Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMSCDY9)

Drug Name
Mannitol Drug Info
Synonyms
Diosmol; Hexahydroxyhexane; Invenex; Isotol; MTL; Manita; Mannazucker; Mannidex; Mannigen; Mannistol; Mannit; Mannite; Osmitrol; Osmofundin; Osmosal; Resectisol; Cordycepic acid; Cpd without stereochemical designation; Manna sugar; Mannitol [USAN]; Marine Crystal; Resectisol In Plastic Container; M0044; Mannidex 16700; Mannogem 2080; D-mannite; D-mannitol; DL-Mannitol; MANNITOL 25%; Maniton-S; Mannitol (USP); Mannitol (VAN); Mannitol 10%; Mannitol 10% In Plastic Container; Mannitol 15%; Mannitol 15% In Plastic Container; Mannitol 20%; Mannitol 20% In Plastic Container; Mannitol 5%; Mannitol 5% In Plastic Container; OSMITROL 10% IN WATER IN PLASTIC CONTAINER; OSMITROL 15% IN WATER IN PLASTIC CONTAINER; OSMITROL 20% IN WATER IN PLASTIC CONTAINER; OSMITROL 5% IN WATER IN PLASTIC CONTAINER; Osmitrol (TN); Osmitrol 10% In Water; Osmitrol 15% In Water; Osmitrol 20% In Water; Osmitrol 5% In Water; SDM No. 35; SORBITOL-MANNITOL IN PLASTIC CONTAINER; Sorbitol-Mannitol; D-Mannitol (JP15); MANNITOL 10% W/ DEXTROSE 5% IN DISTILLED WATER; D-(-)-Mannitol; ED1D1E61-FEFB-430A-AFDC-D1F4A957FC3D; MANNITOL 15% DEXTROSE 5% IN SODIUM CHLORIDE 0.45%; MANNITOL 5% DEXTROSE 5% IN SODIUM CHLORIDE 0.12%; (2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol; (L)-Mannitol
Indication
Disease Entry ICD 11 Status REF
Bronchiectasis CA24 Approved [1]
Cerebral edema 8D60.1 Approved [2]
Cystic fibrosis CA25 Approved [2]
Edema MG29 Approved [2]
Ocular hypertension 9C61.01 Approved [2]
Pseudotumor cerebri Approved [2]
Renal failure GB60-GB6Z Approved [1]
Therapeutic Class
Sweetening Agents
Cross-matching ID
PubChem CID
6251
ChEBI ID
CHEBI:16899
CAS Number
CAS 69-65-8
TTD Drug ID
DMSCDY9
VARIDT Drug ID
DR00859
INTEDE Drug ID
DR2323

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [10]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [11]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [12]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [13]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [14]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [15]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [16]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [17]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [18]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [19]
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Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [20]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [21]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [22]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [23]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [24]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [25]
Meloxicam DM2AR7L Arthritis FA20 Approved [26]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [27]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [28]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [29]
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Drug(s) Affected By Natriuretic peptides A (NPPA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [30]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [31]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [32]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [33]
Cilazapril DM4V6JA Congestive heart failure BD10 Approved [34]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [35]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [36]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [37]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [38]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [39]
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Drug(s) Affected By Tumor necrosis factor alpha-induced protein 3 (TNFAIP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [9]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [21]
Methotrexate DM2TEOL Anterior urethra cancer Approved [40]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [41]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [42]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [9]
Ethacrynic acid DM60QMR Edema MG29 Approved [43]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [44]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [45]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [9]
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Drug(s) Affected By Tumor protein D52 (TPD52)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [9]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [46]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [9]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [47]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [9]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [48]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [49]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [38]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [50]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [51]
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Drug(s) Affected By Programmed cell death protein 4 (PDCD4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [9]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [52]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [53]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [9]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [54]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [47]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [55]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [56]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [9]
Testosterone DM7HUNW Hot flushes GA30 Approved [57]
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Drug(s) Affected By Focal adhesion kinase 1 (PTK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [58]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [59]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [60]
Quercetin DM3NC4M Obesity 5B81 Approved [61]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [62]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [63]
Testosterone DM7HUNW Hot flushes GA30 Approved [64]
Halothane DM80OZ5 Anaesthesia 9A78.6 Approved [65]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [66]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
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Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [68]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [69]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [19]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [70]
Gefitinib DM15F0X Colon adenocarcinoma Approved [71]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [72]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [73]
Selenium DM25CGV N. A. N. A. Approved [74]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [75]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [76]
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Drug(s) Affected By H(+)/Cl(-) exchange transporter 3 (CLCN3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [77]
Selenium DM25CGV N. A. N. A. Approved [74]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [79]
Leflunomide DMR8ONJ Arthritis FA20 Approved [80]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [81]
Testosterone enanthate DMB6871 N. A. N. A. Approved [82]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [38]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [50]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [83]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Aspergillus Mannitol 2-dehydrogenase (Asperg M2DH) TTTX5M8 M2DH_ASPFU Activator [3]
Aspergillus Mannitol-1-phosphate 5-dehydrogenase (Asperg mpdA) TTV0PE2 MTLD_ASPFU Activator [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [4]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Gene/Protein Processing [5]
Focal adhesion kinase 1 (PTK2) OT3Q1JDY FAK1_HUMAN Drug Response [6]
H(+)/Cl(-) exchange transporter 3 (CLCN3) OTEEXNMU CLCN3_HUMAN Drug Response [7]
Natriuretic peptides A (NPPA) OTMQNTNX ANF_HUMAN Gene/Protein Processing [8]
Programmed cell death protein 4 (PDCD4) OTZ6NXUX PDCD4_HUMAN Gene/Protein Processing [9]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Drug Response [6]
Tumor necrosis factor alpha-induced protein 3 (TNFAIP3) OTVLI4DD TNAP3_HUMAN Gene/Protein Processing [9]
Tumor protein D52 (TPD52) OTPKSK43 TPD52_HUMAN Gene/Protein Processing [9]

