Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM4ZLFD)

• Drug Name: Glucosamine Drug Info
• Synonyms: Chitosamine; GCS; Glucosamina; Glucosaminum; D-glucosamine; Glucosamina [INN-Spanish]; Glucosamine [USAN:INN]; Glucosaminum [INN-Latin]; Viartril-S; Beta-D-Glucosamine; Glucosamine (USAN/INN); Partially N-deacetylated poly-beta-1,6-N-acetyl-D-glucosamine; (2R,3R,4R,5S,6R)-3-amino-6-(hydroxymethyl)oxane-2,4,5-triol; (2S,5R)-3-amino-6-(hydroxymethyl)oxane-2,4,5-triol; (3R,4R,5S,6R)-3-amino-6-(hydroxymethyl)oxane-2,4,5-triol; 2-Amino-2-deoxy-D-glucose; 2-Amino-2-deoxy-beta-D-glucopyranose; 2-amino-2-deoxy-D-glucopyranose; 2-amino-2-deoxyglucose

Indication

Disease Entry	ICD 11	Status	REF
Osteoarthritis	FA00-FA05	Approved	[1]

• Therapeutic Class: Antiinflammatory Agents
• Cross-matching ID:
  PubChem CID: 439213
  ChEBI ID: CHEBI:47977
  CAS Number: CAS 3416-24-8
  TTD Drug ID: DM4ZLFD
  VARIDT Drug ID: DR00870
  INTEDE Drug ID: DR0781

Molecule-Related Drug Atlas

Drug(s) Targeting Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rilonacept	DMGLUQS	Arthritis	FA20	Approved	[11]
Gallium nitrate	DMF9O6B	Hypercalcaemia	5B91.0	Approved	[12]
Canakinumab	DM8HLO5	Autosomal dominant familial periodic fever		Approved	[13]
Diacerein	DMN2Q5I	N. A.	N. A.	Phase 4	[14]
XOMA 052	DMOKQV7	Type-2 diabetes	5A11	Phase 3	[15]
ABT-981	DM6PTIX	Osteoarthritis	FA00-FA05	Phase 2	[16]
AC-201	DMB0TNL	Type-2 diabetes	5A11	Phase 2	[17]
LY-2189102	DMU81BH	Cardiovascular disease	BA00-BE2Z	Phase 2	[18]
TT-301	DM4QV8Y	Alzheimer disease	8A20	Phase 1	[19]
CYT-013-IL1bQb	DMNICD4	Inflammation	1A00-CA43.1	Phase 1	[20]

Drug(s) Metabolized By Cytochrome P450 2E1 (CYP2E1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[21]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[22]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[23]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[24]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[25]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[26]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[27]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[28]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[29]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[30]

Drug(s) Metabolized By Mephenytoin 4-hydroxylase (CYP2C19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[31]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[32]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[33]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[34]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[27]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[35]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[38]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[39]

Drug(s) Affected By Rho-related GTP-binding protein RhoC (RHOC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[40]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[43]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[48]
Terbinafine	DMI6HUW	Fungal infection	1F29-1F2F	Approved	[49]

Drug(s) Affected By Chitinase-3-like protein 1 (CHI3L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[52]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[53]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[57]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[58]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[59]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[60]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[61]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[62]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[63]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[64]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[65]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[66]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[67]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[68]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]

Drug(s) Affected By Osteocalcin (BGLAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[71]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[73]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[74]
Falecalcitrol	DMBI9ZJ	Hyperparathyroidism	5A51	Approved	[75]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[76]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[77]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[78]

Drug(s) Affected By Alkaline phosphatase, tissue-nonspecific isozyme (ALPL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[79]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[80]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[81]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[84]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[75]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[85]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]

Drug(s) Affected By TGF-beta receptor type-1 (TGFBR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[86]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[87]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[88]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[89]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[90]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[90]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[93]

Drug(s) Affected By Runt-related transcription factor 2 (RUNX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[81]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[94]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[97]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[98]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[99]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[100]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[101]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[101]

Drug(s) Affected By Mothers against decapentaplegic homolog 2 (SMAD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[102]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[88]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[97]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[103]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[104]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[105]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[48]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[106]

Drug(s) Affected By Dentin sialophosphoprotein (DSPP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[81]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[107]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[108]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[109]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[110]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[111]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[112]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[113]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[114]
phenamil	DMJLUFM	Discovery agent	N.A.	Investigative	[108]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 11 (TNFSF11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[115]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[116]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[103]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[117]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[118]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[121]

Drug(s) Affected By Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[86]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[122]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[123]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[53]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[124]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[125]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[48]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[126]

Drug(s) Affected By Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[128]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[129]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[130]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[131]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[132]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[130]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]

Drug(s) Affected By Collagen alpha-1(I) chain (COL1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[79]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[81]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[87]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[134]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[135]
Ceruletide	DM2WE5K	Caerulein stimulated gastric and pancreatic secretion	5A4Y	Approved	[136]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[137]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[138]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[139]

