Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNFZC6)

• Drug Name: Formic Acid Drug Info
• Synonyms: formate; Formic acid, ion(1-); HCO2 anion; 71-47-6; formylate; aminate; methanoate; hydrogen carboxylate; CHEMBL183491; formiate; Formate ion; a carboxyl group; Hydrogencarboxylic acid; HCOO-; AC1L18W4; GTPL4540; CTK5I5292; CHEBI:15740; DTXSID60221219; BDAGIHXWWSANSR-UHFFFAOYSA-M; BDBM50155538; STL483235

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 284
  ChEBI ID: CHEBI:30751
  CAS Number: CAS 64-18-6
  TTD Drug ID: DMNFZC6

Molecule-Related Drug Atlas

Drug(s) Targeting Nitric-oxide synthase brain (NOS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NXN-188	DMMBAIH	Migraine	8A80	Phase 2	[7]
NXN-462	DMWVBS2	Headache	8A80-8A84	Phase 2	[8]
L-NIL	DM6Y49D	N. A.	N. A.	Terminated	[9]
Alpha-D-Mannose	DMF5DLW	Discovery agent	N.A.	Investigative	[2]
Acetate Ion	DMD08RH	Discovery agent	N.A.	Investigative	[2]
Flavin-Adenine Dinucleotide	DM5S4GK	Discovery agent	N.A.	Investigative	[2]
Heme	DMGC287	Discovery agent	N.A.	Investigative	[10]
2'-Monophosphoadenosine 5'-Diphosphoribose	DME9S8M	Discovery agent	N.A.	Investigative	[2]
6-isobutyl-4-methylpyridin-2-amine	DM2XB68	Discovery agent	N.A.	Investigative	[11]
7-Methyl-[1,4]thiazepan-(5E)-ylideneamine	DMUCJA6	Discovery agent	N.A.	Investigative	[12]

Drug(s) Targeting Heparin-binding growth factor 1 (FGF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CVBT-141H	DMYPXQ2	Coronary artery disease	BA80	Phase 2	[13]
Riferminogene pecaplasmid	DMBKN4P	Critical limb ischemia	BD4Y	Discontinued in Phase 3	[14]
N,O6-Disulfo-Glucosamine	DMYCV7U	Discovery agent	N.A.	Investigative	[2]
O2-Sulfo-Glucuronic Acid	DME78MS	Discovery agent	N.A.	Investigative	[2]
Naphthalene Trisulfonate	DML6FI3	Discovery agent	N.A.	Investigative	[2]
5-AMINO-NAPHTALENE-2-MONOSULFONATE	DMYTUNE	Discovery agent	N.A.	Investigative	[10]
Sucrose Octasulfate	DMET64R	Discovery agent	N.A.	Investigative	[2]

Drug(s) Targeting Glutathione-dependent PGD synthase (HPGDS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Praziquantel	DMOU1PK	Flatworm infection	1F70-1F86	Approved	[15]
HF-0220	DMI4C90	Alzheimer disease	8A20	Phase 2	[16]
Protoporphyrin IX	DMWYE7A	Discovery agent	N.A.	Investigative	[17]
Cibacron blue	DMWE1N8	Discovery agent	N.A.	Investigative	[18]
S-hexylglutathione	DMNWP02	Discovery agent	N.A.	Investigative	[19]
HQL-79	DMSHYQ3	Discovery agent	N.A.	Investigative	[20]

Drug(s) Targeting Carbonic anhydrase II (CA-II)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[21]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[22]
Dorzolamide	DMA17D0	Ocular hypertension	9C61.01	Approved	[23]
Chlorothiazide	DMLHESP	Chronic heart failure	BD1Z	Approved	[24]
Ethoxzolamide	DMVO4ED	Glaucoma/ocular hypertension	9C61	Approved	[10]
Dichlorphenamide	DMH7IDQ	Chronic glaucoma	9C61.0Z	Approved	[10]
Cyclothiazide	DMJ4AWC	Congestive heart failure	BD10	Approved	[25]
Ethinamate	DMK57GB	Insomnia	7A00-7A0Z	Approved	[26]
Benzthiazide	DMQWZ0H	High blood pressure	BA00	Approved	[27]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[28]

