Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1JOXY)

Drug Name
Bryostatin-1 Drug Info
Synonyms
Bryostatin 1; 83314-01-6; Bryostatin-1; NSC 339555; CHEMBL449158; CHEBI:88353; 37O2X55Y9E; BRYOSTATIN; NSC-339555; 2,4-Octadienoic acid, (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(acetyloxy)-1,11,21-trihydroxy-17-((1R)-1-hydroxyethyl)-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo(21.3.1.13,7.111,15)nonacos-8-en-12-yl ester, (2E,4E)-; DTXSID8046876; UNII-37O2X55Y9E; BRN 4349157; BRYOSTATIN 1 [MI]; SCHEMBL182960; BRYOSTATIN 1 [WHO-DD]; Bryostatin 1, >=99%, solid; MJQUEDHRCUIRLF-TVIXENOKSA-N; BDBM50258529; BMY-45618; MFCD00893832; Bryostatin 1 - CAS 83314-01-6; (1S-(1R*,3R*,5Z,7S*,8E,11R*,12R*(2E,4E),13E,15R*,17S*(S*),21S*,23S*,25R*))-25-(Acetyloxy)-1,11,21-trihydroxy-17-(1-hydroxyethyl)-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo(21.3.1.13,7.111,15)nonacos-8-en-12-yl 2,4-octadienoate; 2,4-Octadienoic acid, 25-(acetyloxy)-1,11,21-trihydroxy-17-(1-hydroxyethyl)-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo(21.3.1.13,7.111,15)nonacos-8-en-12-yl ester, (1S-(1R*,3R*,5Z,7S*,8E,11R*,12R*(2E,4E),13E,15R*,17S*(S*),21S*,23S*,25R*))-; HY-105231; CS-0025440; Q27095907; (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(acetyloxy)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.1(3,7).1(11,15)]nonacos-8-en-12-yl (2E,4E)-octa-2,4-dienoate; (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(Acetyloxy)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl-(2E, 4E)-2,4-octadienoic acid ester; [(1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-acetyloxy-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl] (2E,4E)-octa-2,4-dienoate
Indication
Disease Entry ICD 11 Status REF
Alzheimer disease 8A20 Phase 2 [1]
Cross-matching ID
PubChem CID
5280757
TTD Drug ID
DM1JOXY

