Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM3P5DA)

• Drug Name: Rofecoxib Drug Info
• Synonyms: Ceoxx; Refecoxib; Vioxx; Cahill May Roberts brand of rofecoxib; MSD brand of rofecoxib; Merck Frosst brandof rofecoxib; Merck brand of rofecoxib; Vioxx Dolor; MK 0966; MK 0996; MK 966; MK0966; Ceeoxx (TN); Ceoxx (TN); KS-1107; MK-0966; MK-966; Merck Sharp & Dhome brand of rofecoxib; Vioxx (TN); Vioxx (trademark); Rofecoxib (JAN/USAN/INN); 3-(4-methylsulfonylphenyl)-4-phenyl-2H-furan-5-one; 3-Phenyl-4-(4-(methylsulfonyl)phenyl))-2(5H)-furanone; 3-phenyl-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone; 4-(4-(Methylsulfonyl)phenyl)-3-phenyl-2(5H)-furanone; 4-(4-methylsulfonylphenyl)-3-phenyl-5H-furan-2-one; 4-(p-(Methylsulfonyl)phenyl)-3-phenyl-2(5H)-furanone; 4-[4-(methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone; 4-[4-(methylsulfonyl)phenyl]-3-phenylfuran-2(5H)-one

Indication

Disease Entry	ICD 11	Status	REF
Osteoarthritis	FA00-FA05	Approved	[1]

• Therapeutic Class: Antiinflammatory Agents
• Cross-matching ID:
  PubChem CID: 5090
  ChEBI ID: CHEMBL122
  CAS Number: CAS 162011-90-7
  TTD Drug ID: DM3P5DA
  VARIDT Drug ID: DR00753
  INTEDE Drug ID: DR1433

Molecule-Related Drug Atlas

Drug(s) Targeting Prostaglandin G/H synthase 2 (COX-2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[8]
Naproxen	DMZ5RGV	Bursitis		Approved	[9]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[10]
Indomethacin	DMSC4A7	Bursitis		Approved	[11]
Celecoxib	DM6LOQU	Dysmenorrhea	GA34.3	Approved	[12]
Nabumetone	DMAT2XH	Osteoarthritis	FA00-FA05	Approved	[13]
Flurbiprofen	DMGN4BY	Osteoarthritis	FA00-FA05	Approved	[14]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[15]
Aminosalicylic Acid	DMENSL5	Crohn disease	DD70	Approved	[11]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[16]

Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[17]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[18]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[19]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[20]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[21]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[22]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[23]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[24]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[18]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[3]

Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[25]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[26]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[27]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[28]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[29]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[30]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[23]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[31]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[32]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[33]

Drug(s) Metabolized By Cytochrome P450 2C8 (CYP2C8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[25]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[6]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[6]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[34]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[35]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[36]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[37]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[6]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[38]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[39]

Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[40]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[41]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[42]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[34]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[43]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[34]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[44]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[45]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]

Drug(s) Metabolized By Prostaglandin G/H synthase 1 (COX-1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[3]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[3]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[3]
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[3]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Nateglinide	DMLK2QH	Diabetic complication	5A2Y	Approved	[3]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[3]
Ketobemidone	DMM3L6Z	Pain	MG30-MG3Z	Approved	[3]
Irbesartan	DMTP1DC	Diabetic kidney disease	GB61.Z	Approved	[3]

Drug(s) Affected By Stearoyl-CoA desaturase (SCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[49]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[50]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[50]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[50]
Fructose	DM43AN2	Vomiting	MD90	Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[50]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[55]

Drug(s) Affected By Polyunsaturated fatty acid lipoxygenase ALOX15B (ALOX15B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[56]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[58]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[59]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[60]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[61]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[62]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[63]

Drug(s) Affected By Tetraspanin-2 (TSPAN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[67]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[68]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[69]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[70]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[60]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[71]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[62]

Drug(s) Affected By SH2 domain-containing protein 1A (SH2D1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[72]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[73]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[62]

