Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMRJSP8)

• Drug Name: Orlistat Drug Info
• Synonyms: orlistat; 96829-58-2; Tetrahydrolipstatin; Xenical; Alli; Orlipastat; (-)-Tetrahydrolipstatin; Orlipastatum; Orlipastatum [INN-Latin]; THLP; Ro-18-0647; UNII-95M8R751W8; C29H53NO5; Ro 18-0647/002; N-Formyl-L-leucine (1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester; (2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-2-yl (2S)-2-formamido-4-methylpentanoate; Orlistat (Alli, Xenical); MLS002207022; [(2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-2-yl] (2S)-2-formamido-4-methylpentanoate; CHEMBL175247; Alli; GlaxoSmithKline brand of orlistat; Roche brand of orlistat; Alli (TN); Hoffmann-La Roche brand of orlistat; KS-1183; Orlistat [USAN:INN]; R-212; Xenical (TN); Orlistat (USAN/INN); Ro 18-0647/008; Alli, Xenical, Tetrahydrolipstatin, Orlistat; N-Formyl-L-leucine, ester with (3S,4S)-3-hexyl-4-((2S)-2-hydroxytridecyl)-2-oxetanone; L-Leucine, N-formyl-, (1S)-1-(((2S,3S)-3-hexyl-4-oxo-2-oxetanyl)methyl)dodecyl ester; L-Leucine,N-formyl-, (1S)-1-(((2S,3S)-3-hexyl-4-oxo-2-oxetanyl)methyl)dodecyl ester; 1-((3-hexyl-4-oxo-2-oxetanyl)methyl)dodecyl-2-formamido-4-methylvalerate; TETRAHYDROLIPSTATIN

Indication

Disease Entry	ICD 11	Status	REF
Obesity	5B81	Approved	[1]

• Therapeutic Class: Antiobesity Agents
• Cross-matching ID:
  PubChem CID: 3034010
  ChEBI ID: CHEBI:94686
  CAS Number: CAS 96829-58-2
  TTD Drug ID: DMRJSP8
  ACDINA Drug ID: D00491

Molecule-Related Drug Atlas

Drug(s) Targeting Cannabinoid receptor 1 (CB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[11]
NABILONE	DMVRYT2	Insomnia	7A00-7A0Z	Approved	[12]
SR141716A	DMCO5JZ	Obesity	5B81	Approved	[13]
Tebipenem	DMVSX6O	Urinary tract infection	GC08	Phase 3	[14]
Conatumumab	DM2UOSN	Colorectal cancer	2B91.Z	Phase 2	[15]
GW-42004	DMY3KSU	Lipid metabolism disorder	5C52.Z	Phase 2	[16]
SR-147778	DMNAECP	Obesity	5B81	Phase 2	[17]
Nimacimab	DM21Z68	Diabetic nephropathy	GB61.Z	Phase 2	[18]
AEF0117	DMQ1GH4	Marijuana use disorder	6C41	Phase 2	[19]
V-24343	DMJSX9N	Type-2 diabetes	5A11	Phase 1	[20]

Drug(s) Targeting Pancreatic triacylglycerol lipase (PNLIP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dalbavancin	DMGMNH3	Bacterial infection	1A00-1C4Z	Approved	[21]
Pancrecarb	DMOML9Q	Pancreatic malfunction	DC30-DC3Z	NDA filed	[22]
Liprotamase	DMNF4UH	Cystic fibrosis	CA25	Phase 3	[23]
MS-1819	DM35YFC	Exocrine pancreatic insufficiency	DC35.1	Phase 1/2	[24]
AZM-131	DMLCSRF	Obesity	5B81	Terminated	[25]
B-Octylglucoside	DMMO75G	Discovery agent	N.A.	Investigative	[26]
(Hydroxyethyloxy)Tri(Ethyloxy)Octane	DMY6FUD	Discovery agent	N.A.	Investigative	[26]
B-Nonylglucoside	DM48VJR	Discovery agent	N.A.	Investigative	[27]
METHOXYUNDECYLPHOSPHINIC ACID	DMY0O7X	Discovery agent	N.A.	Investigative	[27]
Daio-Orengedokuto (DOT)	DM3M652	Discovery agent	N.A.	Investigative	[28]

