Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM9GRTK)

• Drug Name: ACYLINE Drug Info
• Synonyms: Acyline; UNII-S3439D3B35; CHEMBL262747; S3439D3B35; BDBM50102456; DB11906; D-Alaninamide, N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-4-(acetylamino)-L-phenylalanyl-4-(acetylamino)-D-phenylalanyl-L-leucyl-N6-(1-methylethyl)-L-lysyl-L-prolyl-; Z-3146; Ac-D-Nal-[D-(pCl)Phe]-D-Pal-Ser-[Aph(Ac)]-D-[Aph(Ac)]-Leu-ILys-Pro-DAla-NH2

Indication

Disease Entry	ICD 11	Status	REF
Prostate cancer	2C82.0	Phase 2	[1]

• Cross-matching ID:
  PubChem CID: 16137348
  CAS Number: CAS 170157-13-8
  TTD Drug ID: DM9GRTK

Molecule-Related Drug Atlas

Drug(s) Targeting Gonadotropin-releasing hormone receptor (GNRHR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gonadorelin	DMAQ469	Amenorrhea	GA20.0	Approved	[4]
Relugolix	DMK7IWL	Prostate cancer	2C82.0	Approved	[5]
Ganirelix	DMGMB30	Ovulation dysfunction	5A80	Approved	[6]
Abarelix	DM5WFNP	Prostate cancer	2C82.0	Approved	[7]
Triptorelin	DMTK4LS	Infertility	GB04	Approved	[8]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[9]
Nafarelin	DMAHEFY	Endometriosis	GA10	Approved	[10]
Cetrorelix	DMFD9Q6	Ovarian stimulation	LB45.1	Approved	[11]
Elagolix sodium	DMRDUC0	Endometriosis	GA10	Approved	[12]
Degarelix	DM3O8QY	Prostate cancer	2C82.0	Approved	[13]

Drug(s) Affected By Phospholipid phosphatase 1 (PLPP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[14]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[15]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[16]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[19]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[14]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[20]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[21]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[22]

Drug(s) Affected By Transmembrane protease serine 2 (TMPRSS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[23]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[23]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[14]
Selenium	DM25CGV	N. A.	N. A.	Approved	[24]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[23]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[23]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[23]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[23]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[23]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[23]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein R (HNRNPR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[25]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[29]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[30]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[24]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[31]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[32]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[33]

Drug(s) Affected By Prostate stem cell antigen (PSCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[14]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[37]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[38]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[39]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[40]
Flavonoid derivative 1	DMCQP0B	N. A.	N. A.	Patented	[34]

Drug(s) Affected By Transcription factor Maf (MAF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[45]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[46]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[47]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[48]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[14]

Drug(s) Affected By Pro-epidermal growth factor (EGF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[49]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[53]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[54]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[55]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[56]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]

Drug(s) Affected By Metallothionein-2 (MT2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[58]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[59]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[60]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[61]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[63]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[16]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[65]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[66]

Drug(s) Affected By Trefoil factor 1 (TFF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[67]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[14]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[68]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[69]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[70]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[71]
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[68]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[73]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[74]

Drug(s) Affected By Glycogen phosphorylase, liver form (PYGL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[25]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[56]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[66]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[77]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[78]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[79]

Drug(s) Affected By Prostate-specific antigen (KLK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[80]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[81]
Selenium	DM25CGV	N. A.	N. A.	Approved	[82]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[84]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[85]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[55]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[86]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[87]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]

Drug(s) Affected By Decorin (DCN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[89]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[91]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[56]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[94]

Drug(s) Affected By Heat shock protein HSP 90-alpha (HSP90AA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[95]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[96]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[80]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[97]
Selenium	DM25CGV	N. A.	N. A.	Approved	[24]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[98]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[99]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[100]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]

Drug(s) Affected By Neprilysin (MME)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[101]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[102]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[103]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[77]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[104]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[38]