Drug(s) Affected By Filamin-B (FLNB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[75]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[76]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[77]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[79]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[80]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[81]

Drug(s) Affected By Annexin A9 (ANXA9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[7]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[77]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[83]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[84]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[85]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[86]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[75]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[87]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[88]

Drug(s) Affected By Metastasis-associated protein MTA2 (MTA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[7]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[90]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[83]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[68]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[91]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[61]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[92]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[93]

Drug(s) Affected By Neurofascin (NFASC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[75]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[68]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[98]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[69]

Drug(s) Affected By Angiopoietin-related protein 1 (ANGPTL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[99]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[101]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[83]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[102]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[103]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[60]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[86]

Drug(s) Affected By Integrin beta-like protein 1 (ITGBL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[104]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[105]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[106]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[99]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[7]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[95]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[107]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[108]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[109]
PD-0325901	DM27D4J	Breast cancer	2C60-2C65	Phase 2	[110]

Drug(s) Affected By Alpha-1-antichymotrypsin (SERPINA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[111]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[112]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[113]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[111]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[111]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[111]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[114]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[111]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[115]

Drug(s) Affected By Annexin A1 (ANXA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[117]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[75]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[118]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[119]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[120]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[121]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[7]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[77]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[122]
Selenium	DM25CGV	N. A.	N. A.	Approved	[123]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[124]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[125]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[126]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[127]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[128]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[129]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[124]

Drug(s) Affected By Growth-regulated alpha protein (CXCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[131]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[132]
Selenium	DM25CGV	N. A.	N. A.	Approved	[123]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[133]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[134]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[124]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[114]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[135]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[136]

Drug(s) Affected By Annexin A3 (ANXA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[105]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[75]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[119]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[7]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[137]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[138]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[139]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[112]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[140]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[141]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[142]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]

Drug(s) Affected By Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[91]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[117]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[56]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[145]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[7]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[95]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[77]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[146]

Drug(s) Affected By Phospholipase A2, membrane associated (PLA2G2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[147]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[75]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[7]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[77]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[101]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[148]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[149]

Drug(s) Affected By Fatty acid-binding protein, adipocyte (FABP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[150]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[151]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[152]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[7]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[77]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[153]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[154]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[155]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[156]

Drug(s) Affected By 15-hydroxyprostaglandin dehydrogenase (HPGD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[157]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[158]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[77]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Flurbiprofen	DMGN4BY	Osteoarthritis	FA00-FA05	Approved	[158]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[159]

Drug(s) Affected By Cadherin-2 (CDH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[160]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[75]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[162]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[163]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[164]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[165]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[77]

Drug(s) Affected By Ras GTPase-activating protein 1 (RASA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[145]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[70]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[167]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[168]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[169]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[170]

Drug(s) Affected By Myelin and lymphocyte protein (MAL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[117]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[7]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[70]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[171]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[172]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[173]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[174]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[102]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[175]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[176]

Drug(s) Affected By Cadherin-3 (CDH3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[160]
Selenium	DM25CGV	N. A.	N. A.	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[75]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[136]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[7]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[95]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[179]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[180]

Drug(s) Affected By Trans-acting T-cell-specific transcription factor GATA-3 (GATA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[91]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[181]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[182]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[75]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[183]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[95]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[184]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[172]

Drug(s) Affected By Protein PML (PML)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[177]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[185]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[7]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[180]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[186]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[186]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[68]

Drug(s) Affected By ETS translocation variant 5 (ETV5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[187]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[151]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[77]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[171]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[83]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[188]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[189]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[190]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[191]

Drug(s) Affected By Homeobox protein MOX-2 (MEOX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[192]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[193]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[194]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[62]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[195]

Drug(s) Affected By Cysteine-rich secretory protein 3 (CRISP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[196]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[197]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[190]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[103]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[196]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[62]