References

1 FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 016080.
2 Mannitol FDA Label
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21 Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
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26 Inhibiting AKT signaling pathway with cilostazol and meloxicam synergism for suppressing K562 cells in vitro. J Biochem Mol Toxicol. 2022 Nov;36(11):e23185. doi: 10.1002/jbt.23185. Epub 2022 Aug 3.
27 Ciprofloxacin induces apoptosis and inhibits proliferation of human colorectal carcinoma cells. Br J Cancer. 2002 Feb 1;86(3):443-8. doi: 10.1038/sj.bjc.6600079.
28 Colchicine-induced apoptosis in human normal liver L-02 cells by mitochondrial mediated pathways. Toxicol In Vitro. 2012 Aug;26(5):649-55. doi: 10.1016/j.tiv.2012.01.024. Epub 2012 Feb 8.
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37 1,25-dihydroxyvitamin D inhibits human ANP gene promoter activity. Regul Pept. 2005 Jun 30;128(3):197-202. doi: 10.1016/j.regpep.2004.12.030.
38 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
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45 The hepatotoxic fluoroquinolone trovafloxacin disturbs TNF- and LPS-induced p65 nuclear translocation in vivo and in vitro. Toxicol Appl Pharmacol. 2020 Mar 15;391:114915. doi: 10.1016/j.taap.2020.114915. Epub 2020 Feb 6.
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48 Identification of vitamin D3 target genes in human breast cancer tissue. J Steroid Biochem Mol Biol. 2016 Nov;164:90-97.
49 Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
50 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
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56 Keratinocyte-derived IL-36gama plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes. Arch Toxicol. 2019 Aug;93(8):2307-2320.
57 The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
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59 Cleavage of focal adhesion kinase is an early marker and modulator of oxidative stress-induced apoptosis. Chem Biol Interact. 2008 Jan 10;171(1):57-66. doi: 10.1016/j.cbi.2007.08.009. Epub 2007 Aug 19.
60 Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells. Cancer Sci. 2007 Jun;98(6):890-9.
61 Quercetin inhibits migration and invasion of SAS human oral cancer cells through inhibition of NF-B and matrix metalloproteinase-2/-9 signaling pathways. Anticancer Res. 2013 May;33(5):1941-50.
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64 Monomeric and oligomeric flavanols are agonists of membrane androgen receptors. Exp Cell Res. 2005 Oct 1;309(2):329-39. doi: 10.1016/j.yexcr.2005.06.011.
65 Disruption of FAK signaling: a side mechanism in cytotoxicity. Toxicology. 2008 Mar 12;245(1-2):1-10. doi: 10.1016/j.tox.2007.12.003. Epub 2007 Dec 15.
66 Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
67 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
68 Inhibition of cholesterol metabolism underlies synergy between mTOR pathway inhibition and chloroquine in bladder cancer cells. Oncogene. 2016 Aug 25;35(34):4518-28. doi: 10.1038/onc.2015.511. Epub 2016 Feb 8.
69 Nicotine-induced survival signaling in lung cancer cells is dependent on their p53 status while its down-regulation by curcumin is independent. Mol Cancer. 2010 Aug 20;9:220.
70 -Carotene Induces Apoptosis in Human Esophageal Squamous Cell Carcinoma Cell Lines via the Cav-1/AKT/NF-B Signaling Pathway. J Biochem Mol Toxicol. 2016 Mar;30(3):148-57. doi: 10.1002/jbt.21773. Epub 2016 Jan 6.
71 Dihydromyricetin suppresses tumor growth via downregulation of the EGFR/Akt/survivin signaling pathway. J Biochem Mol Toxicol. 2023 Jun;37(6):e23328. doi: 10.1002/jbt.23328. Epub 2023 Feb 19.
72 Oxidative stress induces parallel autophagy and mitochondria dysfunction in human glioma U251 cells. Toxicol Sci. 2009 Aug;110(2):376-88. doi: 10.1093/toxsci/kfp101. Epub 2009 May 18.
73 Effect of toll-like receptor 7 and 9 targeted therapy to prevent the development of hepatocellular carcinoma. Liver Int. 2015 Mar;35(3):1063-76. doi: 10.1111/liv.12626. Epub 2014 Jul 30.
74 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
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