Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMW0ZBF)

Drug Name
SULFATE Drug Info
Synonyms
sulfate; Sulfate ion; Sulphate; Sulfate(2-); Sulfate ions; Sulfate (ion); Sulfate radical anion; 14808-79-8; Sulfate dianion; Sulfate anion; UNII-7IS9N8KPMG; tetraoxosulfate(2-); Sulfate anion(2-); 7IS9N8KPMG; Sulfate (7CI,8CI,9CI); SO4(2-); Sulfate-35S; SULFATE STANDARD; Sulfate (S-35); Sulphate Ion; tetraoxosulfate(VI); tetraoxidosulfate(2-); Zirconium Basic sulfate; AC1L1ARH; sulfuric acid, ion(2-); Colistin Sulfate (mixture); CHEMBL183495; CHEBI:16189; CTK0H6976; BDBM26992; QAOWNCQODCNURD-UHFFFAOYSA-L; SO42-; SO4-2; SO4--
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
1117
ChEBI ID
CHEMBL16189
CAS Number
CAS 14808-79-8
TTD Drug ID
DMW0ZBF
VARIDT Drug ID
DR00060
INTEDE Drug ID
DR2127

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Carbonic anhydrase I (CA-I)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [14]
Ethoxzolamide DMVO4ED Glaucoma/ocular hypertension 9C61 Approved [15]
Dichlorphenamide DMH7IDQ Chronic glaucoma 9C61.0Z Approved [15]
Methazolamide DM7J2TA Glaucoma/ocular hypertension 9C61 Approved [16]
Acetazolamide DM1AF5U Absence epilepsy Approved [15]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [17]
PARABEN DMEW5Z8 N. A. N. A. Phase 3 [18]
CG-100649 DMIKMA9 Arthritis FA20 Phase 3 [19]
PHENOL DM1QSM3 N. A. N. A. Phase 2/3 [17]
Coumate DMVKW0N Breast cancer 2C60-2C65 Phase 2 [20]
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Drug(s) Transported By Mitochondrial dicarboxylate carrier (SLC25A10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Phosphate DMUXQG7 Constipation DD91.1 Approved [8]
Drug(s) Transported By Sulfate anion transporter 1 (SLC26A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
BICARBONATE DMT5E36 Discovery agent N.A. Investigative [21]
oxalate DM40SEU Discovery agent N.A. Investigative [5]
Drug(s) Transported By Anion exchange transporter (SLC26A6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
BICARBONATE DMT5E36 Discovery agent N.A. Investigative [22]
oxalate DM40SEU Discovery agent N.A. Investigative [23]
Drug(s) Transported By Anion exchange transporter (SLC26A7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
BICARBONATE DMT5E36 Discovery agent N.A. Investigative [24]
NITRATE DMVFB93 Discovery agent N.A. Investigative [6]
oxalate DM40SEU Discovery agent N.A. Investigative [6]
Drug(s) Metabolized By Sulfurylase kinase 1 (PAPSS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Adenylylsulfate DM0YQ2I N. A. N. A. Investigative [9]
Drug(s) Affected By Solute carrier family 13 member 1 (SLC13A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [25]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [26]
Sulforaphane DMQY3L0 Skin disease EA00-EM0Z Investigative [27]
Drug(s) Affected By Carbonic anhydrase 4 (CA4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Panobinostat DM58WKG Chronic graft versus host disease Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [30]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [30]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [31]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [32]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [28]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [33]
PDX-101 DM6OC53 Plasma cell myeloma 2A83.1 Phase 2 [33]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [26]
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Drug(s) Affected By Carbonic anhydrase 9 (CA9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetazolamide DM1AF5U Absence epilepsy Approved [34]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [35]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [36]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [37]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [38]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [39]
Ampicillin DMHWE7P Acute epiglottitis Approved [40]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [41]
Bortezomib DMNO38U Leukemia Approved [42]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [43]
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Drug(s) Affected By Mitogen-activated protein kinase 13 (MAPK13)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Panobinostat DM58WKG Chronic graft versus host disease Approved [28]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [44]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [45]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [46]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [47]
Paclitaxel DMLB81S Breast carcinoma Approved [48]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [49]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [50]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [51]
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Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 7 (MAP3K7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [52]
Selenium DM25CGV N. A. N. A. Approved [53]
Methotrexate DM2TEOL Anterior urethra cancer Approved [54]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [55]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [56]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [57]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [58]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [51]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [59]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [51]
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Drug(s) Affected By Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [60]
Methotrexate DM2TEOL Anterior urethra cancer Approved [61]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [62]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [63]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [46]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [56]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [57]
Bortezomib DMNO38U Leukemia Approved [64]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [50]
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Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [65]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [66]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [52]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [67]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [68]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [69]