Drug(s) Affected By Paired mesoderm homeobox protein 1 (PRRX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[198]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[199]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Indomethacin	DMSC4A7	Bursitis		Approved	[200]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[201]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[200]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[108]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[102]

Drug(s) Affected By Afadin (AFDN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[83]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[98]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[75]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[202]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[71]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[62]

Drug(s) Affected By Insulinoma-associated protein 1 (INSM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[203]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[7]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[193]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[204]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[62]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[146]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[205]
paraquat	DMR8O3X	Discovery agent	N.A.	Investigative	[206]

Drug(s) Affected By Collagen alpha-1(XIV) chain (COL14A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[56]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[75]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[208]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[209]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[210]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[107]

Drug(s) Affected By MBT domain-containing protein 1 (MBTD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[211]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[188]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[189]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[102]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[212]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[213]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[62]

Drug(s) Affected By Myocyte-specific enhancer factor 2C (MEF2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[56]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[77]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[215]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[72]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[216]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[84]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[98]

Drug(s) Affected By Desmocollin-1 (DSC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[114]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[7]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[217]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[114]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[193]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[218]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[196]

Drug(s) Affected By Corneodesmosin (CDSN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[119]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[7]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[68]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[84]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[201]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[63]

Drug(s) Affected By Microtubule-associated protein RP/EB family member 2 (MAPRE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[7]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[219]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[219]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[77]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[86]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[62]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[187]
Okadaic acid	DM47CO1	Discovery agent	N.A.	Investigative	[220]

Drug(s) Affected By Transcriptional enhancer factor TEF-3 (TEAD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[221]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[222]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[146]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[68]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[221]

Drug(s) Affected By Forkhead box protein D1 (FOXD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[131]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[56]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[223]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[68]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[174]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[70]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[175]

Drug(s) Affected By Rho GTPase-activating protein 29 (ARHGAP29)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[91]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[105]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[187]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[224]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[83]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[225]

Drug(s) Affected By Inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2 (NAALADL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[226]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[227]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[93]

Drug(s) Affected By Collectin-12 (COLEC12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[75]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[124]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[124]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[193]

Drug(s) Affected By Adhesion G-protein coupled receptor F1 (ADGRF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[117]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[228]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[83]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[201]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[227]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[62]
QUERCITRIN	DM1DH96	Discovery agent	N.A.	Investigative	[229]
CH-223191	DMMJZYC	Solid tumour/cancer	2A00-2F9Z	Investigative	[230]

Drug(s) Affected By E3 ubiquitin-protein ligase RNF144B (RNF144B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[75]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[228]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[192]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[68]
Indomethacin	DMSC4A7	Bursitis		Approved	[231]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[201]

Drug(s) Affected By Adhesion G-protein coupled receptor G6 (ADGRG6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[83]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[189]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[190]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[232]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[233]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[70]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[60]

Drug(s) Affected By Neuronal PAS domain-containing protein 3 (NPAS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[195]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[234]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[235]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[176]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[62]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[195]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[234]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[236]

Drug(s) Affected By Voltage-dependent calcium channel subunit alpha-2/delta-3 (CACNA2D3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[195]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[7]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[70]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[228]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[237]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[93]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[195]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[205]

Drug(s) Affected By LIM homeobox transcription factor 1-alpha (LMX1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[207]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[70]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[75]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[238]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[62]
NAPQI	DM8F5LR	Autoimmune disease	4A40-4A45	Investigative	[238]

Drug(s) Affected By Secreted frizzled-related protein 3 (FRZB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[75]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[7]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[209]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[107]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[239]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[101]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[176]

Drug(s) Affected By Protein lifeguard 2 (FAIM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[240]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[241]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[242]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[242]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[227]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[62]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[63]
4-[1-(4-hydroxyphenyl)-2-phenylbut-1-enyl]phenol	DMTMLXU	Discovery agent	N.A.	Investigative	[242]

