Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM3P5DA)

• Drug Name: Rofecoxib Drug Info
• Synonyms: Ceoxx; Refecoxib; Vioxx; Cahill May Roberts brand of rofecoxib; MSD brand of rofecoxib; Merck Frosst brandof rofecoxib; Merck brand of rofecoxib; Vioxx Dolor; MK 0966; MK 0996; MK 966; MK0966; Ceeoxx (TN); Ceoxx (TN); KS-1107; MK-0966; MK-966; Merck Sharp & Dhome brand of rofecoxib; Vioxx (TN); Vioxx (trademark); Rofecoxib (JAN/USAN/INN); 3-(4-methylsulfonylphenyl)-4-phenyl-2H-furan-5-one; 3-Phenyl-4-(4-(methylsulfonyl)phenyl))-2(5H)-furanone; 3-phenyl-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone; 4-(4-(Methylsulfonyl)phenyl)-3-phenyl-2(5H)-furanone; 4-(4-methylsulfonylphenyl)-3-phenyl-5H-furan-2-one; 4-(p-(Methylsulfonyl)phenyl)-3-phenyl-2(5H)-furanone; 4-[4-(methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone; 4-[4-(methylsulfonyl)phenyl]-3-phenylfuran-2(5H)-one

Indication

Disease Entry	ICD 11	Status	REF
Osteoarthritis	FA00-FA05	Approved	[1]

• Therapeutic Class: Antiinflammatory Agents
• Cross-matching ID:
  PubChem CID: 5090
  ChEBI ID: CHEBI:8887
  CAS Number: CAS 162011-90-7
  TTD Drug ID: DM3P5DA
  VARIDT Drug ID: DR00753
  INTEDE Drug ID: DR1433

Molecule-Related Drug Atlas

Drug(s) Targeting Prostaglandin G/H synthase 2 (COX-2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[8]
Naproxen	DMZ5RGV	Bursitis		Approved	[9]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[10]
Indomethacin	DMSC4A7	Bursitis		Approved	[11]
Celecoxib	DM6LOQU	Dysmenorrhea	GA34.3	Approved	[12]
Nabumetone	DMAT2XH	Osteoarthritis	FA00-FA05	Approved	[13]
Flurbiprofen	DMGN4BY	Osteoarthritis	FA00-FA05	Approved	[14]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[15]
Aminosalicylic Acid	DMENSL5	Crohn disease	DD70	Approved	[11]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[16]

Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[17]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[18]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[19]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[20]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[21]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[22]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[23]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[24]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[18]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[3]

Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[25]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[26]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[27]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[28]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[29]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[30]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[23]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[31]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[32]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[33]
Zolmitriptan	DM1IB4Q	Migraine	8A80	Approved	[49]
Etoricoxib	DM6A4NW	Rheumatoid arthritis	FA20	Approved	[49]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[50]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[51]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[52]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[53]
Zileuton	DMVRIC2	Allergic asthma	CA23.0	Approved	[54]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[55]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[56]
Caffeine	DMKBJWP	Allergic rhinitis	CA08.0	Approved	[57]

Drug(s) Metabolized By Cytochrome P450 2C8 (CYP2C8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[25]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[6]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[6]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[34]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[35]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[36]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[37]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[6]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[38]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[39]

Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[40]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[41]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[42]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[34]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[43]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[34]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[44]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[45]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]

Drug(s) Metabolized By Prostaglandin G/H synthase 1 (COX-1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[3]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[3]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[3]
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[3]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Nateglinide	DMLK2QH	Diabetic complication	5A2Y	Approved	[3]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[3]
Ketobemidone	DMM3L6Z	Pain	MG30-MG3Z	Approved	[3]
Irbesartan	DMTP1DC	Diabetic kidney disease	GB61.Z	Approved	[3]

Drug(s) Affected By Prostaglandin G/H synthase 1 (PTGS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[58]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[59]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[60]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[61]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Bupivacaine	DM4PRFC	Anaesthesia	9A78.6	Approved	[64]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[63]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[65]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[66]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[67]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[68]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[69]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[70]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[59]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[71]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[72]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[73]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[74]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[75]

Drug(s) Affected By Stearoyl-CoA desaturase (SCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[76]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[77]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[77]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[79]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[77]
Fructose	DM43AN2	Vomiting	MD90	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[82]

Drug(s) Affected By Suppressor of cytokine signaling 3 (SOCS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[73]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[83]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[84]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[85]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Fedratinib	DM4ZBK6	Myelofibrosis	2A20.2	Approved	[86]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[65]
Pyrimethamine	DM5X7VY	Malaria	1F40-1F45	Approved	[86]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[7]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[87]

