Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMU8KTO)

Drug Name
PP121 Drug Info
Synonyms PP-121; PP 121
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
24905142
ChEBI ID
CHEBI:50915
CAS Number
CAS 1092788-83-4
TTD Drug ID
DMU8KTO

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Patented Agent(s)
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting PI3-kinase beta (PIK3CB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Buparlisib DM1WEHC Breast cancer 2C60-2C65 Phase 3 [2]
PQR309 DMMCYZ8 Squamous head and neck cell carcinom 2D60.0 Phase 2 [3]
PA-799 DMLSYJQ Colorectal cancer 2B91.Z Phase 1/2 [4]
AZD8186 DMWYF1H Solid tumour/cancer 2A00-2F9Z Phase 1 [5]
GSK2636771 DMCBGLW Prostate cancer 2C82.0 Phase 1 [6]
BAY 1082439 DMLRGX1 Solid tumour/cancer 2A00-2F9Z Phase 1 [7]
AZD6482 DMVP4E5 Thrombosis DB61-GB90 Terminated [8]
PIK-75 DM9BQTX Discovery agent N.A. Investigative [9]
KU-0060648 DMQWS6U Discovery agent N.A. Investigative [10]
PI-3065 DMCQUWI Discovery agent N.A. Investigative [11]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Hematopoietic cell kinase (HCK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
BK3 DM6YQO3 N. A. N. A. Patented [12]
Doramapimod DM6BU7N Inflammatory bowel disease DD72 Patented [13]
3-(6-allyloxy-2-naphthyl)-1-(4-piperidylmethyl)pyrazolo[3,4-d]pyrimidin-4-amine DM0DYAU N. A. N. A. Patented [12]
Unii-I92MU0V408 DMUD7H8 N. A. N. A. Patented [13]
US8933228, 3 DMPNCOL N. A. N. A. Patented [13]
SB19065 DM2MQD0 N. A. N. A. Patented [14]
US9108950, 1 DMPT2ZS N. A. N. A. Patented [15]
US8933228, Ref 2 DMKEX51 N. A. N. A. Patented [16]
BK7 DMQD4X2 N. A. N. A. Patented [12]
PMID15546730C2 DMOPUIH Discovery agent N.A. Investigative [17]
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Drug(s) Targeting Platelet-derived growth factor receptor alpha (PDGFRA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [18]
Ripretinib DM958QB Gastrointestinal stromal tumour 2B5B Approved [19]
Olaratumab DMNYOIX Soft tissue sarcoma 2B57 Approved [20]
Avapritinib DMK2GZX Gastrointestinal stromal tumour 2B5B Approved [21]
E-3810 DM42PFT Solid tumour/cancer 2A00-2F9Z Phase 3 [22]
CP-868596 DMZIM37 Gastrointestinal cancer 2C11 Phase 3 [23]
Famitinib DMSFWT7 Solid tumour/cancer 2A00-2F9Z Phase 2 [24]
XL-820 DMMHX9K Solid tumour/cancer 2A00-2F9Z Phase 2 [25]
MP470 DMELUAK Solid tumour/cancer 2A00-2F9Z Phase 2 [26]
MEDI-575 DMI9WVM Glioblastoma multiforme 2A00.0 Phase 2 [27]
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Drug(s) Targeting Epidermal growth factor receptor (EGFR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [28]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [29]
Gefitinib DM15F0X Colon adenocarcinoma Approved [30]
Erlotinib DMCMBHA Adrenal gland neoplasm Approved [31]
Vandetanib DMRICNP Solid tumour/cancer 2A00-2F9Z Approved [32]
Dacomitinib DMOH8VY Non-small-cell lung cancer 2C25.Y Approved [33]
BIBW 2992 DMTKD7Q Non-small-cell lung cancer 2C25.Y Approved [34]
SKI-758 DMQ8E9R Ischemia 8B10-8B11 Approved [35]
Epidermal growth factor DMVONE6 Vulnerary ND56.Z Approved [33]
Merimepodib DM0HS92 Breast cancer 2C60-2C65 Approved [36]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Serine/threonine-protein kinase mTOR (mTOR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sirolimus DMGW1ID Advanced cancer 2A00-2F9Z Approved [37]
Temsirolimus DMS104F Renal cell carcinoma 2C90 Approved [38]
PF-04449913 DMSB068 Chronic myelomonocytic leukaemia 2A40 Approved [39]
Everolimus DM8X2EH Advanced cancer 2A00-2F9Z Approved [40]
Novolimus DM6ZPLQ Artery stenosis BD52 Approved [41]
Zotarolimus DMRMCXW Solid tumour/cancer 2A00-2F9Z Approved [42]
Ridaforolimus DMLHEU7 Sarcoma 2A60-2C35 Phase 3 [43]
AZD2014 DMOEARH Solid tumour/cancer 2A00-2F9Z Phase 2 [44]
MM-141 DM2RJ4D Pancreatic cancer 2C10 Phase 2 [45]
PQR309 DMMCYZ8 Squamous head and neck cell carcinom 2D60.0 Phase 2 [41]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Vascular endothelial growth factor receptor 2 (KDR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [46]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [47]
Regorafenib DMHSY1I Gastrointestinal stromal tumour 2B5B Approved [48]
Sunitinib DMCBJSR Acute undifferentiated leukemia Approved [49]
Axitinib DMGVH6N Renal cell carcinoma 2C90 Approved [50]
Vandetanib DMRICNP Solid tumour/cancer 2A00-2F9Z Approved [32]
Pazopanib HCl DM6U9CQ Renal cell carcinoma 2C90 Approved [51]
