Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM72Y01)

• Drug Name: cordycepin Drug Info
• Synonyms: 3'-deoxyadenosine

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 6303
  ChEBI ID: CHEMBL29014
  CAS Number: CAS 73-03-0
  TTD Drug ID: DM72Y01
  VARIDT Drug ID: DR00717

Molecule-Related Drug Atlas

Drug(s) Transported By Equilibrative nucleoside transporter 3 (SLC29A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[2]
tubercidin	DMHICK8	Discovery agent	N.A.	Investigative	[2]

Drug(s) Affected By Microtubule-associated proteins 1A/1B light chain 3A (MAP1LC3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[9]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[10]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[11]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[13]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[15]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[16]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[17]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]

Drug(s) Affected By Gamma-aminobutyric acid receptor subunit pi (GABRP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[19]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[13]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[21]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[22]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[23]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[24]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[25]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[26]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[27]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[28]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[29]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[30]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[31]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[32]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[33]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[34]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[35]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[37]

Drug(s) Affected By Zinc finger protein SNAI2 (SNAI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[19]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[40]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[41]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[42]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]

Drug(s) Affected By Regulator of G-protein signaling 9 (RGS9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[47]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[48]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[49]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[50]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[27]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[51]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[52]

Drug(s) Affected By Ubiquitin-like protein ATG12 (ATG12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Selenium	DM25CGV	N. A.	N. A.	Approved	[54]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[56]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[11]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[57]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[58]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Artesunate	DMR27C8	Infection of P. falciparum	1F40	Approved	[59]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[60]

Drug(s) Affected By Zinc finger protein SNAI1 (SNAI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[61]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[39]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[64]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[65]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[43]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[66]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[67]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[68]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[69]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[70]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[71]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Selenium	DM25CGV	N. A.	N. A.	Approved	[73]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[74]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[75]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[76]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[77]

Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[79]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[80]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[81]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[82]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[83]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[84]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[85]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[86]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[77]

Drug(s) Affected By Interleukin-2 receptor subunit alpha (IL2RA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[87]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[88]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[89]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[90]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[93]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[13]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[95]

Drug(s) Affected By Receptor tyrosine-protein kinase erbB-2 (ERBB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trastuzumab	DMZQOUX	Breast cancer	2C60-2C65	Approved	[79]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[96]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[97]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[70]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[98]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Selenium	DM25CGV	N. A.	N. A.	Approved	[54]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[55]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[19]

Drug(s) Affected By Receptor-type tyrosine-protein phosphatase C (PTPRC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[102]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[103]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[104]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[20]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[105]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[106]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[107]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[109]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[110]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[111]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[31]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[112]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[113]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[112]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[114]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[115]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[116]

Drug(s) Affected By Alpha-amylase 1B (AMY1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[5]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[117]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[118]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[119]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[120]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[121]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[122]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[123]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[124]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[125]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[126]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[127]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[129]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[127]

Drug(s) Affected By Transforming growth factor beta-3 proprotein (TGFB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[130]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[61]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[131]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[132]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[133]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[134]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[135]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[136]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[137]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[138]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[139]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[142]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[40]

Drug(s) Affected By Cadherin-2 (CDH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[139]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[40]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[145]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[146]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[147]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[148]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[134]

Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[149]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[150]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[69]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[151]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[152]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[153]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[154]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[155]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[156]

Drug(s) Affected By Catenin beta-1 (CTNNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[157]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[158]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[159]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[160]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[161]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[162]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[163]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[148]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[164]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[165]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[166]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[167]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[29]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[168]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[169]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[32]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[170]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[113]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[171]

Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[172]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[157]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[173]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[175]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[156]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[176]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[177]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[175]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[178]

Drug(s) Affected By Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PIK3CG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[179]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[181]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[13]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[182]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[183]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[184]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[185]
GDC0941	DM1YAK6	Breast cancer	2C60-2C65	Phase 2	[186]
GDC-0980/RG7422	DMF3MV1	Non-hodgkin lymphoma	2B33.5	Phase 2	[187]

Drug(s) Affected By Aquaporin-5 (AQP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[5]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[188]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[13]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[189]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[190]
Carbachol	DMX9K8F	Glaucoma/ocular hypertension	9C61	Approved	[191]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[51]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[192]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[193]

Drug(s) Affected By BH3-interacting domain death agonist (BID)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[194]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[31]
Selenium	DM25CGV	N. A.	N. A.	Approved	[195]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[156]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[132]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[196]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[197]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[198]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[199]