Drug(s) Targeting Delta-aminolevulinic acid dehydratase (ALAD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aminolevulinic acid hci	DMS4BLQ	Acne vulgaris	ED80	Approved	[29]
Porphobilinogen	DM5HMTB	N. A.	N. A.	Phase 2	[2]
2-Sulfhydryl-Ethanol	DMJBO3D	Discovery agent	N.A.	Investigative	[2]
S,S-(2-Hydroxyethyl)Thiocysteine	DMLPAD8	Discovery agent	N.A.	Investigative	[2]
Delta-Amino Valeric Acid	DMV7IAK	Discovery agent	N.A.	Investigative	[2]
4,7-Dioxosebacic Acid	DML5302	Discovery agent	N.A.	Investigative	[2]
Laevulinic Acid	DMTZ17V	Discovery agent	N.A.	Investigative	[2]
3-(2-Aminoethyl)-4-(Aminomethyl)Heptanedioic Acid	DMQXPM3	Discovery agent	N.A.	Investigative	[2]
5-Fluorolevulinic Acid	DMDV48S	Discovery agent	N.A.	Investigative	[2]
4-Oxosebacic Acid	DMADSUY	Discovery agent	N.A.	Investigative	[2]

Drug(s) Targeting Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Stannsoporfin	DMEG4TC	Neonatal hyperbilirubinemia	KA87	Phase 2	[30]
Heme	DMGC287	Discovery agent	N.A.	Investigative	[10]
2-Propanol, Isopropanol	DML5O0H	Discovery agent	N.A.	Investigative	[2]
2-Phenylheme	DMPIQTE	Discovery agent	N.A.	Investigative	[2]
Biliverdine Ix Alpha	DMCA0WJ	N. A.	N. A.	Investigative	[2]
Verdoheme	DM7NRK5	Discovery agent	N.A.	Investigative	[31]
Tin protoporphyrin	DMTXJ5S	Discovery agent	N.A.	Investigative	[32]
1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone	DMOTJWZ	Discovery agent	N.A.	Investigative	[10]
12-Phenylheme	DMLR2FB	Discovery agent	N.A.	Investigative	[2]

Drug(s) Targeting Candida Mannose-6-phosphate isomerase (Candi PMI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulfacetamide	DMZ6VEY	Acne vulgaris	ED80	Approved	[33]
Sulfoxone	DMAYX6P	Dermatitis herpetiformis	EB44	Approved	[33]
Acetate Ion	DMD08RH	Discovery agent	N.A.	Investigative	[2]
GNF-PF-5134	DM7850H	Discovery agent	N.A.	Investigative	[34]
GNF-PF-2272	DMONK0F	Discovery agent	N.A.	Investigative	[34]
NSC-66209	DMQ0S4B	Discovery agent	N.A.	Investigative	[34]

Drug(s) Targeting Plasmodium Hypoxanthine-guanine phosphoribosyltransferase (Malaria LACZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
US9200020, Table 3, Compound 1B	DMEARS2	N. A.	N. A.	Patented	[35]
US9200020, Table 3, Compound 2B	DMXFB5Z	N. A.	N. A.	Patented	[35]
US9200020, Table 3 compound 8	DMCLHX5	N. A.	N. A.	Patented	[35]
Acetate Ion	DMD08RH	Discovery agent	N.A.	Investigative	[2]
Pyrophosphate 2-	DMZQ75M	Discovery agent	N.A.	Investigative	[10]
Guanosine-5'-Monophosphate	DM3SLZK	Discovery agent	N.A.	Investigative	[2]
Inosinic Acid	DMLR86H	Discovery agent	N.A.	Investigative	[2]
Alpha-Phosphoribosylpyrophosphoric Acid	DMT6KI7	Discovery agent	N.A.	Investigative	[10]
Carboxylic PRPP	DMCTUR1	Discovery agent	N.A.	Investigative	[2]
5--Monophosphate-9-Beta-D-Ribofuranosyl Xanthine	DMX0EAK	Discovery agent	N.A.	Investigative	[2]

