Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1KS78)

Drug Name
Talazoparib Drug Info
Synonyms Talazoparib (BMN 673); UNII-9QHX048FRV; 9QHX048FRV; Talazoparib [USAN:INN]; Talzenna; 4pjt; 2YQ
Indication
Disease Entry ICD 11 Status REF
Breast cancer 2C60-2C65 Approved [1]
Psoriatic arthritis FA21 Phase 3 [2]
Cross-matching ID
PubChem CID
135565082
CAS Number
CAS 1207456-01-6
TTD Drug ID
DM1KS78
ACDINA Drug ID
D01457

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Poly [ADP-ribose] polymerase (PARP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Olaparib DM8QB1D Ovarian cancer 2C73 Approved [7]
Rucaparib DM9PVX8 Ovarian cancer 2C73 Approved [8]
MK-4827 DMLYGH4 Ovarian cancer 2C73 Phase 3 [9]
BSI-201 DMM0VO3 Solid tumour/cancer 2A00-2F9Z Phase 3 [10]
Rubraca rucaparib DM25TMP Ovarian cancer 2C73 Phase 3 [11]
ABT-888 DM4HYMS Breast cancer 2C60-2C65 Phase 3 [9]
INO-1001 DM5L8QT Brain cancer 2A00 Phase 3 [12]
BGP-15 DMYDM68 Type-2 diabetes 5A11 Phase 2 [13]
BGB-290 DMRO6XT Ovarian cancer 2C73 Phase 2 [11]
2X-121 DMX9MSL Breast cancer 2C60-2C65 Phase 2 [11]
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Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [14]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [15]
Methotrexate DM2TEOL Anterior urethra cancer Approved [16]
Folic Acid DMEMBJC Colorectal carcinoma Approved [17]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [16]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [16]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [18]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [16]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [19]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [20]
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Drug(s) Transported By Breast cancer resistance protein (ABCG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [21]
Methotrexate DM2TEOL Anterior urethra cancer Approved [22]
Folic Acid DMEMBJC Colorectal carcinoma Approved [23]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [24]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [25]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [26]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [27]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [26]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [28]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [29]
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Drug(s) Affected By Retinoblastoma-associated protein (RB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [30]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [31]
Gefitinib DM15F0X Colon adenocarcinoma Approved [32]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [33]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [34]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [35]
Methotrexate DM2TEOL Anterior urethra cancer Approved [36]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [37]
Quercetin DM3NC4M Obesity 5B81 Approved [38]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [39]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [40]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [41]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [42]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [43]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [44]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [45]
Verapamil DMA7PEW Angina pectoris BA40 Approved [46]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [47]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [48]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [49]
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Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [50]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [51]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [49]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [52]
Gefitinib DM15F0X Colon adenocarcinoma Approved [53]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [54]
Selenium DM25CGV N. A. N. A. Approved [55]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [56]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [57]
Methotrexate DM2TEOL Anterior urethra cancer Approved [58]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [59]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [60]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [61]
Gefitinib DM15F0X Colon adenocarcinoma Approved [62]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [63]
Etretinate DM2CZFA Keratosis ED56 Approved [64]
Prednisone DM2HG4X Acute asthma CA23 Approved [65]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [66]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [67]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [68]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [40]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [69]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [45]
Verapamil DMA7PEW Angina pectoris BA40 Approved [46]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [70]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [71]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [33]
Meloxicam DM2AR7L Arthritis FA20 Approved [72]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [66]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [73]
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Drug(s) Affected By Poly polymerase 2 (PARP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [74]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [75]
Testosterone DM7HUNW Hot flushes GA30 Approved [76]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [76]
Leflunomide DMR8ONJ Arthritis FA20 Approved [77]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [79]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [80]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [81]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [82]
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Drug(s) Affected By Breast cancer type 1 susceptibility protein (BRCA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [45]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [52]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [83]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [84]
Methotrexate DM2TEOL Anterior urethra cancer Approved [58]
Quercetin DM3NC4M Obesity 5B81 Approved [85]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [86]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [87]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [88]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [75]
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Drug(s) Affected By Fumarate hydratase, mitochondrial (FH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [89]
Quercetin DM3NC4M Obesity 5B81 Approved [90]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [91]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [92]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [93]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [94]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [95]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [96]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [80]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [97]
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Drug(s) Affected By Succinate dehydrogenase iron-sulfur subunit, mitochondrial (SDHB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [98]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [99]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [100]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [101]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [95]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [79]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [97]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [102]
Menthol DMG2KW7 Back pain ME84.Z Approved [103]
Arsenic DMTL2Y1 N. A. N. A. Approved [104]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Poly [ADP-ribose] polymerase (PARP) TTEBCY8 NOUNIPROTAC Inhibitor [1]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [3]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [4]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [4]
Breast cancer type 1 susceptibility protein (BRCA1) OT5BN6VH BRCA1_HUMAN Drug Response [4]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [4]
Fumarate hydratase, mitochondrial (FH) OTEQWU6Q FUMH_HUMAN Drug Response [5]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Gene/Protein Processing [4]
Poly polymerase 2 (PARP2) OTYL81ZI PARP2_HUMAN Gene/Protein Processing [6]
Retinoblastoma-associated protein (RB1) OTQJUJMZ RB_HUMAN Gene/Protein Processing [4]
Succinate dehydrogenase iron-sulfur subunit, mitochondrial (SDHB) OTRE1M1T SDHB_HUMAN Drug Response [5]

References

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