Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMVFB93)

Drug Name
NITRATE Drug Info
Synonyms
nitrate; NITRATE ION; 14797-55-8; Nitrate(1-); UNII-T93E9Y2844; Nitrate(6CI,7CI,8CI,9CI); UN3218; CHEMBL186200; NO3-; Nitrates; CHEBI:17632; T93E9Y2844; NO3; trioxidonitrate; trioxonitrate; nitrooxidane; trioxonitrate(V); trioxonitrate(1-); trioxidonitrate(1-); AC1L1ADK; Nitrates, inorganic, n.o.s.; CTK0H4660; BDBM26988; NHNBFGGVMKEFGY-UHFFFAOYSA-N; 84145-82-4 (Parent); NO3(-); AKOS015904030; MCULE-5142506228; [NO3](-); Nitrates, inorganic, aqueous solution, n.o.s.; I14-18318; Nitrates, inorganic, n.o.s. [UN1447] [Oxidizer]; Nitrates, in
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
943
ChEBI ID
CHEBI:17632
TTD Drug ID
DMVFB93
VARIDT Drug ID
DR00009

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Carbonic anhydrase I (CA-I)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [9]
Ethoxzolamide DMVO4ED Glaucoma/ocular hypertension 9C61 Approved [10]
Dichlorphenamide DMH7IDQ Chronic glaucoma 9C61.0Z Approved [10]
Methazolamide DM7J2TA Glaucoma/ocular hypertension 9C61 Approved [11]
Acetazolamide DM1AF5U Absence epilepsy Approved [10]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [12]
PARABEN DMEW5Z8 N. A. N. A. Phase 3 [13]
CG-100649 DMIKMA9 Arthritis FA20 Phase 3 [14]
PHENOL DM1QSM3 N. A. N. A. Phase 2/3 [12]
Coumate DMVKW0N Breast cancer 2C60-2C65 Phase 2 [15]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Carbonic anhydrase II (CA-II)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [9]
Sulfamylon DMIO1K0 Bacterial infection 1A00-1C4Z Approved [16]
Dorzolamide DMA17D0 Ocular hypertension 9C61.01 Approved [17]
Chlorothiazide DMLHESP Chronic heart failure BD1Z Approved [18]
Ethoxzolamide DMVO4ED Glaucoma/ocular hypertension 9C61 Approved [19]
Dichlorphenamide DMH7IDQ Chronic glaucoma 9C61.0Z Approved [19]
Cyclothiazide DMJ4AWC Congestive heart failure BD10 Approved [20]
Ethinamate DMK57GB Insomnia 7A00-7A0Z Approved [21]
Benzthiazide DMQWZ0H High blood pressure BA00 Approved [22]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [12]
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Drug(s) Transported By Vesicular H(+)/Aspartate-glutamate cotransporter (SLC17A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
NAAG DMFGOW0 Discovery agent N.A. Investigative [23]
Drug(s) Transported By Anion exchange transporter (SLC26A7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
SULFATE DMW0ZBF Discovery agent N.A. Investigative [2]
BICARBONATE DMT5E36 Discovery agent N.A. Investigative [24]
oxalate DM40SEU Discovery agent N.A. Investigative [2]
Drug(s) Affected By Thyrotropin subunit beta (TSHB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [26]
Octreotide DMHIDCJ Acromegaly 5A60.0 Approved [27]
Levodopa DMN3E57 Parkinson disease 8A00.0 Approved [28]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [29]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [30]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [31]
[3H]cAMP DMZRQU7 Discovery agent N.A. Investigative [32]
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Drug(s) Affected By Cystic fibrosis transmembrane conductance regulator (CFTR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ivacaftor DMZC1HS Cystic fibrosis CA25 Approved [33]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [34]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [35]
Quercetin DM3NC4M Obesity 5B81 Approved [36]
Miglustat DM5J64S Niemann-Pick disease type C Approved [37]
Glibenclamide DM8JXPZ Diabetic complication 5A2Y Approved [38]
Milrinone DM8TUPF Congestive heart failure BD10 Approved [35]
Oxidized glutathione DM9EQC0 Breast cancer 2C60-2C65 Approved [39]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [39]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [40]
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Drug(s) Affected By Interleukin-1 beta (IL1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [41]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [42]
Gefitinib DM15F0X Colon adenocarcinoma Approved [43]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [44]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [45]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [44]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [46]
Selenium DM25CGV N. A. N. A. Approved [47]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [48]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [49]
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Drug(s) Affected By Pro-adrenomedullin (ADM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [50]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [51]
Methotrexate DM2TEOL Anterior urethra cancer Approved [52]
Quercetin DM3NC4M Obesity 5B81 Approved [53]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [54]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [55]
Leflunomide DMR8ONJ Arthritis FA20 Approved [56]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [40]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [26]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [57]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Carbonic anhydrase I (CA-I) TTHQPL7 CAH1_HUMAN Inhibitor [1]
Carbonic anhydrase II (CA-II) TTANPDJ CAH2_HUMAN Inhibitor [1]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Anion exchange transporter (SLC26A7) DTOTME4 S26A7_HUMAN Substrate [2]
Sodium/iodide cotransporter (SLC5A5) DTZAH46 SC5A5_HUMAN Substrate [3]
Vesicular H(+)/Aspartate-glutamate cotransporter (SLC17A5) DTWLACT S17A5_HUMAN Substrate [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Cystic fibrosis transmembrane conductance regulator (CFTR) OT6B22QH CFTR_HUMAN Gene/Protein Processing [5]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Regulation of Drug Effects [6]
Pro-adrenomedullin (ADM) OT7T0TA4 ADML_HUMAN Regulation of Drug Effects [7]
Thyrotropin subunit beta (TSHB) OTFDI39D TSHB_HUMAN Gene/Protein Processing [8]

References

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24 Vasopressin induces expression of the Cl-/HCO3- exchanger SLC26A7 in kidney medullary collecting ducts of Brattleboro rats. Am J Physiol Renal Physiol. 2006 May;290(5):F1194-201.
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44 An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury. Arch Toxicol. 2021 Jan;95(1):149-168. doi: 10.1007/s00204-020-02882-4. Epub 2020 Aug 20.
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56 Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
57 Dexamethasone and the inflammatory response in explants of human omental adipose tissue. Mol Cell Endocrinol. 2010 Feb 5;315(1-2):292-8.