Drug(s) Affected By Serum paraoxonase/arylesterase 1 (PON1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[29]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[30]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[31]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[32]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[33]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[35]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[36]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[37]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[29]

Drug(s) Affected By Phosphatidylserine lipase ABHD16A (ABHD16A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[41]
Bortezomib	DMNO38U	Leukemia		Approved	[42]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[44]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[46]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[38]

Drug(s) Affected By Lysophosphatidylserine lipase ABHD12 (ABHD12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[47]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[41]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[48]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[49]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[50]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[51]

Drug(s) Affected By Acyl-coenzyme A thioesterase 8 (ACOT8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[6]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[52]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[53]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[54]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[50]

Drug(s) Affected By ER lumen protein-retaining receptor 3 (KDELR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[56]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[59]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[53]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[60]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[60]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[61]
Vidarabine	DM0N85H	Hepatosplenic T-cell lymphoma		Approved	[61]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[62]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[63]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[64]
Etidronic acid	DM1XHYJ	Bone Paget disease		Approved	[61]
Tiaprofenic acid	DM23D7J	Osteoarthritis	FA00-FA05	Approved	[61]
Bromperidol	DM24XYQ	Schizophrenia	6A20	Approved	[61]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[65]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[66]

Drug(s) Affected By Protein transport protein Sec24D (SEC24D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[35]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[41]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[53]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]

Drug(s) Affected By Pro-glucagon (GCG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Metoclopramide	DMFA5MY	Nausea	MD90	Approved	[71]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[72]
Gatifloxacin	DMSL679	Acute gonococcal cervicitis		Approved	[73]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[74]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[54]
geraniol	DMS3CBD	Discovery agent	N.A.	Investigative	[75]

Drug(s) Affected By Pro-neuropeptide Y (NPY)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[76]
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[35]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[78]
Guanethidine	DM9NSWT	Moderate and severe hypertension	BA00.Z	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[80]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[81]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[35]

Drug(s) Affected By Insulin (INS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[82]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[83]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[84]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[85]
Fructose	DM43AN2	Vomiting	MD90	Approved	[86]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[87]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[88]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[89]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[90]

Drug(s) Affected By Catalase (CAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[91]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[92]
Haloperidol	DM96SE0	Delirium		Approved	[76]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[93]
Selenium	DM25CGV	N. A.	N. A.	Approved	[94]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[95]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[96]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[83]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[97]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[67]

Drug(s) Affected By Receptor tyrosine-protein kinase erbB-2 (ERBB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trastuzumab	DMZQOUX	Breast cancer	2C60-2C65	Approved	[76]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[98]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[99]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[100]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[101]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[102]
Selenium	DM25CGV	N. A.	N. A.	Approved	[103]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[104]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[105]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[106]

Drug(s) Affected By Cholecystokinin (CCK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Octreotide	DMHIDCJ	Acromegaly	5A60.0	Approved	[108]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[53]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[109]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[48]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[110]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[54]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[111]

Drug(s) Affected By Retinoblastoma-associated protein (RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[112]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[113]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[114]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[115]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[102]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[116]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[117]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[118]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[119]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[105]

Drug(s) Affected By Cyclin-dependent kinase 1 (CDK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[120]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[121]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[122]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Selenium	DM25CGV	N. A.	N. A.	Approved	[123]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[124]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[125]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[104]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[126]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[105]

Drug(s) Affected By Eukaryotic translation initiation factor 4E (EIF4E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[127]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[128]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[129]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[130]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[132]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Momelotinib	DMF98Q0	Myelofibrosis	2A20.2	Approved	[133]
Flurbiprofen	DMGN4BY	Osteoarthritis	FA00-FA05	Approved	[132]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[53]

Drug(s) Affected By Lipoprotein lipase (LPL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[76]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[134]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[135]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[136]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[106]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[137]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[138]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[139]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[140]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[139]

Drug(s) Affected By Gastric triacylglycerol lipase (LIPF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[48]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[54]

Drug(s) Affected By Fatty acid-binding protein, liver (FABP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[141]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[142]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[141]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[83]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[141]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[67]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[141]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[143]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[144]

Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[145]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[146]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[147]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[148]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[149]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[149]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[150]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[151]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[152]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[153]

Drug(s) Affected By Gastric inhibitory polypeptide (GIP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[154]
Metoclopramide	DMFA5MY	Nausea	MD90	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[49]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[54]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[38]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[156]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[157]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[158]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[159]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[160]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[161]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[160]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[162]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[163]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]

Drug(s) Affected By Peptide YY (PYY)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[165]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[60]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[60]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[166]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[35]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[54]

Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[167]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[168]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[169]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[170]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[171]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[172]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[173]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[174]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[67]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[175]

Drug(s) Affected By Cyclin-dependent kinase 4 (CDK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[176]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[177]
Selenium	DM25CGV	N. A.	N. A.	Approved	[123]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[178]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[104]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[179]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[180]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[105]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[181]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-4 (ATF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[182]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[183]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[102]
Selenium	DM25CGV	N. A.	N. A.	Approved	[103]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[184]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[185]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[186]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[187]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[188]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[189]

Drug(s) Affected By Cyclin-A2 (CCNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[98]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[121]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[100]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[190]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[191]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[117]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[192]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[126]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[193]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[67]

Drug(s) Affected By Acetylcholinesterase (ACHE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetylcholine	DMDF79Z	Cataract	9B10	Approved	[194]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[195]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[196]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[197]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[198]
L-Glutamic Acid	DM4PUDW	Schizophrenia	6A20	Approved	[196]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[199]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[200]
Neostigmine	DM6T2J3	Myasthenia gravis	8C6Y	Approved	[201]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[202]

Drug(s) Affected By Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[203]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[67]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[204]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[205]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[129]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[206]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[207]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[208]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[209]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[210]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[211]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[212]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[115]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[213]
Selenium	DM25CGV	N. A.	N. A.	Approved	[103]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[214]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[215]

Drug(s) Affected By G1/S-specific cyclin-E1 (CCNE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[156]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[216]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[191]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[161]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[117]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[67]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[217]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[218]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[219]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[220]

Drug(s) Affected By Cyclin-dependent kinase 2 (CDK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[120]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[121]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[216]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[221]
Selenium	DM25CGV	N. A.	N. A.	Approved	[123]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[161]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[222]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[223]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[179]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[105]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[224]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[190]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[159]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[225]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[226]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[227]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[228]
Fructose	DM43AN2	Vomiting	MD90	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[224]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[230]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[231]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[232]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[182]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[183]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[168]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[190]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[171]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[233]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[192]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[67]

Drug(s) Affected By Vascular endothelial growth factor receptor 2 (KDR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[234]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[106]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[235]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[236]
Haloperidol	DM96SE0	Delirium		Approved	[237]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[237]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[238]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[239]

Drug(s) Affected By Sterol regulatory element-binding protein 1 (SREBF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[181]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[76]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[224]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[240]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[241]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[242]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[67]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[204]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[243]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[244]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[245]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[246]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[247]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[106]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[248]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[249]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[228]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[250]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[251]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[252]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[47]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[253]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[254]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[115]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[190]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[124]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[255]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[161]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[203]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[256]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[257]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[258]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[259]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[260]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[261]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[262]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[263]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[264]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[265]

Drug(s) Affected By ETS translocation variant 4 (ETV4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[197]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[266]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[68]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[267]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[206]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[268]
Bortezomib	DMNO38U	Leukemia		Approved	[42]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[53]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[113]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[212]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[255]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[269]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[270]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[271]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[272]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[217]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[273]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[274]

Drug(s) Affected By Fatty acid synthase (FASN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[275]
Selenium	DM25CGV	N. A.	N. A.	Approved	[103]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[276]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[168]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[277]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[278]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[204]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[280]

Drug(s) Affected By Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[281]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[83]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[67]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[204]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[282]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[283]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[284]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[285]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 10 (TNFSF10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[183]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[224]
Selenium	DM25CGV	N. A.	N. A.	Approved	[103]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[286]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[287]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[223]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[67]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[288]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[128]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[289]

