Details of the Drug Reposition

General Information of This Drug (ID: DMTAJQE)

• Drug Name: Amphotericin B (DMTAJQE)
• Synonyms: ABLC; Abelcet; Abelecet; Ambisome; Amphocin; Amphomoronal; Amphotec; Amphotericin; Amphotericinum; Amphotherizin; Amphozone; Fungilin; Fungisome; Fungisone; Fungizone; Halizon; SinuNase; Amfotericina B; Amophotericin B; Amphortericin B; Amphotericin B Cholesterol Dispersion; Amphotericin B Colloidal Dispersion; Amphotericin B liposomal; Amphotericin BETA; Amphotericine B; Amphotericinum B; Amphotherizin [German]; Liposomal Amphotericin B; NCI527017; NS 718; AMPH-B; Abelcet (TN); AmBisome (TN); Amfotericina B [INN-Spanish]; Ampho-Moronal; Amphocil (TN); Amphotec (TN); Amphotericin-B; Amphotericine B [INN-French]; Amphotericinum B [INN-Latin]; Fungilin (TN); Fungisome (TN); Fungizone (TN); LNS-AmB; Mysteclin-F; NKTR-024; Amphotericin B [USAN:INN:JAN]; Amphotericin B, Lipid-based; Amphotericin B, Streptomyces sp.; Amphotericin B (JP15/USP/INN)
• Therapeutic Class: Antifungal Agents
• Drug Type: Small molecular drug

Information on Drug Reposition of This Drug

28 Approved Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Yaws	DISLTH3X	N.A.	Approved	[1]
Typhus	DISJ5JX1	N.A.	Approved	[1]
Trachoma	DIS2WZUR	N.A.	Approved	[1]
Syphilis	DISJ73BS	N.A.	Approved	[1]
Rocky mountain spotted fever	DISFN72S	N.A.	Approved	[1]
Rickettsialpox	DISEMENW	N.A.	Approved	[1]
Relapsing fever	DISEA4L7	N.A.	Approved	[1]
Q fever	DISK1S90	N.A.	Approved	[1]
Ornithosis	DIS4YMZ8	N.A.	Approved	[1]
Mycotic endocarditis	DIS2FMH1	N.A.	Approved	[1]
Lymphogranuloma venereum	DIS0MMFT	N.A.	Approved	[1]
Histoplasmosis	DISGTF4W	N.A.	Approved	[1]
Disseminated sporotrichosis	DISH553L	N.A.	Approved	[1]
Cryptococcosis	DISDYDTK	N.A.	Approved	[1]
Cryptococcal meningitis	DIS1LBC6	N.A.	Approved	[1]
Brucellosis	DISEAYGH	N.A.	Approved	[1]
Acute gonococcal cervicitis	DIS4LKDT	N.A.	Approved	[1]
Actinomycosis	DIS7YFRP	N.A.	Approved	[1]
Aspergillosis	DISAIQP2	1F20	Approved	[1]
Blastomycosis	DISJ3EYJ	1F22	Approved	[1]
Oral candidiasis	DISAVKAH	1F23.0	Approved	[1]
Coccidioidomycosis	DISJ5NW7	1F25	Approved	[1]
Fungal infection	DISGGVL1	1F29-1F2F	Approved	[2]
Leishmaniasis	DISABTW7	1F54	Approved	[1]
Bronchitis	DISBM6EQ	CA20	Approved	[1]
Pneumonia	DIS8EF3M	CA40	Approved	[1]
Acne vulgaris	DISKW8PI	ED80	Approved	[1]
Urinary tract infection	DISMT6UV	GC08	Approved	[1]

1 Withdrawn Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Fungal meningitis	DISZVFGU	N.A.	Withdrawn	[3]

2 Discontinued in Phase 2 Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Gonorrhea	DISQ5AO6	1A7Z	Discontinued in Phase 2	[4]
Pharyngitis	DISSN548	CA02.Z	Discontinued in Phase 2	[5]

1 Discontinued in Phase 1 Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Granuloma inguinale	DISRKXBH	N.A.	Discontinued in Phase 1	[6]

4 Investigative Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Esophageal candidiasis	DISV4PM2	N.A.	Investigative	[1]
Mycoses	DIS9K7PB	1F2Z	Investigative	[7]
Sinusitis	DISX5NCF	CA0A.Z	Investigative	[1]
Pelvic inflammatory disease	DISWQR4J	GA05	Investigative	[1]

References

• [1] Amphotericin B FDA Label
• [2] FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 050724.
• [3] ClinicalTrials.gov (NCT01763541) Study of the Effect of Testosterone and Estradiol on NP Responses to Acute and Chronic Salt Loading
• [4] Lenalidomide With or Without Rituximab in Treating Patients With Progressive or Relapsed Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Prolymphocytic Leukemia, or Non-Hodgkin Lymphoma Previously Treated With Donor Stem Cell Transplant
• [5] ELB245 for 12 Weeks Versus 4mg Tolterodine in Patients With Incontinent Overactive Bladder (OAB)
• [6] Photodynamic Therapy Using Aminolevulinic Acid in Treating Patients With Oral Leukoplakia
• [7] The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.