Prednisone DM2HG4X Acute asthma CA23 Approved [70]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [71]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [72]
Methotrexate DM2TEOL Anterior urethra cancer Approved [73]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [74]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [75]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [76]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [77]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [78]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [79]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [80]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [81]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [82]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [80]
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Drug(s) Affected By Mitogen-activated protein kinase 9 (MAPK9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [83]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [84]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [85]
Methotrexate DM2TEOL Anterior urethra cancer Approved [86]
Quercetin DM3NC4M Obesity 5B81 Approved [87]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [62]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [85]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [88]
Sorbitol DMAN0DE Constipation DD91.1 Approved [89]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [39]
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Drug(s) Affected By Mitogen-activated protein kinase 10 (MAPK10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [90]
Panobinostat DM58WKG Chronic graft versus host disease Approved [28]
Sorbitol DMAN0DE Constipation DD91.1 Approved [91]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [47]
Ethanol DMDRQZU Chronic pain MG30 Approved [92]
Dicumarol DMFQCB1 Bleeding disorder GA20-GA21 Approved [91]
Menthol DMG2KW7 Back pain ME84.Z Approved [93]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [94]
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [95]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [91]
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Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 11 (MAP3K11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [96]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [62]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [39]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [56]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [50]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [59]
Urethane DM7NSI0 N. A. N. A. Phase 4 [97]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [98]
GW7604 DMCA4RM Discovery agent N.A. Investigative [96]
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Drug(s) Affected By Mitogen-activated protein kinase kinase kinase kinase 1 (MAP4K1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [56]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [100]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [30]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [30]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [101]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [102]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [33]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [103]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [26]
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Drug(s) Affected By Band 3 anion transport protein (SLC4A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [104]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [56]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [50]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [32]
Adefovir DMM278X N. A. N. A. Approved [66]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [105]
CHLORIDE DM1TJXA Solid tumour/cancer 2A00-2F9Z Phase 3 [106]
AMG 386 DMQJXL4 Breast cancer 2C60-2C65 Phase 3 [10]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [26]
D-glucose DMMG2TO Discovery agent N.A. Investigative [107]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Carbonic anhydrase I (CA-I) TTHQPL7 CAH1_HUMAN Inhibitor [1]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Sulfate transporter (SLC26A2) DTFSLX5 S26A2_HUMAN Substrate [2]
Sodium/sulfate cotransporter 1 (SLC13A1) DTIZEMV S13A1_HUMAN Substrate [3]
Na(+)/sulfate cotransporter SUT-1 (SLC13A4) DTJZ7W2 S13A4_HUMAN Substrate [4]
Sulfate anion transporter 1 (SLC26A1) DTJ785O S26A1_HUMAN Substrate [5]
Anion exchange transporter (SLC26A7) DTOTME4 S26A7_HUMAN Substrate [6]
Anion exchange transporter (SLC26A6) DTVGOLN S26A6_HUMAN Substrate [7]
Mitochondrial dicarboxylate carrier (SLC25A10) DTJYKDQ DIC_HUMAN Substrate [8]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Sulfurylase kinase 1 (PAPSS1) Main DME DEDG68B PAPS1_HUMAN Substrate [9]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Band 3 anion transport protein (SLC4A1) OT3EFUK8 B3AT_HUMAN Regulation of Drug Effects [10]
Carbonic anhydrase 4 (CA4) OT3K93LZ CAH4_HUMAN Gene/Protein Processing [11]
Carbonic anhydrase 9 (CA9) OTNA51XT CAH9_HUMAN Gene/Protein Processing [11]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Gene/Protein Processing [12]
Mitogen-activated protein kinase 10 (MAPK10) OTC46VX1 MK10_HUMAN Post-Translational Modifications [13]
Mitogen-activated protein kinase 13 (MAPK13) OT0W9GE7 MK13_HUMAN Post-Translational Modifications [13]
Mitogen-activated protein kinase 9 (MAPK9) OTCEVJ9E MK09_HUMAN Post-Translational Modifications [13]
Mitogen-activated protein kinase kinase kinase 11 (MAP3K11) OT0EYZAY M3K11_HUMAN Post-Translational Modifications [13]
Mitogen-activated protein kinase kinase kinase 7 (MAP3K7) OTUXEASC M3K7_HUMAN Post-Translational Modifications [13]
Mitogen-activated protein kinase kinase kinase kinase 1 (MAP4K1) OT6FQ1K3 M4K1_HUMAN Post-Translational Modifications [13]

References

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2 Regulated transport of sulfate and oxalate by SLC26A2/DTDST. Am J Physiol Cell Physiol. 2010 Jun;298(6):C1363-75.
