Details of Disease

General Information of Disease (ID: DISFO5RQ)

• Disease Name: Anorexia nervosa cachexia
• Disease Class: 6B80: Anorexia nervosa
• Definition: A disorder most often seen in adolescent females characterized by a refusal to maintain a minimally normal body weight, an intense fear of gaining weight, a disturbance in body image, and, in postmenarcheal females, the development of amenorrhea.
• Disease Hierarchy:
  DISVGXN0: Eating disorder
  DISFO5RQ: Anorexia nervosa cachexia
• ICD Code:
  ICD-11: ICD-11: 6B80
  ICD-10: ICD-10: R63.0
  ICD-9: ICD-9: 307.1
  Expand ICD-11: 'MG43.7
  Expand ICD-10: 'R63.0
  Expand ICD-9: 307.1
• Disease Identifiers:
  MONDO ID: MONDO_0005351
  MESH ID: D000856
  UMLS CUI: C0003125
  MedGen ID: 316
  Orphanet ID: 36297
  SNOMED CT ID: 56882008

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 2 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Marinol	DM70IK5	Approved	Small molecular drug	[1]
Quetiapine	DM1N62C	Approved	Small molecular drug	[2]

This Disease is Treated as An Indication in 1 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
SUN-11031	DMC1A42	Terminated	Small molecular drug	[3]

This Disease is Treated as An Indication in 1 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Melanocortin-4 Receptor antagonist	DM2ES7Z	Investigative	Small molecular drug	[4]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 35 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
HTR2C	TTWJBZ5	Limited	Biomarker	[5]
KCNN3	TT9JH25	Limited	Genetic Variation	[6]
LEPR	TT0HD6V	Limited	Biomarker	[7]
TPH2	TT3KLDP	Limited	Genetic Variation	[5]
CPN1	TT8V2KD	moderate	Altered Expression	[8]
AGRP	TT4DE1O	Strong	Genetic Variation	[9]
ANGPTL3	TT59GO7	Strong	Altered Expression	[10]
CCKAR	TTCG0AL	Strong	Biomarker	[11]
CGB3	TTUH273	Strong	Biomarker	[12]
DMD	TTWLFXU	Strong	Biomarker	[13]
DRD2	TTEX248	Strong	Genetic Variation	[14]
EPHX2	TT7WVHI	Strong	Biomarker	[15]
FGF21	TTQ916P	Strong	Biomarker	[16]
FOXP1	TT0MUCI	Strong	Genetic Variation	[17]
GHRL	TT1OCL0	Strong	Biomarker	[18]
GHSR	TTWDC17	Strong	Genetic Variation	[19]
GPR55	TTNET8J	Strong	Genetic Variation	[20]
GRIA3	TT82EZV	Strong	Genetic Variation	[21]
HTR1D	TT6MSOK	Strong	Genetic Variation	[22]
HTR3A	TTPC4TU	Strong	Biomarker	[23]
HTR3B	TTR6K75	Strong	Genetic Variation	[23]
HTR4	TT07C3Y	Strong	Biomarker	[24]
MBOAT4	TTSYOWR	Strong	Genetic Variation	[19]
MC3R	TTNI91K	Strong	Genetic Variation	[25]
MC4R	TTD0CIQ	Strong	Biomarker	[26]
MGMT	TTJ8DV7	Strong	Genetic Variation	[17]
OPRD1	TT27RFC	Strong	Genetic Variation	[27]
PGC	TT7K6AD	Strong	Genetic Variation	[14]
PYY	TTVFJLX	Strong	Biomarker	[28]
RSPO1	TTI9HL4	Strong	Biomarker	[16]
SGSH	TTPJ2SH	Strong	Altered Expression	[29]
SLC6A2	TTAWNKZ	Strong	Biomarker	[30]
UCP2	TTSC2YM	Strong	Biomarker	[31]
UCP3	TT12RJK	Strong	Biomarker	[31]
DRD4	TTE0A2F	Definitive	Genetic Variation	[32]

