Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMBD4K3)

Drug Name
Selinexor Drug Info
Synonyms Xpovio; KPT 330; KPT-330; KPT-330(Selinexor); KPT330;Selinexor; 1393477-72-9; 31TZ62FO8F; CHEMBL3545185; SCHEMBL14678327; Selinexor; Selinexor (KPT-330); Selinexor [USAN:INN]; Tube706; UNII-31TZ62FO8F
Indication
Disease Entry ICD 11 Status REF
Multiple myeloma 2A83 Approved [1]
Liposarcoma 2B59 Phase 3 [2]
Neuroendocrine cancer 2B72.1 Phase 3 [2]
Acute myeloid leukaemia 2A60 Phase 2 [3]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 2 [4]
Diffuse large B-cell lymphoma 2A81 Phase 2 [3]
Recurrent glioblastoma 2A00.00 Phase 2 [2]
Solid tumour/cancer 2A00-2F9Z Phase 2 [5]
Cross-matching ID
PubChem CID
71481097
CAS Number
CAS 1393477-72-9
TTD Drug ID
DMBD4K3
INTEDE Drug ID
DR1472
ACDINA Drug ID
D01420

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Clinical Trial Drug(s)
Preclinical Drug(s)
Investigative Drug(s)
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Exportin-1 (XPO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selinexor oral DMDLOBZ Recurrent glioblastoma 2A00.00 Phase 2 [9]
Eltanexor oral DM7CLEZ Colorectal cancer 2B91.Z Phase 1/2 [2]
SL-801 DMIVGYK Solid tumour/cancer 2A00-2F9Z Phase 1 [2]
KOS-1815 DMCGFY6 Solid tumour/cancer 2A00-2F9Z Preclinical [6]
S109 DM2JYQA Solid tumour/cancer 2A00-2F9Z Investigative [10]
Octahydrocurcumin DMUFDR6 Solid tumour/cancer 2A00-2F9Z Investigative [11]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [12]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [13]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [14]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [15]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [16]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [17]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [18]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [19]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [13]
Verapamil DMA7PEW Angina pectoris BA40 Approved [20]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By UDP-glucuronosyltransferase 1A1 (UGT1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [21]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [22]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [23]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [24]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [26]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [27]
Metronidazole DMTIVEN Abscess Approved [28]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [29]
Ethanol DMDRQZU Chronic pain MG30 Approved [30]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Glutathione S-transferase alpha-1 (GSTA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [31]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [32]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [33]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [34]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [35]
Trabectedin DMG3Y89 Leiomyosarcoma 2B58 Approved [36]
Busulfan DMXYJ9C Chronic myelogenous leukaemia 2A20.0 Approved [37]
Artemisinin DMOY7W3 Malaria 1F40-1F45 Approved [38]
Ethacrynic acid DM60QMR Edema MG29 Approved [39]
Tacrine DM51FY6 Alzheimer disease 8A20 Approved [40]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor protein p73 (TP73)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [41]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [42]
Etretinate DM2CZFA Keratosis ED56 Approved [43]
Quercetin DM3NC4M Obesity 5B81 Approved [44]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [45]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [46]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [47]
Menthol DMG2KW7 Back pain ME84.Z Approved [48]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [49]
Bexarotene DMOBIKY Cutaneous T-cell lymphoma 2B01 Approved [43]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Myc proto-oncogene protein (MYC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [50]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [51]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [52]
Gefitinib DM15F0X Colon adenocarcinoma Approved [53]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [54]
Selenium DM25CGV N. A. N. A. Approved [55]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [56]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [57]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [58]
Methotrexate DM2TEOL Anterior urethra cancer Approved [59]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [60]
Methotrexate DM2TEOL Anterior urethra cancer Approved [59]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [61]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [62]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [63]
Paclitaxel DMLB81S Breast carcinoma Approved [64]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [65]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [66]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [67]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [68]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histone H2AX (H2AX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [69]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [70]
Selenium DM25CGV N. A. N. A. Approved [71]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [72]
Etretinate DM2CZFA Keratosis ED56 Approved [73]
Methotrexate DM2TEOL Anterior urethra cancer Approved [74]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [75]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [76]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [77]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
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Drug(s) Affected By E3 ubiquitin-protein ligase Mdm2 (MDM2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [79]
Flucytosine DM13VTW Cryptococcal meningitis Approved [80]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [80]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [81]
Methotrexate DM2TEOL Anterior urethra cancer Approved [82]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [83]
Quercetin DM3NC4M Obesity 5B81 Approved [84]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [61]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [85]
Amifostine DM5FL14 Mucositis CA00 Approved [86]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bcl-2-binding component 3, isoforms 3/4 (BBC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [87]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [88]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [89]
Methotrexate DM2TEOL Anterior urethra cancer Approved [74]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [90]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [91]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [92]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [93]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [94]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [95]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Exportin-1 (XPO1) TTCJUR4 XPO1_HUMAN Inhibitor [6]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [7]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DEYGVN4 UD11_HUMAN Substrate [7]
Glutathione S-transferase alpha-1 (GSTA1) DE4ZHS1 GSTA1_HUMAN Substrate [7]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Bcl-2-binding component 3, isoforms 3/4 (BBC3) OTUAXDAY BBC3B_HUMAN Gene/Protein Processing [8]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Gene/Protein Processing [8]
E3 ubiquitin-protein ligase Mdm2 (MDM2) OTOVXARF MDM2_HUMAN Gene/Protein Processing [8]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Gene/Protein Processing [8]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Gene/Protein Processing [8]
Tumor protein p73 (TP73) OT0LUO47 P73_HUMAN Gene/Protein Processing [8]

