Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZWTY7)

Drug Name
Phorbol 12,13-butyrate Drug Info
Synonyms
Phorbol 12,13-dibutyrate; PDBU; Phorbol dibutyrate; 37558-16-0; Phorbol 12,13-dibutanoate; UNII-67MX82CL58; Phorbol-12,13-dibutyrate; NSC 622507; CHEBI:17598; 67MX82CL58; (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-9aH-cyclopropa[3,4]benzo[1,2-e]azulene-9,9a-diyl dibutanoate; Butanoic acid, (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-9aH-cyclopropa[3,4]be
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
37783
ChEBI ID
CHEBI:17598
CAS Number
CAS 37558-16-0
TTD Drug ID
DMZWTY7

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Protein kinase C delta (PRKCD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
KAI-9803 DMELJDI Acute myocardial infarction BA41 Phase 1/2 [6]
RO-320432 DMFZ1YW N. A. N. A. Terminated [7]
LY-317644 DMM20PI N. A. N. A. Terminated [8]
AD 198 DMJFY2I N. A. N. A. Terminated [9]
RO-316233 DMAGLPW Discovery agent N.A. Investigative [10]
LY-326449 DMN53M4 Discovery agent N.A. Investigative [11]
PROSTRATIN DM1HMJ5 Human immunodeficiency virus infection 1C62 Investigative [12]
[2,2':5',2'']Terthiophen-4-yl-methanol DMRQC1F Discovery agent N.A. Investigative [13]
4-[1-(4-hydroxyphenyl)-3-methyl-1-butenyl]phenol DM8IYG1 Discovery agent N.A. Investigative [14]
2-(4-Hydroxy-phenyl)-3,3-diphenyl-acrylonitrile DMNGW1A Discovery agent N.A. Investigative [14]
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Drug(s) Affected By Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [15]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [16]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [17]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [18]
Bortezomib DMNO38U Leukemia Approved [19]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [20]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [21]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [22]
Isoflavone DM7U58J N. A. N. A. Phase 4 [23]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [24]
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Drug(s) Affected By Amyloid-beta precursor protein (APP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [25]
Selenium DM25CGV N. A. N. A. Approved [26]
Methotrexate DM2TEOL Anterior urethra cancer Approved [27]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [28]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [29]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [30]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [31]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [32]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [33]
Aluminium DM6ECN9 Hyperhidrosis EE00 Approved [34]
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Drug(s) Affected By Protein kinase C alpha type (PRKCA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [35]
Quercetin DM3NC4M Obesity 5B81 Approved [36]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [37]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [38]
Panobinostat DM58WKG Chronic graft versus host disease Approved [39]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [40]
Leflunomide DMR8ONJ Arthritis FA20 Approved [41]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [17]
Capsaicin DMGMF6V Back pain ME84.Z Approved [43]
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Drug(s) Affected By Interleukin-12 subunit alpha (IL12A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [44]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [45]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [46]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [47]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [48]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [49]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [50]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [51]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [52]
Arsenic DMTL2Y1 N. A. N. A. Approved [53]
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Drug(s) Affected By Interleukin-12 subunit beta (IL12B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [54]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [45]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [46]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [55]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [47]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [56]
Capsaicin DMGMF6V Back pain ME84.Z Approved [57]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [58]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [59]
Bryostatin-1 DM1JOXY Alzheimer disease 8A20 Phase 2 [60]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [61]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [62]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [63]
Gefitinib DM15F0X Colon adenocarcinoma Approved [64]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [65]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [66]
Etretinate DM2CZFA Keratosis ED56 Approved [67]
Prednisone DM2HG4X Acute asthma CA23 Approved [68]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [69]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [70]
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Drug(s) Affected By Presenilin-1 (PSEN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [71]
Methotrexate DM2TEOL Anterior urethra cancer Approved [72]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [2]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [73]
Menthol DMG2KW7 Back pain ME84.Z Approved [74]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [18]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [75]
Bortezomib DMNO38U Leukemia Approved [19]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [76]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [77]
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Drug(s) Affected By Beta-secretase 1 (BACE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [71]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [78]
Quercetin DM3NC4M Obesity 5B81 Approved [79]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [38]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [80]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [81]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [82]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [48]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [83]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [73]
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Drug(s) Affected By Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [71]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [84]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [85]
Quercetin DM3NC4M Obesity 5B81 Approved [86]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [2]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [16]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [73]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [17]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [76]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [87]
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Drug(s) Affected By Organic anion transporter 7 (SLC22A9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [88]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [88]
Quercetin DM3NC4M Obesity 5B81 Approved [86]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [89]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [90]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [88]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [88]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [48]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [91]
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Drug(s) Affected By Interleukin-23 subunit alpha (IL23A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [92]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [93]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [92]
Misoprostol DMHVJFK Medical abortion JA00.1Z Approved [94]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [19]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [92]
Bortezomib DMNO38U Leukemia Approved [95]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [76]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [92]
Prednisolone DMQ8FR2 Acute adrenal insufficiency Approved [92]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Protein kinase C delta (PRKCD) TT9WJ8U KPCD_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Amyloid-beta precursor protein (APP) OTKFD7R4 A4_HUMAN Protein Interaction/Cellular Processes [2]
Beta-secretase 1 (BACE1) OTCA7B6A BACE1_HUMAN Protein Interaction/Cellular Processes [2]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [3]
Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) OTOKUXUH ADA10_HUMAN Gene/Protein Processing [2]
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9) OT70Z4II ADAM9_HUMAN Gene/Protein Processing [2]
Interleukin-12 subunit alpha (IL12A) OTDQT8GI IL12A_HUMAN Gene/Protein Processing [4]
Interleukin-12 subunit beta (IL12B) OT0JF8A3 IL12B_HUMAN Gene/Protein Processing [4]
Interleukin-23 subunit alpha (IL23A) OTYO99HC IL23A_HUMAN Gene/Protein Processing [4]
Organic anion transporter 7 (SLC22A9) OTO4BJCC S22A9_HUMAN Gene/Protein Processing [5]
Presenilin-1 (PSEN1) OTKL39RT PSN1_HUMAN Gene/Protein Processing [2]

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62 Cannabidiol Activates Neuronal Precursor Genes in Human Gingival Mesenchymal Stromal Cells. J Cell Biochem. 2017 Jun;118(6):1531-1546. doi: 10.1002/jcb.25815. Epub 2016 Dec 29.
63 Gene expression profiles with activation of the estrogen receptor alpha-selective estrogen receptor modulator complex in breast cancer cells expressing wild-type estrogen receptor. Cancer Res. 2002 Aug 1;62(15):4419-26.
64 Leptomycin B reduces primary and acquired resistance of gefitinib in lung cancer cells. Toxicol Appl Pharmacol. 2017 Nov 15;335:16-27. doi: 10.1016/j.taap.2017.09.017. Epub 2017 Sep 21.
65 BMN 673 (talazoparib): A potent PARP inhibitor for triple negative breast cancer with different genetic profile. J Biochem Mol Toxicol. 2019 May;33(5):e22286. doi: 10.1002/jbt.22286. Epub 2019 Jan 23.
66 Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
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