Drug(s) Affected By Palmitoyl-protein thioesterase 1 (PPT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[6]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[290]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[48]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[291]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[292]

Drug(s) Affected By Pancreatic lipase-related protein 2 (PNLIPRP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[207]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[53]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[49]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[54]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[293]
PARAOXON	DMN4ZKC	Discovery agent	N.A.	Investigative	[294]

Drug(s) Affected By Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[295]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[38]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[296]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[83]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[297]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[298]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[299]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[300]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[202]

Drug(s) Affected By Hemoglobin subunit alpha (HBA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[301]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[154]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[302]
Flucloxacillin	DMNUWST	Bacterial infection	1A00-1C4Z	Approved	[303]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[304]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[107]
Capecitabine	DMTS85L	Adenocarcinoma	2D40	Approved	[305]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[306]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[307]

Drug(s) Affected By Acetyl-CoA carboxylase 1 (ACACA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[308]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[309]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[168]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[227]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[204]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[280]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[310]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[129]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[311]

Drug(s) Affected By Platelet-activating factor acetylhydrolase (PLA2G7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[129]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[35]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[312]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[313]
Vitamin B3	DMQVRZH	Chronic renal failure	GB61.Z	Approved	[314]
Nitrous oxide	DMTHWBI	Anxiety disorder	6B00-6B0Z	Approved	[315]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[316]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[317]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[318]

Drug(s) Affected By S-phase kinase-associated protein 2 (SKP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[156]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[192]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[67]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[319]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[320]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[321]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[206]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]

Drug(s) Affected By Keratin, type II cuticular Hb1 (KRT81)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[322]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[268]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[41]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[323]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[54]
QUERCITRIN	DM1DH96	Discovery agent	N.A.	Investigative	[324]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[38]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[325]

Drug(s) Affected By Probable glutathione peroxidase 8 (GPX8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[326]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[312]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[41]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[53]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[327]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[328]

Drug(s) Affected By Carboxypeptidase B2 (CPB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[329]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[67]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Epanova	DMHEAGL	Hypertriglyceridemia	5C80.1	Approved	[330]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[331]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[53]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[48]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[332]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[333]

Drug(s) Affected By Eukaryotic translation initiation factor 2A (EIF2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[183]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[320]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[334]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[335]
Cerulenin	DM6N4PR	Weight loss	MG43.5	Approved	[10]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[285]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[336]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]

Drug(s) Affected By DNA damage-inducible transcript 4 protein (DDIT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[231]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[337]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[203]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[338]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[67]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[339]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[106]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[340]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[282]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[341]

Drug(s) Affected By Diacylglycerol lipase-alpha (DAGLA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[320]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[322]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[53]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[332]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[320]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[54]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[342]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[343]
ACEA	DMWX3HT	Discovery agent	N.A.	Investigative	[344]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cannabinoid receptor 1 (CB1)	TT6OEDT	CNR1_HUMAN	Inhibitor	[2]
Pancreatic triacylglycerol lipase (PNLIP)	TTXMY0J	LIPP_HUMAN	Modulator	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Acetyl-CoA carboxylase 1 (ACACA)	OT5CQPZY	ACACA_HUMAN	Gene/Protein Processing	[4]
Acetylcholinesterase (ACHE)	OT2H8HG6	ACES_HUMAN	Gene/Protein Processing	[5]
Acyl-coenzyme A thioesterase 8 (ACOT8)	OTHY684G	ACOT8_HUMAN	Gene/Protein Processing	[6]
Carboxypeptidase B2 (CPB2)	OTPIL8IE	CBPB2_HUMAN	Gene/Protein Processing	[7]
Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A)	OTI862QH	CPT1A_HUMAN	Gene/Protein Processing	[6]
Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2)	OTIN6G20	CPT2_HUMAN	Gene/Protein Processing	[6]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Gene/Protein Processing	[8]
Catalase (CAT)	OTHEBX9R	CATA_HUMAN	Gene/Protein Processing	[6]
Cholecystokinin (CCK)	OT1GCG0L	CCKN_HUMAN	Protein Interaction/Cellular Processes	[9]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4)	OTRFV19J	ATF4_HUMAN	Gene/Protein Processing	[10]

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