Fruquintinib DMHOSCQ Colorectal cancer 2B91.Z Approved [52]
Cabozantinib DMIYDT4 Medullary thyroid gland carcinoma Approved [53]
Tivozanib DMUKC5L Renal cell carcinoma 2C90 Approved [54]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting DNA-dependent protein kinase catalytic (PRKDC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
M3814 DMK2L38 Locally advanced rectal cancer 2B92 Phase 1/2 [45]
AZD7648 DMD9Y5T Solid tumour/cancer 2A00-2F9Z Phase 1/2 [55]
M9831 DM59TI2 Solid tumour/cancer 2A00-2F9Z Phase 1 [45]
LY-292223 DML36ZE Discovery agent N.A. Investigative [56]
Ethyl 1-[(1H-benzimidazol-2(3H)one-5-yl)sulfonyl]-1H-pyrrole-2-carboxylate DM3FH02 Discovery agent N.A. Investigative [57]
PIK-75 DM9BQTX Discovery agent N.A. Investigative [58]
KU-0060648 DMQWS6U Discovery agent N.A. Investigative [10]
ALPHA-NAPHTHOFLAVONE DMELOIQ Discovery agent N.A. Investigative [59]
2-Morpholin-4-yl-pyrimido[2,1-a]isoquinolin-4-one DM79ZOV Discovery agent N.A. Investigative [59]
2-(2-Methyl-morpholin-4-yl)-benzo[h]chromen-4-one DMAHZR9 Discovery agent N.A. Investigative [56]
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Drug(s) Targeting Proto-oncogene c-Src (SRC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [32]
Bosutinib DMTI8YE Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [32]
SKI-758 DMQ8E9R Ischemia 8B10-8B11 Approved [35]
Herbimycin A DM6YWBF Solid tumour/cancer 2A00-2F9Z Approved [60]
AL3818 DM3WP0N Alveolar soft part sarcoma 2A60-2C35 Phase 3 [45]
CP-868596 DMZIM37 Gastrointestinal cancer 2C11 Phase 3 [45]
Masitinib DMRSNEU Amyotrophic lateral sclerosis 8B60.0 Phase 3 [61]
KX-01 DMF0NA9 Actinic keratosis EK90.0 Phase 3 [62]
Saracatinib DMBLHGP Hematologic tumour 2B33.Y Phase 2 [63]
TPX-0046 DMIVE67 Solid tumour/cancer 2A00-2F9Z Phase 1/2 [64]
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Drug(s) Targeting ABL messenger RNA (ABL mRNA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
G-1128 DMHOMFK Chronic myelogenous leukaemia 2A20.0 Discontinued in Phase 2 [65]
PMID24900538C2c DM5PATM Discovery agent N.A. Investigative [66]
PMID21561767C8h DMABZH6 Discovery agent N.A. Investigative [67]
PMID23441572C24 DMG4MLA Discovery agent N.A. Investigative [68]
GNF-5 DMGLIPV Discovery agent N.A. Investigative [69]
Drug(s) Targeting PI3-kinase gamma (PIK3CG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
BAY 80-6946 DMLOS5R Follicular lymphoma 2A80 Approved [70]
IPI-145 DMWA24P Follicular lymphoma 2A80 Approved [71]
Buparlisib DM1WEHC Breast cancer 2C60-2C65 Phase 3 [2]
Enzastaurin DM5H0R9 Diffuse large B-cell lymphoma 2A81 Phase 3 [45]
Rigosertib DMOSTXF Myelodysplastic syndrome 2A37 Phase 3 [72]
GDC-0032 DMT4QHD Breast cancer 2C60-2C65 Phase 3 [45]
PQR309 DMMCYZ8 Squamous head and neck cell carcinom 2D60.0 Phase 2 [73]
SAR245409 DMQM7IL Solid tumour/cancer 2A00-2F9Z Phase 2 [74]
XL147 DMML7BE Solid tumour/cancer 2A00-2F9Z Phase 2 [74]
SF1126 DML10K3 Head and neck cancer 2D42 Phase 2 [75]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
ABL messenger RNA (ABL mRNA) TT6B75U ABL1_HUMAN Inhibitor [1]
DNA-dependent protein kinase catalytic (PRKDC) TTK3PY9 PRKDC_HUMAN Inhibitor [1]
Epidermal growth factor receptor (EGFR) TTGKNB4 EGFR_HUMAN Inhibitor [1]
Hematopoietic cell kinase (HCK) TT42OGM HCK_HUMAN Inhibitor [1]
PI3-kinase beta (PIK3CB) TTTHBCA PK3CB_HUMAN Inhibitor [1]
PI3-kinase gamma (PIK3CG) TTHBTOP PK3CG_HUMAN Inhibitor [1]
Platelet-derived growth factor receptor alpha (PDGFRA) TT8FYO9 PGFRA_HUMAN Inhibitor [1]
Proto-oncogene c-Src (SRC) TT6PKBN SRC_HUMAN Inhibitor [1]
Serine/threonine-protein kinase mTOR (mTOR) TTCJG29 MTOR_HUMAN Inhibitor [1]
Vascular endothelial growth factor receptor 2 (KDR) TTUTJGQ VGFR2_HUMAN Inhibitor [1]

References

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70 BAY 80-6946 is a highly selective intravenous PI3K inhibitor with potent p110 and p110 activities in tumor cell lines and xenograft models.Mol Cancer Ther.2013 Nov;12(11):2319-30.
71 PI3K-delta and PI3K-gamma inhibition by IPI-145 abrogates immune responses and suppresses activity in autoimmune and inflammatory disease models. Chem Biol. 2013 Nov 21;20(11):1364-74.
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74 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2156).
75 An integrin-targeted, pan-isoform, phosphoinositide-3 kinase inhibitor, SF1126, has activity against multiple myeloma in vivo.Cancer Chemother Pharmacol.2013 Apr;71(4):867-81.