Drug(s) Affected By Ephrin type-B receptor 6 (EPHB6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[88]
Selenium	DM25CGV	N. A.	N. A.	Approved	[89]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[91]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[7]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[93]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[94]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[95]

Drug(s) Affected By Polyunsaturated fatty acid lipoxygenase ALOX15B (ALOX15B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[96]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[91]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[91]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[97]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[98]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[99]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[100]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[101]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[102]

Drug(s) Affected By Tetraspanin-2 (TSPAN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[105]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[108]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[109]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[99]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[110]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[101]

Drug(s) Affected By SH2 domain-containing protein 1A (SH2D1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[111]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[112]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[101]

Drug(s) Affected By Filamin-B (FLNB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[113]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[65]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[114]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[105]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[115]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[116]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[117]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[118]

Drug(s) Affected By Annexin A9 (ANXA9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[7]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[120]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[121]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[122]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[123]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[65]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[124]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[125]

Drug(s) Affected By Metastasis-associated protein MTA2 (MTA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[7]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[126]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[115]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[127]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[120]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[83]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[100]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[128]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[129]

Drug(s) Affected By Neurofascin (NFASC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[65]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[131]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[115]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[133]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[134]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[108]

Drug(s) Affected By Angiopoietin-related protein 1 (ANGPTL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[66]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[135]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[136]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[120]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[137]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[138]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[99]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[123]

Drug(s) Affected By Integrin beta-like protein 1 (ITGBL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[139]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[140]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[141]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[66]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[7]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[131]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[142]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[143]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[144]
PD-0325901	DM27D4J	Breast cancer	2C60-2C65	Phase 2	[145]

Drug(s) Affected By Alpha-1-antichymotrypsin (SERPINA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[146]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[147]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[148]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[146]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[146]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[146]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[63]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[146]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[149]

Drug(s) Affected By Complement C3 (C3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[73]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[96]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[152]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[153]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[7]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]

Drug(s) Affected By Transferrin receptor protein 1 (TFRC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[154]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[155]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[156]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[157]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[96]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[159]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[160]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[161]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[162]

Drug(s) Affected By Annexin A1 (ANXA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[163]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[65]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[164]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[165]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[166]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[167]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[7]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[168]
Selenium	DM25CGV	N. A.	N. A.	Approved	[169]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[170]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[171]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[172]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[173]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[174]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[175]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[170]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[170]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[177]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[178]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[179]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[180]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[181]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[147]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[182]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[183]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[170]

Drug(s) Affected By Growth-regulated alpha protein (CXCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[178]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Selenium	DM25CGV	N. A.	N. A.	Approved	[169]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[84]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[184]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[170]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[63]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[185]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[186]

Drug(s) Affected By Clusterin (CLU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[187]
Selenium	DM25CGV	N. A.	N. A.	Approved	[89]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[187]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[65]
Levamisole	DM5EN79	Parasitic infection	1D0Y-1G2Z	Approved	[188]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[164]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[189]
Methazolamide	DM7J2TA	Glaucoma/ocular hypertension	9C61	Approved	[187]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[7]

Drug(s) Affected By Annexin A3 (ANXA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[140]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[65]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[165]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[91]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[7]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[91]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[180]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[73]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[190]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[147]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[191]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[192]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[193]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[194]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[195]

Drug(s) Affected By Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[83]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[96]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[189]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[7]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[131]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[196]

Drug(s) Affected By Hepatocyte growth factor (HGF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[197]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[198]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[199]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[199]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[200]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[201]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[202]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[203]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[204]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[201]

Drug(s) Affected By Phospholipase A2, membrane associated (PLA2G2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[205]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[65]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[7]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[105]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[136]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[206]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[207]

Drug(s) Affected By Fatty acid-binding protein, adipocyte (FABP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[208]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[209]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[7]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[210]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[211]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[212]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[213]

Drug(s) Affected By 15-hydroxyprostaglandin dehydrogenase (HPGD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[214]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[91]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[215]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[105]
Flurbiprofen	DMGN4BY	Osteoarthritis	FA00-FA05	Approved	[215]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[216]

Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[217]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[218]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[219]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[220]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[221]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[222]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[223]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[171]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[224]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]

Drug(s) Affected By Interleukin-1 receptor antagonist protein (IL1RN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[170]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[170]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[214]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[225]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[226]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[227]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[115]