Drug(s) Affected By Collagen alpha-1(II) chain (COL2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[140]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[141]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[142]
Indomethacin	DMSC4A7	Bursitis		Approved	[143]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[143]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[144]

Drug(s) Affected By Apolipoprotein A-I (APOA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[145]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[146]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[89]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[147]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[148]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[149]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[150]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[151]
Gemfibrozil	DMD8Q3J	Hyperlipidaemia	5C80	Approved	[152]

Drug(s) Affected By Apolipoprotein B-100 (APOB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[130]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[153]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[130]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[154]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[89]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[130]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[130]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[155]
Bendroflumethiazide	DM7EVLC	High blood pressure	BA00	Approved	[156]

Drug(s) Affected By Interleukin-4 (IL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[157]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[158]
Tolnaftate	DM28MU7	Dermatophytosis	1F28.2	Approved	[159]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[160]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[161]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[162]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[163]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[165]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[166]

Drug(s) Affected By Interleukin-5 (IL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[167]
Tolnaftate	DM28MU7	Dermatophytosis	1F28.2	Approved	[159]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[160]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[168]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[169]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[170]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[171]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[172]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[173]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[174]

Drug(s) Affected By Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[128]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[175]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[176]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[177]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[179]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[132]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[180]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[181]

Drug(s) Affected By Cathepsin D (CTSD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[182]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[183]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[184]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[97]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[186]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[48]

Drug(s) Affected By Stromelysin-1 (MMP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[79]
Fluvastatin	DM4MDJY	Arteriosclerosis	BD40	Approved	[79]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[79]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[79]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[187]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[188]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[189]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[190]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[191]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[192]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[193]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[194]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[195]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[196]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[197]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[198]
Selenium	DM25CGV	N. A.	N. A.	Approved	[199]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[200]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[201]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[203]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[204]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[206]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[207]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[208]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[207]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[209]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[210]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[211]

Drug(s) Affected By Furin (FURIN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[86]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[212]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[213]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[214]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[215]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[216]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[114]
KENPAULLONE	DMAGVXW	Discovery agent	N.A.	Patented	[217]

Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[218]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[130]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[219]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[220]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[221]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[222]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[223]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[224]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[225]

Drug(s) Affected By Cytochrome b-245 light chain (CYBA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[226]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[227]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[97]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[228]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[229]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[227]

Drug(s) Affected By Endoplasmin (HSP90B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[218]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[175]
Selenium	DM25CGV	N. A.	N. A.	Approved	[230]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[231]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[97]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[98]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[232]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[229]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[48]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 4 (SLC2A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[233]
Fructose	DM43AN2	Vomiting	MD90	Approved	[234]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[235]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[236]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[236]
Haloperidol	DM96SE0	Delirium		Approved	[237]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[239]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[240]
Mirtazapine	DML53ZJ	Depression	6A70-6A7Z	Approved	[237]

Drug(s) Affected By Aggrecan core protein (ACAN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[97]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[57]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[241]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[142]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[242]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[243]
Berberine	DMC5Q8X	N. A.	N. A.	Phase 4	[244]
Diacerein	DMN2Q5I	N. A.	N. A.	Phase 4	[245]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[97]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[246]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-4 (ATF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[128]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[247]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[248]
Selenium	DM25CGV	N. A.	N. A.	Approved	[230]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[249]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[132]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[250]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[251]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[252]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[212]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[130]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[253]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[132]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[250]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[130]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[254]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[255]

Drug(s) Affected By Ribosomal protein S6 kinase beta-1 (RPS6KB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[256]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[257]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[258]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[259]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[260]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[261]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[262]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[97]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[263]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[264]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[265]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[266]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[267]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[268]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[269]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[270]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[271]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[272]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[273]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[274]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[275]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[266]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[276]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[277]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[278]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[265]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[79]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[187]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[268]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[269]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[279]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[280]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[281]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[282]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[283]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[259]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[284]
Selenium	DM25CGV	N. A.	N. A.	Approved	[230]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[285]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[286]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[194]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[287]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[128]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[247]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[130]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[288]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[221]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[289]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[290]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[63]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[291]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[292]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[293]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[294]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[295]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[296]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[297]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[298]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[299]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[300]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[301]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[302]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[303]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[304]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[305]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[306]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[307]

Drug(s) Affected By Collagenase 3 (MMP13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[308]
Clindamycin	DM15HL8	Acne vulgaris	ED80	Approved	[309]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[308]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[310]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[311]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[312]
Doxycycline	DM7ICNU	Acne vulgaris	ED80	Approved	[309]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[313]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[314]
Prinomastat	DM9HOKG	Lung cancer	2C25.0	Approved	[315]

Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[316]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[317]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[318]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[198]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[319]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[320]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[180]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[319]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[321]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[322]

