRTH4	N. A.	N. A.	Patented	[11]
PMID27109571-Compound-31	DMU690T	N. A.	N. A.	Patented	[11]
PMID27109571-Compound-16	DMZI25U	N. A.	N. A.	Patented	[11]
PMID27109571-Compound-14	DMVY6B9	N. A.	N. A.	Patented	[11]
PMID27109571-Compound-25	DM435GR	N. A.	N. A.	Patented	[11]
PMID27109571-Compound-30	DM24FSP	N. A.	N. A.	Patented	[11]
PMID27109571-Compound-29	DMDMEHQ	N. A.	N. A.	Patented	[11]
PMID27109571-Compound-18	DM4S5ME	N. A.	N. A.	Patented	[11]
PMID27109571-Compound-28	DMTZVY3	N. A.	N. A.	Patented	[11]
PMID27109571-Compound-20	DMQU9XP	N. A.	N. A.	Patented	[11]

Drug(s) Targeting Fatty acid-binding protein 1 (FABP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
FENOFIBRIC ACID	DMGO2MC	Cardiovascular disease	BA00-BE2Z	Approved	[2]
INDOPROFEN	DM5QSKN	Gout	FA25	Withdrawn from market	[2]
1-anilinonaphthalene-8-sulfonic acid	DMNGY0E	N. A.	N. A.	Investigative	[2]

Drug(s) Affected By Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[12]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[12]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[13]
Sunitinib	DMCBJSR	Acute undifferentiated leukemia		Approved	[14]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[15]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[16]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[17]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[19]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[20]

Drug(s) Affected By Albumin (ALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[21]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[14]
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[22]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[23]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[24]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[25]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[26]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[27]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[28]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[30]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[31]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[32]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[33]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[34]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[35]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[36]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[38]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[36]

Drug(s) Affected By Perilipin-1 (PLIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[41]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[41]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[42]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[43]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[44]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[45]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[46]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[47]

Drug(s) Affected By kinase isozyme 4, mitochondrial (PDK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[48]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[51]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[52]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[52]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[52]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]

Drug(s) Affected By Stearoyl-CoA desaturase (SCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[56]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[57]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[57]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[58]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[59]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[60]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[57]
Fructose	DM43AN2	Vomiting	MD90	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[57]

Drug(s) Affected By 1-acyl-sn-glycerol-3-phosphate acyltransferase beta (AGPAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[63]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[64]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[65]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[67]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[42]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[68]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]

Drug(s) Affected By Short-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[63]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[70]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[71]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[72]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[73]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[63]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[45]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[74]
CITCO	DM0N634	Discovery agent	N.A.	Investigative	[5]

Drug(s) Affected By Phosphoenolpyruvate carboxykinase, cytosolic (PCK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[75]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[58]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[59]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[64]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[76]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[77]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[78]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[79]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]

Drug(s) Affected By Trifunctional enzyme subunit alpha, mitochondrial (HADHA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[63]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[81]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[41]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[68]
Bortezomib	DMNO38U	Leukemia		Approved	[82]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[63]

Drug(s) Affected By Trifunctional enzyme subunit beta, mitochondrial (HADHB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[81]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[83]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[83]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[84]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[41]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[85]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[87]

Drug(s) Affected By Microsomal triglyceride transfer protein large subunit (MTTP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[88]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[88]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[89]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[59]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[88]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[88]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[89]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[91]

Drug(s) Affected By Nuclear receptor subfamily 0 group B member 2 (NR0B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[92]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[93]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[94]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[56]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[93]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[96]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[97]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[59]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[93]

Drug(s) Affected By Glycerol-3-phosphate acyltransferase 3 (GPAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[98]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[99]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[52]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[52]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[52]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]

Drug(s) Affected By Apolipoprotein A-V (APOA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[102]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[95]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[53]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[73]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[45]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[103]

Drug(s) Affected By Stearoyl-CoA desaturase 5 (SCD5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[104]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[105]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[81]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[108]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[45]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[74]
Ganoderic acid A	DM42EVG	Discovery agent	N.A.	Investigative	[109]

Drug(s) Affected By Acetyl-coenzyme A thioesterase (ACOT12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[72]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[53]
GW7647	DM9RD0C	Discovery agent	N.A.	Investigative	[5]
Farnesol	DMV2X1B	Discovery agent	N.A.	Investigative	[5]

Drug(s) Affected By Bile acid receptor (NR1H4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[110]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[111]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[112]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[113]
Nisoldipine	DM7ISKJ	Hypertension	BA00-BA04	Approved	[110]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[111]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[114]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]

Drug(s) Affected By Peroxisomal acyl-coenzyme A oxidase 2 (ACOX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[59]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[64]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[115]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[116]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[116]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[102]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[117]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[117]

Drug(s) Affected By Phosphatidate phosphatase LPIN3 (LPIN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[119]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[72]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[45]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[74]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[120]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[120]