This Disease Is Related to 1 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC18A1	DTM953D	Strong	Genetic Variation	[5]

This Disease Is Related to 1 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
SCLY	DEH4TD6	Strong	Genetic Variation	[33]

This Disease Is Related to 50 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CNTN5	OTWU5FLZ	moderate	Biomarker	[34]
CNTN6	OTXVGVOR	moderate	Biomarker	[34]
CPN2	OTYOYP14	moderate	Altered Expression	[8]
DBI	OT884QY9	moderate	Altered Expression	[8]
ACACA	OT5CQPZY	Strong	Biomarker	[35]
AKAP6	OTN59BZS	Strong	Biomarker	[36]
AMY1A	OT6G4B8O	Strong	Biomarker	[37]
ANGPTL6	OTOQ5W67	Strong	Altered Expression	[38]
ARVCF	OT78DKOU	Strong	Biomarker	[39]
ASB3	OTI3TK38	Strong	Genetic Variation	[17]
ATP8A2	OTDZC2ZT	Strong	Biomarker	[40]
BEST1	OTWHE1ZC	Strong	Biomarker	[13]
BMS1	OTEGQ8ZO	Strong	Biomarker	[35]
C1QL1	OTNQ0G3E	Strong	Biomarker	[41]
CADM1	OTRWG9QS	Strong	Genetic Variation	[17]
CARF	OTWE0T6Q	Strong	Biomarker	[42]
CDH9	OTV9N5XK	Strong	Genetic Variation	[21]
CEP70	OTMY5KAE	Strong	Biomarker	[43]
CNTN4	OTULXVE0	Strong	Biomarker	[34]
CSGALNACT1	OTBML9D9	Strong	Genetic Variation	[44]
CTBP2	OTGZGT87	Strong	Genetic Variation	[42]
DNTT	OTFSEF12	Strong	Genetic Variation	[45]
EBF1	OTZ61YYH	Strong	Genetic Variation	[46]
ERLEC1	OTQO3Z0R	Strong	Genetic Variation	[17]
GDF11	OTOSNMND	Strong	Biomarker	[47]
GFER	OTVK43OK	Strong	Altered Expression	[29]
INHBB	OT2QLD11	Strong	Altered Expression	[48]
KRT7	OTLT3JFN	Strong	Genetic Variation	[33]
NBEAL1	OTLJ11N3	Strong	Biomarker	[42]
NCKIPSD	OT24UORN	Strong	Genetic Variation	[17]
NIPA1	OT9ODC8X	Strong	Biomarker	[49]
NNAT	OTNRLO7G	Strong	Genetic Variation	[50]
NPB	OT0U82T3	Strong	Altered Expression	[51]
NPW	OTO7MT28	Strong	Biomarker	[51]
NTNG1	OTF48IID	Strong	Biomarker	[36]
NUCB2	OTHO6JWN	Strong	Biomarker	[52]
OLIG2	OTMCN6D3	Strong	Genetic Variation	[21]
OR2AG1	OTEITRP4	Strong	Genetic Variation	[23]
PANK2	OTFBW889	Strong	Altered Expression	[29]
RETN	OTW5Z1NH	Strong	Biomarker	[7]
SMIM20	OTZI1KFR	Strong	Altered Expression	[53]
SORCS2	OTBF3DYK	Strong	Genetic Variation	[54]
SPX	OTY3G4AR	Strong	Altered Expression	[53]
SS18L1	OT9ZEGV7	Strong	Biomarker	[55]
STATH	OTQHBHM9	Strong	Biomarker	[56]
SYTL5	OTE7OYQC	Strong	Biomarker	[40]
TAL1	OTX4K6QZ	Strong	Genetic Variation	[33]
TNXB	OTVBWAV5	Strong	Posttranslational Modification	[44]
CARMIL1	OT1A5IX5	Definitive	Genetic Variation	[57]
TAFA2	OTU6WP6J	Definitive	Genetic Variation	[57]

References

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