Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMLB3RT)

• Drug Name: 1,6-hexamethylene diisocyanate Drug Info
• Synonyms: HMDI; HDI

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 13192
  ChEBI ID: CHEMBL53578
  CAS Number: CAS 822-06-0
  TTD Drug ID: DMLB3RT

Molecule-Related Drug Atlas

Drug(s) Targeting Transformation-sensitive protein p120 (TRPA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[7]
LY3526318	DMFXNQM	Chronic low-back pain	MG30	Phase 2	[8]
HX-100	DMFRM15	Diabetic neuropathy	8C0Z	Phase 1	[9]
NPPB	DMFIWAN	Discovery agent	N.A.	Investigative	[10]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[11]
[3H]resolvin D1	DMFT0HU	Discovery agent	N.A.	Investigative	[12]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[13]
icilin	DMYVOL9	Discovery agent	N.A.	Investigative	[14]
4-oxo-nonenal	DMPX1J9	Discovery agent	N.A.	Investigative	[15]
dibutyl phthalate	DMEDGKO	Discovery agent	N.A.	Investigative	[16]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[17]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[18]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[19]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[20]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[21]
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[23]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[24]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[25]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[26]

Drug(s) Affected By Ferritin light chain (FTL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[27]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[28]
Selenium	DM25CGV	N. A.	N. A.	Approved	[29]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[30]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[32]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[33]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[36]

Drug(s) Affected By Ferritin heavy chain (FTH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[27]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[30]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[37]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[38]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[41]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[42]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[43]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[44]

Drug(s) Affected By Troponin T, cardiac muscle (TNNT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[48]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[49]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[50]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[51]
Tacrolimus	DMZ7XNQ	Graft-versus-host disease	4B24	Approved	[52]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[53]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[54]

Drug(s) Affected By AMP deaminase 3 (AMPD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[29]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[55]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[56]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[57]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[49]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[58]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[51]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[59]

Drug(s) Affected By Protein sel-1 homolog 3 (SEL1L3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[57]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[63]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[64]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[65]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]

Drug(s) Affected By Nesprin-2 (SYNE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[69]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[70]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[58]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[51]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[59]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[71]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[72]

Drug(s) Affected By Copper transport protein ATOX1 (ATOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[73]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[57]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[49]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[70]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[73]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[51]
CERC-801	DM3SZ7P	N. A.	N. A.	Phase 2	[74]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[29]

Drug(s) Affected By Receptor-binding cancer antigen expressed on SiSo cells (EBAG9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[76]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[77]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[49]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[78]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[78]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[79]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[68]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[80]

Drug(s) Affected By Monocarboxylate transporter 5 (SLC16A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[55]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[82]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[57]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[84]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[85]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[64]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[77]

Drug(s) Affected By Probable phospholipid-transporting ATPase IIB (ATP9B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[76]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[50]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[87]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[88]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[89]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[90]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[69]

Drug(s) Affected By Voltage-dependent T-type calcium channel subunit alpha-1H (CACNA1H)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Herbimycin A	DM6YWBF	Solid tumour/cancer	2A00-2F9Z	Approved	[91]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[94]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[95]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[70]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[50]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[51]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[54]

Drug(s) Affected By Lebercilin-like protein (LCA5L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[96]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[89]

Drug(s) Affected By Glycophorin-C (GYPC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[76]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[97]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[98]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[58]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[51]
PD-0325901	DM27D4J	Breast cancer	2C60-2C65	Phase 2	[99]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[100]

Drug(s) Affected By Transmembrane protein 253 (TMEM253)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[70]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[101]

Drug(s) Affected By Heat shock 70 kDa protein 6 (HSPA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[102]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[18]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[28]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[103]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[39]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[104]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[105]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[106]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[92]

Drug(s) Affected By Kit ligand (KITLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[107]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[73]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[26]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[108]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[83]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[21]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[109]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[110]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[112]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[113]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[115]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[116]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[117]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[118]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[119]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[120]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[121]

Drug(s) Affected By Neuromedin-B receptor (NMBR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[122]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[123]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[72]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[68]
Octanal	DMTN0OK	N. A.	N. A.	Investigative	[124]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[125]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[113]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[126]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[127]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[128]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[112]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[129]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[130]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[115]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[116]

Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[131]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[132]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[133]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[135]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[108]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[136]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[137]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[135]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[138]

Drug(s) Affected By Mitogen-activated protein kinase 9 (MAPK9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[132]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[122]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[135]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[139]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[135]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[141]
Sorbitol	DMAN0DE	Constipation	DD91.1	Approved	[142]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[57]

Drug(s) Affected By F-box/WD repeat-containing protein 4 (FBXW4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[70]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[96]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[59]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[143]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[59]

Drug(s) Affected By Nexilin (NEXN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[55]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[86]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[56]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[76]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[64]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[145]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[65]