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Protein kinase C epsilon (PRKCE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Meprobamate DMHM93Y Anxiety Approved [10]
RO-320432 DMFZ1YW N. A. N. A. Terminated [11]
LY-317644 DMM20PI N. A. N. A. Terminated [12]
CDE-6960 DMA0DKI Inflammation 1A00-CA43.1 Terminated [13]
RO-316233 DMAGLPW Discovery agent N.A. Investigative [14]
3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione DMDO175 Discovery agent N.A. Investigative [15]
3,4-diphenyl-1H-pyrrole-2,5-dione DMPK6YT Discovery agent N.A. Investigative [15]
3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione DMGC7RY Discovery agent N.A. Investigative [15]
3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione DM3EV9N Discovery agent N.A. Investigative [15]
LY-326449 DMN53M4 Discovery agent N.A. Investigative [16]
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Drug(s) Targeting Protein kinase C (PRKC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Synthetic hypericin DMXU4ON Virus infection 1A24-1D9Z Phase 3 [17]
APH-0812 DM756GE Human immunodeficiency virus-1 infection 1C62 Phase 2 [18]
CYCLOPLATAM DMXR8WN Solid tumour/cancer 2A00-2F9Z Phase 2 [19]
AEB07 DMJVN89 Transplant rejection NE84 Phase 2 [20]
HO/03/03 DMA6HQJ Diabetic foot ulcer BD54 Phase 2 [21]
LXS196 DM65MEL Solid tumour/cancer 2A00-2F9Z Phase 1/2 [22]
SAFINGOL DMBGUDR Psoriasis vulgaris EA90 Phase 1 [23]
GCC-1290K DMJ7WRI Parkinson disease 8A00.0 Phase 1 [24]
AEB701 DM8I4G0 Melanoma 2C30 Phase 1 [25]
Tecadenoson DM9T6MS Atrial fibrillation BC81.3 Discontinued in Phase 3 [26]
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Drug(s) Affected By Protein kinase C gamma type (PRKCG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [27]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [28]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [29]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [30]
phorbol 12-myristate 13-acetate DMJWD62 Acute myeloid leukaemia 2A60 Phase 2 [31]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [32]
Rapamycin Immunosuppressant Drug DM678IB Discovery agent N.A. Investigative [33]
NSC-1771 DMNXDGQ Discovery agent N.A. Investigative [34]
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Drug(s) Affected By Protein kinase C beta type (PRKCB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [35]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [36]
Quercetin DM3NC4M Obesity 5B81 Approved [37]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [38]
Panobinostat DM58WKG Chronic graft versus host disease Approved [39]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [40]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [41]
Leflunomide DMR8ONJ Arthritis FA20 Approved [42]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [43]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [36]
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Drug(s) Affected By Tissue factor (F3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [44]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [8]
Methotrexate DM2TEOL Anterior urethra cancer Approved [45]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [46]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [47]
Quercetin DM3NC4M Obesity 5B81 Approved [48]
Fructose DM43AN2 Vomiting MD90 Approved [49]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [50]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [8]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [51]
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Drug(s) Affected By Protein kinase C alpha type (PRKCA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [52]
Quercetin DM3NC4M Obesity 5B81 Approved [53]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [54]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [55]
Panobinostat DM58WKG Chronic graft versus host disease Approved [39]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [56]
Leflunomide DMR8ONJ Arthritis FA20 Approved [42]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [28]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [57]
Capsaicin DMGMF6V Back pain ME84.Z Approved [58]
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Drug(s) Affected By B-cell receptor CD22 (CD22)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [59]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [60]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [61]
Testosterone DM7HUNW Hot flushes GA30 Approved [62]
Leflunomide DMR8ONJ Arthritis FA20 Approved [42]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [28]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [63]
Urethane DM7NSI0 N. A. N. A. Phase 4 [64]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [38]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [65]
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Drug(s) Affected By Integrin alpha-X (ITGAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [66]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [67]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [68]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [69]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [70]
Cimetidine DMH61ZB Acid-reflux disorder DA22 Approved [71]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [72]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [73]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [73]
Ardeparin DMYRX8B Deep vein thrombosis BD71 Approved [74]
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Drug(s) Affected By Interleukin-10 (IL10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [75]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [76]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [77]
Methotrexate DM2TEOL Anterior urethra cancer Approved [78]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [79]
Quercetin DM3NC4M Obesity 5B81 Approved [80]
Bisoprolol DM3UZ95 Hypertension BA00-BA04 Approved [81]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [82]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [83]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [84]
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Drug(s) Affected By Interleukin-12 subunit beta (IL12B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [76]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [82]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [84]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [85]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [86]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [87]
Capsaicin DMGMF6V Back pain ME84.Z Approved [88]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [89]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [90]
RGI-2001 DM4AC2F Graft-versus-host disease 4B24 Phase 2 [91]
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Drug(s) Affected By Baculoviral IAP repeat-containing protein 3 (BIRC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [92]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [93]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [59]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [94]
Methotrexate DM2TEOL Anterior urethra cancer Approved [95]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [54]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [96]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [97]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [98]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [99]
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Drug(s) Affected By TNF receptor-associated factor 1 (TRAF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [100]
Methotrexate DM2TEOL Anterior urethra cancer Approved [101]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [55]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [61]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [102]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [69]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [103]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [104]
Folic Acid DMEMBJC Colorectal carcinoma Approved [105]
Menthol DMG2KW7 Back pain ME84.Z Approved [106]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Protein kinase C (PRKC) TTYVX59 NOUNIPROTAC Agonist [2]
Protein kinase C epsilon (PRKCE) TTBZ7OD KPCE_HUMAN Activator [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
B-cell receptor CD22 (CD22) OTXDJR9T CD22_HUMAN Gene/Protein Processing [4]
Baculoviral IAP repeat-containing protein 3 (BIRC3) OT3E95KB BIRC3_HUMAN Gene/Protein Processing [5]
Integrin alpha-X (ITGAX) OTOGIMHE ITAX_HUMAN Gene/Protein Processing [4]
Interleukin-10 (IL10) OTIRFRXC IL10_HUMAN Gene/Protein Processing [6]
Interleukin-12 subunit beta (IL12B) OT0JF8A3 IL12B_HUMAN Gene/Protein Processing [6]
Protein kinase C alpha type (PRKCA) OT5UWNRD KPCA_HUMAN Gene/Protein Processing [7]
Protein kinase C beta type (PRKCB) OTYQ0656 KPCB_HUMAN Gene/Protein Processing [7]
Protein kinase C gamma type (PRKCG) OTW52VNZ KPCG_HUMAN Gene/Protein Processing [7]
Tissue factor (F3) OT3MSU3B TF_HUMAN Gene/Protein Processing [8]
TNF receptor-associated factor 1 (TRAF1) OTTLM5RU TRAF1_HUMAN Drug Response [9]

References

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