References

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2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
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45 Arsenic trioxide induces apoptosis in NB-4, an acute promyelocytic leukemia cell line, through up-regulation of p73 via suppression of nuclear factor kappa B-mediated inhibition of p73 transcription and prevention of NF-kappaB-mediated induction of XIAP, cIAP2, BCL-XL and survivin. Med Oncol. 2010 Sep;27(3):833-42. doi: 10.1007/s12032-009-9294-9. Epub 2009 Sep 10.
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64 Gallic acid potentiates the apoptotic effect of paclitaxel and carboplatin via overexpression of Bax and P53 on the MCF-7 human breast cancer cell line. J Biochem Mol Toxicol. 2021 Feb;35(2):e22638. doi: 10.1002/jbt.22638. Epub 2020 Oct 1.
65 Regulation of human dUTPase gene expression and p53-mediated transcriptional repression in response to oxaliplatin-induced DNA damage. Nucleic Acids Res. 2009 Jan;37(1):78-95. doi: 10.1093/nar/gkn910. Epub 2008 Nov 16.
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67 Nitrogen Mustard Alkylates and Cross-Links p53 in Human Keratinocytes. Chem Res Toxicol. 2022 Apr 18;35(4):636-650. doi: 10.1021/acs.chemrestox.1c00420. Epub 2022 Mar 21.
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69 Cannabinoids synergize with carfilzomib, reducing multiple myeloma cells viability and migration. Oncotarget. 2016 Nov 22;7(47):77543-77557. doi: 10.18632/oncotarget.12721.
70 Hsa-let-7g miRNA regulates the anti-tumor effects of gastric cancer cells under oxidative stress through the expression of DDR genes. J Toxicol Sci. 2015 Jun;40(3):329-38. doi: 10.2131/jts.40.329.
71 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
72 Inhibition of cardiomyocyte differentiation of human induced pluripotent stem cells by Ribavirin: Implication for its cardiac developmental toxicity. Toxicology. 2020 Apr 15;435:152422. doi: 10.1016/j.tox.2020.152422. Epub 2020 Feb 26.
73 Synthesis and structure-activity relationships of new antiproliferative and proapoptotic retinoid-related biphenyl-4-yl-acrylic acids. Bioorg Med Chem. 2007 Jul 15;15(14):4863-75. doi: 10.1016/j.bmc.2007.04.057. Epub 2007 May 3.
74 Methotrexate induces apoptosis through p53/p21-dependent pathway and increases E-cadherin expression through downregulation of HDAC/EZH2. Biochem Pharmacol. 2011 Feb 15;81(4):510-7. doi: 10.1016/j.bcp.2010.11.014. Epub 2010 Nov 27.
75 Actinomycin D inhibits the expression of the cystine/glutamate transporter xCT via attenuation of CD133 synthesis in CD133(+) HCC. Chem Biol Interact. 2019 Aug 25;309:108713. doi: 10.1016/j.cbi.2019.06.026. Epub 2019 Jun 19.
76 Simvastatin and purine analogs have a synergic effect on apoptosis of chronic lymphocytic leukemia cells. Ann Hematol. 2010 Nov;89(11):1115-24. doi: 10.1007/s00277-010-0988-z. Epub 2010 May 25.
77 The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib. Toxicol Sci. 2023 Dec 21;197(1):69-78. doi: 10.1093/toxsci/kfad099.
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79 Cannabidiol Modulates the Immunophenotype and Inhibits the Activation of the Inflammasome in Human Gingival Mesenchymal Stem Cells. Front Physiol. 2016 Nov 24;7:559. doi: 10.3389/fphys.2016.00559. eCollection 2016.
80 Mechanisms of thymidine kinase/ganciclovir and cytosine deaminase/ 5-fluorocytosine suicide gene therapy-induced cell death in glioma cells. Oncogene. 2005 Feb 10;24(7):1231-43. doi: 10.1038/sj.onc.1208290.
81 In vitro antioxidant and antigenotoxic potentials of 3,5-O-di-galloylquinic acid extracted from Myrtus communis leaves and modulation of cell gene expression by H2O2. J Appl Toxicol. 2012 May;32(5):333-41.
82 Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
83 HMG-CoA reductase inhibitors, statins, induce phosphorylation of Mdm2 and attenuate the p53 response to DNA damage. FASEB J. 2005 Mar;19(3):476-8. doi: 10.1096/fj.04-2745fje. Epub 2004 Dec 29.
84 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
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86 Amifostine impairs p53-mediated apoptosis of human myeloid leukemia cells. Mol Cancer Ther. 2003 Sep;2(9):893-900.
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