Drug(s) Affected By Large ribosomal subunit protein mL62 (MRPL58)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[146]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[64]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[49]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[51]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[147]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[148]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[69]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[149]

Drug(s) Affected By NGFI-A-binding protein 2 (NAB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[75]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[73]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[21]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[150]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[64]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[65]
Bortezomib	DMNO38U	Leukemia		Approved	[152]

Drug(s) Affected By Cytospin-B (SPECC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[150]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[153]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[76]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[49]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[96]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[72]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[68]

Drug(s) Affected By Immunoglobulin superfamily containing leucine-rich repeat protein 2 (ISLR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[146]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[154]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[51]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[54]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[72]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[155]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[156]

Drug(s) Affected By Olfactory receptor 2W3 (OR2W3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[157]
Fenfluramine	DM0762O	Dravet syndrome	8A61.11	Phase 3	[158]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[72]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[79]

Drug(s) Affected By ATP-dependent RNA helicase DHX29 (DHX29)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[55]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[51]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[79]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[68]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[159]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[148]
Hexadecanoic acid	DMWUXDZ	Discovery agent	N.A.	Investigative	[160]

Drug(s) Affected By Cell adhesion molecule DSCAML1 (DSCAML1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[54]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[72]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[159]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[161]

Drug(s) Affected By Leucine-rich repeat neuronal protein 4 (LRRN4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[162]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[49]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[51]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[53]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[101]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[163]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[57]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[79]

Drug(s) Affected By Interleukin-22 receptor subunit alpha-2 (IL22RA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AMEP	DMFELMQ	Melanoma	2C30	Phase 1	[164]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[72]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[164]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[148]

Drug(s) Affected By Oxysterol-binding protein 2 (OSBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[165]
Selenium	DM25CGV	N. A.	N. A.	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[166]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[167]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[167]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[168]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[169]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[51]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[170]

Drug(s) Affected By Mitoferrin-2 (SLC25A28)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[32]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[154]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[171]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[101]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[57]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[172]

Drug(s) Affected By Interferon-stimulated gene 20 kDa protein (ISG20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[173]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[174]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[173]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[153]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[57]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[97]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[64]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[173]

Drug(s) Affected By Protein FAM210A (FAM210A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[44]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[49]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[44]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[79]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[148]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[175]

Drug(s) Affected By Aquaporin-10 (AQP10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[176]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[48]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[54]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[176]
Urea	DMUK75B	Dermatological disease	DA24.Y	Approved	[177]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[72]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[79]

Drug(s) Affected By Cytochrome c oxidase assembly factor 1 homolog (COA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[178]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[167]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[167]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[50]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[171]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[59]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[179]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[143]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[180]

Drug(s) Affected By Phospholipid-transporting ATPase IB (ATP8A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[50]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[154]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[59]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[54]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[72]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[159]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[181]

Drug(s) Affected By FERM, ARHGEF and pleckstrin domain-containing protein 1 (FARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[159]
Selenium	DM25CGV	N. A.	N. A.	Approved	[29]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[49]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[73]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[58]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[51]

Drug(s) Affected By Arylamine N-acetyltransferase 2 (NAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Procainamide	DMNMXR8	Ventricular arrhythmias	BC71	Approved	[182]
Hydralazine	DMU8JGH	Chronic heart failure	BD1Z	Approved	[183]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[184]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[185]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[186]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[187]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[153]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[188]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[57]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[181]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Transformation-sensitive protein p120 (TRPA1)	TTELV3W	TRPA1_HUMAN	Activator	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
AMP deaminase 3 (AMPD3)	OT5SP1KJ	AMPD3_HUMAN	Gene/Protein Processing	[3]
Aquaporin-10 (AQP10)	OT8Q5UWS	AQP10_HUMAN	Gene/Protein Processing	[4]
Arylamine N-acetyltransferase 2 (NAT2)	OTBPDQOY	ARY2_HUMAN	Drug Response	[5]
ATP-dependent RNA helicase DHX29 (DHX29)	OT0NDSOE	DHX29_HUMAN	Gene/Protein Processing	[4]
Cell adhesion molecule DSCAML1 (DSCAML1)	OT7QURQT	DSCL1_HUMAN	Post-Translational Modifications	[6]
Copper transport protein ATOX1 (ATOX1)	OT05LF59	ATOX1_HUMAN	Post-Translational Modifications	[6]
Cytochrome c oxidase assembly factor 1 homolog (COA1)	OTHSX40F	COA1_HUMAN	Post-Translational Modifications	[6]
Cytospin-B (SPECC1)	OTPEML48	CYTSB_HUMAN	Post-Translational Modifications	[6]
F-box/WD repeat-containing protein 4 (FBXW4)	OTEGSZOX	FBXW4_HUMAN	Post-Translational Modifications	[6]
FERM, ARHGEF and pleckstrin domain-containing protein 1 (FARP1)	OTL1EBTM	FARP1_HUMAN	Post-Translational Modifications	[6]

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