Drug(s) Affected By Transforming growth factor beta-2 proprotein (TGFB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[132]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[201]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[202]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[134]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[203]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[13]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[22]

Drug(s) Affected By Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[204]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[205]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[199]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[206]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[207]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[208]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[209]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[210]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]

Drug(s) Affected By POU domain, class 5, transcription factor 1 (POU5F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[131]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[39]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[211]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[212]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[40]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[213]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[214]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[215]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[216]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[217]

Drug(s) Affected By Transcription factor Sp3 (SP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[218]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[218]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[219]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[220]
Promegestone	DMK4S8I	Gynecological disease	GA6Z	Approved	[221]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[222]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[223]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[224]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[225]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[226]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[227]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[31]
Selenium	DM25CGV	N. A.	N. A.	Approved	[54]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[228]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[55]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[229]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[230]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[156]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[231]

Drug(s) Affected By Acetyl-CoA carboxylase 1 (ACACA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[232]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[233]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[234]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[159]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[132]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[235]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[236]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[102]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[237]

Drug(s) Affected By Frizzled-5 (FZD5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[131]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[19]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[102]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[40]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[238]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[239]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[42]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[199]

Drug(s) Affected By SPARC-like protein 1 (SPARCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[240]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[19]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[203]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[199]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[240]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[241]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[199]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[118]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[225]

Drug(s) Affected By Speedy protein E2 (SPDYE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[193]

Drug(s) Affected By Actin-like protein 10 (ACTL10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[13]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[242]

Drug(s) Affected By Uncharacterized protein C16orf46 (C16ORF46)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[243]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[204]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[244]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[245]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[246]
PMID27336223-Compound-5	DM6E50A	N. A.	N. A.	Patented	[244]

Drug(s) Affected By Mucin-20 (MUC20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[247]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[13]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[95]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[248]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[60]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[246]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[249]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[51]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[250]

Drug(s) Affected By Bcl2-associated agonist of cell death (BAD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[251]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[252]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[194]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[253]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[254]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[255]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[132]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[256]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[257]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[258]

Drug(s) Affected By EF-hand domain-containing protein D1 (EFHD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[259]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[95]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[22]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[260]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[47]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[261]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[262]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[26]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[263]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[249]

Drug(s) Affected By Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[232]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[55]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[139]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[265]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[266]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[267]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[56]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[11]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[57]

Drug(s) Affected By Autophagy protein 5 (ATG5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[268]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[265]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[56]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[11]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[269]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[270]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[271]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[247]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[272]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[249]

Drug(s) Affected By Homeobox protein NANOG (NANOG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[273]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[39]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[211]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[212]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[40]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[213]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[214]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[215]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[274]

Drug(s) Affected By Frizzled-3 (FZD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[87]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[19]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[40]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[247]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[275]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[13]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[16]
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[276]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[277]

Drug(s) Affected By Lymphoid enhancer-binding factor 1 (LEF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[238]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[163]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[134]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[278]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[13]
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[276]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[279]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[225]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[280]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[249]

Molecular Interaction Atlas of This Drug

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Equilibrative nucleoside transporter 3 (SLC29A3)	DTZAWTH	S29A3_HUMAN	Substrate	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Acetyl-CoA carboxylase 1 (ACACA)	OT5CQPZY	ACACA_HUMAN	Gene/Protein Processing	[3]
Actin-like protein 10 (ACTL10)	OT2ECYQJ	ACL10_HUMAN	Gene/Protein Processing	[4]
Alpha-amylase 1B (AMY1A)	OT6G4B8O	AMY1B_HUMAN	Gene/Protein Processing	[5]
Aquaporin-5 (AQP5)	OT77GBY8	AQP5_HUMAN	Gene/Protein Processing	[5]
Autophagy protein 5 (ATG5)	OT4T5SMS	ATG5_HUMAN	Gene/Protein Processing	[6]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Gene/Protein Processing	[7]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Gene/Protein Processing	[8]
Bcl2-associated agonist of cell death (BAD)	OT63ERYM	BAD_HUMAN	Gene/Protein Processing	[8]
BH3-interacting domain death agonist (BID)	OTOSHSHU	BID_HUMAN	Gene/Protein Processing	[8]
Cadherin-1 (CDH1)	OTFJMXPM	CADH1_HUMAN	Gene/Protein Processing	[3]

References

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