Drug(s) Affected By Peroxisomal trans-2-enoyl-CoA reductase (PECR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[58]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[121]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[115]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[104]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[81]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[122]

Drug(s) Affected By Dynamin-1-like protein (DNM1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[123]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[127]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[81]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[128]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[129]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[123]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[130]

Drug(s) Affected By Phospholipid-transporting ATPase ABCA1 (ABCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[131]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[132]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[59]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[133]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[64]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[134]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[135]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[137]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[138]

Drug(s) Affected By Metalloproteinase inhibitor 1 (TIMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pentoxifylline	DMU3DNC	Alcoholic hepatitis	DB94.1	Approved	[14]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[139]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[140]
Selenium	DM25CGV	N. A.	N. A.	Approved	[141]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[140]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[142]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[143]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[144]

Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[145]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[14]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[146]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[147]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[148]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[149]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[150]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[151]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[152]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[58]

Drug(s) Affected By Collagen alpha-1(I) chain (COL1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[14]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[153]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[154]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[155]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[156]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[157]
Ceruletide	DM2WE5K	Caerulein stimulated gastric and pancreatic secretion	5A4Y	Approved	[158]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[159]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[160]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[161]

Drug(s) Affected By Retinoblastoma-associated protein (RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[162]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[163]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[164]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[165]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[166]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[167]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[168]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[169]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[170]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[171]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[172]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[173]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[175]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[176]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[177]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[176]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[178]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[179]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[180]

Drug(s) Affected By Hepatic triacylglycerol lipase (LIPC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[59]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[121]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[115]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[102]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[181]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[71]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[72]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 2 (SLC2A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[182]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[183]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[184]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[59]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[185]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[186]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[187]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[188]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[155]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[189]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[175]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[190]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[191]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[192]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[193]
Fructose	DM43AN2	Vomiting	MD90	Approved	[194]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[155]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[195]

Drug(s) Affected By Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[196]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[58]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[59]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[64]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[197]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[121]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[198]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[199]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[51]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[200]

Drug(s) Affected By Actin, aortic smooth muscle (ACTA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[28]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[201]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[121]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[202]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[203]
Pirfenidone	DM6VZFQ	Idiopathic pulmonary fibrosis	CB03.4	Approved	[204]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[65]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[116]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[205]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[116]

Drug(s) Affected By Transcription factor E2F1 (E2F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[206]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[172]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[207]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[208]
Selenium	DM25CGV	N. A.	N. A.	Approved	[63]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[209]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[168]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[210]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[59]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[211]

Drug(s) Affected By Acetyl-CoA carboxylase 1 (ACACA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[212]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[183]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[88]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[192]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[213]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[214]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[215]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[115]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[216]

Drug(s) Affected By Mixed lineage kinase domain-like protein (MLKL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[121]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[113]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[217]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[218]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[41]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[219]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]

Drug(s) Affected By Aflatoxin B1 aldehyde reductase member 4 (AKR7L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[220]

Drug(s) Affected By Thyroid hormone-inducible hepatic protein (THRSP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[41]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[221]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[41]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[41]
Clopidogrel	DMOL54H	Acute coronary syndrome	BA41	Approved	[222]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Mitotane	DMU1GX0	Adrenocortical carcinoma	2D11.Z	Approved	[222]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[21]

Drug(s) Affected By Hepatitis A virus cellular receptor 1 (HAVCR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[75]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[223]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[224]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[225]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[226]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[227]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[228]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[75]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[229]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[230]

Drug(s) Affected By Perilipin-2 (PLIN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[157]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[231]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[115]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[232]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[52]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[233]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[102]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[81]

Drug(s) Affected By Complex I assembly factor ACAD9, mitochondrial (ACAD9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[81]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[71]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[72]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[234]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[74]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[235]