Drug(s) Affected By Fatty acid synthase (FASN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[323]
Selenium	DM25CGV	N. A.	N. A.	Approved	[230]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[285]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[130]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[324]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[325]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[89]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[326]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[327]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[328]

Drug(s) Affected By Glycogen synthase kinase-3 beta (GSK3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[218]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[329]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[330]
Selenium	DM25CGV	N. A.	N. A.	Approved	[230]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[331]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[332]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[320]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[333]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[334]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[335]

Drug(s) Affected By Serpin H1 (SERPINH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[334]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[336]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[48]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[337]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[338]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[59]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[214]

Drug(s) Affected By A disintegrin and metalloproteinase with thrombospondin motifs 20 (ADAMTS20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[77]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[339]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[340]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[112]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[341]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[342]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[246]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[343]

Drug(s) Affected By Proteasome activator complex subunit 3 (PSME3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[344]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[48]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[109]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[345]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[346]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[59]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[347]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[348]

Drug(s) Affected By Small ribosomal subunit protein eS6 (RPS6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[349]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[350]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[351]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[352]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[353]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[354]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[355]
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[279]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[356]

Drug(s) Affected By Cytochrome c (CYCS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[187]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[357]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[204]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[358]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[219]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[359]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[360]
Pefloxacin	DM49IGF	Gonococcal urethritis	1A70.0Y	Approved	[361]

Drug(s) Affected By Myocyte-specific enhancer factor 2A (MEF2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[362]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[363]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[364]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[342]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[362]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[365]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[366]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[187]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[282]
Selenium	DM25CGV	N. A.	N. A.	Approved	[230]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[367]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[368]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[369]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[370]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[97]
Desloratadine	DM56YN7	Allergic rhinitis	CA08.0	Approved	[371]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[281]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[372]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[206]
Selenium	DM25CGV	N. A.	N. A.	Approved	[230]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[373]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[374]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[375]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[320]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[376]

Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[268]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[134]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[377]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[378]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[379]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[380]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[381]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[382]

Drug(s) Affected By Acetyl-CoA carboxylase 1 (ACACA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[257]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[183]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[130]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[380]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[89]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[328]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[235]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[51]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[383]

Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[384]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[385]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[386]
Triamterene	DM2HU9I	Congestive heart failure	BD10	Approved	[386]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[387]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[388]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[389]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[380]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[390]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[262]

Drug(s) Affected By Inositol polyphosphate 5-phosphatase K (INPP5K)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[230]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[391]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[48]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[392]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[366]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[230]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[393]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[394]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[395]

Drug(s) Affected By Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[128]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[130]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[153]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[130]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[396]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[130]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[132]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[251]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]

Drug(s) Affected By A disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAMTS9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[183]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[397]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[398]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[399]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[400]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[401]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[80]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[360]
Fructose	DM43AN2	Vomiting	MD90	Approved	[234]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[402]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[98]
Ketotifen	DM74XKS	Allergic conjunctivitis	9A60.02	Approved	[403]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[404]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[404]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]

Drug(s) Affected By A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[405]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[335]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[406]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[407]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[397]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[398]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[338]

Drug(s) Affected By A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[230]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[57]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[214]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[80]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[111]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[103]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[408]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Interleukin-1 beta (IL1B)	TTRYK0X	IL1B_HUMAN	Inhibitor	[2]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 2E1 (CYP2E1)	DEVDYN7	CP2E1_HUMAN	Substrate	[3]
Mephenytoin 4-hydroxylase (CYP2C19)	DEGTFWK	CP2CJ_HUMAN	Substrate	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1)	OTTLJH8W	ATS1_HUMAN	Gene/Protein Processing	[4]
A disintegrin and metalloproteinase with thrombospondin motifs 20 (ADAMTS20)	OTU0EKLN	ATS20_HUMAN	Protein Interaction/Cellular Processes	[5]
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5)	OT953SV2	ATS5_HUMAN	Gene/Protein Processing	[4]
A disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAMTS9)	OTV3Q0DS	ATS9_HUMAN	Protein Interaction/Cellular Processes	[5]
Acetyl-CoA carboxylase 1 (ACACA)	OT5CQPZY	ACACA_HUMAN	Gene/Protein Processing	[6]
Aggrecan core protein (ACAN)	OTUOCW8K	PGCA_HUMAN	Gene/Protein Processing	[4]
Alkaline phosphatase, tissue-nonspecific isozyme (ALPL)	OTG7J4BP	PPBT_HUMAN	Gene/Protein Processing	[7]
Apolipoprotein A-I (APOA1)	OT5THARI	APOA1_HUMAN	Protein Interaction/Cellular Processes	[8]
Apolipoprotein B-100 (APOB)	OTH0UOCZ	APOB_HUMAN	Gene/Protein Processing	[9]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Gene/Protein Processing	[10]

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