Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMMIAXO)

Drug Name
Betamethasone Valerate Drug Info
Synonyms Beta-val; Betaderm; Betatrex; Dermabet; Valnac
Indication
Disease Entry ICD 11 Status REF
Dermatological disease DA24.Y Approved [1]
Cross-matching ID
PubChem CID
16533
ChEBI ID
CHEBI:31277
CAS Number
CAS 2152-44-5
TTD Drug ID
DMMIAXO
INTEDE Drug ID
DR2381

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Glucocorticoid receptor (NR3C1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [7]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [2]
Prednisolone DMQ8FR2 Acute adrenal insufficiency Approved [8]
Fluticasone DMGCSVF Allergic rhinitis CA08.0 Approved [9]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [2]
Deflazacort DMV0RNS Duchenne dystrophy 8C70 Approved [2]
Prednisone DM2HG4X Acute asthma CA23 Approved [10]
Budesonide DMJIBAW Allergic rhinitis CA08.0 Approved [11]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [12]
Fluocinolone Acetonide DMG2KI4 Choroiditis Approved [2]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [13]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [14]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [15]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [16]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [17]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [18]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [19]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [20]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [14]
Verapamil DMA7PEW Angina pectoris BA40 Approved [21]
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Drug(s) Metabolized By Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [4]
Cortisone Acetate DMG8K57 Acne vulgaris ED80 Approved [22]
Beclomethasone DMZPHIK Allergic rhinitis CA08.0 Approved [4]
Dehydrocorticosterone DM48KMB N. A. N. A. Investigative [22]
Drug(s) Affected By Interferon gamma (IFNG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [23]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [24]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [25]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [26]
Methotrexate DM2TEOL Anterior urethra cancer Approved [27]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [28]
Quercetin DM3NC4M Obesity 5B81 Approved [29]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [30]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [31]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [32]
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Drug(s) Affected By Granulocyte-macrophage colony-stimulating factor (CSF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [33]
Quercetin DM3NC4M Obesity 5B81 Approved [34]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [35]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [36]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [37]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [38]
Testosterone DM7HUNW Hot flushes GA30 Approved [39]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [40]
Acetylcholine DMDF79Z Cataract 9B10 Approved [41]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [42]
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Drug(s) Affected By Interleukin-4 (IL4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [43]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [44]
Tolnaftate DM28MU7 Dermatophytosis 1F28.2 Approved [45]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [46]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [47]
Prednisone DM2HG4X Acute asthma CA23 Approved [48]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [26]
Methotrexate DM2TEOL Anterior urethra cancer Approved [27]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [28]
Cladribine DM3JDRP Hairy cell leukaemia 2A82.2 Approved [49]
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Drug(s) Affected By Interleukin-5 (IL5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [24]
Tolnaftate DM28MU7 Dermatophytosis 1F28.2 Approved [45]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [46]
Prednisone DM2HG4X Acute asthma CA23 Approved [50]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [51]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [53]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [54]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [55]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [56]
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Drug(s) Affected By Interleukin-3 (IL3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [27]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [57]
Ethanol DMDRQZU Chronic pain MG30 Approved [57]
Menthol DMG2KW7 Back pain ME84.Z Approved [58]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [43]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [59]
Tacrolimus DMZ7XNQ Graft-versus-host disease 4B24 Approved [6]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [60]
Famotidine DMRL3AB Gastric ulcer DA60 Approved [60]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [60]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 5 (CD40)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [61]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [62]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [63]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [64]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [65]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [66]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [62]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [68]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [69]
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Drug(s) Affected By T-lymphocyte activation antigen CD86 (CD86)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [70]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [24]
Kanamycin DM2DMPO Bacteremia 1A73 Approved [71]
Methotrexate DM2TEOL Anterior urethra cancer Approved [27]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [62]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [63]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [71]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [72]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [71]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [73]
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Drug(s) Affected By Interleukin-2 (IL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sirolimus DMGW1ID Advanced cancer 2A00-2F9Z Approved [60]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [44]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [46]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [74]
Methotrexate DM2TEOL Anterior urethra cancer Approved [75]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [76]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [54]
Fentanyl DM8WAHT Analgesia MB40.8 Approved [77]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [78]
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Drug(s) Affected By CD83 antigen (CD83)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [79]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [62]
Quercetin DM3NC4M Obesity 5B81 Approved [80]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [81]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [63]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [82]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [83]
Exemestane DM9HPW3 Hormonally-responsive breast cancer 2C60-2C65 Approved [84]
Leflunomide DMR8ONJ Arthritis FA20 Approved [85]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [86]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Glucocorticoid receptor (NR3C1) TTYRL6O GCR_HUMAN Modulator [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [3]
Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) DEDH7FP DHI2_HUMAN Substrate [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
CD83 antigen (CD83) OT1V4WQF CD83_HUMAN Gene/Protein Processing [5]
Granulocyte-macrophage colony-stimulating factor (CSF2) OT1M7D28 CSF2_HUMAN Gene/Protein Processing [6]
Interferon gamma (IFNG) OTXG9JM7 IFNG_HUMAN Gene/Protein Processing [6]
Interleukin-2 (IL2) OTGI4NSA IL2_HUMAN Gene/Protein Processing [6]
Interleukin-3 (IL3) OT0CQ35N IL3_HUMAN Gene/Protein Processing [6]
Interleukin-4 (IL4) OTOXBWAU IL4_HUMAN Gene/Protein Processing [6]
Interleukin-5 (IL5) OTAFPSCO IL5_HUMAN Gene/Protein Processing [6]
T-lymphocyte activation antigen CD86 (CD86) OTJCSBPC CD86_HUMAN Gene/Protein Processing [5]
Tumor necrosis factor receptor superfamily member 5 (CD40) OT5YU2XB TNR5_HUMAN Gene/Protein Processing [5]

References

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63 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
64 Curcumin reduces the expression of survivin, leading to enhancement of arsenic trioxide-induced apoptosis in myelodysplastic syndrome and leukemia stem-like cells. Oncol Rep. 2016 Sep;36(3):1233-42. doi: 10.3892/or.2016.4944. Epub 2016 Jul 15.
65 Genomic and proteomic analysis of the effects of cannabinoids on normal human astrocytes. Brain Res. 2008 Jan 29;1191:1-11.
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67 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
68 Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
69 Fenofibrate induces effective apoptosis in mantle cell lymphoma by inhibiting the TNFalpha/NF-kappaB signaling axis. Leukemia. 2010 Aug;24(8):1476-86. doi: 10.1038/leu.2010.117. Epub 2010 Jun 3.
70 Responsiveness of human monocyte-derived dendritic cells to thimerosal and mercury derivatives. Toxicol Appl Pharmacol. 2010 Jul;246(1-2):66-73. doi: 10.1016/j.taap.2010.04.007. Epub 2010 Apr 22.
71 A plasmacytoid dendritic cell (CD123+/CD11c-) based assay system to predict contact allergenicity of chemicals. Toxicology. 2009 Oct 1;264(1-2):1-9. doi: 10.1016/j.tox.2009.07.021. Epub 2009 Aug 7.
72 Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
73 Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
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76 Interleukin-2-induced antinociception in morphine-insensitive rats. Acta Pharmacol Sin. 2002 Nov;23(11):981-4.
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