3 Na+-sulfate cotransporter SLC13A1. Pflugers Arch. 2014 Jan;466(1):131-7.
4 Loss of the sulfate transporter Slc13a4 in placenta causes severe fetal abnormalities and death in mice. Cell Res. 2015 Nov;25(11):1273-6.
5 Mutations in SLC26A1 Cause Nephrolithiasis. Am J Hum Genet. 2016 Jun 2;98(6):1228-1234.
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8 SLC25A10 biallelic mutations in intractable epileptic encephalopathy with complex I deficiency. Hum Mol Genet. 2018 Feb 1;27(3):499-504.
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12 Source apportionment of particulate matter in the U.S. and associations with lung inflammatory markers. Inhal Toxicol. 2008 May;20(7):671-83. doi: 10.1080/08958370801935117.
13 Short-term airborne particulate matter exposure alters the epigenetic landscape of human genes associated with the mitogen-activated protein kinase network: a cross-sectional study. Environ Health. 2014 Nov 13;13:94. doi: 10.1186/1476-069X-13-94.
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21 SLC26A Gene Family Participate in pH Regulation during Enamel Maturation. PLoS One. 2015 Dec 15;10(12):e0144703.
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23 Oxalate (urine, plasma)
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30 Acute hypersensitivity of pluripotent testicular cancer-derived embryonal carcinoma to low-dose 5-aza deoxycytidine is associated with global DNA Damage-associated p53 activation, anti-pluripotency and DNA demethylation. PLoS One. 2012;7(12):e53003. doi: 10.1371/journal.pone.0053003. Epub 2012 Dec 27.
31 Differential expression of microRNAs and their predicted targets in renal cells exposed to amphotericin B and its complex with copper (II) ions. Toxicol Mech Methods. 2017 Sep;27(7):537-543. doi: 10.1080/15376516.2017.1333554. Epub 2017 Jun 8.
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37 Keratinocyte-derived IL-36gama plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes. Arch Toxicol. 2019 Aug;93(8):2307-2320.
38 Identification of vitamin D3 target genes in human breast cancer tissue. J Steroid Biochem Mol Biol. 2016 Nov;164:90-97.
39 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
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41 Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
42 A phase II trial with pharmacodynamic endpoints of the proteasome inhibitor bortezomib in patients with metastatic colorectal cancer. Clin Cancer Res. 2005 Aug 1;11(15):5526-33. doi: 10.1158/1078-0432.CCR-05-0081.
43 Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
44 A comprehensive analysis of Wnt/beta-catenin signaling pathway-related genes and crosstalk pathways in the treatment of As2O3 in renal cancer. Ren Fail. 2018 Nov;40(1):331-339.
45 Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
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47 Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes. Toxicol Lett. 2018 Jun 1;289:1-13.
48 Proteomic analysis of anti-cancer effects by paclitaxel treatment in cervical cancer cells. Gynecol Oncol. 2005 Jul;98(1):45-53. doi: 10.1016/j.ygyno.2005.04.010.
49 A transcriptomics-based in vitro assay for predicting chemical genotoxicity in vivo. Carcinogenesis. 2012 Jul;33(7):1421-9.
50 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
51 Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNF-mediated hepatotoxicity. Toxicol Sci. 2014 Jul;140(1):144-59. doi: 10.1093/toxsci/kfu072. Epub 2014 Apr 20.
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