Drug(s) Affected By Transmembrane protease serine 4 (TMPRSS4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[117]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[7]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[176]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[190]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[176]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[62]

Drug(s) Affected By A disintegrin and metalloproteinase with thrombospondin motifs 8 (ADAMTS8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[7]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[149]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[149]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[193]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[109]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[102]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[60]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[227]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[62]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[195]

Drug(s) Affected By Krueppel-like factor 12 (KLF12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[77]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[205]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[192]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[68]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[84]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[98]

Drug(s) Affected By E3 ubiquitin-protein ligase TRIM17 (TRIM17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[62]

Drug(s) Affected By Interstitial collagenase (MMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[243]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[244]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[245]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[246]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[247]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[248]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[249]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[250]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[203]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[119]

Drug(s) Affected By Antileukoproteinase (SLPI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[251]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[251]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[91]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[251]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[251]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[251]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[251]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[251]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[251]

Drug(s) Affected By Stromelysin-1 (MMP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[252]
Fluvastatin	DM4MDJY	Arteriosclerosis	BD40	Approved	[252]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[252]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[252]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[253]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[132]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[246]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[254]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[255]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[256]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[257]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[258]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[259]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[260]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[261]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[251]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[262]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[263]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[251]

Drug(s) Affected By Protachykinin-1 (TAC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[264]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[112]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[265]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[77]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Nizatidine	DMGFV3Z	Acid-reflux disorder	DA22	Approved	[264]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[266]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[217]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[201]

Drug(s) Affected By Metalloproteinase inhibitor 3 (TIMP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[267]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[268]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[247]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[269]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[211]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[77]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[209]

Drug(s) Affected By Major histocompatibility complex class I-related gene protein (MR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[270]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[270]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[271]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[270]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[270]
Repaglinide	DM5SXUV	Diabetic complication	5A2Y	Approved	[270]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[118]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[77]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Prostaglandin G/H synthase 2 (COX-2)	TTVKILB	PGH2_HUMAN	Inhibitor	[2]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Substrate	[3]
Cytochrome P450 2C9 (CYP2C9)	DE5IED8	CP2C9_HUMAN	Substrate	[4]
Cytochrome P450 1A2 (CYP1A2)	DEJGDUW	CP1A2_HUMAN	Substrate	[5]
Cytochrome P450 2C8 (CYP2C8)	DES5XRU	CP2C8_HUMAN	Substrate	[6]
Prostaglandin G/H synthase 1 (COX-1)	DE073H6	PGH1_HUMAN	Substrate	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
15-hydroxyprostaglandin dehydrogenase (HPGD)	OTYZI6JB	PGDH_HUMAN	Gene/Protein Processing	[7]
A disintegrin and metalloproteinase with thrombospondin motifs 8 (ADAMTS8)	OT2KFY1S	ATS8_HUMAN	Gene/Protein Processing	[7]
Adhesion G-protein coupled receptor F1 (ADGRF1)	OTRAOBYH	AGRF1_HUMAN	Gene/Protein Processing	[7]
Adhesion G-protein coupled receptor G6 (ADGRG6)	OTY2UBXO	AGRG6_HUMAN	Gene/Protein Processing	[7]
Afadin (AFDN)	OTTRU341	AFAD_HUMAN	Gene/Protein Processing	[7]
Alpha-1-antichymotrypsin (SERPINA3)	OT9BP2S0	AACT_HUMAN	Gene/Protein Processing	[7]
Angiopoietin-related protein 1 (ANGPTL1)	OTXIN6V5	ANGL1_HUMAN	Gene/Protein Processing	[7]
Annexin A1 (ANXA1)	OT5OFDJC	ANXA1_HUMAN	Gene/Protein Processing	[7]
Annexin A3 (ANXA3)	OTDD8OI7	ANXA3_HUMAN	Gene/Protein Processing	[7]
Annexin A9 (ANXA9)	OTKNYMU2	ANXA9_HUMAN	Gene/Protein Processing	[7]

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