Drug(s) Affected By Glutathione S-transferase Mu 1 (GSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[105]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[21]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[107]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[108]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[108]
Methyldopa	DM5I621	Hypertension	BA00-BA04	Approved	[109]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[25]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]

Drug(s) Affected By 60 kDa heat shock protein, mitochondrial (HSPD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[110]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[111]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[112]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[115]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[116]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[117]

Drug(s) Affected By Endothelin-3 (EDN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[118]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[119]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[120]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[121]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[122]

Drug(s) Affected By Protein C-ets-1 (ETS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[123]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[125]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[53]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[25]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[126]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[17]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[127]

Drug(s) Affected By Protein SON (SON)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[110]
Selenium	DM25CGV	N. A.	N. A.	Approved	[24]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[66]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[66]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]

Drug(s) Affected By Tetraspanin-8 (TSPAN8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[15]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[17]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[79]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[131]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[132]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[21]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[133]

Drug(s) Affected By Alpha-1-acid glycoprotein 2 (ORM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[134]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[125]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[53]
Disopyramide	DM5SYZP	Long QT syndrome	BC65.0	Approved	[134]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[134]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]

Drug(s) Affected By C-C motif chemokine 1 (CCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[136]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[137]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[138]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[139]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[140]
ANW-32821	DMMJOZD	N. A.	N. A.	Phase 2	[141]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[142]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[143]
Nickel chloride	DMI12Y8	Discovery agent	N.A.	Investigative	[144]

Drug(s) Affected By Insulin-like growth factor-binding protein 5 (IGFBP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[80]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[60]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[145]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[116]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[146]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[147]

Drug(s) Affected By CCN family member 2 (CCN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[59]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[80]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[148]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[130]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[149]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[150]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[151]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[152]

Drug(s) Affected By 14-3-3 protein sigma (SFN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[153]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[154]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[155]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[156]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[41]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[156]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[53]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[157]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[158]

Drug(s) Affected By Neuroblastoma suppressor of tumorigenicity 1 (NBL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[159]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[160]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[161]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[77]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[162]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[163]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[164]

Drug(s) Affected By Matrin-3 (MATR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[136]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[165]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[110]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[166]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[53]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[167]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein F (HNRNPF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[168]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[169]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[166]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[170]
PEITC	DMOMN31	Prostate cancer	2C82.0	Phase 2	[171]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[31]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[122]

Drug(s) Affected By Small ribosomal subunit protein uS8 (RPS15A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[172]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[15]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[173]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[174]
Artesunate	DMR27C8	Infection of P. falciparum	1F40	Approved	[175]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[53]
Nabiximols	DMHKJ5I	Cancer related pain	MG30	Phase 3	[176]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[122]

Drug(s) Affected By Actin, aortic smooth muscle (ACTA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[177]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[125]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[179]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[180]
Pirfenidone	DM6VZFQ	Idiopathic pulmonary fibrosis	CB03.4	Approved	[181]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[43]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[182]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]

Drug(s) Affected By Myosin-binding protein C, slow-type (MYBPC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[29]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[45]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[122]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[183]

Drug(s) Affected By Glutamate carboxypeptidase 2 (FOLH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[24]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[184]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Pentobarbital	DMFNH7L	Brain ischaemia	8B1Z	Approved	[185]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[186]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[24]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[122]
1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane	DMDJYHK	Discovery agent	N.A.	Investigative	[187]
NAAG	DMFGOW0	Discovery agent	N.A.	Investigative	[188]
[3H]methyltrienolone	DMTSGOW	Discovery agent	N.A.	Investigative	[186]

Drug(s) Affected By Platelet-activating factor acetylhydrolase (PLA2G7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[116]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[53]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[189]
Vitamin B3	DMQVRZH	Chronic renal failure	GB61.Z	Approved	[190]
Orlistat	DMRJSP8	Obesity	5B81	Approved	[189]
Nitrous oxide	DMTHWBI	Anxiety disorder	6B00-6B0Z	Approved	[191]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[192]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[193]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase FKBP5 (FKBP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[194]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[195]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[196]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[197]