Drug(s) Affected By Receptor-interacting serine/threonine-protein kinase 3 (RIPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[236]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[237]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[238]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[230]
Phenylephrine	DMZHUO5	Allergic rhinitis	CA08.0	Approved	[239]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[240]
GSK618334	DMJPXZ4	Drug abuse	6C4G.1Z	Phase 1	[241]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[45]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Fatty acid-binding protein 1 (FABP1)	TTIV96N	FABPL_HUMAN	Inhibitor	[2]
Fatty acid-binding protein 4 (FABP4)	TTHWMFZ	FABP4_HUMAN	Inhibitor	[3]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Fatty acid transport protein 1 (SLC27A1)	DTKDTML	S27A1_HUMAN	Substrate	[4]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
1-acyl-sn-glycerol-3-phosphate acyltransferase beta (AGPAT2)	OT5I4Y9K	PLCB_HUMAN	Gene/Protein Processing	[5]
Acetyl-CoA carboxylase 1 (ACACA)	OT5CQPZY	ACACA_HUMAN	Gene/Protein Processing	[6]
Acetyl-coenzyme A thioesterase (ACOT12)	OTN4RQK8	ACO12_HUMAN	Gene/Protein Processing	[5]
Actin, aortic smooth muscle (ACTA2)	OTEDLG8E	ACTA_HUMAN	Gene/Protein Processing	[7]
Aflatoxin B1 aldehyde reductase member 4 (AKR7L)	OTV1WM0N	ARK74_HUMAN	Gene/Protein Processing	[8]
Albumin (ALB)	OTVMM513	ALBU_HUMAN	Protein Interaction/Cellular Processes	[9]
Apolipoprotein A-V (APOA5)	OTEVKLVA	APOA5_HUMAN	Gene/Protein Processing	[5]
Bile acid receptor (NR1H4)	OTWZLPTB	NR1H4_HUMAN	Gene/Protein Processing	[5]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)	OTW8V2V1	ABCG2_HUMAN	Gene/Protein Processing	[10]
Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A)	OTI862QH	CPT1A_HUMAN	Gene/Protein Processing	[7]

References

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• [2] Characterization of the drug binding specificity of rat liver fatty acid binding protein. J Med Chem. 2008 Jul 10;51(13):3755-64.
• [3] Discovery of highly selective inhibitors of human fatty acid binding protein 4 (FABP4) by virtual screening. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3675-9.
• [4] The blood-brain barrier fatty acid transport protein 1 (FATP1/SLC27A1) supplies docosahexaenoic acid to the brain, and insulin facilitates transport. J Neurochem. 2017 May;141(3):400-412.
• [5] Farnesol induces fatty acid oxidation and decreases triglyceride accumulation in steatotic HepaRG cells. Toxicol Appl Pharmacol. 2019 Feb 15;365:61-70.
• [6] Lambda-cyhalothrin induces lipid accumulation in mouse liver is associated with AMPK inactivation. Food Chem Toxicol. 2023 Feb;172:113563. doi: 10.1016/j.fct.2022.113563. Epub 2022 Dec 15.
• [7] Sorafenib reduces steatosis-induced fibrogenesis in a human 3D co-culture model of non-alcoholic fatty liver disease. Environ Toxicol. 2021 Feb;36(2):168-176. doi: 10.1002/tox.23021. Epub 2020 Sep 12.
• [8] Exposure to dietary fatty acids oleic and palmitic acid alters structure and mechanotransduction of intestinal cells in vitro. Arch Toxicol. 2023 Jun;97(6):1659-1675. doi: 10.1007/s00204-023-03495-3. Epub 2023 Apr 29.
• [9] Quercetin ameliorate insulin resistance and up-regulates cellular antioxidants during oleic acid induced hepatic steatosis in HepG2 cells. Toxicol In Vitro. 2013 Mar;27(2):945-53.
• [10] Oleic acid decreases BCRP mediated efflux of mitoxantrone in Caco-2 cell monolayers. Food Chem Toxicol. 2012 Oct;50(10):3635-45.
• [11] Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76.
• [12] Localization of breast cancer resistance protein (Bcrp) in endocrine organs and inhibition of its transport activity by steroid hormones. Cell Tissue Res. 2012 Aug;349(2):551-63. doi: 10.1007/s00441-012-1417-5. Epub 2012 May 13.
• [13] Pharmacogenetics of ABCG2 and adverse reactions to gefitinib. J Natl Cancer Inst. 2006 Dec 6;98(23):1739-42.
• [14] ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
• [15] ABCG2 polymorphism is associated with the low-density lipoprotein cholesterol response to rosuvastatin. Clin Pharmacol Ther. 2010 May;87(5):558-62.
• [16] Ciprofloxacin mediates cancer stem cell phenotypes in lung cancer cells through caveolin-1-dependent mechanism. Chem Biol Interact. 2016 Apr 25;250:1-11.
• [17] Proteomic identification of differentially expressed proteins associated with the multiple drug resistance in methotrexate-resistant human breast cancer cells. Int J Oncol. 2014 Jul;45(1):448-58.
• [18] Activation of beta-catenin signalling by GSK-3 inhibition increases p-glycoprotein expression in brain endothelial cells. J Neurochem. 2008 Aug;106(4):1855-65. doi: 10.1111/j.1471-4159.2008.05537.x. Epub 2008 Jul 4.
• [19] Differential gene expression in human hepatocyte cell lines exposed to the antiretroviral agent zidovudine. Arch Toxicol. 2014 Mar;88(3):609-23. doi: 10.1007/s00204-013-1169-3. Epub 2013 Nov 30.
• [20] Chronic imatinib mesylate exposure leads to reduced intracellular drug accumulation by induction of the ABCG2 (BCRP) and ABCB1 (MDR1) drug transport pumps. Cancer Biol Ther. 2005 Jul;4(7):747-52.
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