Drug(s) Targeting Bacterial Phosphoshikimate1-carboxyvinyltransferase (Bact aroA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[36]
Shikimate-3-Phosphate	DMBE0CT	Discovery agent	N.A.	Investigative	[2]

Drug(s) Targeting Staphylococcus Peptide deformylase (Stap-coc def)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GSK1322322	DM1EPMF	Bacterial infection	1A00-1C4Z	Phase 2	[37]
Actinonin	DMT4P89	N. A.	N. A.	Terminated	[38]
Double Oxidized Cysteine	DM6TU84	Discovery agent	N.A.	Investigative	[2]
Cysteinesulfonic Acid	DMXI8FP	Discovery agent	N.A.	Investigative	[2]
3-Sulfinoalanine	DMILTRN	N. A.	N. A.	Investigative	[2]
HYDROXY[3-(6-METHYLPYRIDIN-2-YL)PROPYL]FORMAMIDE	DMA4SIN	Discovery agent	N.A.	Investigative	[10]
2-(3-BENZOYLPHENOXY)ETHYL(HYDROXY)FORMAMIDE	DMWMFTJ	Discovery agent	N.A.	Investigative	[10]
[HYDROXY(3-PHENYLPROPYL)AMINO]METHANOL	DM7NXMB	Discovery agent	N.A.	Investigative	[10]
VRC3375	DM1QKVL	Discovery agent	N.A.	Investigative	[39]
N-alkyl urea hydroxamic acids	DM9T0OK	Discovery agent	N.A.	Investigative	[40]

Drug(s) Affected By DNA topoisomerase 2-alpha (TOP2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[41]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[42]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[43]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[44]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[45]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[46]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[48]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[49]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[50]

Drug(s) Affected By Ornithine decarboxylase (ODC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[51]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[54]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[55]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[56]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[57]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[58]

Drug(s) Affected By Pendrin (SLC26A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[59]
Epanova	DMHEAGL	Hypertriglyceridemia	5C80.1	Approved	[60]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[62]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[63]
CHLORIDE	DM1TJXA	Solid tumour/cancer	2A00-2F9Z	Phase 3	[64]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[65]
IODIDE	DM3FZ6P	Discovery agent	N.A.	Investigative	[66]

Drug(s) Affected By Protein DEK (DEK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[67]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[68]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[69]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[69]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[72]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[73]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[74]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial Phosphoshikimate1-carboxyvinyltransferase (Bact aroA)	TTB30PF	AROA_ECOLI	Inhibitor	[2]
Candida Mannose-6-phosphate isomerase (Candi PMI1)	TT915ZD	MPI_CANAL	Inhibitor	[2]
Carbonic anhydrase II (CA-II)	TTANPDJ	CAH2_HUMAN	Inhibitor	[2]
Delta-aminolevulinic acid dehydratase (ALAD)	TTJHKYD	HEM2_HUMAN	Inhibitor	[2]
Glutathione-dependent PGD synthase (HPGDS)	TTCYE56	HPGDS_HUMAN	Inhibitor	[2]
Heme oxygenase 1 (HMOX1)	TTI6V2A	HMOX1_HUMAN	Inhibitor	[2]
Heparin-binding growth factor 1 (FGF1)	TTMY81X	FGF1_HUMAN	Inhibitor	[2]
Nitric-oxide synthase brain (NOS1)	TTZUFI5	NOS1_HUMAN	Inhibitor	[2]
Plasmodium Hypoxanthine-guanine phosphoribosyltransferase (Malaria LACZ)	TTBL49X	HGXR_PLAFG	Inhibitor	[2]
Staphylococcus Peptide deformylase (Stap-coc def)	TTICO5G	DEF_STAAU	Inhibitor	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
DNA topoisomerase 2-alpha (TOP2A)	OT6LPS08	TOP2A_HUMAN	Gene/Protein Processing	[3]
Ornithine decarboxylase (ODC1)	OTNDAGRR	DCOR_HUMAN	Gene/Protein Processing	[4]
Pendrin (SLC26A4)	OTXUTLVS	S26A4_HUMAN	Regulation of Drug Effects	[5]
Protein DEK (DEK)	OTYCJ5H6	DEK_HUMAN	Biotransformations	[6]

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