Drug(s) Affected By Nuclear receptor coactivator 4 (NCOA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[183]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[130]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[25]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[65]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[17]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[198]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[199]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[200]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[79]

Drug(s) Affected By Myosin light chain kinase, smooth muscle (MYLK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[201]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[53]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[54]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[126]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]

Drug(s) Affected By Tubulin-specific chaperone E (TBCE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[14]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[21]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[202]

Drug(s) Affected By TBC1 domain family member 25 (TBC1D25)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[112]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[203]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[166]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[204]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[122]

Drug(s) Affected By Uncharacterized protein C6orf136 (C6ORF136)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[56]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[77]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[29]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[163]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[122]

Drug(s) Affected By Saccharopine dehydrogenase-like oxidoreductase (SCCPDH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[205]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[79]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[206]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[207]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[166]

Drug(s) Affected By Protein NDRG1 (NDRG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[208]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[209]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[210]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[211]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[212]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[77]

Drug(s) Affected By Spondin-2 (SPON2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[213]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[214]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[73]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[131]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[203]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[215]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[21]

Drug(s) Affected By Cysteine-rich secretory protein LCCL domain-containing 1 (CRISPLD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[183]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[15]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[53]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[216]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[38]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[217]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[166]

Drug(s) Affected By Conserved oligomeric Golgi complex subunit 4 (COG4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[56]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[79]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[38]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[166]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[204]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[218]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[128]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[219]

Drug(s) Affected By Protein ERGIC-53-like (LMAN1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[183]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[220]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[221]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[221]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[122]

Drug(s) Affected By SIN3-HDAC complex-associated factor (SINHCAF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[17]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[222]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[77]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[79]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[14]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[131]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[220]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[166]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[223]

Drug(s) Affected By DmX-like protein 1 (DMXL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[224]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[225]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[224]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[226]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[227]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[79]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[37]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[131]

Drug(s) Affected By Progonadoliberin-1 (GNRH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[220]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[228]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[14]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[229]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[229]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[206]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[230]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[231]

Drug(s) Affected By Interferon gamma (IFNG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[232]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[233]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[234]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[235]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[159]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[236]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[237]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[238]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[239]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[240]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Gonadotropin-releasing hormone receptor (GNRHR)	TT8R70G	GNRHR_HUMAN	Inhibitor	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
14-3-3 protein sigma (SFN)	OTLJCZ1U	1433S_HUMAN	Gene/Protein Processing	[3]
60 kDa heat shock protein, mitochondrial (HSPD1)	OTTO1Y11	CH60_HUMAN	Gene/Protein Processing	[3]
Actin, aortic smooth muscle (ACTA2)	OTEDLG8E	ACTA_HUMAN	Gene/Protein Processing	[3]
Alpha-1-acid glycoprotein 2 (ORM2)	OTRJGZP8	A1AG2_HUMAN	Gene/Protein Processing	[3]
AN1-type zinc finger protein 5	OT4F47U6	ZFAN5_HUMAN	Gene/Protein Processing	[3]
C-C motif chemokine 1 (CCL1)	OT23NON8	CCL1_HUMAN	Gene/Protein Processing	[3]
CCN family member 2 (CCN2)	OTC39NSU	CCN2_HUMAN	Gene/Protein Processing	[3]
Conserved oligomeric Golgi complex subunit 4 (COG4)	OT6U94UE	COG4_HUMAN	Gene/Protein Processing	[3]
Cysteine-rich secretory protein LCCL domain-containing 1 (CRISPLD1)	OT38HXJP	CRLD1_HUMAN	Gene/Protein Processing	[3]
Decorin (DCN)	OTWLJL7K	PGS2_HUMAN	Gene/Protein Processing	[3]

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