Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMVFB93)

Drug Name
Nitrate Drug Info
Synonyms
nitrate; NITRATE ION; 14797-55-8; Nitrate(1-); UNII-T93E9Y2844; Nitrate(6CI,7CI,8CI,9CI); UN3218; CHEMBL186200; NO3-; Nitrates; CHEBI:17632; T93E9Y2844; NO3; trioxidonitrate; trioxonitrate; nitrooxidane; trioxonitrate(V); trioxonitrate(1-); trioxidonitrate(1-); AC1L1ADK; Nitrates, inorganic, n.o.s.; CTK0H4660; BDBM26988; NHNBFGGVMKEFGY-UHFFFAOYSA-N; 84145-82-4 (Parent); NO3(-); AKOS015904030; MCULE-5142506228; [NO3](-); Nitrates, inorganic, aqueous solution, n.o.s.; I14-18318; Nitrates, inorganic, n.o.s. [UN1447] [Oxidizer]; Nitrates, in
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
943
ChEBI ID
CHEBI:17632
TTD Drug ID
DMVFB93
VARIDT Drug ID
DR00009

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
Drug Status:
Investigative Drug(s)
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Transported By Vesicular H(+)/Aspartate-glutamate cotransporter (SLC17A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
NAAG DMFGOW0 Discovery agent N.A. Investigative [5]
Drug(s) Transported By Anion exchange transporter (SLC26A7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulfate DMW0ZBF Discovery agent N.A. Investigative [2]
Bicarbonate DMT5E36 Discovery agent N.A. Investigative [6]
Oxalate DM40SEU Discovery agent N.A. Investigative [2]
Drug(s) Targeting Carbonic anhydrase I (CA-I)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Salicyclic acid DM2F8XZ Seborrhoeic dermatitis EA81 Approved [7]
Ethoxzolamide DMVO4ED Glaucoma/ocular hypertension 9C61 Approved [8]
Dichlorphenamide DMH7IDQ Chronic glaucoma 9C61.0Z Approved [8]
Methazolamide DM7J2TA Glaucoma/ocular hypertension 9C61 Approved [9]
Acetazolamide DM1AF5U Glaucoma/ocular hypertension 9C61 Approved [8]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [10]
PARABEN DMEW5Z8 N. A. N. A. Phase 3 [11]
CG-100649 DMIKMA9 Arthritis FA20 Phase 3 [12]
Phenol DM1QSM3 N. A. N. A. Phase 2/3 [10]
Coumate DMVKW0N Breast cancer 2C60-2C65 Phase 2 [13]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Carbonic anhydrase II (CA-II)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Salicyclic acid DM2F8XZ Seborrhoeic dermatitis EA81 Approved [7]
Sulfamylon DMIO1K0 Bacterial infection 1A00-1C4Z Approved [14]
Dorzolamide DMA17D0 Open-angle glaucoma 9C61 Approved [15]
Chlorothiazide DMLHESP Congestive heart failure BD10 Approved [16]
Ethoxzolamide DMVO4ED Glaucoma/ocular hypertension 9C61 Approved [17]
Dichlorphenamide DMH7IDQ Chronic glaucoma 9C61.0Z Approved [17]
Cyclothiazide DMJ4AWC Congestive heart failure BD10 Approved [18]
Ethinamate DMK57GB Insomnia 7A00-7A0Z Approved [19]
Benzthiazide DMQWZ0H High blood pressure BA00 Approved [20]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [10]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Carbonic anhydrase I (CA-I) TTHQPL7 CAH1_HUMAN Inhibitor [1]
Carbonic anhydrase II (CA-II) TTANPDJ CAH2_HUMAN Inhibitor [1]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Anion exchange transporter (SLC26A7) DTOTME4 S26A7_HUMAN Substrate [2]
Sodium/iodide cotransporter (SLC5A5) DTZAH46 SC5A5_HUMAN Substrate [3]
Vesicular H(+)/Aspartate-glutamate cotransporter (SLC17A5) DTWLACT S17A5_HUMAN Substrate [4]

References

1 Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. Bioorg Med Chem Lett. 2004 Nov 1;14(21):5435-9.
2 The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9. (ID: 2.A.53.2.6)
3 The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9. (ID: 2.A.21.5.1)
4 Sialin (SLC17A5) functions as a nitrate transporter in the plasma membrane. Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13434-9.
5 Vesicular uptake of N-acetylaspartylglutamate is catalysed by sialin (SLC17A5). Biochem J. 2013 Aug 15;454(1):31-8.
6 Vasopressin induces expression of the Cl-/HCO3- exchanger SLC26A7 in kidney medullary collecting ducts of Brattleboro rats. Am J Physiol Renal Physiol. 2006 May;290(5):F1194-201.
7 Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid. Bioorg Med Chem. 2008 Aug 1;16(15):7424-8.
8 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
9 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2597).
10 Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3.
11 Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164.
12 Understanding the Dual Inhibition of COX-2 and Carbonic Anhydrase-II by Celecoxib and CG100649 Using Density Functional Theory Calculations and other Molecular Modelling Approaches. Protein Pept Lett. 2015;22(10):903-12.
13 Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-r... Bioorg Med Chem Lett. 2008 Aug 1;18(15):4282-6.
14 Sulfonamide linked neoglycoconjugates--a new class of inhibitors for cancer-associated carbonic anhydrases. J Med Chem. 2010 Apr 8;53(7):2913-26.
15 Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides. Bioorg Med Chem. 2009 Jul 15;17(14):5054-8.
16 Localization of diuretic effects along the loop of Henle: an in vivo microperfusion study in rats. Clin Sci (Lond). 2000 Apr;98(4):481-8.
17 The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
18 Selective effect of thiazides on the human osteoblast-like cell line MG-63. Kidney Int. 1996 Nov;50(5):1476-82.
19 Inhibition of carbonic anhydrases I and II by N-unsubstituted carbamate esters. J Biol Chem. 1992 Dec 15;267(35):25044-50.
20 Nature of the inhibition of carbonic anhydrase by acetazolamide and benzthiazide. J Pharmacol Exp Ther. 1961 Mar;131:271-4.