Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMV62ED)

Drug Name

Fotemustine Drug Info

Synonyms

Fotemustine; 92118-27-9; Diethyl (1-(3-(2-chloroethyl)-3-nitrosoureido)ethyl)phosphonate; Muphoran; Mustophorane; Servier-10036; Fotemustinum [Latin]; Fotemustina [Spanish]; S 10036; C9H19ClN3O5P; CCRIS 6337; S-10036; Fotemustinum; Diethyl-1-(3-(2-chloroethyl)-3-nitrosoureido)ethylphosphonate; (+-)-Diethyl (1-(3-(2-chloroethyl)-3-nitrosoureido)ethyl)phosphonate; Mustoforan; 1-(2-chloroethyl)-3-(1-diethoxyphosphorylethyl)-1-nitrosourea; Fotemustine [BAN:INN]

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Approved	[1]

Cross-matching ID

PubChem CID: 104799
ChEBI ID: CHEBI:131852
CAS Number: CAS 92118-27-9
TTD Drug ID: DMV62ED

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

Approved Drug(s)

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Drug(s) Targeting Cytoplasmic thioredoxin reductase (TXNRD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Spermidine	DMVJNFI	Plaque psoriasis	EA90.0	Phase 3	[2]
Golden phosphorous acetyletic compound 2	DMYJ15A	N. A.	N. A.	Patented	[7]
Terpyridineplatinum(II) complexe 3	DM54EFD	N. A.	N. A.	Patented	[7]
Terpyridineplatinum(II) complexe 4	DMOV86T	N. A.	N. A.	Patented	[7]
Golden phosphorous acetyletic compound 1	DMVAKUI	N. A.	N. A.	Patented	[7]
Acyl oxymethyl acrylamide ester derivative 1	DMXTUE1	N. A.	N. A.	Patented	[7]
PMID27977313-Compound-18	DMIA3GH	N. A.	N. A.	Patented	[7]
Triazole gold complexe 1	DMCWES7	N. A.	N. A.	Patented	[7]
4-aryl quinol derivative 2	DM7TW5Z	N. A.	N. A.	Patented	[7]
PMID27977313-Compound-46	DMGF04T	N. A.	N. A.	Patented	[7]
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Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[8]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[9]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[10]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[11]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[10]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[12]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[13]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[14]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[15]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
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Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[17]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[18]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[19]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[20]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[21]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[22]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[23]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[24]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[25]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[26]
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Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[28]
Fructose	DM43AN2	Vomiting	MD90	Approved	[29]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[30]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[31]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[11]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[32]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[34]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[35]
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Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[36]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Selenium	DM25CGV	N. A.	N. A.	Approved	[38]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[39]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[40]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[41]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[42]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[43]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[44]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
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Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[46]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[11]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[47]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[48]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[49]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[50]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[53]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[55]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[57]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[58]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[59]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[60]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[61]
Fructose	DM43AN2	Vomiting	MD90	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[63]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[64]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[9]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[32]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[65]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[66]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[67]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[68]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[69]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[70]
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Drug(s) Affected By Heat shock factor protein 1 (HSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[71]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[4]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[4]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[72]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[73]
Ceftazidime	DM41GRA	Bacteremia	1A73	Approved	[4]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Chlorpheniramine	DM5URA2	Allergic rhinitis	CA08.0	Approved	[4]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[4]
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Drug(s) Affected By Three-prime repair exonuclease 1 (TREX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[38]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[75]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[77]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[78]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[6]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[79]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[6]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[38]
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Drug(s) Affected By DNA polymerase eta (POLH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[81]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[84]
Lomustine	DMMWSUL	Brain cancer	2A00	Approved	[3]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[3]
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Drug(s) Affected By Methylated-DNA--protein-cysteine methyltransferase (MGMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[85]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[86]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[87]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[88]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[90]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[91]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[92]
Dacarbazine	DMNPZL4	Adenocarcinoma	2D40	Approved	[93]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[94]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cytoplasmic thioredoxin reductase (TXNRD1)	TTR7UJ3	TRXR1_HUMAN	Inhibitor	[2]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Gene/Protein Processing	[3]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Gene/Protein Processing	[3]
DNA polymerase eta (POLH)	OTN07WXU	POLH_HUMAN	Gene/Protein Processing	[3]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)	OTDRV63V	GA45A_HUMAN	Gene/Protein Processing	[3]
Heat shock factor protein 1 (HSF1)	OTYNJ4KP	HSF1_HUMAN	Gene/Protein Processing	[4]
Histone H2AX (H2AX)	OT18UX57	H2AX_HUMAN	Gene/Protein Processing	[3]
Methylated-DNA--protein-cysteine methyltransferase (MGMT)	OT40A9WH	MGMT_HUMAN	Drug Response	[5]
Protein c-Fos (FOS)	OTJBUVWS	FOS_HUMAN	Gene/Protein Processing	[6]
Three-prime repair exonuclease 1 (TREX1)	OTQG7K12	TREX1_HUMAN	Gene/Protein Processing	[6]
Transcription factor Jun (JUN)	OTCYBO6X	JUN_HUMAN	Gene/Protein Processing	[6]

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