Drug(s) Affected By Cadherin-2 (CDH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[197]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[228]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[65]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[229]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[230]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[231]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[232]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[233]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]

Drug(s) Affected By Atrial natriuretic peptide receptor 2 (NPR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[133]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[234]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[137]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[109]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[123]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[235]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[236]

Drug(s) Affected By Ras GTPase-activating protein 1 (RASA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[189]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[109]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[115]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[237]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[133]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[238]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[239]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[240]

Drug(s) Affected By Myelin and lymphocyte protein (MAL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[7]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[109]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[241]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[242]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[243]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[244]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[137]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[245]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[246]

Drug(s) Affected By Cadherin-3 (CDH3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[197]
Selenium	DM25CGV	N. A.	N. A.	Approved	[89]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[65]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[186]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[7]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[131]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[247]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[248]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[249]

Drug(s) Affected By Trans-acting T-cell-specific transcription factor GATA-3 (GATA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[83]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[250]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[251]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[65]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[252]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[131]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[253]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[242]

Drug(s) Affected By Tenascin (TNC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[254]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[255]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[7]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[256]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[257]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[58]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[258]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[259]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[133]

Drug(s) Affected By Ephrin type-A receptor 3 (EPHA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[105]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[196]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[133]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[143]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[143]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[137]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[260]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[99]

Drug(s) Affected By Nitric oxide synthase 1 (NOS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[261]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[262]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[263]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[7]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[264]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[249]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[265]
Bortezomib	DMNO38U	Leukemia		Approved	[266]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[267]
Interferon gamma-1b	DMWUMRL	Chronic granulomatous disease	4A00.0Y	Approved	[56]

Drug(s) Affected By Protein PML (PML)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[89]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[268]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[7]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[115]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[249]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[269]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[269]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]

Drug(s) Affected By Signal transducer and activator of transcription 3 (STAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[56]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[270]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[71]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[271]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[272]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[273]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[84]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[274]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[275]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[276]

Drug(s) Affected By ETS translocation variant 5 (ETV5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[277]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[105]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[241]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[120]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[94]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[278]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[279]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[280]

Drug(s) Affected By Phosphatidylinositol 4-kinase alpha (PI4KA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[88]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[281]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[282]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[283]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[135]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[94]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[134]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[236]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[277]

Drug(s) Affected By Leukemia inhibitory factor receptor (LIFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[65]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[91]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[105]
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[284]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[285]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[286]

Drug(s) Affected By Prostaglandin E2 receptor EP3 subtype (PTGER3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[7]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[105]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[136]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[287]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[137]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[288]
Terbinafine	DMI6HUW	Fungal infection	1F29-1F2F	Approved	[289]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[287]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[290]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[291]

Drug(s) Affected By Homeobox protein MOX-2 (MEOX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[292]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[293]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[294]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[101]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[88]

Drug(s) Affected By Nuclear receptor ROR-gamma (RORC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[85]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[131]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[142]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[295]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[296]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[278]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[92]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[297]

Drug(s) Affected By Cysteine-rich secretory protein 3 (CRISP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[247]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[298]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[299]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[279]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[138]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[298]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[101]

Drug(s) Affected By Paired mesoderm homeobox protein 1 (PRRX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[300]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[301]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[105]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[133]
Indomethacin	DMSC4A7	Bursitis		Approved	[302]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[303]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[302]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[143]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[137]

Drug(s) Affected By Afadin (AFDN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[131]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[135]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[115]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[120]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[134]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[65]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[304]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[110]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[101]

Drug(s) Affected By Fractalkine (CX3CL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[79]
Fructose	DM43AN2	Vomiting	MD90	Approved	[305]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[255]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[65]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[306]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[7]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[135]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[216]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[307]

Drug(s) Affected By Insulinoma-associated protein 1 (INSM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[200]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[7]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[105]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[293]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[308]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[101]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[196]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[309]
paraquat	DMR8O3X	Discovery agent	N.A.	Investigative	[310]

Drug(s) Affected By Collagen alpha-1(XIV) chain (COL14A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[89]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[96]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[65]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[311]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[312]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[313]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[105]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[314]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[142]

Drug(s) Affected By MBT domain-containing protein 1 (MBTD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[227]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[135]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[94]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[278]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[137]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[315]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[316]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[101]

Drug(s) Affected By Aldehyde oxidase (AOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[84]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[79]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[170]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[317]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[65]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[106]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[133]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[136]

Drug(s) Affected By Myocyte-specific enhancer factor 2C (MEF2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[255]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[96]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[65]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[318]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[133]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[111]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[319]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[121]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[134]

Drug(s) Affected By Desmocollin-1 (DSC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[63]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[91]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[7]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[91]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[320]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[63]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[293]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[321]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[298]

Drug(s) Affected By Periostin (POSTN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[89]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[66]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[115]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[322]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[136]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[323]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[278]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[143]

Drug(s) Affected By Angiopoietin-1 (ANGPT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[324]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[83]
Selenium	DM25CGV	N. A.	N. A.	Approved	[89]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[325]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[326]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[65]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[311]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[313]

Drug(s) Affected By Corneodesmosin (CDSN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[165]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[7]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[121]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[303]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[102]

Drug(s) Affected By Microtubule-associated protein RP/EB family member 2 (MAPRE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[7]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[217]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[217]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[105]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[115]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[123]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[101]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[277]
Okadaic acid	DM47CO1	Discovery agent	N.A.	Investigative	[327]

Drug(s) Affected By Transcriptional enhancer factor TEF-3 (TEAD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[328]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[255]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[91]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[91]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[257]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[196]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[328]

Drug(s) Affected By Forkhead box protein D1 (FOXD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[178]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[133]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[329]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[244]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[109]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[245]

Drug(s) Affected By Rho GTPase-activating protein 29 (ARHGAP29)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[83]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[140]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[277]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[115]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[93]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[120]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[330]

Drug(s) Affected By Inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2 (NAALADL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[331]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[332]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[129]

Drug(s) Affected By Collectin-12 (COLEC12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[65]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[91]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[105]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[170]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[170]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[293]

Drug(s) Affected By Adhesion G-protein coupled receptor F1 (ADGRF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[259]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[120]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[303]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[332]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[101]
QUERCITRIN	DM1DH96	Discovery agent	N.A.	Investigative	[333]
CH-223191	DMMJZYC	Solid tumour/cancer	2A00-2F9Z	Investigative	[334]

Drug(s) Affected By E3 ubiquitin-protein ligase RNF144B (RNF144B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[65]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[105]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[259]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[292]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]
Indomethacin	DMSC4A7	Bursitis		Approved	[335]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[303]

Drug(s) Affected By Adhesion G-protein coupled receptor G6 (ADGRG6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[135]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[105]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[120]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[278]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[279]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[336]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[337]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[109]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[99]

Drug(s) Affected By Neuronal PAS domain-containing protein 3 (NPAS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[88]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[338]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[339]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[246]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[101]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[88]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[338]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[340]

Drug(s) Affected By Voltage-dependent calcium channel subunit alpha-2/delta-3 (CACNA2D3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[88]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[7]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[109]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[259]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[341]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[129]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[88]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[309]

Drug(s) Affected By LIM homeobox transcription factor 1-alpha (LMX1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[311]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[109]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[65]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[342]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[101]
NAPQI	DM8F5LR	Autoimmune disease	4A40-4A45	Investigative	[342]

Drug(s) Affected By Secreted frizzled-related protein 3 (FRZB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[65]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[7]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[313]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[247]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[142]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[343]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[136]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[246]

Drug(s) Affected By Protein lifeguard 2 (FAIM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[261]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[344]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[345]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[345]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[332]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[101]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[102]
4-[1-(4-hydroxyphenyl)-2-phenylbut-1-enyl]phenol	DMTMLXU	Discovery agent	N.A.	Investigative	[345]

Drug(s) Affected By Transmembrane protease serine 4 (TMPRSS4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[7]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[247]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[246]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[279]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[246]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[101]

Drug(s) Affected By FAS-associated factor 1 (FAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[88]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[115]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[249]
Bortezomib	DMNO38U	Leukemia		Approved	[346]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[117]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[83]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[123]

Drug(s) Affected By A disintegrin and metalloproteinase with thrombospondin motifs 8 (ADAMTS8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[7]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[207]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[207]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[293]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[144]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[137]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[99]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[332]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[101]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[88]

Drug(s) Affected By Krueppel-like factor 12 (KLF12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[169]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[255]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[186]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[309]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[133]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[292]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[121]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[134]

Drug(s) Affected By E3 ubiquitin-protein ligase TRIM17 (TRIM17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[101]

Drug(s) Affected By Prostacyclin synthase (PTGIS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[131]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[106]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[65]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[332]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[101]
NAFAZATROM	DM31CV2	N. A.	N. A.	Terminated	[56]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[347]

Drug(s) Affected By Tissue-type plasminogen activator (PLAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[348]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[349]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[350]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[351]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[352]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[79]
Fructose	DM43AN2	Vomiting	MD90	Approved	[305]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[63]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[353]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[354]
Fructose	DM43AN2	Vomiting	MD90	Approved	[56]
Ketoprofen	DMRKXPT	Bursitis		Approved	[56]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[355]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[356]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[357]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[358]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[359]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[147]

Drug(s) Affected By Interleukin-1 alpha (IL1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[178]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[74]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[74]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[147]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[74]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[360]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[74]

Drug(s) Affected By Interstitial collagenase (MMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[361]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[362]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[363]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[364]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[351]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[365]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[366]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[367]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[200]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[165]

Drug(s) Affected By Antileukoproteinase (SLPI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[74]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[74]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[83]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[74]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[74]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[74]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[74]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[74]

Drug(s) Affected By Stromelysin-1 (MMP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[56]
Fluvastatin	DM4MDJY	Arteriosclerosis	BD40	Approved	[56]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[56]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[56]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[270]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[364]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[368]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[369]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[370]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[371]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[372]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[179]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[373]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[181]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[74]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[220]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[374]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[74]

Drug(s) Affected By Protachykinin-1 (TAC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[375]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[147]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[376]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[65]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[105]
Nizatidine	DMGFV3Z	Acid-reflux disorder	DA22	Approved	[375]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[377]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[320]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[303]

Drug(s) Affected By Metalloproteinase inhibitor 3 (TIMP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[378]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[379]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[351]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[96]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[380]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[227]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[313]

Drug(s) Affected By Major histocompatibility complex class I-related gene protein (MR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[381]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[381]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[382]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[381]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[381]
Repaglinide	DM5SXUV	Diabetic complication	5A2Y	Approved	[381]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[164]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Prostaglandin G/H synthase 2 (COX-2)	TTVKILB	PGH2_HUMAN	Inhibitor	[2]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Substrate	[3]
Cytochrome P450 2C9 (CYP2C9)	DE5IED8	CP2C9_HUMAN	Substrate	[4]
Cytochrome P450 1A2 (CYP1A2)	DEJGDUW	CP1A2_HUMAN	Substrate	[5]
Cytochrome P450 2C8 (CYP2C8)	DES5XRU	CP2C8_HUMAN	Substrate	[6]
Prostaglandin G/H synthase 1 (COX-1)	DE073H6	PGH1_HUMAN	Substrate	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
15-hydroxyprostaglandin dehydrogenase (HPGD)	OTYZI6JB	PGDH_HUMAN	Gene/Protein Processing	[7]
A disintegrin and metalloproteinase with thrombospondin motifs 8 (ADAMTS8)	OT2KFY1S	ATS8_HUMAN	Gene/Protein Processing	[7]
Adhesion G-protein coupled receptor F1 (ADGRF1)	OTRAOBYH	AGRF1_HUMAN	Gene/Protein Processing	[7]
Adhesion G-protein coupled receptor G6 (ADGRG6)	OTY2UBXO	AGRG6_HUMAN	Gene/Protein Processing	[7]
Afadin (AFDN)	OTTRU341	AFAD_HUMAN	Gene/Protein Processing	[7]
Aldehyde oxidase (AOX1)	OT2FZP6H	AOXA_HUMAN	Gene/Protein Processing	[7]
Alpha-1-antichymotrypsin (SERPINA3)	OT9BP2S0	AACT_HUMAN	Gene/Protein Processing	[7]
Angiopoietin-1 (ANGPT1)	OTVZ1NG3	ANGP1_HUMAN	Gene/Protein Processing	[7]
Angiopoietin-related protein 1 (ANGPTL1)	OTXIN6V5	ANGL1_HUMAN	Gene/Protein Processing	[7]
Annexin A1 (ANXA1)	OT5OFDJC	ANXA1_HUMAN	Gene/Protein Processing	[7]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2893).
• [2] Privileged structures: a useful concept for the rational design of new lead drug candidates. Mini Rev Med Chem. 2007 Nov;7(11):1108-19.
• [3] Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
• [4] Impact of CYP2C9 genotype on pharmacokinetics: are all cyclooxygenase inhibitors the same? Drug Metab Dispos. 2005 Nov;33(11):1567-75.
• [5] Rofecoxib is a potent inhibitor of cytochrome P450 1A2: studies with tizanidine and caffeine in healthy subjects. Br J Clin Pharmacol. 2006 Sep;62(3):345-57.
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